sorbitol has been researched along with Liver Cirrhosis in 47 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A significant correlation was found between the alfentanil AUC(infinity(p)) and AUC(infinity)((miosis)) (r = 0." | 7.74 | Alfentanil-induced miosis as a surrogate measure of alfentanil pharmacokinetics in patients with mild and moderate liver cirrhosis. ( Baririan, N; Desager, JP; Horsmans, Y; Starkel, P; Van Obbergh, L; Verbeeck, RK; Wallemacq, P, 2007) |
| "We have determined the extrarenal sorbitol clearance (14 cases) and the Congestion Index (seven cases) before and at 30, 60, and 90 min after the oral administration of 25 mg dipyridamole in patients with liver cirrhosis." | 5.08 | Beneficial hemodynamic effects of dipyridamole on portal circulation in cirrhosis. ( D'Alimonte, P; Ferrari, A; Manenti, F; Romagnoli, R; Sansoè, G; Trenti, T; Villa, E; Zoboli, P, 1998) |
| "A significant correlation was found between the alfentanil AUC(infinity(p)) and AUC(infinity)((miosis)) (r = 0." | 3.74 | Alfentanil-induced miosis as a surrogate measure of alfentanil pharmacokinetics in patients with mild and moderate liver cirrhosis. ( Baririan, N; Desager, JP; Horsmans, Y; Starkel, P; Van Obbergh, L; Verbeeck, RK; Wallemacq, P, 2007) |
| " An interesting opportunity for reconsidering the problem has been provided by the use, in the study of liver function, of D-sorbitol, a substance whose first-pass hepatic extraction is very high in normal subjects, while being directly related to circulatory alterations in liver cirrhosis." | 3.70 | Arterial-venous shunting in liver cirrhosis. ( Avagnina, P; Bar, F; Battista, S; Fava, C; Garello, E; Grosso, M; Molino, G; Niro, AG; Spalluto, F; Torchio, M, 1998) |
| "Three groups (6 patients with liver cirrhosis, 6 patients with diabetes mellitus, 6 controls) have been infused for 48 h with a 20% (w/v) glucose/sorbitol-solution (1:1)." | 3.66 | [Carbohydrate infusions in internal diseases. A comparative study in metabolically normal subjects, patients with liver diseases and diabetics. V. Infusion of a glucose-sorbitol mixture (ratio 1:1) for 48 hours]. ( Beerenfeld, A; Egberts, EH; Horbach, L; Malchow, H; Müller, PH; Prestele, H; Schmülling, R, 1982) |
| " For the glucuronide conjugate of 4-hydroxyatomoxetine, the mean half-life was longer and the mean area under the concentration-time curve from time 0 to infinity and the maximum concentration were lower (P =." | 1.32 | Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites. ( Chalon, SA; Desager, JP; Desante, KA; Frye, RF; Golnez, JL; Horsmans, Y; Long, AJ; Sauer, JM; Smith, BP; Thomasson, HR; Witcher, J, 2003) |
| "In this study a mathematical model was applied to predict how changes in hepatic extraction ratio (E), fractional portal inflow (P) and renal elimination ratio (R) may affect fractional D-sorbitol bioavailability in cirrhotic patients." | 1.30 | Prediction by mathematical simulation of different pathophysiological effects on D-sorbitol bioavailability. ( Bar, F; Battista, S; Molino, G; Torchio, M, 1998) |
