sorbitol has been researched along with Diabetic Retinopathy in 66 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myo-inositol is a precursor of inositol phospholipids (IPLs), whose metabolism is responsible for a number of signal transduction processes." | 5.28 | [Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy]. ( Li, WY, 1989) |
| "Aldose reductase (AR) appears to initiate the cataractous process in galactosemic and diabetic animals." | 4.76 | Aldose reductase in diabetic complications of the eye. ( Fukushi, S; Kador, P; Kinoshita, JH; Merola, LO, 1979) |
| " This indicates the following metabolic derangements in DME: (a) a higher amount of oxidized fatty acids but a lower amount of endogenous antioxidants (oxidative stress); (b) higher levels of β-glucose and homocysteine but a lower level of sorbitol (hyperglycemia); (c) a higher amount of prostaglandin metabolites (inflammation); (d) higher amounts of acylcarnitines, odd-numbered fatty acids, and 7,8-diaminononanoate (respiration deterioration); (e) a higher amount of neurotransmitter metabolites and homovanillic acid (neuronal damage); (f) a lower amount of extracellular matrix (ECM) constituents (ECM deterioration); and (g) a higher amount of di-amino peptides (microvascular damage)." | 4.12 | Untargeted metabolomic analysis of aqueous humor in diabetic macular edema. ( Bakthavatsalam, M; Brelen, ME; Chan, KP; Chan, TI; Chu, KO; Pang, CP; Wang, CC; Yip, YW, 2022) |
| "Oral administration of fidarestat attenuated leukocyte accumulation in the retina of STZ induced-diabetic rats, suggesting that fidarestat may have a therapeutic role in preventing the progression of diabetic retinopathy." | 3.76 | Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. ( Hattori, T; Matsubara, A; Ogura, Y; Taniguchi, K, 2010) |
| "MRI measurement of the retinal oxygenation response to a carbogen challenge appears to be a powerful new and noninvasive approach that may be useful for assessing aspects of pathophysiology underlying the development of diabetic retinopathy in galactosemic rats." | 3.70 | Subnormal retinal oxygenation response precedes diabetic-like retinopathy. ( Berkowitz, BA; Frank, RN; Hohman, TC; Kern, TS; Kowluru, RA; Prakash, M, 1999) |
| "The relationship between red blood cell sorbitol content and diabetic complications (cataract, retinopathy, neuropathy, and nephropathy) was examined in 23 non-insulin-dependent diabetic (NIDD) patients." | 3.68 | Studies on clinical markers of diabetes mellitus. 6. Red blood cell sorbitol and diabetic complications. ( Aro, T; Fuda, H; Hatano, M; Hiyoshi, S; Katsu, K; Maruyama, S; Sugiura, M; Taguchi, H, 1990) |
| "Diabetic retinopathy is the most common microvascular complication of diabetes and the most severe of diabetic ocular complications." | 2.47 | Aldose reductase / polyol inhibitors for diabetic retinopathy. ( Kador, PF; Obrosova, IG, 2011) |
| "Diabetic retinopathy is one of the leading causes of vision loss in industrialized countries." | 2.38 | Current hypotheses for the biochemical basis of diabetic retinopathy. ( Mandarino, LJ, 1992) |
