Compounds > sorbitol
Page last updated: 2024-11-06

sorbitol and Insulin Sensitivity

sorbitol has been researched along with Insulin Sensitivity in 16 studies

D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).

Research Excerpts

ExcerptRelevanceReference
"SGL5213 and miglitol improved obesity, liver dysfunction, insulin resistance, and the NAFLD severity."4.02Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice. ( Honda, Y; Imajo, K; Iwaki, M; Kessoku, T; Kobayashi, T; Nagashima, Y; Nakajima, A; Nogami, A; Ogawa, Y; Ozaki, A; Saito, S; Tomeno, W; Yoneda, M, 2021)
"On SAC administration in the rats with diabetes, the levels of blood glucose, insulin resistance, glycated hemoglobin, AR, SDH, sorbitol, fructose, TBARS and hydroperoxide increased significantly (p<0."3.83Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes. ( Begum, MS; Meriga, B; Munipally, PK; Naidu, PB; Naik, RR; Pandiyan, R; Pothani, S; Saravanan, G; Sathibabu Uddandrao, VV; Varatharaju, C, 2016)
"There is no significant difference in insulin sensitivity in adipose tissue from pregnant or nonpregnant women; hyperosmolarity stimulates glucose uptake in subcutaneous adipose tissue from nonpregnant women, and adipose tissue from pregnant women is sorbitol resistant."3.73Adipose tissue from pregnant women with and without gestational diabetes mellitus: insulin-sensitive but resistant to hyperosomolarity. ( McIntyre, HD; Prins, JB; Russell, AW; Whitehead, JP, 2005)
" Insulin responses to tolbutamide, glucagon, arginine and leucine were determined and insulin resistance was measured with exogenous iv insulin."3.65Carbohydrate metabolism and insulin resistance in myotonia dystrophica. ( Hudson, AJ; Tevaarwerk, GJ, 1977)
"Obviously, in a certain group of polytraumatized patients a "metabolic insulin resistence" exists."1.26[Insulin concentration in polytraumatized patients during infusion of glucose, fructose and sorbitol]. ( Albrecht, H; Dudziak, R; Förster, H; Quadbeck, R; Steuer, A, 1978)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19905 (31.25)18.7374
1990's1 (6.25)18.2507
2000's6 (37.50)29.6817
2010's2 (12.50)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Tan, S1
Ignatenko, S1
Wagner, F1
Dokras, A1
Seufert, J1
Zwanziger, D1
Dunschen, K1
Zakaria, M1
Huseinovic, N1
Basson, CT1
Mahling, P1
Fuhrer, D1
Hinder, M1
Honda, Y1
Ozaki, A1
Iwaki, M1
Kobayashi, T1
Nogami, A1
Kessoku, T1
Ogawa, Y1
Tomeno, W1
Imajo, K1
Yoneda, M1
Saito, S1
Nagashima, Y1
Nakajima, A1
Giesbertz, P1
Padberg, I1
Rein, D1
Ecker, J1
Höfle, AS1
Spanier, B1
Daniel, H1
Naidu, PB1
Sathibabu Uddandrao, VV1
Naik, RR1
Pothani, S1
Munipally, PK1
Meriga, B1
Begum, MS1
Varatharaju, C1
Pandiyan, R1
Saravanan, G1
Howard, BV1
Wylie-Rosett, J1
Yamada, N1
Kumeda, Y1
Inaba, M1
Nishizawa, Y1
Yagihashi, S1
Russell, AW1
McIntyre, HD1
Whitehead, JP1
Prins, JB1
Lin, HJ1
Loh, CH1
Liao, MT1
Liu, TT1
Hsieh, PS1
Dayhaw-Barker, P1
Förster, H1
Steuer, A1
Albrecht, H1
Quadbeck, R1
Dudziak, R1
Tevaarwerk, GJ1
Hudson, AJ1
Gutman, A1
Andreus, A1
Adler, JH1
Misbin, RI1
Green, A1
Alvarez, IM1
Almira, EC1
Dohm, GL1
Caro, JF1
Cavallo-Perin, P1
Bruno, A1
Nuccio, P1
Dall'omo, AM1
Fronda, GR1
Avagnina, P1
Molino, G1
Bozzo, C1
Pagano, G1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Influence of Food Liking of Adding Spices to Replace Dietary Sugar Using Sequential Monadic CLT Methodology[NCT03139552]150 participants (Actual)Interventional2016-10-17Completed
Influence on Food Liking of Adding Spices to Replace Dietary Sugar[NCT03134079]160 participants (Actual)Interventional2015-09-10Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Liking of Apple Crisp

Overall liking of apple crisp with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: Day of taste testing

Interventionscore on likert rating scale (Mean)
Full Sugar Recipe7.31
Reduced Sugar Recipe6.83
Reduced Sugar Plus Spice Recipe7.22

Overall Liking of Oatmeal

Overall liking of oatmeal with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing

Interventionscore on a likert rating scale (Mean)
Full Sugar Recipe6.84
Reduced Sugar Recipe5.70
Reduced Sugar Plus Spice Recipe6.15

Overall Liking of Tea

Overall liking of tea with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing

Interventionscore on a likert rating scale (Mean)
Full Sugar Recipe6.00
Reduced Sugar Recipe5.62
Reduced Sugar Plus Spice Recipe5.85

Ranking of Full Sugar Recipe of Apple Crisp

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking54
Second Place Ranking63
Third Place Ranking33

Ranking of Full Sugar Recipe of Oatmeal

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking88
Second Place Ranking39
Third Place Ranking21