| " The fractional bioavailability (Fma) of D-sorbitol was calculated as the ratio between the net cumulative urinary outputs obtained after infusion through the catheter into the superior mesenteric artery and the systemic vein, respectively." | 1.29 | Determination of functional portal-systemic shunting in patients submitted to hepatic angiography. ( Avagnina, P; Bar, F; Battista, S; Garello, E; Grosso, M; Molino, G; Spalluto, F, 1996) |
| " Bioavailability of sorbitol, calculated as ratio of the areas under the plasma concentration/time curve after p." | 1.27 | Non-invasive evaluation of portal-systemic shunting in man by D-sorbitol bioavailability. ( Avagnina, P; Ballarè, M; Bircher, J; Cavanna, A; Fracchia, M; Molino, G; Torchio, M, 1987) |
| " Mixed solutions (20% w/v) containing glucose + fructose (n = 6), glucose + sorbite (n = 36), glucose + xylit (n = 37) in a 1:1 ratio, and glucose + fructose + xylit (n = 6) in a 1:2:1 ratio as well as glucose alone (n = 6) were administered in a dosage of 0." | 1.26 | [Carbohydrate infusions in internal diseases. A comparative study in metabolically healthy, liver diseased and diabetic patients. VIII. Continuous infusions of low dosage carbohydrate mixtures in patients with liver cirrhosis]. ( Egberts, EH; Müller, PH, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (59.57) | 18.7374 |
| 1990's | 12 (25.53) | 18.2507 |
| 2000's | 7 (14.89) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chalon, SA | 1 |
| Desager, JP | 2 |
| Desante, KA | 1 |
| Frye, RF | 1 |
| Witcher, J | 1 |
| Long, AJ | 1 |
| Sauer, JM | 1 |
| Golnez, JL | 1 |
| Smith, BP | 1 |
| Thomasson, HR | 1 |
| Horsmans, Y | 2 |
| Li, YM | 1 |
| Lv, F | 1 |
| Xu, X | 1 |
| Ji, H | 1 |
| Gao, WT | 1 |
| Lei, TJ | 1 |
| Ren, GB | 1 |
| Bai, ZL | 1 |
| Li, Q | 1 |
| PREISICH, P | 1 |
| PINTER, Z | 1 |
| BIRO, G | 1 |
| MARCHESI, E | 1 |
| PADULA, F | 1 |
| PASQUIER, J | 1 |
| MESTRALLET, G | 1 |
| SITE, M | 1 |
| FUKUTA, Y | 1 |
| HOSHI, M | 1 |
| MONGES, H | 1 |
| HANCY, A | 1 |
| OHRESSER, P | 1 |
| TETE, R | 1 |
| ZECH, P | 1 |
| KONO, H | 1 |
| Pan, Z | 1 |
| Wu, XJ | 1 |
| Li, JS | 1 |
| Liu, FN | 1 |
| Li, WS | 1 |
| Han, JM | 1 |
| Baririan, N | 1 |
| Van Obbergh, L | 1 |
| Verbeeck, RK | 1 |
| Wallemacq, P | 1 |
| Starkel, P | 1 |
| Beaven, J | 1 |
| Bjørneklett, A | 1 |
| Jenssen, E | 1 |
| Blomhoff, JP | 1 |
| Skrede, S | 1 |
| Luft, D | 1 |
| Egberts, EH | 2 |
| Müller, PH | 2 |
| Beerenfeld, A | 1 |
| Schmülling, R | 1 |
| Prestele, H | 1 |
| Horbach, L | 1 |
| Malchow, H | 1 |
| Zoli, M | 2 |
| Magalotti, D | 2 |
| Bianchi, G | 2 |
| Ghigi, G | 1 |
| Orlandini, C | 1 |
| Grimaldi, M | 1 |
| Marchesini, G | 2 |
| Pisi, E | 1 |
| Avagnina, P | 7 |
| Sansoè, G | 2 |
| Martini, M | 1 |
| Peretti, P | 1 |
| Tinivella, M | 1 |
| Molino, G | 9 |
| Battista, S | 4 |
| Bar, F | 4 |
| Garello, E | 3 |
| Grosso, M | 2 |
