sotalol has been researched along with Cardiac Complex, Premature in 29 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to dissociate the Class III effects of sotalol on QT interval and arrhythmias from those of chronic beta-receptor blockade, we compared the effects of sotalol 160 mg b." | 9.06 | A comparison of the long-term effects of sotalol and atenolol on QT interval and arrhythmias after myocardial infarction. ( Alexopoulos, D; Cobbe, PC; Cobbe, SM; Johnston, J; McCaie, CP; Winner, SJ, 1988) |
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 7.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "The authors envisage the hypothesis of an embryofetal intoxication by a beta-blocker (B-), sotalol, taken by the mother, not hypertensive, during all her pregnancy (160 mg/day)." | 7.67 | [Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy]. ( Babin, JP; Carre, M; Martin, C, 1985) |
| "The efficacy and safety of sotalol were assessed by electrophysiologic testing and ambulatory recordings in 16 patients with recurrent sustained ventricular tachycardia (VT) or nonfatal cardiac arrest who were refractory to an average of 4." | 7.67 | Sotalol for refractory sustained ventricular tachycardia and nonfatal cardiac arrest. ( Chen, YW; Cohen, A; Fletcher, RD; Gottdiener, J; Peralba, J; Singh, SN; Thoben-O'Grady, L; Wish, M, 1988) |
| "Sotalol is a unique beta-blocking drug, possessing significant class III antiarrhythmic activity." | 6.67 | Usefulness of d, I sotalol for suppression of chronic ventricular arrhythmias. ( Anastasiou-Nana, MI; Anderson, JL; Freedman, RA; Gilbert, EM; Keefe, DL; MacNeil, DJ; Miller, RH; Saksena, S; Singh, S, 1991) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 5.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| "In order to dissociate the Class III effects of sotalol on QT interval and arrhythmias from those of chronic beta-receptor blockade, we compared the effects of sotalol 160 mg b." | 5.06 | A comparison of the long-term effects of sotalol and atenolol on QT interval and arrhythmias after myocardial infarction. ( Alexopoulos, D; Cobbe, PC; Cobbe, SM; Johnston, J; McCaie, CP; Winner, SJ, 1988) |
| " In patients refractory to amiodarone alone or to a combination with mexiletine, the combined treatment with amiodarone and class-I-C drugs such as flecainide and encainide prolongs the cycle length of ventricular tachycardia, but does not suppress induction of ventricular tachycardia during programmed stimulation." | 3.68 | [Combination anti-arrhythmic drug therapy]. ( Jung, W; Lüderitz, B; Manz, M, 1992) |
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 3.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "The authors envisage the hypothesis of an embryofetal intoxication by a beta-blocker (B-), sotalol, taken by the mother, not hypertensive, during all her pregnancy (160 mg/day)." | 3.67 | [Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy]. ( Babin, JP; Carre, M; Martin, C, 1985) |
| "The efficacy and safety of sotalol were assessed by electrophysiologic testing and ambulatory recordings in 16 patients with recurrent sustained ventricular tachycardia (VT) or nonfatal cardiac arrest who were refractory to an average of 4." | 3.67 | Sotalol for refractory sustained ventricular tachycardia and nonfatal cardiac arrest. ( Chen, YW; Cohen, A; Fletcher, RD; Gottdiener, J; Peralba, J; Singh, SN; Thoben-O'Grady, L; Wish, M, 1988) |
