Page last updated: 2024-11-04

sotalol and Drug Overdose

sotalol has been researched along with Drug Overdose in 7 studies

Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"Torsade de pointes is a well-established toxic effect of sotalol hydrochloride."7.69Torsade de pointes and prolonged QT interval from surreptitious use of sotalol: use of drug levels in diagnosis. ( Estes, NA; Foote, CB; Homoud, MK; Link, MS; Sloan, SB; Wang, PJ, 1997)
" We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse."7.69Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997)
"Torsade de pointes is a polymorphic ventricular tachyarrhythmia associated with a long QT interval."6.40Torsade de pointes with sotalol overdose treated successfully with lidocaine. ( Assimes, TL; Malcolm, I, 1998)
"Torsade de pointes is a well-established toxic effect of sotalol hydrochloride."3.69Torsade de pointes and prolonged QT interval from surreptitious use of sotalol: use of drug levels in diagnosis. ( Estes, NA; Foote, CB; Homoud, MK; Link, MS; Sloan, SB; Wang, PJ, 1997)
" We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse."3.69Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997)
"Torsade de pointes is a polymorphic ventricular tachyarrhythmia associated with a long QT interval."2.40Torsade de pointes with sotalol overdose treated successfully with lidocaine. ( Assimes, TL; Malcolm, I, 1998)
"Sotalol is a beta-blocker with additional class III activity."2.38Class III antiarrhythmics in overdose. Presenting features and management principles. ( Holt, DW; Leatham, EW; McKenna, WJ, 1993)
"Propranolol was the only beta blocker associated with seizure; of those who ingested more than 2 g of propranolol, two thirds had a seizure."1.29Relative toxicity of beta blockers in overdose. ( Buckley, NA; Dawson, AH; Epid, D; Reith, DM; Sayer, GP; Whyte, IM, 1996)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (85.71)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lauterbach, M1
Lip, GY1
Ferner, RE1
Leatham, EW1
Holt, DW1
McKenna, WJ1
Reith, DM1
Dawson, AH1
Epid, D1
Whyte, IM1
Buckley, NA1
Sayer, GP1
Link, MS1
Foote, CB1
Sloan, SB1
Homoud, MK1
Wang, PJ1
Estes, NA1
Sandeman, DJ1
Alahakoon, TI1
Bentley, SC1
Assimes, TL1
Malcolm, I1

Reviews

3 reviews available for sotalol and Drug Overdose

ArticleYear
Poisoning with anti-hypertensive drugs: beta-adrenoceptor blocker drugs.
    Journal of human hypertension, 1995, Volume: 9, Issue:4

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cardiovascular System; Central Nervous System;

1995
Class III antiarrhythmics in overdose. Presenting features and management principles.
    Drug safety, 1993, Volume: 9, Issue:6

    Topics: Amiodarone; Anti-Arrhythmia Agents; Biological Availability; Bretylium Compounds; Drug Overdose; Hum

1993
Torsade de pointes with sotalol overdose treated successfully with lidocaine.
    The Canadian journal of cardiology, 1998, Volume: 14, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Follo

1998

Other Studies

4 other studies available for sotalol and Drug Overdose

ArticleYear
Response to Neuvonen et al: Sotalol, unlike the other beta-blockers, increases the QT
    Basic & clinical pharmacology & toxicology, 2019, Volume: 125, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Drug Overdose; Humans; Sotalol; Torsades

2019
Relative toxicity of beta blockers in overdose.
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:3

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child, Preschool; Databases, Factual

1996
Torsade de pointes and prolonged QT interval from surreptitious use of sotalol: use of drug levels in diagnosis.
    Chest, 1997, Volume: 112, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Female; Humans; Long QT Syndrome;

1997
Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine.
    Anaesthesia and intensive care, 1997, Volume: 25, Issue:5

    Topics: Adrenergic Agonists; Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Critical Care;

1997