sorbitol has been researched along with Hyperglycemia in 98 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract." | 8.02 | Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021) |
| " We report a case where hyperglycaemia and lactic acidosis complicated the TURP syndrome caused by the massive absorption (approximately 15 litres) of a sorbitol- mannitol irrigation solution." | 7.71 | Another feature of TURP syndrome: hyperglycaemia and lactic acidosis caused by massive absorption of sorbitol. ( Brochu, J; Lessard, MR; Trépanier, CA; Turcotte, G, 2001) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 7.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| "myo-Inositol accumulation and incorporation into phosphoinositides was decreased in neuroblastoma cells chronically exposed to medium containing 30 mmol/L glucose or 30 mmol/L galactose." | 7.68 | Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993) |
| " The sorbitol content of erythrocytes was increased during the period of hyperglycemia from a mean basal value of 65 +/- 9 to 106 -/+ 6 mumol/L." | 7.66 | Sorbitol content of plasma and erythrocytes during induced short-term hyperglycemia. ( Hubinont, C; Malaisse, WJ; Sener, A, 1981) |
| " The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract." | 4.02 | Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021) |
| " A single, intraperitoneal injection of streptozotocin (STZ) (35 mg/kg) resulted in hyperglycemia, accumulation of sorbitol and formation of advanced glycation end product (AGE) in eye lens." | 3.80 | Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. ( Manikandan, R; Raman, T; Sai Varsha, MK, 2014) |
| "In sugar cataract formation in rats, aldose reductase (AR) activity is not only linked to lenticular sorbitol (diabetic) or galactitol (galactosemic) formation but also to signal transduction changes, cytotoxic signals and activation of apoptosis." | 3.78 | Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation. ( Blessing, K; Kador, PF; Lou, MF; Randazzo, J; Xing, K; Zhang, P, 2012) |
| "Peripheral hyperglycemia was associated with significant increases in brain sorbitol (7." | 3.74 | Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. ( Chong, L; Diamond, DM; Hanna, S; Malone, JI; Mervis, RF; Park, CR; Saporta, S, 2008) |
| " We report a case where hyperglycaemia and lactic acidosis complicated the TURP syndrome caused by the massive absorption (approximately 15 litres) of a sorbitol- mannitol irrigation solution." | 3.71 | Another feature of TURP syndrome: hyperglycaemia and lactic acidosis caused by massive absorption of sorbitol. ( Brochu, J; Lessard, MR; Trépanier, CA; Turcotte, G, 2001) |
| "The process of sorbitol accumulation is more evident than glycation in the initial stage of hyperglycemia." | 3.71 | Region-specific pathophysiological alterations occurring in calf lenses in vitro during hyperglycemia. ( Argirov, OK; Argirova, MD, 2002) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 3.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| "myo-Inositol accumulation and incorporation into phosphoinositides was decreased in neuroblastoma cells chronically exposed to medium containing 30 mmol/L glucose or 30 mmol/L galactose." | 3.68 | Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993) |
