sotalol has been researched along with Cardiomyopathy, Dilated in 13 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is limited experience on sotalol use in the management of childhood arrhythmias." | 7.71 | Sotalol in treatment of pediatric cardiac arrhythmias. ( Ayabakan, C; Celiker, A; Ozer, S; Ozme, S, 2001) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 5.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| "There is limited experience on sotalol use in the management of childhood arrhythmias." | 3.71 | Sotalol in treatment of pediatric cardiac arrhythmias. ( Ayabakan, C; Celiker, A; Ozer, S; Ozme, S, 2001) |
| " 1 and 2, atrial fibrillation was treated with either quinidine or quinidine and sotalol in combination." | 3.69 | Torsade de pointes complicating drug treatment of low-malignant forms of arrhythmia: four cases reports. ( Faber, TS; Hohnloser, S; Just, H; Van de Loo, A; Zehender, M, 1994) |
| "In 32 subjects, 10 with postischemic dilated cardiomyopathy, 12 with hypertensive cardiomyopathy, and 10 healthy, we assessed QT(c) and QT variability index (QTVI) after administration of fresh pink grapefruit juice, placebo, amiodarone, or sotalol." | 2.73 | Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects. ( Ghiselli, A; Magnanti, M; Magrì, D; Marigliano, V; Matera, S; Mitra, M; Paroli, M; Pasquazzi, E; Piccirillo, G; Schifano, E; Velitti, S, 2008) |
| "Ranolazine is a drug that exerts antianginal and antiischemic effects and also acts as an antiarrhythmic in isolation and in combination with other class III medications." | 1.37 | Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks. ( Anderson, JL; Bair, TL; Bunch, TJ; Crandall, BG; Day, JD; Lappe, DL; Mader, KM; Mahapatra, S; May, HT; Molden, J; Muhlestein, JB; Murdock, D; Osborn, JS; Weiss, JP, 2011) |
| "Chronic treatment of heart failure patients with beta-adrenoceptor antagonists leads to an up-regulation of cardiac beta-adrenoceptors, but in a subtype-selective fashion: beta 1-selective antagonists increase only cardiac beta 1-adrenoceptors, whereas non-selective antagonists increase both beta 1- and beta 2-adrenoceptors." | 1.28 | Drug- and disease-induced changes of human cardiac beta 1- and beta 2-adrenoceptors. ( Borst, HG; Brodde, OE; Maier, W; Michel, MC; Zerkowski, HR, 1989) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 1.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bunch, TJ | 1 |
| Mahapatra, S | 1 |
| Murdock, D | 1 |
| Molden, J | 1 |
| Weiss, JP | 1 |
| May, HT | 1 |
| Bair, TL | 1 |
| Mader, KM | 1 |
| Crandall, BG | 1 |
| Day, JD | 1 |
| Osborn, JS | 1 |
| Muhlestein, JB | 1 |
| Lappe, DL | 1 |
| Anderson, JL | 1 |
| Muto, S | 1 |
| Ashizawa, N | 1 |
| Arakawa, S | 1 |
| Tanaka, K | 1 |
| Komiya, N | 1 |
| Toda, G | 1 |
| Seto, S | 1 |
| Yano, K | 1 |
| Piccirillo, G | 1 |
| Magrì, D | 1 |
| Matera, S | 1 |
| Magnanti, M | 1 |
| Pasquazzi, E | 1 |
| Schifano, E | 1 |
| Velitti, S | 1 |
| Mitra, M | 1 |
| Marigliano, V | 1 |
| Paroli, M | 1 |
| Ghiselli, A | 1 |
| Montero, M | 1 |
| Schmitt, C | 1 |
| Faber, TS | 1 |
| Zehender, M | 1 |
| Van de Loo, A | 1 |
| Hohnloser, S | 1 |
| Just, H | 1 |
| Höher, M | 1 |
| Axmann, J | 1 |
| Eggeling, T | 1 |
| Kochs, M | 1 |
| Weismüller, P | 1 |
| Hombach, V | 1 |
| Bänsch, D | 1 |
| Böcker, D | 1 |
| Brunn, J | 1 |
| Weber, M | 1 |
| Breithardt, G | 1 |
| Block, M | 1 |
| Celiker, A | 1 |
| Ayabakan, C | 1 |
| Ozer, S | 1 |
| Ozme, S | 1 |
| Chugh, SS | 1 |
| Johnson, SB | 1 |
| Packer, DL | 1 |
| Mary-Rabine, L | 1 |
| Soumagne, D | 1 |
| Stiels, B | 1 |
| Brodde, OE | 1 |
| Zerkowski, HR | 1 |
| Borst, HG | 1 |
| Maier, W | 1 |
| Michel, MC | 1 |
| Ginestes, J | 1 |
| Wehr, M | 1 |
1 trial available for sotalol and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects.
Topics: Administration, Oral; Aged; Amiodarone; Anti-Arrhythmia Agents; Beverages; Cardiomyopathy, Dilated; | 2008 |
12 other studies available for sotalol and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.
Topics: Acetanilides; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cohort Studies; Def | 2011 |
Sotalol-induced coronary spasm in a patient with dilated cardiomyopathy associated with sustained ventricular tachycardia.
Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cardiomyopathy, Dilated; Coronary Angiography; Cor | 2004 |
Differential effects of D-sotalol on endocardial and epicardial action potentials of human ventricular myocardium in dilated cardiomyopathy.
Topics: Action Potentials; Cardiomyopathy, Dilated; Electric Stimulation; Electrophysiology; Endocardium; He | 1994 |
Torsade de pointes complicating drug treatment of low-malignant forms of arrhythmia: four cases reports.
Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiomyopathy, Dilated; Drug Combinati | 1994 |
Beat-to-beat variability of ventricular late potentials in the unaveraged high resolution electrocardiogram--effects of antiarrhythmic drugs.
Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Coronary Disease; Electroc | 1993 |
Clusters of ventricular tachycardias signify impaired survival in patients with idiopathic dilated cardiomyopathy and implantable cardioverter defibrillators.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Defibrillators, Implantable; Hear | 2000 |
Sotalol in treatment of pediatric cardiac arrhythmias.
Topics: Adolescent; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Child; Child, Pre | 2001 |
Amplified effects of d,l-sotalol in canine dilated cardiomyopathy.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiomyopathy, Dila | 2001 |
Long-term sotalol therapy in patients with ventricular arrhythmias.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; | 1986 |
Drug- and disease-induced changes of human cardiac beta 1- and beta 2-adrenoceptors.
Topics: Adolescent; Adult; Cardiomyopathy, Dilated; Child; Child, Preschool; Coronary Disease; Heart Failure | 1989 |
[Therapeutic indications for sotalol 160 mg].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dil | 1985 |
[QT time and the ventricular refractory period in programmed electrical stimulation of the heart in patients with ventricular and supraventricular tachycardias--effect of sotalol].
Topics: Adult; Aged; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Electrocardiography; Female; Heart | 1986 |