sordaricin and Bacterial-Infections

sordaricin has been researched along with Bacterial-Infections* in 1 studies

Other Studies

1 other study(ies) available for sordaricin and Bacterial-Infections

Article	Year
Synthesis of Sordaricin analogues as potent antifungal agents against Candida albicans. Bioorganic & medicinal chemistry letters, 2002, Mar-11, Volume: 12, Issue:5 Sordaricin derivatives possessing a cyclohexane ring appendage attached via an ether, thioether, amine, oxime, ester or amide linkage were synthesized and their antifungal activity was evaluated in vitro. Compounds containing a thioether bond or an oxime bond as a linkage exhibited potent MICs (< or = 0.125 microg/mL) against four Candida albicans strains including azole-low-susceptible strains. They were also active (MIC < or = 0.125 microg/mL) against Candida glabrata. Their in vivo efficacy was confirmed in a murine intravenous infection model with Candida albicans. Topics: Animals; Antifungal Agents; Bacterial Infections; Bridged-Ring Compounds; Candida albicans; Diterpenes; Mice; Microbial Sensitivity Tests	2002

Article

Year

Synthesis of Sordaricin analogues as potent antifungal agents against Candida albicans.

Bioorganic & medicinal chemistry letters, 2002, Mar-11, Volume: 12, Issue:5

Sordaricin derivatives possessing a cyclohexane ring appendage attached via an ether, thioether, amine, oxime, ester or amide linkage were synthesized and their antifungal activity was evaluated in vitro. Compounds containing a thioether bond or an oxime bond as a linkage exhibited potent MICs (< or = 0.125 microg/mL) against four Candida albicans strains including azole-low-susceptible strains. They were also active (MIC < or = 0.125 microg/mL) against Candida glabrata. Their in vivo efficacy was confirmed in a murine intravenous infection model with Candida albicans.

Topics: Animals; Antifungal Agents; Bacterial Infections; Bridged-Ring Compounds; Candida albicans; Diterpenes; Mice; Microbial Sensitivity Tests

2002