| "The Elimination of Ventricular Premature Beats with Catheter Ablation versus Optimal Antiarrhythmic Drug Treatment (ECTOPIA) trial is a randomized, multicenter, prospective clinical trial to compare the efficacy of catheter ablation versus optimal AAD treatment with sotalol or flecainide/verapamil." | 2.94 | Elimination of Benign Ventricular Premature Beats or Ventricular Tachycardia with Catheter Ablation versus Two Different Optimal Antiarrhythmic Drug Treatment Regimens (Sotalol or Verapamil/Flecainide). ( Adiyaman, A; Beukema, RJ; de Jong, JSSG; Delnoy, PPHM; Elvan, A; Haanschoten, DM; Khan, M; Otten, AM; Ramdat Misier, AR; Smit, JJJ; Szili-Torok, T; Ter Bekke, RMA; Vernooy, K, 2020) |
| "Sotalol is a unique beta-blocking drug, possessing significant class III antiarrhythmic activity." | 2.67 | Usefulness of d, I sotalol for suppression of chronic ventricular arrhythmias. ( Anastasiou-Nana, MI; Anderson, JL; Freedman, RA; Gilbert, EM; Keefe, DL; MacNeil, DJ; Miller, RH; Saksena, S; Singh, S, 1991) |
| "Sotalol is a unique beta-adrenergic blocking agent with additional actions characteristic of Vaughn-Williams class III antiarrhythmic agents in experimental models." | 2.66 | Multicenter trial of sotalol for suppression of frequent, complex ventricular arrhythmias: a double-blind, randomized, placebo-controlled evaluation of two doses. ( Anderson, JL; Askins, JC; Freedman, RA; Gilbert, EM; Haft, LR; Keefe, DL; Lessem, JN; Mason, JW; Miller, RH; Somberg, JC, 1986) |
| "Sotalol is a unique beta-blocker that prolongs repolarization." | 2.38 | Efficacy and safety of sotalol in patients with complex ventricular arrhythmias. ( Hohnloser, SH; Just, H; Klingenheben, T; van de Loo, A; Zabel, M, 1992) |
| "Typical arrhythmias are torsade de pointes occurring during treatment with K(+)-channel inhibitors (e." | 1.31 | [Ion channels and arrhythmias]. ( Borchard, U; Hafner, D, 2000) |
| "d-Sotalol was less effective in the dilated left ventricle, narrowing the excitable gap only 9%, a difference that was not statistically significant." | 1.29 | Interaction of acute ventricular dilatation and d-sotalol during sustained reentrant ventricular tachycardia around a fixed obstacle. ( Allessie, MA; Boersma, L; Kirchhof, CJ; Reiter, MJ; Zetelaki, Z, 1994) |
| "Sotalol was administered to 32 patients with a mean age of 8." | 1.29 | [Results of oral sotalol therapy in children with supraventricular and ventricular arrhythmias]. ( Kallfelz, HC; Lehmann, C; Paul, T; Pfammatter, JP, 1994) |
| "Association of long QT with arrhythmia does not, therefore, invalidate the principle that homogeneously prolonged APD should be anti-arrhythmic." | 1.27 | Delayed ventricular repolarization as an anti-arrhythmic principle. ( Vaughan Williams, EM, 1985) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 1.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (41.38) | 18.7374 |
| 1990's | 13 (44.83) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Sonesson, SE | 1 |
| Acharya, G | 1 |
| Haanschoten, DM | 1 |
| Vernooy, K | 1 |
| Beukema, RJ | 1 |
| Szili-Torok, T | 1 |
| Ter Bekke, RMA | 1 |
| Khan, M | 1 |
| de Jong, JSSG | 1 |
| Otten, AM | 1 |
| Adiyaman, A | 1 |
| Smit, JJJ | 1 |
| Delnoy, PPHM | 1 |
| Ramdat Misier, AR | 1 |
| Elvan, A | 1 |
| Thomsen, MB | 1 |
| Verduyn, SC | 1 |
| Stengl, M | 1 |
| Beekman, JD | 1 |
| de Pater, G | 1 |
| van Opstal, J | 1 |
| Volders, PG | 1 |
| Vos, MA | 1 |
| Eibs, HG | 1 |
| Oberdisse, U | 1 |
| Brambach, U | 1 |
| McKibbin, JK | 1 |
