sorbitol has been researched along with Diabetic Neuropathies in 148 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Development of a simple, sensitive and rapid method for sorbitol detection is of considerable significance to efficient monitoring of diabetes-associated disorders like cataract, neuropathy, and nephropathy at initial stages." | 5.05 | Bioengineered Polymer/Composites as Advanced Biological Detection of Sorbitol: An Application in Healthcare Sector. ( Batra, K; Minakshi, P; Rani, R; Singh, G, 2020) |
| "An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose." | 3.65 | Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. ( Dvornik, E; Gabbay, KH; Kinoshita, JH; Krami, M; Merola, LO; Sestanj, K; Simard-Duquesne, N; Varma, SD, 1973) |
| "Diabetic retinopathy is similarly related to sorbitol accumulation and may be prevented or reversed by inhibition of aldose reductase." | 2.37 | NIH conference. Aldose reductase and complications of diabetes. ( Cobo, LM; Cogan, DG; Datilis, MB; Kador, PF; Kinoshita, JH; Kupfer, C; Robison, G, 1984) |
| "Mononeuritis (or mononeuritis multiplex) seems to be the result of ischaemia due to intrinsic or extrinsic (altered coagulability) vascular disease." | 2.37 | [Pathogenesis of diabetic neuropathies]. ( Arlot, S; Lalau, JD; Quichaud, J, 1985) |
| "Fidarestat treatment did not affect diabetes-induced increase in glucose concentrations, but normalized sorbitol and fructose concentrations (enzymatic spectrofluorometric assays) as well as 12(S)-hydroxyeicosatetraenoic concentration (ELISA), a measure of 12/15-lipoxygenase activity, in the sciatic nerve and spinal cord." | 1.38 | Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. ( Hirooka, H; Nadler, JL; Obrosova, IG; Shevalye, H; Stavniichuk, R, 2012) |
| "At 8 months galactosemia reduced NCV to 58% of control values, while ARI-treatment for 8 months improved NCV to 71% of control values." | 1.29 | Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy. ( Basso, M; Cherian, PV; Hohman, TC; Kamijo, M; Sima, AA, 1994) |
| "Iloprost was administered intraperitoneally to streptozotocin-induced diabetic rats at a dose of 10 micrograms/kg/day for a month." | 1.28 | Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats. ( Ito, H; Kanazawa, A; Miwa, T; Ohno, A; Tanaka, A, 1992) |
| "Myo-inositol was reduced approximately 50%." | 1.28 | [Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats]. ( Lu, KM; Zhong, XL; Zhu, QY; Zhu, XX, 1990) |