| Spalluto, F | 2 |
| Wensing, G | 1 |
| Lotterer, E | 2 |
| Link, I | 1 |
| Hahn, EG | 2 |
| Fleig, WE | 1 |
| Torchio, M | 4 |
| Niro, AG | 1 |
| Fava, C | 1 |
| Ferrari, A | 1 |
| D'Alimonte, P | 1 |
| Trenti, T | 1 |
| Zoboli, P | 1 |
| Romagnoli, R | 1 |
| Villa, E | 1 |
| Manenti, F | 1 |
| Belforte, G | 1 |
| Bircher, J | 5 |
| Fabbri, A | 1 |
| Brizi, M | 1 |
| Niro, GA | 1 |
| Cappello, N | 1 |
| Rizzetto, M | 1 |
| Ott, P | 1 |
| Clemmesen, O | 1 |
| Keiding, S | 3 |
| Herold, C | 1 |
| Heinz, R | 1 |
| Radespiel-Tröger, M | 1 |
| Schneider, HT | 1 |
| Schuppan, D | 1 |
| Winkler, G | 1 |
| Kempler, P | 1 |
| Brodanová, M | 2 |
| Brodan, V | 2 |
| Filip, J | 2 |
| Kuhn, E | 1 |
| Gressner, AM | 1 |
| Kropf, J | 1 |
| Grobe, E | 1 |
| von Knebel, D | 1 |
| Cavallo-Perin, P | 1 |
| Bruno, A | 1 |
| Nuccio, P | 1 |
| Dall'omo, AM | 1 |
| Fronda, GR | 1 |
| Bozzo, C | 1 |
| Pagano, G | 1 |
| Cavanna, A | 2 |
| Ballaré, M | 2 |
| Fracchia, M | 1 |
| Vollerthun, R | 1 |
| Lämmler, G | 1 |
| Schuster, J | 1 |
| Müller, J | 1 |
| Guggenheim, P | 1 |
| Haemmerli, UP | 2 |
| Lechat, S | 1 |
| Pattin, S | 1 |
| Vigne, J | 1 |
| Strec, V | 1 |
| Zajacová, O | 1 |
| Dzúriková, V | 1 |
| Kordac, V | 1 |
| Marecek, Z | 1 |
| Slabochová, Z | 1 |
| Elkington, SG | 1 |
| Floch, MH | 1 |
| Conn, HO | 1 |
| Geser, CA | 1 |
| Pitkänen, E | 1 |
| Servo, C | 1 |
| Wolf, HP | 1 |
| Queisser, W | 1 |
| Beck, K | 1 |
| Williams, R | 1 |
| Brown, H | 1 |
| Trey, C | 1 |
| McDermott, WV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Hydromorphone High Resolution Pharmacokinetic-Pharmacodynamic Fingerprint as the Basis for Identifying Sex Differences in Opioid Pharmacokinetics and Pharmacodynamics[NCT01123486] | 0 participants (Actual) | Interventional | 2015-01-31 | Withdrawn (stopped due to PI relocated to new university) | |||
| Effect of Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Liver Cirrhosis; a Randomized Clinical Trial (PEGHE Trial)[NCT04436601] | Phase 4 | 102 participants (Anticipated) | Interventional | 2020-03-09 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for sorbitol and Liver Cirrhosis
| Article | Year |
|---|---|
Assessment of the hepatic circulation in humans: new concepts based on evidence derived from a D-sorbitol clearance method.
Topics: Coloring Agents; Humans; Indicators and Reagents; Indocyanine Green; Liver; Liver Circulation; Liver | 1998 |
[The pathogenesis of diabetic and hepatic neuropathies].
Topics: Chronic Disease; Diabetic Neuropathies; Glucose; Hemodynamics; Hemorheology; Humans; Lipid Peroxidat | 2001 |
6 trials available for sorbitol and Liver Cirrhosis
| Article | Year |
|---|---|
Beneficial hemodynamic effects of dipyridamole on portal circulation in cirrhosis.
Topics: Administration, Oral; Adult; Aged; Dipyridamole; Female; Hemodynamics; Humans; Liver Circulation; Li | 1998 |
Prostaglandin E1 infusion and functional hepatic flow in control subjects and in patients with cirrhosis.
