sotalol has been researched along with A-V Dissociation in 19 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 7.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "Sotalol is a beta-blocking agent endowed with class III electrophysiological properties." | 5.27 | [Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia]. ( Cheymol, G; Chezalviel, F; Davy, JM; Ertzbischoff, O; Lainée, P; Motte, G; Poirier, JM; Weissenburger, J, 1988) |
| "Sotalol is a unique beta-blocker that lengthens cardiac repolarization and effective refractory period (ERP)." | 5.27 | Electrophysiologic and antiarrhythmic effects of sotalol in patients with life-threatening ventricular tachyarrhythmias. ( Feld, G; Hendrickson, J; Nademanee, K; Singh, BN; Singh, PN, 1985) |
| "7 mM and Mg2+=1 mM), d,l-sotalol (10 and 30 microM), a class III antiarrhythmic drug, prolonged ventricular repolarization, such as QT intervals and monophasic action potential duration, and induced early after-depolarization and polymorphic ventricular tachyarrhythmia." | 3.71 | Drug-induced ventricular tachyarrhythmia in isolated rabbit hearts with atrioventricular block. ( Ito, T; Kii, Y, 2002) |
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 3.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "Sotalol is a beta-adrenergic blocking agent that prolongs the duration of the cardiac action potential in humans, without affecting the upstroke velocity of depolarization." | 2.66 | Electrophysiologic effects of d-sotalol in humans. ( Garan, H; McComb, JM; McGovern, B; McGowan, JB; Ruskin, JN, 1987) |
| "Prior to polymorphic ventricular tachycardia, dispersion of APD further increased (APD70max-min: 17 +/- 3 ms; APD90max-min: 25 +/- 3 ms; p < 0." | 1.32 | Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia. ( Breithardt, G; Eckardt, L; Fabritz, L; Franz, MR; Haverkamp, W; Kirchhof, P; Milberg, P; Mönnig, G, 2003) |
| "In amiodarone-treated, hypokalemic hearts, no EAD or TdP occurred." | 1.32 | Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block. ( Breithardt, G; Eckardt, L; Haverkamp, W; Milberg, P; Mönnig, G; Osada, N; Ramtin, S; Wasmer, K, 2004) |
| "Polymorphic ventricular tachycardias (PVT) occur spontaneously in canine hearts under the combination of D-sotalol (S), bradycardia and phenylephrine (PE)." | 1.30 | Polymorphic ventricular tachycardias induced by D-sotalol and phenylephrine in canine preparations of atrioventricular block: initiation in the conduction system followed by spatially unstable re-entry. ( Brunet, S; Cardinal, R; Derakhchan, K; Klug, D; Kuś, T; Pharand, C; Sasyniuk, BI, 1998) |
| "d-Sotalol was less effective in the dilated left ventricle, narrowing the excitable gap only 9%, a difference that was not statistically significant." | 1.29 | Interaction of acute ventricular dilatation and d-sotalol during sustained reentrant ventricular tachycardia around a fixed obstacle. ( Allessie, MA; Boersma, L; Kirchhof, CJ; Reiter, MJ; Zetelaki, Z, 1994) |
| " But further programmed ventricular stimulation was uneventful after the sotalol dosage had been increased to 160 mg three times daily." | 1.29 | [Reproducible ventricular flutter during programming of a DDD pacemaker]. ( Bienstein, B; Grosse-Heitmeyer, W; Liebetrau, M; Stauff, L, 1993) |
| "Complete heart block was produced in dogs using an 8 French hexapolar ablation catheter, anterior skin electrode, and radiofrequency current (30 W, 13." | 1.28 | A simple in vivo model to evaluate the effects of antiarrhythmic agents. ( Barbey, JT; Solomon, AJ; Syn, D, 1992) |
| "Sotalol is a beta-blocking agent endowed with class III electrophysiological properties." | 1.27 | [Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia]. ( Cheymol, G; Chezalviel, F; Davy, JM; Ertzbischoff, O; Lainée, P; Motte, G; Poirier, JM; Weissenburger, J, 1988) |
| "Sotalol is a unique beta-blocker that lengthens cardiac repolarization and effective refractory period (ERP)." | 1.27 | Electrophysiologic and antiarrhythmic effects of sotalol in patients with life-threatening ventricular tachyarrhythmias. ( Feld, G; Hendrickson, J; Nademanee, K; Singh, BN; Singh, PN, 1985) |
| " In a further seven experiments dl-sotalol was administered using the same dosage regimen." | 1.27 | d-Sotalol: a new potent class III anti-arrhythmic agent. ( Donaldson, R; Sutton, P; Taggart, P, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fabritz, L | 1 |
| Kirchhof, P | 1 |
| Franz, MR | 1 |
| Eckardt, L | 2 |
| Mönnig, G | 2 |
| Milberg, P | 2 |
| Breithardt, G | 2 |
| Haverkamp, W | 2 |
| Ramtin, S | 1 |
| Osada, N | 1 |
| Wasmer, K | 1 |
| Thomsen, MB | 1 |
| Verduyn, SC | 2 |
| Stengl, M | 1 |
| Beekman, JD | 1 |
| de Pater, G | 1 |
| van Opstal, J | 1 |
| Volders, PG | 1 |
| Vos, MA | 3 |
| Desoutter, P | 1 |
| Medioni, J | 1 |
| Lerasle, S | 1 |
| Haiat, R | 1 |
| Reiter, MJ | 1 |
| Zetelaki, Z | 1 |
| Kirchhof, CJ | 1 |
| Boersma, L | 1 |