| "Myo-inositol treatment did not affect nerve levels." | 1.28 | The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats. ( Cameron, NE; Cotter, MA; Robertson, S, 1989) |
| "Treatment with Sorbinil (25 mg/kg/day, p." | 1.27 | Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. ( Mayer, JH; Moriarty, RJ; Tomlinson, DR, 1984) |
| "Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration." | 1.26 | The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats. ( Hanwell, MA; Satchell, PM; Turtle, JR; Yue, DK, 1982) |
| "Myoinositol concentration was significantly decreased in patients with polyneuropathy compared with the controls." | 1.26 | Cerebrospinal fluid sorbitol and myoinositol in diabetic polyneuropathy. ( Bergström, L; Fogelholm, R; Servo, C, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (47.30) | 18.7374 |
| 1990's | 54 (36.49) | 18.2507 |
| 2000's | 18 (12.16) | 29.6817 |
| 2010's | 4 (2.70) | 24.3611 |
| 2020's | 2 (1.35) | 2.80 |
| Authors | Studies |
|---|---|
| Rani, R | 1 |
| Singh, G | 1 |
| Batra, K | 1 |
| Minakshi, P | 1 |
| Srivastava, B | 1 |
| Sen, S | 1 |
| Sen, K | 1 |
| Li, G | 1 |
| Sun, C | 1 |
| Wang, Y | 1 |
| Liu, Y | 1 |
| Gang, X | 1 |
| Gao, Y | 1 |
| Li, F | 2 |
| Xiao, X | 1 |
| Wang, G | 1 |
| Hao, W | 1 |
| Tashiro, S | 1 |
| Hasegawa, T | 1 |
| Sato, Y | 1 |
| Kobayashi, T | 1 |
| Tando, T | 1 |
| Katsuyama, E | 1 |
| Fujie, A | 1 |
| Watanabe, R | 1 |
| Morita, M | 1 |
| Miyamoto, K | 1 |
| Morioka, H | 1 |
| Nakamura, M | 1 |
| Matsumoto, M | 1 |
| Amizuka, N | 1 |
| Toyama, Y | 1 |
| Miyamoto, T | 1 |
| Freeman, OJ | 1 |
| Unwin, RD | 1 |
| Dowsey, AW | 1 |
| Begley, P | 1 |
| Ali, S | 1 |
| Hollywood, KA | 1 |
| Rustogi, N | 1 |
| Petersen, RS | 1 |
| Dunn, WB | 1 |
| Cooper, GJ | 1 |
| Gardiner, NJ | 1 |
| Matsumoto, T | 1 |
| Ono, Y | 2 |
| Kurono, M | 2 |
| Kuromiya, A | 1 |
| Nakamura, K | 1 |
| Bril, V | 4 |
| Sim, HJ | 1 |
| Jeong, JS | 1 |
| Kwon, HJ | 1 |
| Kang, TH | 1 |
| Park, HM | 1 |
| Lee, YM | 1 |
| Kim, SY | 1 |
| Hong, SP | 1 |
| Stavniichuk, R | 1 |
| Shevalye, H | 1 |
| Hirooka, H | 1 |
| Nadler, JL | 1 |
| Obrosova, IG | 2 |
| Oates, PJ | 2 |
| Hotta, N | 9 |
| Hamada, Y | 6 |
| Suzuki, Y | 1 |
| Buchanan, RA | 1 |
| Szabó, C | 1 |
| Pacher, P | 1 |
| Southan, GJ | 1 |
| Abatan, OI | 1 |
| Charniauskaya, T | 1 |
| Stevens, MJ | 4 |
| Yagihashi, S | 4 |
| Romanovsky, D | 1 |
| Cruz, NF | 1 |
| Dienel, GA | 1 |
| Dobretsov, M | 1 |
| Perkins, BA | 1 |
| Brownlee, M | 1 |
| Cerami, A | 1 |
| Mayer, JH | 4 |
| Tomlinson, DR | 11 |
| Moriarty, RJ | 1 |
| Cogan, DG | 1 |
| Kinoshita, JH | 3 |
| Kador, PF | 2 |
| Robison, G | 1 |
