sorbitol has been researched along with TDP-43 Proteinopathies in 1 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
TDP-43 Proteinopathies: Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dewey, CM | 1 |
| Cenik, B | 1 |
| Sephton, CF | 1 |
| Dries, DR | 1 |
| Mayer, P | 1 |
| Good, SK | 1 |
| Johnson, BA | 1 |
| Herz, J | 1 |
| Yu, G | 1 |
1 other study available for sorbitol and TDP-43 Proteinopathies
| Article | Year |
|---|---|
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Biological Assay; Cell Line; Cells, Cul | 2011 |