sotalol has been researched along with Abnormalities, Drug-Induced in 2 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors envisage the hypothesis of an embryofetal intoxication by a beta-blocker (B-), sotalol, taken by the mother, not hypertensive, during all her pregnancy (160 mg/day)." | 7.67 | [Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy]. ( Babin, JP; Carre, M; Martin, C, 1985) |
| "The authors envisage the hypothesis of an embryofetal intoxication by a beta-blocker (B-), sotalol, taken by the mother, not hypertensive, during all her pregnancy (160 mg/day)." | 3.67 | [Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy]. ( Babin, JP; Carre, M; Martin, C, 1985) |
| " Dosing on gestational day (GD) 11 was associated with right-sided oblique cleft lip and short tail, while dosing on day 13 caused digital hypoplasia and/or amputation." | 1.29 | Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity. ( Brown-Woodman, PD; Danielsson, BR; Snow, MD; Webster, WS, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Webster, WS | 1 |
| Brown-Woodman, PD | 1 |
| Snow, MD | 1 |
| Danielsson, BR | 1 |
| Babin, JP | 1 |
| Carre, M | 1 |
| Martin, C | 1 |
2 other studies available for sotalol and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Cleft Palate; Dose-Response Relationsh | 1996 |
[Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Bradycardia; Cardiac Complexes, Premature; Facial Bones; Female; | 1985 |