| Datilis, MB | 1 |
| Cobo, LM | 1 |
| Kupfer, C | 1 |
| Clarke, BF | 2 |
| Young, RJ | 2 |
| Martyn, CN | 2 |
| Ewing, DJ | 2 |
| Kikkawa, R | 4 |
| Hatanaka, I | 4 |
| Yasuda, H | 5 |
| Kobayashi, N | 2 |
| Shigeta, Y | 5 |
| Terashima, H | 3 |
| Morimura, T | 2 |
| Tsuboshima, M | 1 |
| Jacobson, M | 1 |
| Sharma, YR | 1 |
| Cotlier, E | 1 |
| Hollander, JD | 1 |
| Finegold, D | 1 |
| Lattimer, SA | 10 |
| Nolle, S | 1 |
| Bernstein, M | 1 |
| Greene, DA | 15 |
| Gabbay, KH | 6 |
| Ward, JD | 2 |
| Low, PA | 3 |
| Tuck, RR | 1 |
| Dyck, PJ | 3 |
| Schmelzer, JD | 3 |
| Yao, JK | 4 |
| Fagius, J | 1 |
| Jameson, S | 1 |
| Yue, DK | 1 |
| Hanwell, MA | 1 |
| Satchell, PM | 1 |
| Turtle, JR | 1 |
| Winegrad, AI | 1 |
| Simmons, DA | 1 |
| Martin, DB | 1 |
| Sherman, WR | 3 |
| Hallcher, LM | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Grina, LA | 1 |
| Palumbo, PJ | 1 |
| Swanson, CJ | 1 |
| Koh, N | 6 |
| Sakakibara, F | 5 |
| Nakamura, J | 4 |
| Wakao, T | 3 |
| Hara, T | 3 |
| Mori, K | 3 |
| Naruse, K | 3 |
| Nakashima, W | 1 |
| Kakuta, H | 3 |
| Fukasawa, H | 3 |
| Wright, RA | 1 |
| Nukada, H | 1 |
| Kamijo, M | 5 |
| Basso, M | 1 |
| Cherian, PV | 1 |
| Hohman, TC | 2 |
| Sima, AA | 11 |
| Thurston, JH | 1 |
| McDougal, DB | 1 |
| Hauhart, RE | 1 |
| Schulz, DW | 1 |
| Tilton, RG | 2 |
| Chang, K | 1 |
| Nyengaard, JR | 1 |
| Van den Enden, M | 1 |
| Ido, Y | 3 |
| Williamson, JR | 3 |
| McHowat, J | 1 |
| Chang, KC | 1 |
| Arrigoni-Martelli, E | 1 |
| Orfalian, Z | 1 |
| Kilo, C | 2 |
| Corr, PB | 1 |
| Suzuki, E | 1 |
| Yasuda, K | 2 |
| Miyazaki, S | 1 |
| Takeda, N | 1 |
| Inouye, H | 1 |
| Omawari, N | 1 |
| Miura, K | 1 |
| Matsui, T | 1 |
| Nakamura, Y | 1 |
| Ishikawa, H | 1 |
| Matsuura, A | 3 |
| Kobayashi, F | 1 |
| Frank, RN | 1 |
| Carrington, AL | 1 |
| Diemel, LT | 1 |
| Ettlinger, CB | 1 |
| Smith, WJ | 1 |
| Fernyhough, P | 1 |
| Van Huysen, C | 1 |
| Wada, R | 1 |
| Nagai, K | 1 |
| Cameron, NE | 4 |
| Cotter, MA | 4 |
| Maxfield, EK | 1 |
| Inukai, S | 1 |
| Agata, M | 1 |
| Sato, M | 1 |
| Naitou, A | 1 |
| Matsukawa, H | 1 |
| Goto, M | 1 |
| Hirano, F | 1 |
| Tanaka, H | 1 |
| Okamoto, K | 1 |
| Makino, Y | 1 |
| Inaba, M | 1 |
| Nomura, Y | 1 |
| Fukawa, E | 1 |
| Miura, T | 1 |
| Tani, T | 1 |
| Makino, I | 1 |
| Shindo, H | 3 |
| Thomas, TP | 1 |
| Larkin, DD | 1 |
| Karihaloo, AK | 1 |
| Inada, H | 1 |
| Onaya, T | 3 |
| Ristic, H | 1 |
| Merry, A | 1 |
| Nakashima, E | 2 |
| Ashizawa, N | 2 |
| Yoshida, M | 2 |
| Sugiyama, Y | 2 |
| Akaike, N | 2 |
| Ohbayashi, S | 2 |