| "The isolated cultured rat lens has been used to examine the effects of the aldose reductase inhibitor sorbinil on lenticular polyol accumulation and sugar cataract formation." | 3.67 | Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens. ( Beyer, TA; Hutson, NJ; Rafford, CE; Yeh, LA, 1986) |
| " The sorbitol content of erythrocytes was increased during the period of hyperglycemia from a mean basal value of 65 +/- 9 to 106 -/+ 6 mumol/L." | 3.66 | Sorbitol content of plasma and erythrocytes during induced short-term hyperglycemia. ( Hubinont, C; Malaisse, WJ; Sener, A, 1981) |
| "Diabetic retinopathy is one of the leading causes of vision loss in industrialized countries." | 2.38 | Current hypotheses for the biochemical basis of diabetic retinopathy. ( Mandarino, LJ, 1992) |
| " [14C]Luseogliflozin was rapidly and well absorbed (>86% of the dose) after oral administration to rats and dogs." | 1.42 | Preclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent. ( Chino, Y; Fukasawa, Y; Hachiuma, K; Hasegawa, M; Horiuchi, N; Ishida, M; Nakai, Y; Yamaguchi, J, 2015) |
| " Single oral dosing studies were performed in rats, mice and dogs to assess the abilities of TS-071 to increase urinary glucose excretion and to lower plasma glucose levels." | 1.37 | TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity. ( Arai, M; Asami, J; Fukuhara, N; Gunji, E; Kitano, K; Kojima, N; Kozakai, A; Okumura-Kitajima, L; Takahashi, K; Takahashi, T; Tomoike, H; Toyoda, H; Uchida, S; Yamamoto, K, 2011) |
| " These data suggest that increasing NO bioavailability by L-arginine corrects the major biochemical abnormalities of diabetes." | 1.35 | L-Arginine prevents metabolic effects of high glucose in diabetic mice. ( Bhatnagar, A; Kaiserova, K; Ramana, KV; Srivastava, SK; West, MB, 2008) |
| "Hyperglycemia is a causal factor in the development of the vascular complications of diabetes." | 1.33 | Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. ( Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C, 2006) |
| "Pre-treatment with epalrestat completely prevented the increased urinary excretion of NAG, AAP and GGT." | 1.31 | Effects of renal sorbitol accumulation on urinary excretion of enzymes in hyperglycaemic rats. ( Aoki, Y; Ikenaga, H; Ishii, N; Ogawa, Z; Saruta, T; Suga, T, 2001) |
| "Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave." | 1.27 | The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (34.69) | 18.7374 |
| 1990's | 28 (28.57) | 18.2507 |
| 2000's | 21 (21.43) | 29.6817 |
| 2010's | 12 (12.24) | 24.3611 |
| 2020's | 3 (3.06) | 2.80 |
| Authors | Studies |
|---|---|
| Tigchelaar, C | 1 |
| van Zuylen, ML | 1 |
| Hulst, AH | 1 |
| Preckel, B | 1 |
| van Beek, AP | 1 |
| Kema, IP | 1 |
| Hermanides, J | 1 |
| Absalom, AR | 1 |
| Singh, A | 1 |
| Bodakhe, SH | 1 |
| Papachristoforou, E | 1 |
| Lambadiari, V | 1 |
| Maratou, E | 1 |
| Makrilakis, K | 1 |
| Nakatsu, Y | 1 |
| Kokubo, H | 1 |
| Bumdelger, B | 1 |
| Yoshizumi, M | 1 |
| Yamamotoya, T | 1 |
| Matsunaga, Y | 1 |
| Ueda, K | 1 |
| Inoue, Y | 1 |
| Inoue, MK | 1 |
| Fujishiro, M | 1 |
| Kushiyama, A | 1 |
| Ono, H | 1 |
| Sakoda, H | 1 |
| Asano, T | 1 |
| Rusak, T | 1 |
| Misztal, T | 1 |
| Rusak, M | 1 |
| Branska-Januszewska, J | 1 |
| Tomasiak, M | 1 |
| Higashi, Y | 1 |
| Higashi, K | 1 |
| Mori, A | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 1 |