Topics: Aged; Alprostadil; Blood Pressure; Female; Heart Rate; Hemodynamics; Humans; Liver Circulation; Live | 1999 |
Evaluation of hepatic function in liver cirrhosis: clinical utility of galactose elimination capacity, hepatic clearance of D-sorbitol, and laboratory investigations.
Topics: Adolescent; Adult; Aged; Butyrylcholinesterase; Child; Female; Galactose; Humans; Liver Cirrhosis; L | 1999 |
Lactulose in the treatment of chronic portal-systemic encephalopathy. A double-blind clinical trial.
Topics: Adult; Aged; Alcoholism; Ammonia; Brain Diseases; Chronic Disease; Clinical Trials as Topic; Colon; | 1969 |
Lactulose in the treatment of portal-systemic encephalopathy. Report of a symposium.
Topics: Adult; Animals; Brain Diseases; Child; Dogs; Electroencephalography; Fructose; Hepatic Encephalopath | 1970 |
Lactulose treatment of hepatic encephalopathy in outpatients.
Topics: Adolescent; Aged; Alcoholism; Ambulatory Care; Ammonia; Brain Diseases; Colon; Diet Therapy; Dietary | 1971 |
39 other studies available for sorbitol and Liver Cirrhosis
| Article | Year |
|---|---|
Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites.
Topics: Administration, Oral; Adult; Antidepressive Agents; Area Under Curve; Atomoxetine Hydrochloride; Att | 2003 |
Evaluation of liver functional reserve by combining D-sorbitol clearance rate and CT measured liver volume.
Topics: Adult; Female; Humans; Indicators and Reagents; Liver; Liver Cirrhosis; Male; Middle Aged; Sorbitol; | 2003 |
[The role of sorbitol dehydrogenase in the diagnosis of liver diseases].
Topics: Hepatitis; Jaundice; Jaundice, Obstructive; L-Iditol 2-Dehydrogenase; Liver Cirrhosis; Liver Disease | 1963 |
[THE ASSOCIATION OF SORBITOL, GLUTAMIC ACID AND CHOLINE HYPOSULFITE IN THE THERAPY OF HEPATIC DISEASES AND MINOR HEPATIC INSUFFICIENCY].
Topics: Adolescent; Biliary Dyskinesia; Child; Cholangitis; Cholecystitis; Cholelithiasis; Choline; Dithioni | 1963 |
[CLINICAL USE OF A NEW COMBINATION FOR THE PURPOSE OF HEPATO-BILIARY THERAPY].
Topics: Abdomen; Abdomen, Acute; Atropine; Cholagogues and Choleretics; Cholelithiasis; Dyspepsia; Hepatitis | 1964 |
INFLUENCE OF HEXOSE ON DETOXICATION. 2. EFFECT OF HEXOSE LOADS ON BLOOD ALCOHOL LEVELS IN RABBITS.
Topics: Blood Chemical Analysis; Blood Glucose; Ethanol; Fructose; Hexoses; Humans; Liver Cirrhosis; Liver C | 1963 |
CLINICAL APPLICATION OF SORBITOL IN PATIENTS WITH DIABETES MELLITUS AND IN PATIENTS WITH LIVER DISEASE.
Topics: Biomedical Research; Blood Chemical Analysis; Blood Glucose; Carbohydrate Metabolism; Diabetes Melli | 1963 |
[CLINICAL EXPERIMENTATION WITH DIBILENE].
Topics: Atropine; Biliary Dyskinesia; Biomedical Research; Cholagogues and Choleretics; Cholangitis; Cholecy | 1964 |
[TRIAL OF ORNITAINE IN THE HEPATIC INSUFFICIENCY OF CIRRHOTICS].
