sotalol has been researched along with Aging in 8 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to test the hypothesis that women are more prone than men to develop torsade de pointes (TdP) in a defined cohort of patients exposed to the QT-prolonging antiarrhythmic drug d,l-sotalol." | 7.69 | Sex difference in risk of torsade de pointes with d,l-sotalol. ( Archibald, D; Hardy, S; Lehmann, MH; MacNeil, DJ; quart, B, 1996) |
| "The present study was undertaken to test the hypothesis that women are more prone than men to develop torsade de pointes (TdP) in a defined cohort of patients exposed to the QT-prolonging antiarrhythmic drug d,l-sotalol." | 3.69 | Sex difference in risk of torsade de pointes with d,l-sotalol. ( Archibald, D; Hardy, S; Lehmann, MH; MacNeil, DJ; quart, B, 1996) |
| "Sotalol was rapidly absorbed, with mean peak concentrations occurring 2 to 3 hours after administration." | 2.70 | Single-dose pharmacokinetics of sotalol in a pediatric population with supraventricular and/or ventricular tachyarrhythmia. ( Cai, B; Epstein, MR; Erickson, CC; Hinderling, PH; Karara, AH; Karpawich, PP; Melikian, AP; Saul, JP; Schaffer, MS; Shi, J, 2001) |
| "Propranolol did not cause this pressor effect in prehypertensive (seven week old) SHRs." | 1.26 | Beta-adrenergic receptor blocking drugs in spontaneous hypertension. ( Levy, JV, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kelcher, S | 1 |
| Carr, RA | 1 |
| Pasutto, FM | 1 |
| Lewanczuk, RZ | 1 |
| Foster, RT | 1 |
| Case, CL | 1 |
| Le, FK | 1 |
| McKay, CA | 1 |
| Gillette, PC | 1 |
| Hewett, KW | 1 |
| Lehmann, MH | 1 |
| Hardy, S | 1 |
| Archibald, D | 1 |
| quart, B | 1 |
| MacNeil, DJ | 1 |
| Saul, JP | 1 |
| Schaffer, MS | 1 |
| Karpawich, PP | 1 |
| Erickson, CC | 1 |
| Epstein, MR | 1 |
| Melikian, AP | 1 |
| Shi, J | 1 |
| Karara, AH | 1 |
| Cai, B | 1 |
| Hinderling, PH | 1 |
| Läer, S | 1 |
| Meibohm, B | 1 |
| Mir, TS | 1 |
| Hulpke-Wette, M | 1 |
| Piccirillo, G | 1 |
| Cacciafesta, M | 1 |
| Lionetti, M | 1 |
| Nocco, M | 1 |
| Di Giuseppe, V | 1 |
| Moisè, A | 1 |
| Naso, C | 1 |
| Marigliano, V | 1 |
| Levy, JV | 1 |
1 trial available for sotalol and Aging
| Article | Year |
|---|---|
Single-dose pharmacokinetics of sotalol in a pediatric population with supraventricular and/or ventricular tachyarrhythmia.
Topics: Adrenergic beta-Antagonists; Aging; Anti-Arrhythmia Agents; Child; Child, Preschool; Drug Administra | 2001 |
7 other studies available for sotalol and Aging
| Article | Year |
|---|---|
Taking age into account.
Topics: Aged; Aged, 80 and over; Aging; Bradycardia; Creatinine; Female; Humans; Kidney; Renal Circulation; | 1995 |
Protein binding of sotalol enantiomers in young and elderly human and rat serum using ultrafiltration.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Analysis of Variance; Animals; Blood Proteins; Chro | 1995 |
Developmental effects of d-sotalol on anterograde and retrograde atrioventricular conduction in the rabbit.
Topics: Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Atrioventricular Node; Bundle of His; In V | 1996 |
Sex difference in risk of torsade de pointes with d,l-sotalol.
Topics: Adult; Aged; Aging; Anti-Arrhythmia Agents; Female; Heart Rate; Humans; Information Systems; Male; M | 1996 |
Termination of automatic atrial tachycardia in an infant by adequate sotalol dosing. Indication of clinically relevant age-dependent pharmacokinetics of sotalol.
Topics: Adult; Aging; Anti-Arrhythmia Agents; Humans; Infant; Sotalol; Tachycardia, Ectopic Atrial; Treatmen | 2001 |
Influence of age, the autonomic nervous system and anxiety on QT-interval variability.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Analysis of Variance; Anti-Arrhythmia Agents; Anxie | 2001 |
Beta-adrenergic receptor blocking drugs in spontaneous hypertension.
Topics: Adrenergic beta-Antagonists; Aging; Alprenolol; Animals; Blood Pressure; Hypertension; Male; Metopro | 1976 |