| "Diabetic retinopathy is similarly related to sorbitol accumulation and may be prevented or reversed by inhibition of aldose reductase." | 2.37 | NIH conference. Aldose reductase and complications of diabetes. ( Cobo, LM; Cogan, DG; Datilis, MB; Kador, PF; Kinoshita, JH; Kupfer, C; Robison, G, 1984) |
| "Hyperglycemia is a causal factor in the development of the vascular complications of diabetes." | 1.33 | Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. ( Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C, 2006) |
| "Diabetic retinopathy was absent in 9/12 subjects (75%), with 3 having mild non-proliferative retinopathy." | 1.30 | Does mitochondrial genome mutation in subjects with maternally inherited diabetes and deafness decrease severity of diabetic retinopathy? ( Boyages, SC; Holmes-Walker, DJ; Mitchell, P, 1998) |
| "Diaminoguanidine was a stronger inhibitor than monoaminoguanidine." | 1.28 | Inhibition of diabetes-associated complications by nucleophilic compounds. ( Bansal, V; Kumari, K; Sahib, MK; Umar, S, 1991) |
| "myo-Inositol was taken up by two Na-dependent transport systems, at least one of which was competitively inhibited by glucose." | 1.28 | Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications. ( Brennan, MC; Del Monte, MA; Diaz, TC; Greene, DA; Lattimer, SA; Nakamura, J; Rabbani, R, 1991) |
| "Myo-inositol is a precursor of inositol phospholipids (IPLs), whose metabolism is responsible for a number of signal transduction processes." | 1.28 | [Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy]. ( Li, WY, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (34.85) | 18.7374 |
| 1990's | 26 (39.39) | 18.2507 |
| 2000's | 12 (18.18) | 29.6817 |
| 2010's | 4 (6.06) | 24.3611 |
| 2020's | 1 (1.52) | 2.80 |
| Authors | Studies |
|---|---|
| Chu, KO | 1 |
| Chan, TI | 1 |
| Chan, KP | 1 |
| Yip, YW | 1 |
| Bakthavatsalam, M | 1 |
| Wang, CC | 1 |
| Pang, CP | 1 |
| Brelen, ME | 1 |
| Ferreira, FN | 1 |
| Crispim, D | 1 |
| Canani, LH | 1 |
| Gross, JL | 1 |
| dos Santos, KG | 1 |
| Saraswat, M | 1 |
| Muthenna, P | 1 |
| Suryanarayana, P | 1 |
| Petrash, JM | 2 |
| Reddy, GB | 2 |
| Hattori, T | 1 |
| Matsubara, A | 1 |
| Taniguchi, K | 1 |
| Ogura, Y | 1 |
| Obrosova, IG | 2 |
| Kador, PF | 3 |
| Li, X | 2 |
| Cui, X | 1 |
| Wang, J | 1 |
| Yang, J | 1 |
| Sun, X | 1 |
| Zhu, Q | 1 |
| Li, W | 1 |
| Funatsu, H | 1 |
| Yamashita, H | 1 |
| Amano, S | 1 |
| Yamagishi, S | 1 |
| Koda, Y | 1 |
| Tsuneoka, M | 1 |
| Soejima, M | 1 |
| Okamoto, T | 1 |
| Inagaki, Y | 1 |
| Yamada, K | 1 |
| Kimura, H | 1 |
| Donaldson, M | 1 |
| Dodson, PM | 1 |
| NAKAO, S | 1 |
| OGURI, F | 1 |
| TAKEUCHI, J | 1 |
| KATAGAWA, W | 1 |
| Minchenko, AG | 1 |
| Frank, RN | 4 |
| Seigel, GM | 1 |
| Zsengeller, Z | 1 |
| Pacher, P | 1 |
| Stevens, MJ | 1 |
| Szabó, C | 1 |
| Dagher, Z | 1 |
| Park, YS | 1 |
| Asnaghi, V | 1 |
| Hoehn, T | 1 |
| Gerhardinger, C | 1 |
| Lorenzi, M | 2 |
| Mitka, M | 1 |
| Jung, SH | 1 |
| Lee, YS | 1 |