| Nakahara, T | 1 |
| Sai Varsha, MK | 1 |
| Raman, T | 1 |
| Manikandan, R | 1 |
| Snow, A | 1 |
| Shieh, B | 1 |
| Chang, KC | 1 |
| Pal, A | 1 |
| Lenhart, P | 1 |
| Ammar, D | 1 |
| Ruzycki, P | 1 |
| Palla, S | 1 |
| Reddy, GB | 1 |
| Petrash, JM | 1 |
| Hao, W | 1 |
| Tashiro, S | 1 |
| Hasegawa, T | 1 |
| Sato, Y | 1 |
| Kobayashi, T | 1 |
| Tando, T | 1 |
| Katsuyama, E | 1 |
| Fujie, A | 1 |
| Watanabe, R | 1 |
| Morita, M | 1 |
| Miyamoto, K | 1 |
| Morioka, H | 1 |
| Nakamura, M | 1 |
| Matsumoto, M | 1 |
| Amizuka, N | 1 |
| Toyama, Y | 1 |
| Miyamoto, T | 1 |
| Hasegawa, M | 1 |
| Chino, Y | 1 |
| Horiuchi, N | 1 |
| Hachiuma, K | 1 |
| Ishida, M | 1 |
| Fukasawa, Y | 1 |
| Nakai, Y | 1 |
| Yamaguchi, J | 1 |
| Samukawa, Y | 1 |
| Omiya, H | 1 |
| Watase, H | 1 |
| Nozaki, K | 1 |
| Sakai, S | 1 |
| Nishimura, R | 1 |
| Yabe, D | 1 |
| Iwasaki, M | 1 |
| Kuwata, H | 1 |
| Haraguchi, T | 1 |
| Hamamoto, Y | 1 |
| Kurose, T | 1 |
| Sumita, K | 1 |
| Yamazato, H | 1 |
| Kanada, S | 1 |
| Seino, Y | 1 |
| Chukwuma, CI | 1 |
| Islam, MS | 1 |
| West, MB | 1 |
| Ramana, KV | 1 |
| Kaiserova, K | 1 |
| Srivastava, SK | 2 |
| Bhatnagar, A | 2 |
| Kato, A | 1 |
| Minoshima, Y | 1 |
| Yamamoto, J | 1 |
| Adachi, I | 1 |
| Watson, AA | 1 |
| Nash, RJ | 1 |
| Malone, JI | 2 |
| Hanna, S | 1 |
| Saporta, S | 1 |
| Mervis, RF | 1 |
| Park, CR | 1 |
| Chong, L | 1 |
| Diamond, DM | 1 |
| Yamamoto, K | 1 |
| Uchida, S | 1 |
| Kitano, K | 1 |
| Fukuhara, N | 1 |
| Okumura-Kitajima, L | 1 |
| Gunji, E | 1 |
| Kozakai, A | 1 |
| Tomoike, H | 1 |
| Kojima, N | 1 |
| Asami, J | 1 |
| Toyoda, H | 1 |
| Arai, M | 1 |
| Takahashi, T | 1 |
| Takahashi, K | 1 |
| Zhang, P | 1 |
| Xing, K | 1 |
| Randazzo, J | 1 |
| Blessing, K | 1 |
| Lou, MF | 1 |
| Kador, PF | 1 |
| Tilton, RG | 1 |
| Hosojima, H | 1 |
| Fujita, T | 1 |
| Ouchi, H | 1 |
| Isogai, S | 1 |
| Kumeda, Y | 1 |
| Inaba, M | 1 |
| Nishizawa, Y | 1 |
| Donaldson, M | 1 |
| Dodson, PM | 1 |
| PATTERSON, JW | 1 |
| PATTERSON, ME | 1 |
| KINSEY, VE | 1 |
| REDDY, DV | 1 |
| VERRON, G | 1 |
| Campbell, M | 1 |
| Trimble, ER | 1 |
| Mitka, M | 1 |
| Yagihashi, S | 1 |
| Berrone, E | 1 |
| Beltramo, E | 1 |
| Solimine, C | 1 |
| Ape, AU | 1 |
| Porta, M | 1 |
| Comazzi, S | 1 |
| Bertazzolo, W | 1 |
| Bonfanti, U | 1 |
| Spagnolo, V | 1 |
| Sartorelli, P | 1 |
| Koya, D | 1 |
| Tomlinson, DR | 2 |
| Mayer, JH | 1 |
| Eva, PR | 1 |
| Pascoe, PT | 1 |
| Vaughan, DG | 1 |
| Hubinont, C | 1 |
| Sener, A | 1 |
| Malaisse, WJ | 1 |
| Sakata, T | 1 |
| Tsutsui, K | 1 |
| Fukushima, M | 1 |
| Arase, K | 1 |
| Kita, H | 1 |
| Oomura, Y | 1 |
| Ohki, K | 1 |
| Nicolaidis, S | 1 |
| Yamashita, T | 1 |
| Mimura, K | 1 |
| Umeda, F | 1 |
| Kobayashi, K | 1 |
| Hashimoto, T | 1 |
| Nawata, H | 1 |
| Anaja, HP | 1 |
| Calcutt, NA | 2 |
| Malmberg, AB | 1 |
| Yamamoto, T | 1 |
| Yaksh, TL | 1 |
| Guillausseau, PJ | 1 |
| Ansari, NH | 1 |
| Fulep, E | 1 |
| Khanna, P | 1 |
| Stevens, MJ | 1 |
| Henry, DN | 1 |
| Thomas, TP | 1 |
| Killen, PD | 1 |
| Greene, DA | 1 |
| Yorek, MA | 2 |
| Dunlap, JA | 1 |
| Stefani, MR | 1 |
| Davidson, EP | 1 |
| Mizisin, AP | 1 |
| Li, L | 1 |
| Perello, M | 1 |
| Freshwater, JD | 1 |
| Kalichman, MW | 1 |
| Roux, L | 1 |
| Freund, N | 1 |
| Prieur, B | 1 |
| Bismuth, J | 1 |
| Delaval, E | 1 |
| Keogh, RJ | 1 |
| Dunlop, ME | 2 |