| Allessie, MA | 1 |
| Gorgels, AP | 1 |
| Lipcsei, GC | 1 |
| Wellens, HJ | 2 |
| Bienstein, B | 1 |
| Grosse-Heitmeyer, W | 1 |
| Liebetrau, M | 1 |
| Stauff, L | 1 |
| Manning, AS | 1 |
| Bruyninckx, C | 1 |
| Ramboux, J | 1 |
| Chatelain, P | 1 |
| Leerssen, HM | 1 |
| den Dulk, K | 1 |
| van der Zande, J | 1 |
| Muijtjens, AM | 1 |
| Begemann, MJ | 1 |
| Derakhchan, K | 1 |
| Cardinal, R | 1 |
| Brunet, S | 1 |
| Klug, D | 1 |
| Pharand, C | 1 |
| Kuś, T | 1 |
| Sasyniuk, BI | 1 |
| Kii, Y | 1 |
| Ito, T | 1 |
| Solomon, AJ | 1 |
| Syn, D | 1 |
| Barbey, JT | 1 |
| Weissenburger, J | 2 |
| Davy, JM | 2 |
| Chézalviel, F | 2 |
| Ertzbischoff, O | 2 |
| Poirier, JM | 2 |
| Engel, F | 1 |
| Lainée, P | 2 |
| Penin, E | 1 |
| Motté, G | 2 |
| Cheymol, G | 2 |
| McComb, JM | 1 |
| McGovern, B | 1 |
| McGowan, JB | 1 |
| Ruskin, JN | 1 |
| Garan, H | 1 |
| Nademanee, K | 1 |
| Feld, G | 1 |
| Hendrickson, J | 1 |
| Singh, PN | 1 |
| Singh, BN | 1 |
| Taggart, P | 1 |
| Sutton, P | 1 |
| Donaldson, R | 1 |
| Khan, MI | 1 |
| Hamilton, JT | 1 |
| Manning, GW | 1 |
| Aviado, DM | 1 |
| Belej, MA | 1 |
1 trial available for sotalol and A-V Dissociation
| Article | Year |
|---|---|
Electrophysiologic effects of d-sotalol in humans.
Topics: Adolescent; Adult; Aged; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Heart B | 1987 |
18 other studies available for sotalol and A-V Dissociation
| Article | Year |
|---|---|
Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; Elect | 2003 |
Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block.
Topics: Action Potentials; Administration, Oral; Amiodarone; Animals; Disease Models, Animal; Drug Administr | 2004 |
Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Cardiac Complexes, Premature; Chronic Disea | 2004 |
[Atrioventricular block and torsade de pointes following sotalol overdose].
Topics: Electrocardiography; Heart Block; Humans; Male; Middle Aged; Sotalol; Tachycardia | 1982 |
Interaction of acute ventricular dilatation and d-sotalol during sustained reentrant ventricular tachycardia around a fixed obstacle.
Topics: Animals; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Female; Heart Block; Heart Conduc | 1994 |
Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block.
Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Chronic Disease; Disease Models, Animal; Dog | 1995 |
[Reproducible ventricular flutter during programming of a DDD pacemaker].
Topics: Female; Heart Block; Humans; Middle Aged; Pacemaker, Artificial; Sotalol; Ventricular Fibrillation | 1993 |
SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats.
Topics: Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans | 1995 |
Steady-state and dynamic behavior of ventricular repolarization and refractoriness in the dog: the effect of multiple cycle length changes and d-sotalol administration.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Electrocardi | 1998 |
Polymorphic ventricular tachycardias induced by D-sotalol and phenylephrine in canine preparations of atrioventricular block: initiation in the conduction system followed by spatially unstable re-entry.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Dogs; Electrocardi | 1998 |
Drug-induced ventricular tachyarrhythmia in isolated rabbit hearts with atrioventricular block.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Cisapride; Dimethyl Sulfoxide; Disea | 2002 |
A simple in vivo model to evaluate the effects of antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Cardiac Pacing, Artificial; Catheter Ablatio | 1992 |
Arrhythmogenic activities of antiarrhythmic drugs in conscious hypokalemic dogs with atrioventricular block: comparison between quinidine, lidocaine, flecainide, propranolol and sotalol.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Consciousness; Diuretics; Dogs; Electrocardiography, A | 1991 |
[Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia].
Topics: Animals; Dogs; Electrocardiography; Female; Heart Block; Hypokalemia; Male; Research Design; Sotalol | 1988 |
Electrophysiologic and antiarrhythmic effects of sotalol in patients with life-threatening ventricular tachyarrhythmias.
Topics: Adult; Aged; Electrocardiography; Electrophysiology; Female; Heart Block; Humans; Injections, Intrav | 1985 |
d-Sotalol: a new potent class III anti-arrhythmic agent.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Endocardium; Female; Heart Block; Heart Ra | 1985 |
Early arrhythmias following experimental coronary occlusion in conscious dogs and their modification by beta-adrenoceptor blocking drugs.
Topics: Acetanilides; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Consciousn | 1973 |
Toxicity of aerosol propellants on the respiratory and circulatory systems. I. Cardiac arrhythmia in the mouse.
Topics: Aerosol Propellants; Aerosols; Animals; Arrhythmias, Cardiac; Atropine; Electrocardiography; Heart B | 1974 |