| Shim, SH | 1 |
| Lee, S | 1 |
| Shin, KH | 1 |
| Kim, JS | 1 |
| Kim, YS | 1 |
| Kang, SS | 1 |
| Berrone, E | 1 |
| Beltramo, E | 1 |
| Solimine, C | 1 |
| Ape, AU | 1 |
| Porta, M | 1 |
| Satyanarayana, A | 1 |
| Balakrishna, N | 1 |
| Ayyagari, R | 1 |
| Padma, M | 1 |
| Viswanath, K | 1 |
| Brownlee, M | 1 |
| Cerami, A | 1 |
| Cogan, DG | 1 |
| Kinoshita, JH | 3 |
| Robison, G | 1 |
| Datilis, MB | 1 |
| Cobo, LM | 1 |
| Kupfer, C | 1 |
| Sato, S | 1 |
| Sugimoto, S | 1 |
| Ando, T | 1 |
| Miyajima, H | 1 |
| Chiba, S | 1 |
| Jacobson, M | 1 |
| Sharma, YR | 1 |
| Cotlier, E | 1 |
| Hollander, JD | 1 |
| Van den Enden, MK | 1 |
| Nyengaard, JR | 1 |
| Ostrow, E | 1 |
| Burgan, JH | 1 |
| Williamson, JR | 1 |
| Lowe, WL | 1 |
| Florkiewicz, RZ | 1 |
| Yorek, MA | 1 |
| Spanheimer, RG | 1 |
| Albrecht, BN | 1 |
| Yamaoka, T | 1 |
| Nishimura, C | 2 |
| Yamashita, K | 1 |
| Itakura, M | 1 |
| Yamada, T | 1 |
| Fujimoto, J | 1 |
| Kokai, Y | 1 |
| Vinson, J | 1 |
| Hsu, C | 1 |
| Possanza, C | 1 |
| Drack, A | 1 |
| Pane, D | 1 |
| Davis, R | 1 |
| Klock, C | 1 |
| Graser, K | 1 |
| Wang, X | 1 |
| Matsui, T | 1 |
| Nakamura, Y | 1 |
| Ishikawa, H | 1 |
| Matsuura, A | 1 |
| Kobayashi, F | 1 |
| Lowitt, S | 1 |
| Malone, JI | 1 |
| Salem, A | 1 |
| Kozak, WM | 1 |
| Orfalian, Z | 1 |
| Malenfant, M | 1 |
| Hotta, N | 3 |
| Koh, N | 3 |
| Sakakibara, F | 3 |
| Nakamura, J | 4 |
| Hamada, Y | 3 |
| Hara, T | 3 |
| Takeuchi, N | 1 |
| Inukai, S | 2 |
| Kasama, N | 2 |
| Fukasawa, H | 2 |
| Kakuta, H | 1 |
| Sakamoto, N | 2 |
| Ito, T | 1 |
| Takahashi, Y | 1 |
| Saito, T | 1 |
| Omori, Y | 1 |
| Mori, K | 1 |
| Nakashima, E | 1 |
| Sasaki, H | 1 |
| Akira, T | 1 |
| Naka, H | 1 |
| Hayashi, R | 1 |
| Hayakawa, N | 1 |
| Makino, M | 1 |
| Nagata, M | 1 |
| Kakizawa, H | 1 |
| Uchimura, K | 1 |
| Hamada, M | 1 |
| Aono, T | 1 |
| Fujita, T | 1 |
| Shinohara, R | 1 |
| Nagasaka, A | 1 |
| Itoh, M | 1 |
| Holmes-Walker, DJ | 1 |
| Mitchell, P | 1 |
| Boyages, SC | 1 |
| Berkowitz, BA | 1 |
| Kowluru, RA | 1 |
| Kern, TS | 1 |
| Hohman, TC | 1 |
| Prakash, M | 1 |
| Tomlinson, DR | 1 |
| Yoshii, H | 1 |
| Uchino, H | 1 |
| Ohmura, C | 1 |
| Watanabe, K | 1 |
| Tanaka, Y | 1 |
| Kawamori, R | 1 |
| Fukushi, S | 1 |
| Kador, P | 1 |
| Merola, LO | 1 |
| Daumerie-Goffinet, C | 1 |
| Lambert, AE | 1 |
| Solomon, YC | 1 |
| Balasse, EO | 1 |
| van Heyningen, R | 1 |
| Mandarino, LJ | 1 |
| Matsui, M | 1 |
| Kawazu, S | 1 |
| Tomono, S | 1 |
| Ao, S | 1 |
| Shingu, Y | 1 |
| Kikuchi, C | 1 |
| Takano, Y | 1 |
| Nomura, K | 1 |
| Fujiwara, T | 1 |
| Ohkubo, Y | 1 |
| Notsu, Y | 1 |
| Yamaguchi, I | 1 |
| Kumari, K | 1 |
| Umar, S | 1 |
| Bansal, V | 1 |
| Sahib, MK | 1 |
| Del Monte, MA | 1 |
| Rabbani, R | 1 |
| Diaz, TC | 1 |
| Lattimer, SA | 1 |
| Brennan, MC | 1 |
| Greene, DA | 1 |
| Hatano, M | 1 |
| Katsu, K | 1 |
| Fuda, H | 1 |
| Taguchi, H | 1 |
| Aro, T | 1 |
| Hiyoshi, S | 1 |
| Sugiura, M | 1 |
| Maruyama, S | 1 |
| Aida, K | 1 |
| Tawata, M | 1 |
| Shindo, H | 1 |
| Onaya, T | 1 |