| Aotsuka, T | 2 |
| Abe, N | 1 |
| Fukushima, K | 1 |
| Ito, T | 1 |
| Nishimura, C | 1 |
| Takahashi, Y | 1 |
| Saito, T | 1 |
| Omori, Y | 1 |
| Hounsom, L | 1 |
| Akira, T | 1 |
| Naka, H | 1 |
| Hayashi, R | 1 |
| Hayakawa, N | 1 |
| Makino, M | 2 |
| Nagata, M | 1 |
| Kakizawa, H | 1 |
| Uchimura, K | 1 |
| Hamada, M | 1 |
| Aono, T | 1 |
| Fujita, T | 1 |
| Shinohara, R | 1 |
| Nagasaka, A | 1 |
| Itoh, M | 1 |
| Pierzchala, K | 1 |
| Kishi, Y | 1 |
| Zollman, PJ | 1 |
| Nickander, KK | 1 |
| Tritschler, HJ | 1 |
| Kato, K | 3 |
| Nakayama, M | 1 |
| Chaya, S | 1 |
| Kasuya, Y | 1 |
| Mizubayashi, R | 1 |
| Miwa, K | 1 |
| Yasuda, Y | 1 |
| Kamiya, H | 1 |
| Ienaga, K | 1 |
| Sundkvist, G | 1 |
| Dahlin, LB | 2 |
| Nilsson, H | 1 |
| Eriksson, KF | 1 |
| Lindgärde, F | 1 |
| Rosén, I | 1 |
| Sullivan, K | 1 |
| Kato, N | 2 |
| Mizuno, K | 2 |
| Suzuki, T | 1 |
| Yoshii, H | 1 |
| Uchino, H | 1 |
| Ohmura, C | 1 |
| Watanabe, K | 1 |
| Tanaka, Y | 1 |
| Kawamori, R | 1 |
| Coppey, LJ | 1 |
| Davidson, EP | 1 |
| Dunlap, JA | 1 |
| Lund, DD | 1 |
| Yorek, MA | 1 |
| Winkler, G | 1 |
| Kempler, P | 1 |
| Liang, X | 1 |
| Cui, L | 1 |
| Guo, S | 1 |
| Daumerie-Goffinet, C | 1 |
| Lambert, AE | 1 |
| Balasse, EO | 1 |
| Mehnert, H | 1 |
| Servo, C | 1 |
| Bergström, L | 1 |
| Fogelholm, R | 1 |
| Ohno, A | 1 |
| Kanazawa, A | 1 |
| Tanaka, A | 1 |
| Miwa, T | 1 |
| Ito, H | 1 |
| Sonobe, M | 3 |
| Hisanaga, T | 1 |
| Kawabata, T | 1 |
| Maeda, K | 1 |
| Matsubara, A | 1 |
| Nakano, K | 2 |
| Tawata, M | 2 |
| Aida, K | 2 |
| Komori, H | 1 |
| Sakamoto, N | 3 |
| Nathaniel, V | 2 |
| Das, AK | 1 |
| Vijayaraghavan, MV | 1 |
| Kito, S | 1 |
| Yamamura, Y | 1 |
| Wasada, T | 1 |
| Ao, S | 1 |
| Shingu, Y | 1 |
| Kikuchi, C | 1 |
| Takano, Y | 1 |
| Nomura, K | 1 |
| Fujiwara, T | 1 |
| Ohkubo, Y | 1 |
| Notsu, Y | 1 |
| Yamaguchi, I | 1 |
| Nishikawa, M | 1 |
| Yoshida, K | 1 |
| Okamoto, M | 1 |
| Itoh, Y | 1 |
| Kohsaka, M | 1 |
| Nakayama, K | 1 |
| Mizota, M | 1 |
| Miwa, I | 1 |
| Okuda, J | 1 |
| Iwamoto, Y | 1 |
| Mirrlees, DJ | 1 |
| Lu, KM | 1 |
| Zhong, XL | 1 |
| Zhu, XX | 1 |
| Zhu, QY | 1 |
| Suzuki, K | 1 |
| Saito, N | 1 |
| Sakata, Y | 1 |
| Toyota, T | 1 |
| Goto, Y | 1 |
| Willars, GB | 1 |
| Robinson, JP | 2 |
| Archer, DR | 1 |
| McLean, WG | 1 |
| Compton, AM | 1 |
| Keen, P | 1 |
| Schmidt, RE | 1 |
| Plurad, SB | 1 |
| Robertson, S | 1 |
| Yamashita, M | 2 |
| Terada, M | 2 |
| Huitian, Z | 1 |
| Lattimer-Greene, S | 1 |
| Umehara, F | 1 |
| Greene, D | 1 |
| Ward, KK | 1 |
| Yoshida, T | 1 |
| Nishioka, H | 1 |