| Larkins, RG | 2 |
| Kanda, M | 1 |
| Eto, K | 1 |
| Tanabe, N | 1 |
| Sugiyama, A | 1 |
| Hashimoto, K | 1 |
| Ueno, A | 1 |
| De la Cruz, JP | 1 |
| Maximo, MA | 1 |
| Blanco, E | 1 |
| Moreno, A | 1 |
| Sánchez de la Cuesta, F | 1 |
| Byrne, MM | 1 |
| Pluntke, K | 1 |
| Wank, U | 1 |
| Schirra, J | 1 |
| Arnold, R | 1 |
| Göke, B | 1 |
| Katschinski, M | 1 |
| Nishikawa, T | 1 |
| Edelstein, D | 1 |
| Du, XL | 1 |
| Yamagishi, S | 1 |
| Matsumura, T | 1 |
| Kaneda, Y | 1 |
| Beebe, D | 1 |
| Oates, PJ | 1 |
| Hammes, HP | 1 |
| Giardino, I | 1 |
| Brownlee, M | 2 |
| Lee, PG | 1 |
| Hohman, TC | 1 |
| Cai, F | 1 |
| Regalia, J | 1 |
| Helke, CJ | 1 |
| Ishii, N | 1 |
| Ikenaga, H | 1 |
| Ogawa, Z | 1 |
| Aoki, Y | 1 |
| Saruta, T | 1 |
| Suga, T | 1 |
| Trépanier, CA | 1 |
| Lessard, MR | 1 |
| Brochu, J | 1 |
| Turcotte, G | 1 |
| Gupta, S | 1 |
| Chough, E | 1 |
| Daley, J | 1 |
| Oates, P | 1 |
| Tornheim, K | 1 |
| Ruderman, NB | 2 |
| Keaney, JF | 1 |
| Argirova, MD | 1 |
| Argirov, OK | 1 |
| Gabbay, KH | 2 |
| Tsvetanov, L | 1 |
| Lenner, RA | 1 |
| Gutman, A | 1 |
| Andreus, A | 1 |
| Adler, JH | 1 |
| Kowluru, RA | 1 |
| Kowluru, A | 1 |
| Hothersall, JS | 1 |
| Muirhead, RP | 1 |
| Taylaur, CE | 1 |
| Jones, RH | 1 |
| Mandarino, LJ | 1 |
| McCaleb, ML | 1 |
| Sredy, J | 1 |
| Williamson, JR | 1 |
| Matsui, M | 1 |
| Lowitt, S | 1 |
| Hod, M | 2 |
| Star, S | 2 |
| Passonneau, JV | 1 |
| Unterman, TG | 2 |
| Freinkel, N | 2 |
| Kawazu, S | 1 |
| Tomono, S | 1 |
| Kuzuya, T | 1 |
| Bylander, JE | 1 |
| Sens, DA | 1 |
| Hashimoto, M | 1 |
| Akazawa, S | 1 |
| Akazawa, M | 1 |
| Akashi, M | 1 |
| Yamamoto, H | 1 |
| Maeda, Y | 1 |
| Yamaguchi, Y | 1 |
| Yamasaki, H | 1 |
| Tahara, D | 1 |
| Nakanishi, T | 1 |
| Passonneau, J | 1 |
| Jain, SK | 1 |
| Sakamoto, N | 1 |
| Engerman, RL | 1 |
| Kern, TS | 1 |
| Yeh, LA | 1 |
| Rafford, CE | 1 |
| Beyer, TA | 1 |
| Hutson, NJ | 1 |
| Segawa, M | 1 |
| Hirata, Y | 1 |
| Fujimori, S | 1 |
| Okada, K | 1 |
| Clements, RS | 8 |
| Prockop, LD | 4 |
| Winegrad, AI | 7 |
| Morrison, AD | 6 |
| Fink, CJ | 1 |
| Lacy, PE | 1 |
| Lekishvili, VP | 1 |
| O'Sullivan, JB | 1 |
| Gault, MH | 1 |
| Arieff, AI | 1 |
| Kleeman, CR | 1 |
| Matschinsky, FM | 1 |
| Ellerman, JE | 1 |
| Suslov, VS | 1 |
| Winegard, AI | 2 |
| Pansu, D | 1 |
| Chapuy, MC | 1 |
| Blumenthal, SA | 1 |
| Korec, R | 1 |
| Sofranková, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes[NCT05478707] | Phase 2 | 64 participants (Anticipated) | Interventional | 2023-10-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for sorbitol and Hyperglycemia
| Article | Year |
|---|---|
Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathi | 2020 |
Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF.
Topics: Animals; Capillary Permeability; Cell Hypoxia; Diabetic Angiopathies; Endothelial Growth Factors; Gl | 2002 |
[Erythrocyte sorbitol, sorbitol dehydrogenase (SDH), and glyceraldehyde reductase (GAR) in diabetes mellitus].
Topics: Animals; Biomarkers; Diabetes Mellitus; Diabetic Angiopathies; Erythrocytes; Glucose; Humans; Hyperg | 2002 |
[Expression mechanisms and incident factors of diabetic nephropathy].
Topics: Animals; Cytokines; Diabetic Nephropathies; Fructose; Genetic Predisposition to Disease; Glomerular | 2002 |
[Diabetic nephropathy--predictive methods].