Ranking of Full Sugar Recipe of Tea

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking66
Second Place Ranking41
Third Place Ranking42

Ranking of Reduced Sugar Plus Spice Oatmeal

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking48
Second Place Ranking60
Third Place Ranking40

Ranking of Reduced Sugar Plus Spice Recipe of Apple Crisp

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking63
Second Place Ranking44
Third Place Ranking43

Ranking of Reduced Sugar Plus Spice Recipe of Tea

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking49
Second Place Ranking50
Third Place Ranking50

Ranking of Reduced Sugar Recipe of Apple Crisp

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking33
Second Place Ranking43
Third Place Ranking74

Ranking of Reduced Sugar Recipe of Oatmeal

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing

InterventionParticipants (Count of Participants)
First Place Ranking12
Second Place Ranking49
Third Place Ranking87

Ranking of Reduced Sugar Recipe of Tea

Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: Day of taste testings

InterventionParticipants (Count of Participants)
First Place Ranking34
Second Place Ranking58
Third Place Ranking57

Reviews

4 reviews available for sorbitol and Insulin Sensitivity

ArticleYear
[Molecular mechanisms of diabetic atherosclerosis].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10

    Topics: Arteriosclerosis; Diabetes Complications; Glycation End Products, Advanced; Humans; Hyperinsulinism;

2002
[Diabetes mellitus and osteoporosis].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10

    Topics: Animals; Bone and Bones; Chronic Disease; Diabetes Complications; Diagnosis, Differential; Humans; H

2002
[Early diagnosis of peripheral neuropathy in patients with impaired glucose tolerance (IGT)].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6

    Topics: Diabetic Neuropathies; Glucose Intolerance; Glycation End Products, Advanced; Humans; Hyperglycemia;

2005
Mechanisms of pathogenesis in diabetes mellitus.
    Optometry and vision science : official publication of the American Academy of Optometry, 1995, Volume: 72, Issue:6

    Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Histocompatibilit

1995

Trials

1 trial available for sorbitol and Insulin Sensitivity

ArticleYear
Licogliflozin versus placebo in women with polycystic ovary syndrome: A randomized, double-blind, phase 2 trial.
    Diabetes, obesity & metabolism, 2021, Volume: 23, Issue:11

    Topics: Anhydrides; Double-Blind Method; Female; Humans; Hyperandrogenism; Insulin Resistance; Polycystic Ov

2021

Other Studies

11 other studies available for sorbitol and Insulin Sensitivity

ArticleYear
Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice.
    Journal of pharmacological sciences, 2021, Volume: 147, Issue:2

    Topics: 1-Deoxynojirimycin; Animals; Chronic Disease; Diet, High-Fat; Dietary Sucrose; Disease Models, Anima

2021
Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes.
    Diabetologia, 2015, Volume: 58, Issue:9

    Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Fatty Acids; Gas Chromato

2015
Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes.
    Canadian journal of diabetes, 2016, Volume: 40, Issue:5

    Topics: Aldehyde Reductase; Animals; Biomarkers; Blood Glucose; Cysteine; Diabetes Mellitus, Experimental; F

2016
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
    Circulation, 2002, Jul-23, Volume: 106, Issue:4

    Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca

2002
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
    Circulation, 2002, Jul-23, Volume: 106, Issue:4

    Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca

2002
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
    Circulation, 2002, Jul-23, Volume: 106, Issue:4

    Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca

2002
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
    Circulation, 2002, Jul-23, Volume: 106, Issue:4

    Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca

2002
Adipose tissue from pregnant women with and without gestational diabetes mellitus: insulin-sensitive but resistant to hyperosomolarity.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:6

    Topics: Adipose Tissue; Adult; Diabetes, Gestational; Female; Glucose; Glucose Transporter Type 4; Humans; I

2005
Attenuation of hypertriglyceridemia-induced pressor effect in rats with fructose-induced insulin resistance.
    The Chinese journal of physiology, 2007, Feb-28, Volume: 50, Issue:1

    Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Diet; Drug Combinations; Fructose; Heart Rate;

2007
[Insulin concentration in polytraumatized patients during infusion of glucose, fructose and sorbitol].
    Infusionstherapie und klinische Ernahrung, 1978, Volume: 5, Issue:4

    Topics: Dietary Carbohydrates; Energy Metabolism; Fructose; Glucose; Humans; Insulin; Insulin Resistance; Pa

1978
Carbohydrate metabolism and insulin resistance in myotonia dystrophica.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:3

    Topics: Adult; Aged; Arginine; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose;

1977
Hyperinsulinemia, insulin resistance and cataract formation in sand rats.
    Israel journal of medical sciences, 1975, Volume: 11, Issue:7

    Topics: Adipose Tissue; Animals; Cataract; Diet; Disease Models, Animal; Galactitol; Glucose; Hyperglycemia;

1975
Inhibition of insulin-stimulated glucose transport by factor extracted from serum of insulin-resistant patient.
    Diabetes, 1988, Volume: 37, Issue:9

    Topics: 3-O-Methylglucose; Acanthosis Nigricans; Adipose Tissue; Adult; Animals; Binding, Competitive; Deoxy

1988
Insulin resistance in human liver cirrhosis is not modified by porto-systemic surgical shunt.
    Acta endocrinologica, 1986, Volume: 112, Issue:3

    Topics: Adult; Blood Glucose; C-Peptide; Fasting; Female; Glucose Tolerance Test; Humans; Insulin; Insulin R

1986