| Yoshioka, K | 1 |
| Kondo, M | 1 |
| Chandler, CE | 1 |
| Miller, LJ | 1 |
| Pitts, NE | 1 |
| Vreeland, F | 1 |
| Shaw, GL | 1 |
| Peterson, MJ | 1 |
| Mehta, DJ | 1 |
| Collier, J | 1 |
| Gundersen, K | 1 |
| Reid, W | 1 |
| McEwen, TA | 1 |
| Brown, MB | 1 |
| Zimmerman, BR | 1 |
| Vilen, TH | 1 |
| Minnerath, SR | 1 |
| Karnes, JL | 1 |
| Poduslo, JF | 1 |
| Miyamoto, Y | 1 |
| Amenomori, M | 1 |
| Motoyama, Y | 1 |
| Gregersen, G | 1 |
| Lehtinen, JM | 1 |
| Hyvönen, SK | 1 |
| Uusitupa, M | 1 |
| Puhakainen, E | 1 |
| Halonen, T | 1 |
| Kilpeläinen, H | 1 |
| Bertelsmann, FW | 1 |
| Heimans, JJ | 1 |
| van Rooy, JC | 1 |
| Popp-Snijders, C | 1 |
| van der Veen, EA | 1 |
| Inaba, H | 1 |
| Yano, T | 1 |
| Lalau, JD | 1 |
| Arlot, S | 1 |
| Quichaud, J | 1 |
| Kimura, M | 1 |
| Iida, M | 1 |
| Sharpless, NE | 1 |
| Dvornik, E | 1 |
| Simard-Duquesne, N | 1 |
| Krami, M | 1 |
| Sestanj, K | 1 |
| Varma, SD | 1 |
| Merola, LO | 2 |
| Wieland, OH | 1 |
| Sharkey, TP | 1 |
| Lekishvili, VP | 1 |
| O'Sullivan, JB | 1 |
| Ahuja, MM | 1 |
| Draznin, NM | 1 |
| Ide, T | 1 |
| Field, RA | 1 |
| Stewart, MA | 1 |
| Anthony, S | 1 |
42 reviews available for sorbitol and Diabetic Neuropathies
| Article | Year |
|---|---|
Bioengineered Polymer/Composites as Advanced Biological Detection of Sorbitol: An Application in Healthcare Sector.
Topics: Biosensing Techniques; Cataract; Diabetic Nephropathies; Diabetic Neuropathies; Electrochemical Tech | 2020 |
Polyol pathway and diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Enzyme Activation; Enzyme Inhibitors; Humans; L- | 2002 |
[Risk factors for diabetic complications: Abnormality of polyol metabolism].
Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; F | 2002 |
[Risk factors and onset mechanisms of diabetic neuropathy].
Topics: Aldehyde Reductase; Animals; Blood Glucose; Capillary Permeability; Diabetic Neuropathies; Genetic P | 2002 |
[Early detection of diabetic neuropathy].
Topics: Aldehyde Reductase; Chronic Disease; Diabetic Neuropathies; Evidence-Based Medicine; Glycation End P | 2002 |
Sural nerve sorbitol in patients with diabetic sensorimotor polyneuropathy.
Topics: Adult; Aged; Diabetic Neuropathies; Humans; MEDLINE; Middle Aged; Reference Values; Sorbitol; Sural | 2004 |
[Metabolic factors in the pathogenesis of diabetic neuropathies].
Topics: Aldehyde Reductase; Diabetic Neuropathies; Genetic Predisposition to Disease; Glucose; Glycation End | 2005 |
[Early diagnosis of peripheral neuropathy in patients with impaired glucose tolerance (IGT)].