Topics: Albuminuria; Animals; Biomarkers; Collagen Type IV; Diabetic Nephropathies; Fibronectins; Fructose; | 2002 |
[Diabetes mellitus and osteoporosis].
Topics: Animals; Bone and Bones; Chronic Disease; Diabetes Complications; Diagnosis, Differential; Humans; H | 2002 |
Medical treatment of diabetic retinopathy.
Topics: Anticholesteremic Agents; Antihypertensive Agents; Diabetic Retinopathy; Glycosylation; Growth Subst | 2003 |
[Early diagnosis of peripheral neuropathy in patients with impaired glucose tolerance (IGT)].
Topics: Diabetic Neuropathies; Glucose Intolerance; Glycation End Products, Advanced; Humans; Hyperglycemia; | 2005 |
[Molecular understanding of adverse effects of hyperglycemia in diabetic nephropathy].
Topics: Animals; Diabetic Nephropathies; Energy Metabolism; Fructose; Glucose; Glycation End Products, Advan | 2007 |
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy.
Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1984 |
[Preventive treatment of diabetic microangiopathy: blocking the pathogenic mechanisms].
Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Glucose; Glycosylation; Humans; Hyperglycemia; O | 1994 |
Future prevention and treatment of diabetic neuropathy.
Topics: Diabetic Neuropathies; Forecasting; Glycosylation; Humans; Hyperglycemia; Nerve Growth Factors; Oxid | 1998 |
Hyperglycemia, polyol metabolism, and complications of diabetes mellitus.
Topics: Animals; Blood Glucose; Body Fluids; Cataract; Chemical Phenomena; Chemistry; Diabetes Complications | 1975 |
[Possibilities of preventing diabetic angiopathy (pathogenetic factors in angiopathy)].
Topics: Animals; Diabetic Angiopathies; Epinephrine; Fructose; Glucagon; Growth Hormone; Humans; Hyperglycem | 1976 |
Current hypotheses for the biochemical basis of diabetic retinopathy.
Topics: Basement Membrane; Capillaries; Diabetic Retinopathy; Glucose; Humans; Hyperglycemia; Retinal Vessel | 1992 |
The link between hyperglycaemia and diabetic nephropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; Glyco | 1992 |
Glucose and diabetic vascular disease.
Topics: Animals; Diabetic Angiopathies; Diglycerides; Extracellular Matrix; Glucose; Humans; Hyperglycemia; | 1992 |
[New theories of the pathogenesis of diabetic neuropathies].
Topics: Animals; Carbohydrate Metabolism; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic | 1974 |
Alterations in the composition and metabolism of the inner aortic wall associated with increased polyol pathway activity.
Topics: Alcohol Oxidoreductases; Animals; Aorta, Thoracic; Cataract; Fructose; Glucose; Glycolysis; Hexokina | 1974 |
[Sorbit and its application in medicine (review of literature)].
Topics: Adult; Animals; Biliary Tract Diseases; Child; Diabetes Mellitus; Female; Humans; Hyperglycemia; Int | 1969 |
3 trials available for sorbitol and Hyperglycemia
| Article | Year |
|---|---|
Substantial Effects of Luseogliflozin Revealed by Analyzing Responses to Postprandial Hyperglycemia: Post Hoc Subanalyses of a Randomized Controlled Study.
Topics: Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Hum | 2016 |
Sodium-glucose co-transporter-2 inhibitor use and dietary carbohydrate intake in Japanese individuals with type 2 diabetes: A randomized, open-label, 3-arm parallel comparative, exploratory study.
Topics: Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Diet, Ca | 2017 |
Inhibitory effects of hyperglycaemia on fed jejunal motility: potential role of hyperinsulinaemia.
Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Drug Combinations; Gastrointestinal Motility; Gast | 1998 |
75 other studies available for sorbitol and Hyperglycemia
| Article | Year |
|---|---|
Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Fructose; Glucose; Humans; Hyperglycemia; Polymers; | 2022 |
Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract.
Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; | 2021 |
The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cell Adhesion Molecules; Cytokines; Diabetes Mel | 2017 |
Involvement of hyperglycemia in the development of platelet procoagulant response: the role of aldose reductase and platelet swelling.
Topics: Adolescent; Adult; Aldehyde Reductase; Blood Coagulation; Blood Platelets; Cell Size; Diabetes Melli | 2017 |
Anti-cataract Effect of Resveratrol in High-Glucose-Treated Streptozotocin-Induced Diabetic Rats.
Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Crystallins; Diabetes Complicati | 2018 |
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis.
Topics: Animals; Blood Glucose; Calcium; Calcium-Transporting ATPases; Cataract; Diabetes Mellitus, Experime | 2014 |
Aldose reductase expression as a risk factor for cataract.
