sotalol has been researched along with Abnormality, Heart in 15 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sotalol is a class III antiarrhythmic agent that is highly effective for tachyarrhythmias in adults, but its efficacy in patients with congenital heart disease (CHD) remains unclear." | 7.74 | Efficacy and safety of sotalol for refractory tachyarrhythmias in congenital heart disease. ( Kamakura, S; Kurosaki, K; Miyazaki, A; Ohuchi, H; Yagihara, T; Yamada, O, 2008) |
| "This study sought to assess the efficacy of oral sotalol for various arrhythmias in pediatric patients and to evaluate the incidence of proarrhythmia and systemic side effects." | 7.69 | Efficacy and proarrhythmia of oral sotalol in pediatric patients. ( Kallfelz, HC; Lehmann, C; Paul, T; Pfammatter, JP, 1995) |
| "This study describes the efficacy of oral sotalol in the treatment and prevention of atrial flutter in children after surgery for congenital heart disease." | 7.69 | Effectiveness of sotalol for atrial flutter in children after surgery for congenital heart disease. ( Beaufort-Krol, GC; Bink-Boelkens, MT, 1997) |
| " Conversion to sinus rhythm was achieved in 16 out of 22 hemodynamically stable children with a dosage of 4." | 5.30 | Sotalol for atrial tachycardias after surgery for congenital heart disease. ( Beaufort-Krol, GC; Bink-Boelkens, MT, 1997) |
| "Sotalol is a class III antiarrhythmic agent that is highly effective for tachyarrhythmias in adults, but its efficacy in patients with congenital heart disease (CHD) remains unclear." | 3.74 | Efficacy and safety of sotalol for refractory tachyarrhythmias in congenital heart disease. ( Kamakura, S; Kurosaki, K; Miyazaki, A; Ohuchi, H; Yagihara, T; Yamada, O, 2008) |
| "This study sought to assess the efficacy of oral sotalol for various arrhythmias in pediatric patients and to evaluate the incidence of proarrhythmia and systemic side effects." | 3.69 | Efficacy and proarrhythmia of oral sotalol in pediatric patients. ( Kallfelz, HC; Lehmann, C; Paul, T; Pfammatter, JP, 1995) |
| "This study describes the efficacy of oral sotalol in the treatment and prevention of atrial flutter in children after surgery for congenital heart disease." | 3.69 | Effectiveness of sotalol for atrial flutter in children after surgery for congenital heart disease. ( Beaufort-Krol, GC; Bink-Boelkens, MT, 1997) |
| "Amiodarone was successful in treating JET in 75% of cases; sotalol was successful in 83%." | 1.72 | Sotalol versus amiodarone for postoperative junctional tachycardia after congenital heart surgery. ( Asadourian, V; Howard, TS; Kim, JJ; Lemming, K; Miyake, CY; Patel, R; Pham, TDN; Rochelson, E; Valdés, SO, 2022) |
| " A multicenter registry study was designed to evaluate the safety, efficacy, and dosing of IV sotalol." | 1.72 | IV Sotalol Use in Pediatric and Congenital Heart Patients: A Multicenter Registry Study. ( Asaki, SY; Avari Silva, JN; Balaji, S; Chang, PM; Fischbach, PS; Garnreiter, JM; Kirk, C; Malloy-Walton, LE; Moak, JP; Nguyen, HH; Ochoa, LA; Patel, AR; Saul, JP; Sherman, AK; Von Bergen, NH, 2022) |
| "Sotalol is an attractive alternative antiarrhythmic to amiodarone in this younger patient population, given the latter's toxicity profile, but it may have proarrhythmic effects." | 1.51 | Efficacy and adverse effects of sotalol in adults with congenital heart disease. ( Celermajer, DS; Cordina, RL; McGuire, MA; Moore, BM, 2019) |
| "IV sotalol is an effective antiarrhythmic option for pediatric patients and may be an excellent agent for acute termination of active arrhythmias." | 1.48 | Early experience with intravenous sotalol in children with and without congenital heart disease. ( Asaki, SY; de la Uz, CM; Kim, JJ; Lam, WW; Landstrom, AP; Miyake, CY; Niu, MC; Patel, R; Rusin, CG; Schneider, AE; Valdés, SO, 2018) |
| " High-dose sotalol allows for safe and rapid control of refractory tachyarrhythmias in this young age group." | 1.37 | High-dose sotalol is safe and effective in neonates and infants with refractory supraventricular tachyarrhythmias. ( Cannon, BC; Kim, JJ; Knudson, JD; Moffett, BS, 2011) |
| " Conversion to sinus rhythm was achieved in 16 out of 22 hemodynamically stable children with a dosage of 4." | 1.30 | Sotalol for atrial tachycardias after surgery for congenital heart disease. ( Beaufort-Krol, GC; Bink-Boelkens, MT, 1997) |
| "Sotalol was administered to 32 patients with a mean age of 8." | 1.29 | [Results of oral sotalol therapy in children with supraventricular and ventricular arrhythmias]. ( Kallfelz, HC; Lehmann, C; Paul, T; Pfammatter, JP, 1994) |
