sotalol has been researched along with Angina Pectoris in 24 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical trials have demonstrated a prophylactic role for aspirin in myocardial infarction and in unstable angina pectoris." | 9.07 | Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group. ( Edvardsson, N; Jahnmatz, B; Juul-Möller, S; Omblus, R; Rosén, A; Sørensen, S, 1992) |
| "The efficacy of chronic oral treatment with a total daily dose of 320 mg sotalol, given as a single or as two divided doses, was compared with placebo in a double-blind cross-over study of 12 patients with angina pectoris." | 9.05 | Comparison of once and twice daily sotalol in exercise-induced angina pectoris. ( Aberg, A; Descamps, R; Thomis, JA; Ulvenstam, G; Vedin, A; Wilhelmsson, C, 1982) |
| "The effect of sotalol, a beta-adrenergic blocking drug, on the frequency of angina pectoris attacks and on exercise tolerance was evaluated by a double-blind cross-over study in 30 selected patients suffering from stable angina pectoris." | 9.04 | Sotalol in angina pectoris. A double-blind study. ( Slome, R, 1976) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 5.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| "Clinical trials have demonstrated a prophylactic role for aspirin in myocardial infarction and in unstable angina pectoris." | 5.07 | Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group. ( Edvardsson, N; Jahnmatz, B; Juul-Möller, S; Omblus, R; Rosén, A; Sørensen, S, 1992) |
| "In order to evaluate the negative inotropic effects of sotalol, metoprolol, and propranolol in patients with chronic stable angina pectoris, left ventricular ejection fraction (LVEF) was measured with radionuclide angiography and echocardiography." | 5.05 | Beta-blocker therapy evaluated by radionuclide angiography: a study in chronic stable angina. ( Lessem, J, 1982) |
| "The efficacy of chronic oral treatment with a total daily dose of 320 mg sotalol, given as a single or as two divided doses, was compared with placebo in a double-blind cross-over study of 12 patients with angina pectoris." | 5.05 | Comparison of once and twice daily sotalol in exercise-induced angina pectoris. ( Aberg, A; Descamps, R; Thomis, JA; Ulvenstam, G; Vedin, A; Wilhelmsson, C, 1982) |
| "The effect of sotalol, a beta-adrenergic blocking drug, on the frequency of angina pectoris attacks and on exercise tolerance was evaluated by a double-blind cross-over study in 30 selected patients suffering from stable angina pectoris." | 5.04 | Sotalol in angina pectoris. A double-blind study. ( Slome, R, 1976) |
| "The role of hepatic drug-metabolizing enzyme activity for plasma propranolol and sotalol levels was investigated in 68 patients with hypertension or angina pectoris by comparing elimination rate with antipyrine kinetics and cytochrome P-450 content in the liver." | 3.66 | Plasma clearance of propranolol and sotalol and hepatic drug-metabolizing enzyme activity. ( Anttila, M; Järvensivu, P; Pelkonen, RO; Sotaniemi, EA; Sundquist, H, 1979) |
| " After a two dose trial (Gillam and Prichard, 1966,) demonstrated a dose dependent anti-anginal effect, a log-dose response study demonstrated a progressive reduction in angina attacks as dosage was increased (Prichard and Gillam, 1971)." | 2.35 | Propranolol in the treatment of angina: a review. ( Prichard, BN, 1976) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 1.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (87.50) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lessem, J | 1 |
| Frishman, WH | 1 |
| Furberg, CD | 1 |
| Friedewald, WT | 1 |
| Raju, PK | 1 |
| Wasir, HS | 1 |
| Bhatia, ML | 1 |
| Milei, J | 1 |
| Piñeiro, DJ | 1 |
| Blanco, MV | 1 |
| Buceta, JE | 1 |
| Krebs, AR | 1 |
| Wilhelmsson, C | 1 |
| Vedin, A | 1 |
| Ulvenstam, G | 1 |
| Aberg, A | 1 |
| Descamps, R | 1 |
| Thomis, JA | 1 |
| Henderson, A | 1 |
| Errington, J | 1 |
| Blümchen, G | 1 |
| Esche, HH | 1 |
| Dunnington, CS | 1 |
| Sowton, E | 1 |
| Das Gupta, DS | 1 |
| Baker, I | 1 |
| Sotaniemi, EA | 1 |
| Anttila, M | 1 |
| Pelkonen, RO | 1 |
| Järvensivu, P | 1 |
| Sundquist, H | 1 |
| Forfar, JC | 1 |
| Brown, GJ | 1 |
| Cull, RE | 1 |
| Prichard, BN | 4 |
| Slome, R | 1 |
| Areskog, NH | 1 |
| Cullhed, I | 1 |
| Ringqvist, I | 1 |
| Ström, G | 1 |
| Juul-Möller, S | 1 |
| Edvardsson, N | 1 |
| Jahnmatz, B | 1 |
| Rosén, A | 1 |
| Sørensen, S | 1 |
| Omblus, R | 1 |
| Mary-Rabine, L | 1 |
| Soumagne, D | 1 |
| Stiels, B | 1 |
| Tarnow, J | 1 |
| Komar, K | 1 |
| Lawrence, T | 1 |
| Frankl, WS | 1 |
| Gooding, PG | 1 |
| Berman, E | 1 |
| Horn, ME | 1 |
| Kentala, E | 1 |
| Pyörälä, K | 1 |
| Frick, MH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Heart Rate Lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease[NCT01365286] | Phase 4 | 40 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for sotalol and Angina Pectoris
| Article | Year |
|---|---|
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans | 1984 |
Sotalol hydrochloride (Betapace): a new antiarrhythmic drug.