Topics: Aldehyde Reductase; Animals; Apoptosis; Cataract; Diabetes Complications; Diabetes Mellitus, Experim | 2015 |
Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation.
Topics: Aldehyde Reductase; Animals; Calcitriol; Cell Dedifferentiation; Cells, Cultured; Demyelinating Dise | 2015 |
Preclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent.
Topics: Animals; Biotransformation; Blood Proteins; Dogs; Feces; Humans; Hyperglycemia; Hypoglycemic Agents; | 2015 |
Sorbitol increases muscle glucose uptake ex vivo and inhibits intestinal glucose absorption ex vivo and in normal and type 2 diabetic rats.
Topics: Absorption, Physiological; Animals; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Gastric Emptyi | 2017 |
L-Arginine prevents metabolic effects of high glucose in diabetic mice.
Topics: Aldehyde Reductase; Animals; Aortitis; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2008 |
Protective effects of dietary chamomile tea on diabetic complications.
Topics: Aldehyde Reductase; alpha-Amylases; Animals; Beverages; Blood Glucose; Diabetes Complications; Diabe | 2008 |
Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Dendrites; Dendritic Spines; Diabetes Mellitus, Experimen | 2008 |
TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity.
Topics: Animals; Blood Glucose; CHO Cells; Cricetinae; Cricetulus; Deoxyglucose; Diabetes Mellitus; Diabetes | 2011 |
Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation.
Topics: Aldehyde Reductase; Animals; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Electroph | 2012 |
LENS ASSAYS ON DIABETIC AND GALACTOSEMIC RATS RECEIVING DIETS THAT MODIFY CATARACT DEVELOPMENT.
Topics: Amino Acids; Animals; Caseins; Cataract; Diabetes Mellitus, Experimental; Diet; Dietary Carbohydrate | 1965 |
[COMPARATIVE STUDIES ON SORBITE METABOLISM WITH AND WITHOUT ALCOHOL ADDITION].
Topics: Child; Ethanol; Fructose; Humans; Hyperglycemia; Infant; Sorbitol | 1965 |
Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII.
Topics: Aorta; Becaplermin; Cell Adhesion; Chemotaxis; Enzyme Activation; Enzyme Induction; Focal Adhesion K | 2005 |
Diabetic retinopathy mechanism probed.
Topics: Animals; Diabetic Retinopathy; Free Radicals; Glucose; Humans; Hyperglycemia; NAD; Rats; Retina; Sor | 2005 |
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy | 2006 |
Advanced glycation end products and sorbitol in blood from differently compensated diabetic dogs.
Topics: Animals; Diabetes Mellitus; Dog Diseases; Dogs; Female; Glycation End Products, Advanced; Hyperglyce | 2008 |
Refractive change in hyperglycaemia: hyperopia, not myopia.
Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Female; Glucose; Humans; Hyperglycemia; Hype | 1982 |
Sorbitol content of plasma and erythrocytes during induced short-term hyperglycemia.
Topics: Adult; Blood Glucose; Erythrocytes; Fasting; Humans; Hyperglycemia; Male; Sorbitol | 1981 |
Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat.
Topics: Adrenal Medulla; Animals; Blood Glucose; Deoxyglucose; Dose-Response Relationship, Drug; Drinking Be | 1981 |
Increased transendothelial permeation of albumin by high glucose concentration.
Topics: Animals; Capillary Permeability; Cattle; Dextrans; Endothelium, Vascular; Fluorescein; Fluoresceins; | 1995 |
Effect of short-term hyperglycaemia of oral glucose on red cell sorbitol and plasma glucose concentrations in diabetic and non-diabetic Nigerians.
Topics: Adult; Aged; Aldehyde Reductase; Black People; Blood Glucose; Case-Control Studies; Diabetes Complic | 1995 |
Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats.
Topics: Aldehyde Reductase; Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Female; | 1994 |
Trolox protects hyperglycemia-induced cataractogenesis in cultured rat lens.
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Cataract; Cells, Cultured; Chromans; Drug Interacti | 1994 |
Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells.
Topics: Aldehyde Reductase; Blood Glucose; Cell Line; Fructose; Gene Expression; Glucose; Humans; Hyperglyce | 1993 |
Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels.
Topics: Animals; Biological Transport; Blood Glucose; Galactose; Glucose; Hyperglycemia; Inositol; Neuroblas | 1993 |
Polyol pathway and osmoregulation in JS1 Schwann cells grown in hyperglycemic and hyperosmotic conditions.
Topics: Aldehyde Reductase; Cell Count; Cell Division; Cell Line; Galactose; Glucose; Hyperglycemia; Immunoh | 1996 |
Effect of hyperglycemia on the polyol pathway in rat kidney during the perinatal period.