Topics: Alkaloids; Citrates; Geriatrics; Hepatic Insufficiency; Humans; Liver Cirrhosis; Magnesium; Ornithin | 1964 |
[CLINICAL RESEARCH ON PYRUVIC ACID METABOLISM IN LIVER DISEASES. II. EFFECTS OF DIFFERENT DRUGS ON THE PYRUVIC ACID BLOOD LEVEL IN LIVER DISEASES].
Topics: Adrenal Cortex Hormones; Asparagine; Blood Chemical Analysis; Glucose; Hepatitis; Hepatitis A; Liver | 1964 |
Functional hepatic flow in patients with liver cirrhosis.
Topics: Adult; Aged; Case-Control Studies; Female; Hepatic Artery; Humans; Hypertension, Portal; Indicators | 2004 |
Alfentanil-induced miosis as a surrogate measure of alfentanil pharmacokinetics in patients with mild and moderate liver cirrhosis.
Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Bi | 2007 |
Pulmonary hydrogen and methane and plasma ammonia after the administration of lactulose or sorbitol.
Topics: Adult; Ammonia; Breath Tests; Disaccharides; Female; Fermentation; Humans; Hydrogen; Intestinal Muco | 1983 |
[Carbohydrate infusion in internal diseases. A comparative study in metabolically healthy patients, patients with liver diseases and diabetic patients. I. Physiopathologic aspects in the parenteral administration of monosaccharides].
Topics: Blood Glucose; Diabetes Mellitus; Fructose; Humans; Liver Cirrhosis; Monosaccharides; Parenteral Nut | 1981 |
[Carbohydrate infusions in internal diseases. A comparative study in metabolically healthy, liver diseased and diabetic patients. VIII. Continuous infusions of low dosage carbohydrate mixtures in patients with liver cirrhosis].
Topics: Bicarbonates; Blood Glucose; Carbon Dioxide; Energy Metabolism; Fructose; Glucose; Glucose Solution, | 1982 |
[Carbohydrate infusions in internal diseases. A comparative study in metabolically normal subjects, patients with liver diseases and diabetics. V. Infusion of a glucose-sorbitol mixture (ratio 1:1) for 48 hours].
Topics: Diabetes Mellitus; Glucose; Humans; Infusions, Parenteral; Liver Cirrhosis; Sorbitol; Triglycerides | 1982 |
Functional hepatic flow and Doppler-assessed total hepatic flow in control subjects and in patients with cirrhosis.
Topics: Adult; Aged; Diuretics, Osmotic; Female; Humans; Liver Circulation; Liver Cirrhosis; Male; Middle Ag | 1995 |
Effects of nifedipine on functional liver plasma flow in normal subjects and in patients with cirrhosis.
Topics: Adult; Aged; Female; Humans; Liver Circulation; Liver Cirrhosis; Male; Middle Aged; Nifedipine; Refe | 1993 |
Determination of functional portal-systemic shunting in patients submitted to hepatic angiography.
Topics: Adult; Aged; Aged, 80 and over; Angiography; Female; Humans; Liver Circulation; Liver Cirrhosis; Mal | 1996 |
Urinary sodium balance in patients with cirrhosis: relationship to quantitative parameters of liver function.
Topics: Adult; Aged; Aminopyrine; Ascites; Breath Tests; Female; Galactose; Humans; Indocyanine Green; Liver | 1997 |
Arterial-venous shunting in liver cirrhosis.
Topics: Adult; Aged; Biological Availability; Female; Hepatic Artery; Humans; Liver Circulation; Liver Cirrh | 1998 |
Prediction by mathematical simulation of different pathophysiological effects on D-sorbitol bioavailability.
Topics: Biological Availability; Cohort Studies; Computer Simulation; Humans; Liver; Liver Circulation; Live | 1998 |
Interpretation of simultaneous measurements of hepatic extraction fractions of indocyanine green and sorbitol: evidence of hepatic shunts and capillarization?