| Pocock, WA | 1 |
| Barlow, JB | 1 |
| Millar, RN | 1 |
| Obel, IW | 1 |
| Reiter, MJ | 1 |
| Zetelaki, Z | 1 |
| Kirchhof, CJ | 1 |
| Boersma, L | 1 |
| Allessie, MA | 1 |
| Martínez-Rubio, A | 1 |
| Shenasa, M | 1 |
| Chen, X | 1 |
| Wichter, T | 1 |
| Breithardt, G | 1 |
| Borggrefe, M | 1 |
| Cui, G | 1 |
| Sen, L | 1 |
| Sager, P | 1 |
| Uppal, P | 1 |
| Singh, BN | 1 |
| Paul, T | 1 |
| Lehmann, C | 1 |
| Pfammatter, JP | 1 |
| Kallfelz, HC | 1 |
| Hohnloser, SH | 2 |
| Zabel, M | 2 |
| Just, H | 2 |
| Raeder, EA | 1 |
| Zhang, YI | 1 |
| Ritchie, RH | 1 |
| Horowitz, JD | 1 |
| Borchard, U | 1 |
| Hafner, D | 1 |
| van de Loo, A | 1 |
| Klingenheben, T | 1 |
| Lüderitz, B | 2 |
| Jung, W | 1 |
| Manz, M | 2 |
| Deedwania, PC | 1 |
| Wagner, X | 1 |
| Jouglard, J | 1 |
| Moulin, M | 1 |
| Miller, AM | 1 |
| Petitjean, J | 1 |
| Pisapia, A | 1 |
| Giorgi, C | 1 |
| Nadeau, R | 1 |
| Agha, A | 1 |
| Primeau, R | 1 |
| de Champlain, J | 1 |
| Sieber, C | 1 |
| Weiss, P | 1 |
| Follath, F | 1 |
| Anastasiou-Nana, MI | 1 |
| Gilbert, EM | 2 |
| Miller, RH | 2 |
| Singh, S | 1 |
| Freedman, RA | 2 |
| Keefe, DL | 2 |
| Saksena, S | 1 |
| MacNeil, DJ | 1 |
| Anderson, JL | 2 |
| Babin, JP | 1 |
| Carre, M | 1 |
| Martin, C | 1 |
| Vaughan Williams, EM | 1 |
| Mary-Rabine, L | 1 |
| Soumagne, D | 1 |
| Stiels, B | 1 |
| Askins, JC | 1 |
| Somberg, JC | 1 |
| Haft, LR | 1 |
| Mason, JW | 1 |
| Lessem, JN | 1 |
| Stroobandt, R | 1 |
| Holvoet, G | 1 |
| Verbeke, N | 1 |
| Kesteloot, H | 1 |
| Wagner, WL | 1 |
| Cobbe, SM | 1 |
| Alexopoulos, D | 1 |
| Winner, SJ | 1 |
| McCaie, CP | 1 |
| Cobbe, PC | 1 |
| Johnston, J | 1 |
| Singh, SN | 1 |
| Cohen, A | 1 |
| Chen, YW | 1 |
| Wish, M | 1 |
| Thoben-O'Grady, L | 1 |
| Peralba, J | 1 |
| Gottdiener, J | 1 |
| Fletcher, RD | 1 |
| Ginestes, J | 1 |
| Prakash, R | 1 |
| Parmley, WW | 1 |
| Allen, HN | 1 |
| Matloff, JM | 1 |
2 reviews available for sotalol and Cardiac Complex, Premature
| Article | Year |
|---|---|
Efficacy and safety of sotalol in patients with complex ventricular arrhythmias.
Topics: Adult; Aged; Aged, 80 and over; Cardiac Complexes, Premature; Clinical Trials as Topic; Databases, F | 1992 |
Suppressant effects of conventional beta blockers and sotalol on complex and repetitive ventricular premature complexes.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Heart Vent | 1990 |
8 trials available for sotalol and Cardiac Complex, Premature
| Article | Year |
|---|---|
Elimination of Benign Ventricular Premature Beats or Ventricular Tachycardia with Catheter Ablation versus Two Different Optimal Antiarrhythmic Drug Treatment Regimens (Sotalol or Verapamil/Flecainide).
Topics: Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Catheter Ablation; Flecainide; Humans; Prospec | 2020 |
Effects of amiodarone, sematilide, and sotalol on QT dispersion.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Electrocardiography; Follow- | 1994 |
Postextrasystolic potentiation in patients with ischaemic heart disease: influence of inotropic agents.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiac Complexes, Premature; Cardiotonic Agents; Female; | 1995 |
Usefulness of d, I sotalol for suppression of chronic ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Chronic Disease; Circadian Rhythm; | 1991 |
Multicenter trial of sotalol for suppression of frequent, complex ventricular arrhythmias: a double-blind, randomized, placebo-controlled evaluation of two doses.
