sotalol has been researched along with Asystole in 14 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patient was under amiodarone and sotalol therapy for atrial fibrillation, with no obvious QT prolongation prior to ciprofloxacin therapy." | 7.75 | Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy. ( Arnaoutoglou, C; Chrisopoulos, C; Keivanidou, A; Kirpizidis, C; Krommydas, A; Papanikolaou, G; Tsiptses, K, 2009) |
| " We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse." | 7.69 | Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997) |
| "The efficacy and safety of sotalol were assessed by electrophysiologic testing and ambulatory recordings in 16 patients with recurrent sustained ventricular tachycardia (VT) or nonfatal cardiac arrest who were refractory to an average of 4." | 7.67 | Sotalol for refractory sustained ventricular tachycardia and nonfatal cardiac arrest. ( Chen, YW; Cohen, A; Fletcher, RD; Gottdiener, J; Peralba, J; Singh, SN; Thoben-O'Grady, L; Wish, M, 1988) |
| "Sotalol overdose has special features because this beta-blocker has the potential to lengthen the Q-T interval and to initiate severe arrhythmias such as ventricular tachycardia or fibrillation." | 5.29 | Sotalol poisoning associated with asystole. ( Alderfliegel, F; Demaeyer, P; Kahn, RJ; Leeman, M, 1993) |
| "We aimed to compare the efficacy of sotalol versus lignocaine for the treatment of patients with out-of-hospital ventricular fibrillation refractory to > or = 4 defibrillatory shocks." | 5.11 | Randomized double-blind trial of sotalol versus lignocaine in out-of-hospital refractory cardiac arrest due to ventricular tachyarrhythmia. ( Adelstein, BA; Hall, J; Ho, D; Kovoor, P; Kruit, R; Love, A; Ross, DL; Sadick, N, 2005) |
| " The patient was under amiodarone and sotalol therapy for atrial fibrillation, with no obvious QT prolongation prior to ciprofloxacin therapy." | 3.75 | Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy. ( Arnaoutoglou, C; Chrisopoulos, C; Keivanidou, A; Kirpizidis, C; Krommydas, A; Papanikolaou, G; Tsiptses, K, 2009) |
| "The aim of this study was to assess the antiarrhythmic efficacy and safety of d,l-sotalol in patients with ventricular tachycardia (VT) or ventricular fibrillation (VF) and in survivors of cardiac arrest and to identify the factors that are associated with arrhythmia suppression and therefore might be helpful in predicting drug efficacy." | 3.69 | Efficacy and safety of d,l-sotalol in patients with ventricular tachycardia and in survivors of cardiac arrest. ( Borggrefe, M; Breithardt, G; Haverkamp, W; Hief, C; Lammers, A; Martinez-Rubio, A; Mühlenkamp, S; Wichter, T, 1997) |
| " We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse." | 3.69 | Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997) |
| "The efficacy and safety of sotalol were assessed by electrophysiologic testing and ambulatory recordings in 16 patients with recurrent sustained ventricular tachycardia (VT) or nonfatal cardiac arrest who were refractory to an average of 4." | 3.67 | Sotalol for refractory sustained ventricular tachycardia and nonfatal cardiac arrest. ( Chen, YW; Cohen, A; Fletcher, RD; Gottdiener, J; Peralba, J; Singh, SN; Thoben-O'Grady, L; Wish, M, 1988) |
| "Patients with symptomatic ventricular tachycardia, ventricular fibrillation, or aborted sudden cardiac death remain at high risk for arrhythmia recurrence." | 2.40 | Drugs versus devices in controlling ventricular tachycardia, ventricular fibrillation, and recurrent cardiac arrest. ( Borggrefe, M; Breithardt, G; Eckardt, L; Haverkamp, W, 1997) |
| "Arrhythmogenic right ventricular cardiomyopathy is a desmosomal disease." | 1.37 | Guidelines for the diagnosis and management of arrhythmogenic right ventricular cardiomyopathy. ( Smith, W, 2011) |
| "Sudden cardiac arrest survivors have a high risk of suffering from recurrent arrhythmic events." | 1.32 | Long-term follow-up of sudden cardiac arrest survivors and electrophysiologically guided antiarrhythmic therapy. ( Hennersdorf, MG; Niebch, V; Perings, C; Strauer, BE; Vester, EG; Winter, J, 2003) |
| "Sotalol overdose has special features because this beta-blocker has the potential to lengthen the Q-T interval and to initiate severe arrhythmias such as ventricular tachycardia or fibrillation." | 1.29 | Sotalol poisoning associated with asystole. ( Alderfliegel, F; Demaeyer, P; Kahn, RJ; Leeman, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keivanidou, A | 1 |