Topics: Aldehyde Reductase; Ampholyte Mixtures; Animals; Hyperglycemia; Kidney; Kinetics; Polymers; Rats; Ra | 1996 |
Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation.
Topics: Aldehyde Reductase; Animals; Arachidonic Acids; Cell Membrane; Diabetes Mellitus, Experimental; Digl | 1997 |
Effects of ONO-2235, an aldose reductase inhibitor, on muscarinic receptors and contractile response of the urinary bladder in rats with streptozotocin-induced diabetes.
Topics: Acetylcholine; Aldehyde Reductase; Analysis of Variance; Animals; Binding, Competitive; Blood Glucos | 1997 |
Effect of erythrocytes and prostacyclin production in the effect of fructose and sorbitol on platelet activation in human whole blood in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adenosine Diphosphate; Adult; Animals; Aorta; Blood Glucose | 1997 |
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.
Topics: Animals; Aspartic Acid; Blood Glucose; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carrier Proteins; | 2000 |
Streptozotocin-induced diabetes causes metabolic changes and alterations in neurotrophin content and retrograde transport in the cervical vagus nerve.
Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Fructose; Glucose; Hyperglycemia; Insuli | 2001 |
Effects of renal sorbitol accumulation on urinary excretion of enzymes in hyperglycaemic rats.
Topics: Acetylglucosaminidase; Analysis of Variance; Animals; Biomarkers; Blood Glucose; CD13 Antigens; Dipe | 2001 |
Another feature of TURP syndrome: hyperglycaemia and lactic acidosis caused by massive absorption of sorbitol.
Topics: Acidosis, Lactic; Aged; Humans; Hyperglycemia; Intraoperative Care; Male; Pharmaceutic Aids; Sorbito | 2001 |
Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity.
Topics: Aldehyde Reductase; Animals; Aorta; Arginine; Benzothiazoles; Endothelium, Vascular; Enzyme Inhibito | 2002 |
Region-specific pathophysiological alterations occurring in calf lenses in vitro during hyperglycemia.
Topics: Animals; Cattle; Glucose; Hyperglycemia; L-Lactate Dehydrogenase; Lens, Crystalline; Organ Culture T | 2002 |
Specially designed sweeteners and food for diabetics--a real need?
Topics: Aged; Blood Glucose; Diabetes Mellitus; Diet, Diabetic; Dietary Carbohydrates; Evaluation Studies as | 1976 |
Hyperinsulinemia, insulin resistance and cataract formation in sand rats.
Topics: Adipose Tissue; Animals; Cataract; Diet; Disease Models, Animal; Galactitol; Glucose; Hyperglycemia; | 1975 |
Erythrocyte sodium-potassium ATPase activity and thiol metabolism in genetically hyperglycemic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocyte Membrane; Erythrocytes; Glutathione; Glycated | 1992 |
Anti-oxidant status in an in vitro model for hyperglycaemic lens cataract formation: competition for available nicotinamide adenine dinucleotide phosphate between glutathione reduction and the polyol pathway.
Topics: Animals; Binding, Competitive; Cataract; Esters; Glutathione; Hydrogen Peroxide; Hyperglycemia; In V | 1992 |
Metabolic abnormalities of the hyperglycemic obese Zucker rat.
Topics: Animals; Fructose; Glucose; Glycosuria; Hyperglycemia; Inositol; Male; Obesity; Rats; Rats, Zucker; | 1992 |
[Ocular complications of diabetes mellitus--pathogenesis and risk factors of development].
Topics: Diabetic Retinopathy; Glycoproteins; Glycosylation; Humans; Hyperglycemia; Insulin; Neovascularizati | 1991 |
Measurements of tissue sorbitol in diabetes mellitus: enzyme method versus gas-liquid chromatography.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Chromatography, Gas; Diabetes Mellitus; Diabetes | 1992 |
Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: prevention of dysmorphogenesis with aldose reductase inhibitors and myo-inositol.
Topics: Aldehyde Reductase; Animals; Blood; Congenital Abnormalities; Culture Media; Culture Techniques; Fem | 1991 |
[Diabetic microangiopathy--its biochemical bases].
Topics: Animals; Basement Membrane; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Glu | 1991 |
[Etiology of chronic complications diabetes mellitus and the plan for their management].
Topics: Arteriosclerosis; Blood Glucose; Collagen; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glycosylati | 1991 |
Elicitation of sorbitol accumulation in cultured human proximal tubule cells by elevated glucose concentrations.