Topics: Adult; Angina Pectoris; Child; Clinical Protocols; Drug Interactions; Electrophysiology; Female; Hem | 1993 |
Propranolol in the treatment of angina: a review.
Topics: Alprenolol; Angina Pectoris; Dose-Response Relationship, Drug; Heart Rate; Humans; Isosorbide; Pract | 1976 |
Beta-adrenergic receptor blocking drugs.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Aortic Aneurysm; Aortic Valve; Arrhythmias | 1973 |
Beta-adrenergic receptor blocking drugs in angina pectoris.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Blood Pressure; Dose-Response Relationship | 1974 |
-Receptor antagonists in angina pectoris.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; | 1971 |
10 trials available for sotalol and Angina Pectoris
| Article | Year |
|---|---|
Beta-blocker therapy evaluated by radionuclide angiography: a study in chronic stable angina.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Cardiac Volume; Chronic Disease; Echoc | 1982 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans | 1984 |
Comparison of once and twice daily sotalol in exercise-induced angina pectoris.
Topics: Adult; Angina Pectoris; Drug Administration Schedule; Drug Evaluation; Electrocardiography; Humans; | 1982 |
Comparative effects of beta adrenergic blocking drugs.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Clinical Trials as T | 1975 |
Sotalol in angina pectoris. A double-blind study.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Electrocardiography; Exercis | 1976 |
Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group.
Topics: Aged; Angina Pectoris; Aspirin; Double-Blind Method; Female; Hemorrhage; Humans; Male; Myocardial In | 1992 |
An evaluation of sotalol, a beta-blocking agent, in patients with angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Drug Evaluation | 1974 |
-Receptor antagonists in angina pectoris.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; | 1971 |
Variable dose comparative trial of propranolol and sotalol in angina pectoris.
Topics: Angina Pectoris; Clinical Trials as Topic; Humans; Propranolol; Sotalol | 1973 |
Sotalol in the treatment of angina pectoris. A double-blind cross-over study.
Topics: Acute Disease; Administration, Oral; Adult; Angina Pectoris; Blood Pressure; Cardiac Volume; Clinica | 1974 |
10 other studies available for sotalol and Angina Pectoris
| Article | Year |
|---|---|
Sotalol and pacing induced angina.
Topics: Aged; Angina Pectoris; Blood Pressure; Cardiac Output; Cardiac Pacing, Artificial; Drug Evaluation; | 1983 |
Long-term antianginal efficacy of sotalol.
Topics: Angina Pectoris; Female; Humans; Male; Middle Aged; Sotalol; Time Factors | 1983 |
Sudden versus gradual withdrawal of sotalol in ambulant patients with ischaemic heart disease.
Topics: Angina Pectoris; Blood Pressure; Coronary Disease; Heart Rate; Humans; Hypertension; Risk; Sotalol; | 1982 |
[Chronic administration of beta blocking agents: left ventricular hemodynamics in myocardial infarctions during exercise (author's transl)].
Topics: Adult; Angina Pectoris; Cardiac Catheterization; Electrocardiography; Heart Ventricles; Hemodynamics | 1981 |
Which beta-blocker?
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Bradycardia; Heart Failure; Huma | 2001 |
Plasma clearance of propranolol and sotalol and hepatic drug-metabolizing enzyme activity.
Topics: Adult; Aged; Angina Pectoris; Antipyrine; Cytochrome P-450 Enzyme System; Female; Half-Life; Humans; | 1979 |
Proximal myopathy during beta-blockade.
Topics: Aged; Angina Pectoris; Female; Humans; Muscular Diseases; Propranolol; Sotalol | 1979 |
Cardiovascular and respiratory effects of the beta-adrenoceptive antagonist sotalol: studies in health, angina pectoris and obstructive lung disease.
Topics: Adult; Aged; Airway Resistance; Angina Pectoris; Blood Pressure; Chronic Disease; Exercise Test; Fem | 1975 |
Long-term sotalol therapy in patients with ventricular arrhythmias.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; | 1986 |
Altered hemodynamic response to dobutamine in relation to the degree of preoperative beta-adrenoceptor blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Atenolol; Bupranolol; Dobutamine; Hemodyn | 1988 |