Topics: Aged; Blood Pressure; Cardiac Complexes, Premature; Clinical Trials as Topic; Double-Blind Method; E | 1986 |
Effects of intravenous sotalol, aprindine and the combination of sotalol and aprindine on chronic high frequency ventricular arrhythmias in man.
Topics: Aged; Aged, 80 and over; Aprindine; Cardiac Complexes, Premature; Clinical Trials as Topic; Drug The | 1987 |
[Combination of sotalol with the class I B substances mexiletine or tocainide in complex ventricular extrasystole].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electr | 1987 |
A comparison of the long-term effects of sotalol and atenolol on QT interval and arrhythmias after myocardial infarction.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atenolol; Cardiac Complexes, Premature; Clinical Trials as Topic; | 1988 |
19 other studies available for sotalol and Cardiac Complex, Premature
| Article | Year |
|---|---|
How to differentiate second-degree atrioventricular block from extrasystoles in fetuses with a bigeminal ventricular rhythm.
Topics: Atrioventricular Block; Cardiac Complexes, Premature; Digoxin; Female; Fetus; Flecainide; Humans; Pr | 2020 |
Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Cardiac Complexes, Premature; Chronic Disea | 2004 |
[Intoxication with beta-receptor blockers (author's transl)].
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Antidotes; Bradycardia; Bundle-Branch Block; Buprano | 1982 |
Sotalol, hypokalaemia, syncope, and torsade de pointes.
Topics: Adult; Aged; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; H | 1984 |
Interaction of acute ventricular dilatation and d-sotalol during sustained reentrant ventricular tachycardia around a fixed obstacle.
Topics: Animals; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Female; Heart Block; Heart Conduc | 1994 |
Response to sotalol predicts the response to amiodarone during serial drug testing in patients with sustained ventricular tachycardia and coronary artery disease.
Topics: Amiodarone; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Cohort Studies; Coronary Disea | 1994 |
[Results of oral sotalol therapy in children with supraventricular and ventricular arrhythmias].
Topics: Administration, Oral; Adolescent; Adult; Atrial Flutter; Atrioventricular Node; Cardiac Complexes, P | 1994 |
Relation of diurnal variation of ventricular repolarization to ventricular ectopic activity and modification by sotalol.
Topics: Cardiac Complexes, Premature; Circadian Rhythm; Electrocardiography, Ambulatory; Female; Heart Condu | 1993 |
[Ion channels and arrhythmias].
Topics: Action Potentials; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Atrial Fib | 2000 |
[Combination anti-arrhythmic drug therapy].
Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electro | 1992 |
Coadministration of flecainide acetate and sotalol during pregnancy: lack of teratogenic effects, passage across the placenta, and excretion in human breast milk.
Topics: Adult; Cardiac Complexes, Premature; Drug Therapy, Combination; Female; Flecainide; Humans; Maternal | 1990 |
Efficacy of oral sotalol in suppression of premature ventricular complexes and analysis of its beta-adrenergic blocking activity.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Cardiac Complexes, Premature; Electrocardiography | 1990 |
[Hemiparesis and torsade de pointes under low-dose sotalol therapy].
Topics: Aged; Aged, 80 and over; Cardiac Complexes, Premature; Electrocardiography; Epilepsy; Female; Hemipl | 1990 |
[Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Bradycardia; Cardiac Complexes, Premature; Facial Bones; Female; | 1985 |
Delayed ventricular repolarization as an anti-arrhythmic principle.
Topics: Adrenergic beta-Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bund | 1985 |
Long-term sotalol therapy in patients with ventricular arrhythmias.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; | 1986 |
Sotalol for refractory sustained ventricular tachycardia and nonfatal cardiac arrest.
Topics: Adult; Aged; Cardiac Complexes, Premature; Electrocardiography; Female; Heart Arrest; Heart Rate; Hu | 1988 |
[Therapeutic indications for sotalol 160 mg].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dil | 1985 |
Effect of Sotalol on clinical arrhythmias.
Topics: Administration, Oral; Aged; Amino Alcohols; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1972 |