| Barr, CC | 1 |
| Li, WY | 1 |
| MacGregor, LC | 1 |
| Matschinsky, FM | 1 |
| Pitts, NE | 1 |
| Vreeland, F | 1 |
| Shaw, GL | 1 |
| Peterson, MJ | 1 |
| Mehta, DJ | 1 |
| Collier, J | 1 |
| Gundersen, K | 1 |
| Aguayo, JB | 1 |
| McLennan, IJ | 1 |
| Aguiar, E | 1 |
| Cheng, HM | 1 |
| Kilo, C | 1 |
| Sharpless, NE | 1 |
| Beaumont, P | 3 |
| Schofield, PJ | 1 |
| Hollows, FC | 2 |
| Wiows, FC | 1 |
| Steinbeck, AW | 2 |
| Williams, JF | 1 |
| Wieland, OH | 1 |
| Dawidowicz, A | 1 |
18 reviews available for sorbitol and Diabetic Retinopathy
| Article | Year |
|---|---|
Aldose reductase / polyol inhibitors for diabetic retinopathy.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetic Retinopathy; Disease Models, Animal; | 2011 |
[Molecular biology in development and progression of diabetic retinopathy].
Topics: Animals; Capillary Permeability; Chronic Disease; Cytokines; Diabetic Retinopathy; Disease Progressi | 2002 |
Medical treatment of diabetic retinopathy.
Topics: Anticholesteremic Agents; Antihypertensive Agents; Diabetic Retinopathy; Glycosylation; Growth Subst | 2003 |
The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient.
Topics: Aldehyde Reductase; Animals; Diabetic Retinopathy; Fructose; Glucose; Humans; Oxidation-Reduction; S | 2007 |
The biochemistry of the complications of diabetes mellitus.
Topics: Animals; Axonal Transport; Basement Membrane; Blood Platelets; Blood Proteins; Cataract; Diabetes Co | 1981 |
NIH conference. Aldose reductase and complications of diabetes.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Cataract; Corneal Diseases; Diabetic Neuropathies; Di | 1984 |
Lipid peroxidation and diabetic complications: effect of antioxidant vitamins C and E.
Topics: Animals; Antioxidants; Ascorbic Acid; Controlled Clinical Trials as Topic; Diabetic Retinopathy; Gly | 1994 |
The aldose reductase controversy.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimen | 1994 |
[Diabetic retinopathy: pathogenesis, risk factors, clinical picture, classification].
Topics: Blood Glucose; Diabetic Retinopathy; Glycation End Products, Advanced; Hemostasis; Humans; Neovascul | 1995 |
[SG-210].
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inh | 1997 |
Mitogen-activated protein kinases as glucose transducers for diabetic complications.
Topics: Animals; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Glucose; Humans; Mitog | 1999 |
Aldose reductase in diabetic complications of the eye.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Chromans; Cornea; Diabetes Complications; Diabetic Re | 1979 |
[Diabetic microangiopathies].
Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies | 1978 |
Current hypotheses for the biochemical basis of diabetic retinopathy.
Topics: Basement Membrane; Capillaries; Diabetic Retinopathy; Glucose; Humans; Hyperglycemia; Retinal Vessel | 1992 |
Diabetic retinopathy.
Topics: Adult; Aldehyde Reductase; Aneurysm; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 1986 |
Value of glucose control in preventing complications of diabetes.
