sorbitol has been researched along with Protein Aggregation, Pathological in 4 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hans, F | 1 |
| Glasebach, H | 1 |
| Kahle, PJ | 1 |
| Aravindan, S | 1 |
| Chen, S | 1 |
| Choudhry, H | 1 |
| Molfetta, C | 1 |
| Chen, KY | 1 |
| Liu, AYC | 1 |
| Guiberson, NGL | 1 |
| Pineda, A | 1 |
| Abramov, D | 1 |
| Kharel, P | 1 |
| Carnazza, KE | 1 |
| Wragg, RT | 1 |
| Dittman, JS | 1 |
| Burré, J | 1 |
| Choudhary, S | 1 |
| Kishore, N | 1 |
| Hosur, RV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for sorbitol and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.
Topics: Acetylcysteine; Adenine; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; Frontotemporal Dementi | 2020 |
Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models.
Topics: Animals; Autophagy; Cyclic AMP Response Element-Binding Protein; Gene Knockdown Techniques; Glycerol | 2020 |
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones.
Topics: Animals; Brain Diseases; Caenorhabditis elegans Proteins; Cell Line, Tumor; Cells, Cultured; HEK293 | 2018 |
Inhibition of insulin fibrillation by osmolytes: Mechanistic insights.
Topics: Amyloid; Betaine; Calorimetry; Insulin; Kinetics; Models, Biological; Osmolar Concentration; Proline | 2015 |