Topics: Acute Disease; Adult; Aged; Capillaries; Chronic Disease; Female; Humans; Indocyanine Green; Liver; | 2000 |
Quantitative testing of liver function in patients with cirrhosis due to chronic hepatitis C to assess disease severity.
Topics: Aminopyrine; Biopsy; Breath Tests; Female; Galactose; Hepatitis C, Chronic; Humans; Indocyanine Gree | 2001 |
[Metabolic effects of parenteral administration of glucose, fructose, sorbitol and xylitol in cirrhotic and healthy subjects].
Topics: Adult; Aged; Fructose; Glucose; Humans; Injections, Intravenous; Liver Cirrhosis; Middle Aged; Sorbi | 1976 |
Higher levels of serum aminoterminal type III procollagen peptide, and laminin in alcoholic than in nonalcoholic cirrhosis of equal severity.
Topics: Adult; Aged; Biomarkers; Female; Galactose; Humans; Laminin; Liver Cirrhosis; Liver Cirrhosis, Alcoh | 1992 |
Can intrahepatic shunting be measured?
Topics: Blood Flow Velocity; Hepatic Veins; Humans; Indocyanine Green; Liver Circulation; Liver Cirrhosis; L | 1991 |
Sorbitol clearance: shift from flow-limitation in controls to enzyme-flow dependence in cirrhosis.
Topics: Blood Flow Velocity; Humans; Liver Circulation; Liver Cirrhosis; Sorbitol | 1989 |
Insulin resistance in human liver cirrhosis is not modified by porto-systemic surgical shunt.
Topics: Adult; Blood Glucose; C-Peptide; Fasting; Female; Glucose Tolerance Test; Humans; Insulin; Insulin R | 1986 |
Hepatic clearance of D-sorbitol. Noninvasive test for evaluating functional liver plasma flow.
Topics: Humans; Liver; Liver Circulation; Liver Cirrhosis; Metabolic Clearance Rate; Sorbitol | 1987 |
Non-invasive evaluation of portal-systemic shunting in man by D-sorbitol bioavailability.
Topics: Adult; Aged; Biological Availability; Female; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; | 1987 |
[Capillaria hepatica infection of Mastomys natalensis: alterations of enzyme activities in serum (author's transl)].
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Alkaline Phosphatase; Animals; Aspartate Aminotransfe | 1974 |
Treatment of chronic portal-systemic encephalopathy with lactulose.
Topics: Brain Diseases; Diet Therapy; Dietary Proteins; Disaccharides; Humans; Liver Cirrhosis; Male; Middle | 1966 |
[Value of an orotic acid-sorbitol combination in hepato-intestinal diseases. Point of view of a general practitioner].
Topics: Adult; Aged; Alcoholism; Dyspepsia; Female; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Male | 1967 |
[Administration of sorbitol infusion to patients with chronic renal failure and to patients with liver cirrhosis].
Topics: Adult; Humans; Injections, Intravenous; Kidney Failure, Chronic; Liver Cirrhosis; Sorbitol | 1973 |
[Metabolic reflection of fructose, xylitol and sorbitol infusion in healthy persons and in persons with cirrhosis].
Topics: Antigens; Fatty Acids, Nonesterified; Fructose; Humans; Injections, Intravenous; Insulin; Liver Cirr | 1973 |
[Clinical use of xylitol].
Topics: Acidosis; Diabetes Mellitus; Fructose; Glucose; Glycosuria; Humans; Liver Cirrhosis; Parenteral Nutr | 1971 |
Polyol oxidoreductase activity in human blood serum during acute hepatitis.
Topics: Acute Disease; Alcohol Oxidoreductases; Aspartate Aminotransferases; Carbohydrates; Electrophoresis; | 1971 |
[Initial drop of serum phosphate in healthy persons and patients with liver diseases following intravenous administration of hexoses and sugar alcohols].
Topics: Alcohols; Fatty Liver; Fructose; Glucose; Hexoses; Humans; Injections, Intravenous; Liver; Liver Cir | 1969 |