Topics: Aldehyde Reductase; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Histocytochemistry; | 1990 |
Effects of hyperglycaemia on sorbitol and myo-inositol contents of cultured embryos: treatment with aldose reductase inhibitor and myo-inositol supplementation.
Topics: Aldehyde Reductase; Animals; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fetal Disea | 1990 |
Glucose-induced dysmorphogenesis in the cultured rat conceptus: prevention by supplementation with myo-inositol.
Topics: Animals; Congenital Abnormalities; Culture Media; Culture Techniques; Disease Models, Animal; Embryo | 1990 |
Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells.
Topics: Adult; Barbital; Erythrocyte Membrane; Glucose; Humans; Hyperglycemia; In Vitro Techniques; Lipid Pe | 1989 |
[Causes and treatment of diabetic complications].
Topics: Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Glycosylatio | 1989 |
Hyperglycemia and development of glomerular pathology: diabetes compared with galactosemia.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dogs; Galactitol; Galactosemias; H | 1989 |
Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Hyperglycemia; Imidazoles; Imidazolid | 1986 |
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias; | 1988 |
Acute cerebral oedema during treatment of hyperglycaemia. An experimentsl model.
Topics: Animals; Blood Glucose; Brain Chemistry; Brain Edema; Dogs; Fructose; Glucose; Hyperglycemia; Intrac | 1968 |
Polyol pathway in aorta: regulation by hormones.
Topics: Alcohol Oxidoreductases; Angiotensin II; Animals; Aorta, Thoracic; Cyclic AMP; Epinephrine; Humans; | 1969 |
Sorbitol synthesis in isolated rat pancreatic islets.
Topics: Animals; Fluorescence; Fructose; Glucose; Hyperglycemia; Islets of Langerhans; Microbial Collagenase | 1970 |
Polyol pathway activity in aorta.
Topics: Animals; Aorta; Arteriosclerosis; Diabetic Angiopathies; Fructose; Fructose-Bisphosphate Aldolase; G | 1973 |
The sorbitol pathway. Enzyme localization and content in normal and diabetic nerve and cord.
Topics: Animals; Axons; Blood Glucose; Cauda Equina; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1968 |
Effects of elevated glucose concentrations on the metabolism of the aortic wall.
Topics: Alcohol Oxidoreductases; Animals; Aorta, Thoracic; Blood Glucose; Diabetes Mellitus, Experimental; F | 1972 |
Peritoneal dialysis solutions.
Topics: Acetates; Acute Kidney Injury; Blood Urea Nitrogen; Calcium; Chlorides; Coma; Glucose; Humans; Hyper | 1973 |
Cerebral edema in diabetic comas. II. Effects of hyperosmolality, hyperglycemia and insulin in diabetic rabbits.
Topics: Amino Acids; Animals; Blood; Body Water; Brain Chemistry; Brain Edema; Cerebrospinal Fluid; Chloride | 1974 |
Metabolism of glucose in the islets of Langerhans.
Topics: Acetone; Adenosine Triphosphate; Animals; Blood Glucose; Fluorometry; Glucose; Glycogen; Hexosephosp | 1968 |
A mechanism to explain acute cerebral edema during the treatment of diabetic acidosis.
Topics: Animals; Blood Glucose; Brain Edema; Carbohydrates; Diabetic Ketoacidosis; Dogs; Electrolytes; Fruct | 1968 |
[Relationship in humans between the action of some glucidic compounds and their digestive utilization].
Topics: Blood Glucose; Calcium; Diarrhea; Glucose; Humans; Hyperglycemia; Intestinal Absorption; Lactose; So | 1970 |
Hyperglycemia, polyol accumulation, and increased intracranial pressure.
Topics: Animals; Brain; Brain Edema; Cerebrospinal Fluid Proteins; Diabetic Ketoacidosis; Disease Models, An | 1971 |
Increased cerebrospinal fluid pressure during therapy for diabetic acidosis.
Topics: Adult; Alcohol Oxidoreductases; Animals; Blood Glucose; Brain; Brain Edema; Carbon Dioxide; Cerebros | 1971 |
[Hyperglycemic and glycogenetic effect of sorbitol, fructose and glucose in diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Glycogen; Hyperglycemia; Rats; Sorbitol | 1972 |
Glucose-dependent changes in aortic wall metabolism.
Topics: Animals; Aorta; Blood Glucose; Diabetic Angiopathies; Humans; Hyperglycemia; Rabbits; Sorbitol | 1970 |
Polyol metabolism and the development of elevated cerebrospinal fluid pressure following sustained hyperglycemia.
Topics: Alcohols; Animals; Brain Edema; Dogs; Fructose; Glucose; Humans; Hyperglycemia; Hypertonic Solutions | 1968 |