sorbitol has been researched along with Galactosemias in 25 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Galactosemias: A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (PRIMARY OVARIAN INSUFFICIENCY); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)
| Excerpt | Relevance | Reference |
|---|---|---|
| "MRI measurement of the retinal oxygenation response to a carbogen challenge appears to be a powerful new and noninvasive approach that may be useful for assessing aspects of pathophysiology underlying the development of diabetic retinopathy in galactosemic rats." | 3.70 | Subnormal retinal oxygenation response precedes diabetic-like retinopathy. ( Berkowitz, BA; Frank, RN; Hohman, TC; Kern, TS; Kowluru, RA; Prakash, M, 1999) |
| "Aldose reductase catalyzes the NADPH-linked reduction of hexoses to their respective sugar-alcohols, which are involved in the pathogenesis of "sugar-cataracts"." | 3.68 | Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies. ( Alvarez, A; Chávez, M; Chávez-Anaya, E; Medina, C; Medina, MD; Mendoza, R; Ramírez, MG; Sáenz, G; Vaca, G; Vargas, M, 1992) |
| "An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose." | 3.65 | Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. ( Dvornik, E; Gabbay, KH; Kinoshita, JH; Krami, M; Merola, LO; Sestanj, K; Simard-Duquesne, N; Varma, SD, 1973) |
| "Diabetic retinopathy is similarly related to sorbitol accumulation and may be prevented or reversed by inhibition of aldose reductase." | 2.37 | NIH conference. Aldose reductase and complications of diabetes. ( Cobo, LM; Cogan, DG; Datilis, MB; Kador, PF; Kinoshita, JH; Kupfer, C; Robison, G, 1984) |
| "At 8 months galactosemia reduced NCV to 58% of control values, while ARI-treatment for 8 months improved NCV to 71% of control values." | 1.29 | Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy. ( Basso, M; Cherian, PV; Hohman, TC; Kamijo, M; Sima, AA, 1994) |
| "Galactitol is a component of normal amniotic fluid with a mean concentration of 0." | 1.27 | Stable isotope dilution analysis of galactitol in amniotic fluid: an accurate approach to the prenatal diagnosis of galactosemia. ( Jakobs, C; Nyhan, WL; Sweetman, L; Warner, TG, 1984) |
| "Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave." | 1.27 | The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (80.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| PATTERSON, JW | 2 |
| BUNTING, KW | 1 |
| PATTERSON, ME | 1 |
| KINSEY, VE | 1 |
| REDDY, DV | 1 |
| Gitzelmann, R | 1 |
| Curtius, HC | 1 |
| Schneller, I | 1 |
| Stewart, MA | 1 |
| Sherman, WR | 1 |
| Kurien, MM | 1 |
| Moonsammy, GI | 1 |
| Wisgerhof, M | 1 |
| Cogan, DG | 1 |
| Kinoshita, JH | 2 |
| Kador, PF | 1 |
| Robison, G | 1 |
| Datilis, MB | 1 |
| Cobo, LM | 1 |
| Kupfer, C | 1 |
| Jakobs, C | 1 |
| Warner, TG | 1 |
| Sweetman, L | 1 |
| Nyhan, WL | 1 |
| Yue, DK | 1 |
| Hanwell, MA | 1 |
| Satchell, PM | 1 |
| Handelsman, DJ | 1 |
| Turtle, JR | 1 |
| Kamijo, M | 1 |
| Basso, M | 1 |
| Cherian, PV | 1 |
| Hohman, TC | 2 |
| Sima, AA | 1 |
| Frank, RN | 2 |
| Berkowitz, BA | 1 |
| Kowluru, RA | 1 |
| Kern, TS | 2 |
| Prakash, M | 1 |
| Peterson, MJ | 2 |
| Sarges, R | 2 |
| Aldinger, CE | 2 |
| MacDonald, DP | 2 |
| van Heyningen, R | 2 |
| Vaca, G | 1 |
| Ramírez, MG | 1 |
| Vargas, M | 1 |
| Mendoza, R | 1 |
| Chávez-Anaya, E | 1 |
| Medina, MD | 1 |
| Alvarez, A | 1 |
| Medina, C | 1 |
| Sáenz, G | 1 |
| Chávez, M | 1 |
| Miwa, I | 2 |
| Hirano, M | 1 |
| Kanbara, M | 2 |
| Okuda, J | 2 |
| Brivet, M | 1 |
| Migayron, F | 1 |
| Roger, J | 1 |
| Cheron, G | 1 |
| Lemonnier, A | 1 |
| Engerman, RL | 1 |
| Burg, MB | 1 |
| Lou, MF | 1 |
| Dickerson, JE | 1 |
| Garadi, R | 1 |
| York, BM | 1 |
| Wakazono, H | 1 |
| Segawa, M | 1 |
| Hirata, Y | 1 |
| Fujimori, S | 1 |
| Okada, K | 1 |
| Simard-Duquesne, N | 2 |
| Greselin, E | 1 |
| Dubuc, J | 1 |
| Dvornik, D | 1 |
| Dvornik, E | 1 |
| Krami, M | 1 |
| Sestanj, K | 1 |
| Gabbay, KH | 2 |
| Varma, SD | 1 |
| Merola, LO | 1 |
| O'Sullivan, JB | 1 |
4 reviews available for sorbitol and Galactosemias
| Article | Year |
|---|---|
NIH conference. Aldose reductase and complications of diabetes.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Cataract; Corneal Diseases; Diabetic Neuropathies; Di | 1984 |
Sugar alcohols in the pathogenesis of galactose and diabetic cataracts.
Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism, Inborn Errors; Cataract; Chemical Phenomena; C | 1976 |
Role of aldose reductase and sorbitol in maintaining the medullary intracellular milieu.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Galactosemias; Humans; Kidney Medulla | 1988 |
Galactose cataract: a review.
Topics: Age Factors; Alcohol Oxidoreductases; Aminoisobutyric Acids; Animals; Cataract; Dairy Products; Gala | 1971 |
21 other studies available for sorbitol and Galactosemias
| Article | Year |
|---|---|
LENS CELL MEMBRANE PERMEABILITY AND CATARACT FORMATION.
Topics: Adenosine Triphosphate; Alcohols; Animals; Biological Transport; Cataract; Cell Biology; Cell Membra | 1964 |
LENS ASSAYS ON DIABETIC AND GALACTOSEMIC RATS RECEIVING DIETS THAT MODIFY CATARACT DEVELOPMENT.
Topics: Amino Acids; Animals; Caseins; Cataract; Diabetes Mellitus, Experimental; Diet; Dietary Carbohydrate | 1965 |
Galactitol and galactose-1-phosphate in the lens of a galactosemic infant.
Topics: Alcohols; Cataract; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Female; | 1967 |
Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia.
Topics: Animals; Blood Glucose; Brain; Chromatography, Gas; Diabetes Mellitus, Experimental; Female; Fluorom | 1967 |
Stable isotope dilution analysis of galactitol in amniotic fluid: an accurate approach to the prenatal diagnosis of galactosemia.
Topics: Amniotic Fluid; Female; Galactitol; Galactosemias; Gas Chromatography-Mass Spectrometry; Humans; Ino | 1984 |
The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Galactosemias; I | 1984 |
Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Body Weight; Diabetic Neuropathies; Fructose; Galactitol; Galact | 1994 |
The galactosemic dog. A valid model for both early and late stages of diabetic retinopathy.
Topics: Animals; Diabetic Retinopathy; Disease Models, Animal; Dogs; Galactose; Galactosemias; Optic Disk; R | 1995 |
Subnormal retinal oxygenation response precedes diabetic-like retinopathy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Diabetic Retinopathy; Fructose; Galactitol; Galactose; Galac | 1999 |
Inhibition of polyol pathway activity in diabetic and galactosemic rats by the aldose reductase inhibitor CP-45,634.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Galactitol; Gal | 1979 |
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Benzopyrans; Cataract; Chromans; Diabetes Mellitus, Experimental; Galac | 1979 |
Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aldehyde Reductase; Animals; Black People | 1992 |
In vivo activities of aldose reductase inhibitors having a 1-(arylsulfonyl)hydantoin structure.
Topics: Aldehyde Reductase; Animals; Body Weight; Cataract; Diabetes Mellitus, Experimental; Galactosemias; | 1990 |
Lens hexitols and cataract formation during lactation in a woman heterozygote for galactosaemia.
Topics: Adult; Cataract; Female; Galactitol; Galactokinase; Galactosemias; Genetic Carrier Screening; Humans | 1989 |
Hyperglycemia and development of glomerular pathology: diabetes compared with galactosemia.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dogs; Galactitol; Galactosemias; H | 1989 |
Glutathione depletion in the lens of galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Aminoisobutyric Acids; Animals; Cell Membrane Permeability; Diabetes Mellitus, E | 1988 |
Analysis of sorbitol, galactitol, and myo-inositol in lens and sciatic nerve by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Galactitol; Galactos | 1988 |
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias; | 1988 |
The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dr | 1985 |
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.
Topics: Acetates; Administration, Oral; Alcohol Oxidoreductases; Animals; Cataract; Culture Techniques; Diab | 1973 |
The sorbitol pathway in diabetes and galactosemia: enzyme and sobstrate localization and changes in kidney.
Topics: Alcohol Oxidoreductases; Animals; Diabetes Mellitus; Galactose; Galactosemias; Kidney; Nerve Tissue; | 1968 |