Topics: Diabetic Neuropathies; Glucose Intolerance; Glycation End Products, Advanced; Humans; Hyperglycemia; | 2005 |
Emerging therapies for diabetic neuropathy: a clinical overview.
Topics: Aldehyde Reductase; Autonomic Nervous System Diseases; Blood Glucose; Diabetes Mellitus, Type 2; Dia | 2005 |
Aldose reductase, still a compelling target for diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Controlled Clinical Trials as Topic; Diabetic Neuropathies; Disease Mod | 2008 |
The biochemistry of the complications of diabetes mellitus.
Topics: Animals; Axonal Transport; Basement Membrane; Blood Platelets; Blood Proteins; Cataract; Diabetes Co | 1981 |
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy.
Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1984 |
NIH conference. Aldose reductase and complications of diabetes.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Cataract; Corneal Diseases; Diabetic Neuropathies; Di | 1984 |
[The biochemical basis of the complications of diabetes].
Topics: Aldehyde Reductase; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Fruc | 1984 |
The aldose reductase controversy.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimen | 1994 |
Limitations of the polyol hypothesis in the pathobiology of experimental diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Humans; Models, Ne | 1993 |
Metabolic alterations of peripheral nerve in diabetes.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Disease Models, Animal; Enzyme Inhibitors; Fatty | 1996 |
Does neuropathy develop in animal models?
Topics: Animals; Axotomy; Biological Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dise | 1997 |
[Metabolic disorder of polyol pathway].
Topics: Diabetes Mellitus; Diabetic Neuropathies; Fructose; Glucose; Humans; NAD; NADP; Sorbitol | 1997 |
[SG-210].
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inh | 1997 |
New concepts and insights on pathogenesis and treatment of diabetic complications: polyol pathway and its inhibition.
Topics: Animals; Diabetes Complications; Diabetic Neuropathies; Humans; Sorbitol | 1997 |
[Contemporary views on the pathogenesis of diabetic neuropathy].
Topics: Adenosine Triphosphatases; Basement Membrane; Diabetic Neuropathies; Endothelium, Vascular; Free Rad | 1998 |
Future prevention and treatment of diabetic neuropathy.
Topics: Diabetic Neuropathies; Forecasting; Glycosylation; Humans; Hyperglycemia; Nerve Growth Factors; Oxid | 1998 |
Mitogen-activated protein kinases as glucose transducers for diabetic complications.
Topics: Animals; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Glucose; Humans; Mitog | 1999 |
[The pathogenesis of diabetic and hepatic neuropathies].
Topics: Chronic Disease; Diabetic Neuropathies; Glucose; Hemodynamics; Hemorheology; Humans; Lipid Peroxidat | 2001 |
[Diabetic microangiopathies].
Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies | 1978 |
Review: pathogenesis, progression, and therapeutic intervention of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Cataract; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Huma | 1992 |
Diabetic peripheral neuropathy.
Topics: Diabetic Neuropathies; Humans; Inositol; Sorbitol | 1991 |
[Diabetic neuropathy--a review of pathological studies].
Topics: Adolescent; Adult; Aged; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mo | 1991 |
Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Humans; Inositol; Neural Conduction; Periphe | 1989 |
Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?
Topics: Animals; Diabetic Neuropathies; Glucose; Humans; Inositol; Neural Conduction; Peripheral Nerves; Pho | 1988 |
[Sorbitol, phosphoinositides and Na K-ATPase in the pathogenesis of diabetic complications].
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Human | 1988 |
Sorbitol, myo-inositol and sodium-potassium ATPase in diabetic peripheral nerve.
Topics: Animals; Blood Glucose; Diabetic Neuropathies; Energy Metabolism; Humans; Inositol; Sodium-Potassium | 1986 |
Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and (Na,K)-ATPase regulation in diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves | 1986 |
[Diabetic neuropathy: theories on its metabolic pathogenesis].
