sorbitol has been researched along with Huntington Disease in 3 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Aravindan, S | 1 |
| Chen, S | 1 |
| Choudhry, H | 1 |
| Molfetta, C | 1 |
| Chen, KY | 2 |
| Liu, AYC | 2 |
| Chen, JY | 1 |
| Parekh, M | 1 |
| Seliman, H | 1 |
| Bakshinskaya, D | 1 |
| Dai, W | 1 |
| Kwan, K | 1 |
| Chun, W | 1 |
| Lesort, M | 1 |
| Lee, M | 1 |
| Johnson, GV | 1 |
3 other studies available for sorbitol and Huntington Disease
| Article | Year |
|---|---|
Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models.
Topics: Animals; Autophagy; Cyclic AMP Response Element-Binding Protein; Gene Knockdown Techniques; Glycerol | 2020 |
Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.
Topics: Animals; Cell Nucleus; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Cytosol; Ecdyst | 2018 |
Mutant huntingtin aggregates do not sensitize cells to apoptotic stressors.
Topics: Apoptosis; Caspase 3; Caspases; Enzyme Activation; Enzyme Inhibitors; Humans; Huntingtin Protein; Hu | 2002 |