sorivudine has been researched along with Leukemia-Lymphoma--Adult-T-Cell* in 1 studies
1 other study(ies) available for sorivudine and Leukemia-Lymphoma--Adult-T-Cell
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A facile, alternative synthesis of 4'-thioarabinonucleosides and their biological activities.
4'-Thioarabinonucleosides, which are potential antiviral agents, were synthesized from D-glucose. 1,4-Anhydro-4-thioarabitol (8), which can be derived from diacetone glucose in nine steps, was subjected to Pummerer rearrangement after protection of the hydroxyl groups to give 1-O-acetyl-4-thioarabinose (11), which was condensed with nucleobases to give 4'-thioarabinonucleosides. The 5-substituted-4'-thioaraU (6a-e) derivatives showed anti-HSV-1 activity (ED50 = 0.43-3.50 micrograms/mL). 4'-ThioaraG (6h) and 2,6-diaminopurine 4'-thioarabinonucleoside (4'-thioaraDAP, 6g) showed antiviral activity against several herpes viruses and were particularly potent against human cytomegalovirus (0.010 and 0.022 microgram/mL, respectively). Topics: Antiviral Agents; Arabinonucleosides; Cell Division; Cell Line; Cytarabine; Cytomegalovirus; Herpesviridae; Humans; Indicators and Reagents; Leukemia-Lymphoma, Adult T-Cell; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thionucleosides; Tumor Cells, Cultured | 1997 |