Topics: Adult; Animals; Blood Glucose; Blood Pressure; Blood Vessels; Body Weight; Collagen; Diabetes Compli | 1985 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; | 1985 |
[Diabetic cataract and modern views on the etiology and pathogenesis of vascular complications during diabetes].
Topics: Age Factors; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus, Type 1; Diabe | 1971 |
1 trial available for sorbitol and Diabetic Retinopathy
| Article | Year |
|---|---|
Clinical experience with sorbinil--an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Blood Glucose; Clinical Trials as To | 1986 |
47 other studies available for sorbitol and Diabetic Retinopathy
| Article | Year |
|---|---|
Untargeted metabolomic analysis of aqueous humor in diabetic macular edema.
Topics: Antioxidants; Aqueous Humor; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Fatty Acids; Glucose; | 2022 |
Association study of sorbitol dehydrogenase -888G>C polymorphism with type 2 diabetic retinopathy in Caucasian-Brazilians.
Topics: Adult; Aldehyde Reductase; Brazil; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinop | 2013 |
Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications.
Topics: Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Complications; Diabetic Retinopathy; | 2008 |
Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo.
Topics: Acridine Orange; Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus | 2010 |
Rhizome of Anemarrhena asphodeloides counteracts diabetic ophthalmopathy progression in streptozotocin-induced diabetic rats.
Topics: Anemarrhena; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy | 2013 |
Polymorphisms of sorbitol dehydrogenase (SDH) gene and susceptibility to diabetic retinopathy.
Topics: Aldehyde Reductase; Diabetic Retinopathy; Genetic Predisposition to Disease; Genotype; Humans; L-Idi | 2003 |
[THE TREATMENT OF DIABETIC RETINOPATHY WITH SORBITOL (A PRELIMINARY REPORT)].
Topics: Blood Glucose; Blood Protein Electrophoresis; Diabetic Retinopathy; Fructose; Geriatrics; Glucose; H | 1964 |
Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.
Topics: Animals; Benzamides; Cell Hypoxia; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inh | 2004 |
Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy.
Topics: Aged; Aldehyde Reductase; Animals; Apoptosis; Capillaries; Diabetic Retinopathy; Enzyme Inhibitors; | 2004 |
Diabetic retinopathy mechanism probed.
Topics: Animals; Diabetic Retinopathy; Free Radicals; Glucose; Humans; Hyperglycemia; NAD; Rats; Retina; Sor | 2005 |
Inhibitory effects of Ganoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; E | 2005 |
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy | 2006 |
Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy.
Topics: Aldehyde Reductase; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinop | 2008 |
[An electrophysiological method for detecting diabetic retinopathy in rats].
Topics: Animals; Blood Glucose; Diabetic Retinopathy; Electroretinography; Evoked Potentials, Visual; Insuli | 1984 |
Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Diabetic Retinopathy; Imidazoles; Imidazolidines | 1983 |
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.
Topics: Aldehyde Reductase; Animals; Diabetic Retinopathy; Fluorenes; Fructose; Glucose; Glycolysis; Hydanto | 1995 |
Regulation of growth factor mRNA levels in the eyes of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retino | 1995 |
Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA.
Topics: Aldehyde Reductase; Animals; Base Sequence; Blotting, Southern; Blotting, Western; Diabetic Angiopat | 1995 |
The galactosemic dog. A valid model for both early and late stages of diabetic retinopathy.
Topics: Animals; Diabetic Retinopathy; Disease Models, Animal; Dogs; Galactose; Galactosemias; Optic Disk; R | 1995 |
Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cattle; Diabetes Mellitus, Experimental; Diabetic Neuro | 1994 |
Acetyl-L-carnitine corrects electroretinographic deficits in experimental diabetes.
Topics: Acetylcarnitine; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; | 1993 |
An aldose reductase inhibitor, TAT, prevents electroretinographic abnormalities and ADP-induced hyperaggregability in streptozotocin-induced diabetic rats.
Topics: Adenosine Diphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Retino | 1995 |
Effect of propionyl-L-carnitine on oscillatory potentials in electroretinogram in streptozotocin-diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; | 1996 |
The level of erythrocyte aldose reductase: a risk factor for diabetic neuropathy?