| "Sotalol is a beta blocker with class III activity." | 1.28 | Effectiveness of oral sotalol for treatment of pediatric arrhythmias. ( Fournier, A; Maragnès, P; Tipple, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rochelson, E | 1 |
| Valdés, SO | 2 |
| Asadourian, V | 1 |
| Patel, R | 2 |
| Lemming, K | 1 |
| Howard, TS | 1 |
| Pham, TDN | 1 |
| Miyake, CY | 2 |
| Kim, JJ | 3 |
| Kikano, S | 1 |
| Kannankeril, PJ | 1 |
| Malloy-Walton, LE | 1 |
| Von Bergen, NH | 1 |
| Balaji, S | 1 |
| Fischbach, PS | 1 |
| Garnreiter, JM | 1 |
| Asaki, SY | 2 |
| Moak, JP | 2 |
| Ochoa, LA | 1 |
| Chang, PM | 1 |
| Nguyen, HH | 1 |
| Patel, AR | 1 |
| Kirk, C | 1 |
| Sherman, AK | 1 |
| Avari Silva, JN | 1 |
| Saul, JP | 1 |
| Moore, BM | 1 |
| Cordina, RL | 1 |
| McGuire, MA | 1 |
| Celermajer, DS | 1 |
| Niu, MC | 1 |
| de la Uz, CM | 1 |
| Landstrom, AP | 1 |
| Schneider, AE | 1 |
| Rusin, CG | 1 |
| Lam, WW | 1 |
| Sakurai, K | 1 |
| Takahashi, K | 1 |
| Nakayashiro, M | 1 |
| Rao, SO | 1 |
| Boramanand, NK | 1 |
| Burton, DA | 1 |
| Perry, JC | 1 |
| Miyazaki, A | 1 |
| Ohuchi, H | 1 |
| Kurosaki, K | 1 |
| Kamakura, S | 1 |
| Yagihara, T | 1 |
| Yamada, O | 1 |
| Knudson, JD | 1 |
| Cannon, BC | 1 |
| Moffett, BS | 1 |
| Paul, T | 2 |
| Lehmann, C | 2 |
| Pfammatter, JP | 2 |
| Kallfelz, HC | 2 |
| Beaufort-Krol, GC | 2 |
| Bink-Boelkens, MT | 2 |
| Maragnès, P | 1 |
| Tipple, M | 1 |
| Fournier, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety Assessment for Sotalol Protocol in Outpatient Unit[NCT05418036] | Phase 4 | 110 participants (Anticipated) | Interventional | 2020-10-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for sotalol and Abnormality, Heart
| Article | Year |
|---|---|
Atrial tachycardias in young adults and adolescents with congenital heart disease: conversion using single dose oral sotalol.
Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Atrial Flutter; Child; Heart Defect | 2009 |
14 other studies available for sotalol and Abnormality, Heart
| Article | Year |
|---|---|
Sotalol versus amiodarone for postoperative junctional tachycardia after congenital heart surgery.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Child; Heart Defects, Congenital; Humans; Retrospective St | 2022 |
Sotalol vs amiodarone for postoperative junctional ectopic tachycardia: Citius, Altius, Fortius?
Topics: Amiodarone; Heart Defects, Congenital; Humans; Sotalol; Tachycardia, Ectopic Junctional | 2022 |
IV Sotalol Use in Pediatric and Congenital Heart Patients: A Multicenter Registry Study.
Topics: Arrhythmias, Cardiac; Child; Heart Defects, Congenital; Humans; Infant; Registries; Sotalol; Tachyca | 2022 |
Efficacy and adverse effects of sotalol in adults with congenital heart disease.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Australia; Child; Drug-Relate | 2019 |
Early experience with intravenous sotalol in children with and without congenital heart disease.
Topics: Administration, Intravenous; Adolescent; Anti-Arrhythmia Agents; Child; Child, Preschool; Dose-Respo | 2018 |
Has intravenous sotalol come of age as an alternative treatment for arrhythmias in the young heart?
Topics: Arrhythmias, Cardiac; Child; Heart; Heart Defects, Congenital; Humans; Sotalol | 2018 |
Combined flecainide and sotalol therapy for multifocal atrial tachycardia in cardio-facio-cutaneous syndrome.
Topics: Anti-Arrhythmia Agents; Drug Therapy, Combination; Ectodermal Dysplasia; Electrocardiography; Facies | 2018 |
Efficacy and safety of sotalol for refractory tachyarrhythmias in congenital heart disease.
Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Natriur | 2008 |
High-dose sotalol is safe and effective in neonates and infants with refractory supraventricular tachyarrhythmias.
Topics: Anti-Arrhythmia Agents; Child, Preschool; Dose-Response Relationship, Drug; Electrocardiography, Amb | 2011 |
[Results of oral sotalol therapy in children with supraventricular and ventricular arrhythmias].
Topics: Administration, Oral; Adolescent; Adult; Atrial Flutter; Atrioventricular Node; Cardiac Complexes, P | 1994 |
Efficacy and proarrhythmia of oral sotalol in pediatric patients.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Case-Control Studies; Child; Chi | 1995 |
Effectiveness of sotalol for atrial flutter in children after surgery for congenital heart disease.
Topics: Adolescent; Anti-Arrhythmia Agents; Atrial Flutter; Child; Child, Preschool; Heart Defects, Congenit | 1997 |
Sotalol for atrial tachycardias after surgery for congenital heart disease.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Bradycardi | 1997 |
Effectiveness of oral sotalol for treatment of pediatric arrhythmias.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Female; Heart Defects, Congenital; | 1992 |