| Arnaoutoglou, C | 1 |
| Krommydas, A | 1 |
| Papanikolaou, G | 1 |
| Tsiptses, K | 1 |
| Chrisopoulos, C | 1 |
| Kirpizidis, C | 1 |
| Smith, W | 1 |
| Hennersdorf, MG | 1 |
| Niebch, V | 1 |
| Vester, EG | 1 |
| Winter, J | 1 |
| Perings, C | 1 |
| Strauer, BE | 1 |
| Kovoor, P | 1 |
| Love, A | 1 |
| Hall, J | 1 |
| Kruit, R | 1 |
| Sadick, N | 1 |
| Ho, D | 1 |
| Adelstein, BA | 1 |
| Ross, DL | 1 |
| Rygnestad, T | 1 |
| Moen, S | 1 |
| Wahba, A | 1 |
| Lien, S | 1 |
| Ingul, CB | 1 |
| Schrader, H | 1 |
| Knapstad, SE | 1 |
| Hohnloser, SH | 1 |
| Dorian, P | 1 |
| Roberts, R | 1 |
| Gent, M | 1 |
| Israel, CW | 1 |
| Fain, E | 1 |
| Champagne, J | 1 |
| Connolly, SJ | 1 |
| Cherpanath, TG | 1 |
| Geisler, FE | 1 |
| van der Meer, BJ | 1 |
| van Veer, NE | 1 |
| Alings, AM | 1 |
| Bystedt, T | 1 |
| Vitols, S | 1 |
| Alderfliegel, F | 1 |
| Leeman, M | 1 |
| Demaeyer, P | 1 |
| Kahn, RJ | 1 |
| Huynh-Do, U | 1 |
| Wahl, C | 1 |
| Sulzer, M | 1 |
| Bühler, H | 1 |
| Keusch, G | 1 |
| Haverkamp, W | 2 |
| Martinez-Rubio, A | 1 |
| Hief, C | 1 |
| Lammers, A | 1 |
| Mühlenkamp, S | 1 |
| Wichter, T | 1 |
| Breithardt, G | 2 |
| Borggrefe, M | 2 |
| Sandeman, DJ | 1 |
| Alahakoon, TI | 1 |
| Bentley, SC | 1 |
| Eckardt, L | 1 |
| Singh, SN | 1 |
| Cohen, A | 1 |
| Chen, YW | 1 |
| Wish, M | 1 |
| Thoben-O'Grady, L | 1 |
| Peralba, J | 1 |
| Gottdiener, J | 1 |
| Fletcher, RD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| aMsa and amiOdarone Study in cArdiaC Arrest[NCT04997980] | 500 participants (Anticipated) | Observational | 2015-01-01 | Recruiting | |||
| [NCT00257959] | Phase 4 | 400 participants | Interventional | 2001-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for sotalol and Asystole
| Article | Year |
|---|---|
Drugs versus devices in controlling ventricular tachycardia, ventricular fibrillation, and recurrent cardiac arrest.
Topics: Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Heart Arrest; Humans; Randomized Co | 1997 |
2 trials available for sotalol and Asystole
| Article | Year |
|---|---|
Randomized double-blind trial of sotalol versus lignocaine in out-of-hospital refractory cardiac arrest due to ventricular tachyarrhythmia.
Topics: Aged; Anti-Arrhythmia Agents; Female; Follow-Up Studies; Heart Arrest; Humans; Lidocaine; Male; Outp | 2005 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprol | 2006 |
11 other studies available for sotalol and Asystole
| Article | Year |
|---|---|
Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anti-Infective Agents; Atrial Fibrillation; Ciprofloxacin; | 2009 |
Guidelines for the diagnosis and management of arrhythmogenic right ventricular cardiomyopathy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Defibrillators, Impl | 2011 |
Long-term follow-up of sudden cardiac arrest survivors and electrophysiologically guided antiarrhythmic therapy.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Electrophysiologic Tec | 2003 |
Severe poisoning with sotalol and verapamil. Recovery after 4 h of normothermic CPR followed by extra corporeal heart lung assist.
Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Cardiopulmonary Resuscitation; Female; | 2005 |
[Suicide attempt with sotalol: a proarrhythmic intoxication].
Topics: Heart Arrest; Heart Rate; Humans; Male; Middle Aged; Pacemaker, Artificial; Sotalol; Suicide, Attemp | 2007 |
[A case report. Sotalol-disopyramide caused asystole].
Topics: Administration, Oral; Aged; Disopyramide; Drug Interactions; Heart Arrest; Humans; Infusions, Intrav | 1994 |
Sotalol poisoning associated with asystole.
Topics: Aged; Female; Heart Arrest; Humans; Poisoning; Resuscitation; Sotalol; Suicide, Attempted | 1993 |
Torsades de pointes during low-dosage sotalol therapy in haemodialysis patients.
Topics: Adrenergic beta-Antagonists; Aged; Electrocardiography; Female; Heart Arrest; Humans; Male; Middle A | 1996 |
Efficacy and safety of d,l-sotalol in patients with ventricular tachycardia and in survivors of cardiac arrest.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Electric Stimulation; Female; Follow-Up Studies; Heart | 1997 |
Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine.
Topics: Adrenergic Agonists; Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Critical Care; | 1997 |
Sotalol for refractory sustained ventricular tachycardia and nonfatal cardiac arrest.
Topics: Adult; Aged; Cardiac Complexes, Premature; Electrocardiography; Female; Heart Arrest; Heart Rate; Hu | 1988 |