sotalol has been researched along with Cleft Palate, Isolated in 1 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dosing on gestational day (GD) 11 was associated with right-sided oblique cleft lip and short tail, while dosing on day 13 caused digital hypoplasia and/or amputation." | 1.29 | Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity. ( Brown-Woodman, PD; Danielsson, BR; Snow, MD; Webster, WS, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Webster, WS | 1 |
| Brown-Woodman, PD | 1 |
| Snow, MD | 1 |
| Danielsson, BR | 1 |
1 other study available for sotalol and Cleft Palate, Isolated
| Article | Year |
|---|---|
Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Cleft Palate; Dose-Response Relationsh | 1996 |