Topics: Adult; Age Factors; Aged; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neu | 1997 |
Electroretinogram in sucrose-fed diabetic rats treated with an aldose reductase inhibitor or an anticoagulant.
Topics: 2,3-Diphosphoglycerate; Aldehyde Reductase; Animals; Anticoagulants; Blood Glucose; Body Weight; Cil | 1997 |
Changes in erythrocyte sorbitol concentrations measured using an improved assay system in patients with diabetic complications and treated with aldose reductase inhibitor.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Blood Glucose; Child; Diabetes Mellitus, Type 1; Diabet | 1998 |
Does mitochondrial genome mutation in subjects with maternally inherited diabetes and deafness decrease severity of diabetic retinopathy?
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Blood Glucose; Deafness; Diabetes Mellitus, Type 2; Di | 1998 |
Subnormal retinal oxygenation response precedes diabetic-like retinopathy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Diabetic Retinopathy; Fructose; Galactitol; Galactose; Galac | 1999 |
Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity.
Topics: Adult; Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retino | 2001 |
Diabetic retinopathy and carbohydrate metabolism.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dietary Car | 1979 |
[Physiopathology of chronic complications in diabetes: therapeutic implications].
Topics: Adult; Aged; Arteriosclerosis; Blood Platelets; Diabetes Complications; Diabetic Angiopathies; Diabe | 1979 |
Experimental studies on cataract.
Topics: Aging; Animals; Ascorbic Acid; Cataract; Crystallins; Diabetic Retinopathy; Humans; Lens, Crystallin | 1976 |
[Ocular complications of diabetes mellitus--pathogenesis and risk factors of development].
Topics: Diabetic Retinopathy; Glycoproteins; Glycosylation; Humans; Hyperglycemia; Insulin; Neovascularizati | 1991 |
[Diabetic microangiopathy--its biochemical bases].
Topics: Animals; Basement Membrane; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Glu | 1991 |
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Neuropathies; Diabetic Retinopathy; Female; Kinetics | 1991 |
Inhibition of diabetes-associated complications by nucleophilic compounds.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Reti | 1991 |
Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications.
Topics: Adult; Aldehyde Reductase; Cells, Cultured; Diabetic Retinopathy; Glucose; Humans; Imidazoles; Imida | 1991 |
Studies on clinical markers of diabetes mellitus. 6. Red blood cell sorbitol and diabetic complications.
Topics: Biomarkers; Cataract; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Eryth | 1990 |
Clinical significance of erythrocyte sorbitol-blood glucose ratios in type II diabetes mellitus.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; E | 1990 |
[Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy].
Topics: Aldehyde Reductase; Animals; Cattle; Cell Line; Diabetic Retinopathy; Glucose; Imidazoles; Imidazoli | 1989 |
[Causes and treatment of diabetic complications].
Topics: Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Glycosylatio | 1989 |
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Glucose; Imidaz | 1986 |
The study of diabetic cataractogenesis in the intact rabbit lens by deuterium NMR spectroscopy.
Topics: Aldehyde Reductase; Animals; Cataract; Deuterium; Diabetic Retinopathy; Glucose; In Vitro Techniques | 1987 |
Growth hormone, sorbitol, and diabetic capillary disease.
Topics: Capillaries; Diabetic Angiopathies; Diabetic Retinopathy; Fatty Acids; Glucose; Growth Hormone; Huma | 1971 |
Sorbitol and the lens.
Topics: Diabetic Retinopathy; Humans; Lens, Crystalline; Sorbitol | 1971 |
[Pathobiochemistry of the late-onset diabetic syndrome].
Topics: Age Factors; Alcohol Oxidoreductases; Animals; Basement Membrane; Cataract; Diabetes Mellitus; Diabe | 1974 |
Factors in diabetic microangiopathy.
Topics: Diabetic Angiopathies; Diabetic Retinopathy; Fatty Acids, Nonesterified; Humans; Retinal Vessels; So | 1970 |