Topics: Animals; Diabetic Neuropathies; Humans; Peripheral Nerves; Phosphatidylinositols; Sorbitol | 1987 |
Value of glucose control in preventing complications of diabetes.
Topics: Adult; Animals; Blood Glucose; Blood Pressure; Blood Vessels; Body Weight; Collagen; Diabetes Compli | 1985 |
[Pathogenesis of diabetic neuropathies].
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Energy Metabolism; Humans; | 1985 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; | 1985 |
The sorbitol pathway and the complications of diabetes.
Topics: Alcohol Oxidoreductases; Animals; Carbohydrate Metabolism; Cataract; Central Nervous System; Diabete | 1973 |
Diabetes mellitus--present problems and new research. VI. Nephropathy and neuropathy.
Topics: Adult; Alcohol Oxidoreductases; Animals; Cerebrospinal Fluid; Child; Diabetes Mellitus, Type 1; Diab | 1971 |
[New theories of the pathogenesis of diabetic neuropathies].
Topics: Animals; Carbohydrate Metabolism; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic | 1974 |
Diabetic neuropathy.
Topics: Cranial Nerves; Diabetic Neuropathies; Lipid Metabolism; Nerve Tissue; Neural Conduction; Peripheral | 1972 |
8 trials available for sorbitol and Diabetic Neuropathies
| Article | Year |
|---|---|
Aldose reductase inhibition in diabetes.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mel | 1984 |
Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study.
Topics: Adult; Albuminuria; Aldehyde Reductase; Autonomic Nervous System; Clinical Trials as Topic; Diabetic | 1981 |
[Clinical study on jinmaitong composita on diabetic peripheral neuropathy].
Topics: Aged; Aldehyde Reductase; Diabetic Neuropathies; Drugs, Chinese Herbal; Erythrocytes; Humans; Male; | 1999 |
Peripheral nerve repair following ARI treatment.
Topics: Aldehyde Reductase; Axons; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazoli | 1991 |
Clinical experience with sorbinil--an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Blood Glucose; Clinical Trials as To | 1986 |
Six-month treatment with sorbinil in asymptomatic diabetic neuropathy. Failure to improve abnormal nerve function.
Topics: Adult; Aldehyde Reductase; Autonomic Nervous System; Clinical Trials as Topic; Diabetic Neuropathies | 1987 |
Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil.
Topics: Action Potentials; Aldehyde Reductase; Biopsy; Clinical Trials as Topic; Demyelinating Diseases; Dia | 1988 |
The effect of sorbinil treatment on red cell sorbitol levels and clinical and electrophysiological parameters of diabetic neuropathy.
Topics: Adult; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Erythrocytes; Female; H | 1986 |
98 other studies available for sorbitol and Diabetic Neuropathies
| Article | Year |
|---|---|
Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy.
Topics: Caffeine; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Humans; Sorbitol; Spectr | 2022 |
A clinical and neuropathological study of Chinese patients with diabetic peripheral neuropathy.
Topics: Adult; Biopsy; Blood Glucose; Case-Control Studies; China; Diabetes Mellitus, Type 2; Diabetic Neuro | 2014 |
Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation.
Topics: Aldehyde Reductase; Animals; Calcitriol; Cell Dedifferentiation; Cells, Cultured; Demyelinating Dise | 2015 |
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; | 2016 |
Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Diabetic Neuropathies; Enzyme Inhibitors; Male; Neur | 2008 |
HPLC with pulsed amperometric detection for sorbitol as a biomarker for diabetic neuropathy.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Diabetic Neuropathies; Humans; Male; Mice | 2009 |
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Gluco | 2012 |
Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diureti | 2004 |
Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Anim | 2006 |
Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Diabe | 1983 |
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Exper | 1984 |
Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; I | 1983 |
Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Diabetic Retinopathy; Imidazoles; Imidazolidines | 1983 |
Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Gluco | 1983 |
Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Male; Motor Neu | 1984 |
[The problem of the complications of diabetes].
Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellit | 1984 |
Prevention of some electrophysiologic and biochemical abnormalities with oxygen supplementation in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetic Neuropath | 1984 |
The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Female; Imidazoles; Imidazolidines; Motor Neuron | 1982 |
Has one diabetic complication been explained?
Topics: Animals; Axons; Diabetes Mellitus; Diabetic Neuropathies; Fructose; Humans; Imidazoles; Imidazolidin | 1983 |
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Fructose; Humans; Inositol; Middle Aged; Periphera | 1980 |
Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetic Neuro | 1995 |
Effect of a potent new aldose reductase inhibitor, (5-(3-thienyltetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1995 |
Vascular and metabolic factors in the pathogenesis of experimental diabetic neuropathy in mature rats.
Topics: Animals; Diabetic Neuropathies; Fructose; Glucose; Inositol; Male; Neural Conduction; Peripheral Ner | 1994 |
Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Body Weight; Diabetic Neuropathies; Fructose; Galactitol; Galact | 1994 |
Effects of acute, subacute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve. Relation to mechanisms of peripheral neuropathy.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Carbohydrate Metabolism; Chronic Disease; Diabetes M | 1995 |
Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Eye; Fructos | 1995 |
Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Ca(2+) Mg(2+)-ATPase; Carnitine; Diabetes Mellitus, Experimental; Diabetic | 1994 |
1H-NMR analysis of nerve edema in the streptozotocin-induced diabetic rat.
Topics: Aldehyde Reductase; Animals; Body Water; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ede | 1994 |
Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cattle; Diabetes Mellitus, Experimental; Diabetic Neuro | 1994 |
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1993 |
Peripheral neuropathy in the WBN/Kob rat with chronic pancreatitis and spontaneous diabetes.
Topics: Action Potentials; Animals; Axons; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; | 1993 |
Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats.
Topics: Action Potentials; Animals; Butylated Hydroxytoluene; Capillaries; Diabetes Mellitus, Experimental; | 1993 |
Characterization of a novel aldose reductase inhibitor, TAT, and its effects on streptozotocin-induced diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Humans; In Vitro Techniques; Male; Mice; Mice, I | 1993 |
Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters.
Topics: Aging; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrophy | 1995 |
Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells.
Topics: Base Sequence; Cholinergic Fibers; Cyclic GMP; Diabetic Neuropathies; Glucose; Humans; Inositol; Mod | 1996 |
Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcarnitine; Alprostadil; Animals; Diabetic Neuropathies; Dinopros | 1996 |
Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats.
Topics: Acetanilides; Aldehyde Reductase; Analysis of Variance; Animals; Arginine; Blood Glucose; Body Weigh | 1996 |
Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats.
Topics: 2,3-Diphosphoglycerate; Aldehyde Reductase; Animals; Body Weight; Diabetic Neuropathies; Diphosphogl | 1995 |
Effects of a novel potent aldose reductase inhibitor, GP-1447, on aldose reductase activity in vitro and on diabetic neuropathy and cataract formation in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; | 1997 |
The level of erythrocyte aldose reductase: a risk factor for diabetic neuropathy?
Topics: Adult; Age Factors; Aged; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neu | 1997 |
Changes in erythrocyte sorbitol concentrations measured using an improved assay system in patients with diabetic complications and treated with aldose reductase inhibitor.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Blood Glucose; Child; Diabetes Mellitus, Type 1; Diabet | 1998 |
Amelioration of neurovascular deficits in diabetic rats by a novel aldose reductase inhibitor, GP-1447: minor contribution of nitric oxide.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1998 |
Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relati | 1999 |
A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, C | 1999 |
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Human | 2000 |
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 2000 |
Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity.
Topics: Adult; Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retino | 2001 |
Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve.
Topics: Acetylcholine; Animals; Arterioles; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 2000 |
[Physiopathology of chronic complications in diabetes: therapeutic implications].
Topics: Adult; Aged; Arteriosclerosis; Blood Platelets; Diabetes Complications; Diabetic Angiopathies; Diabe | 1979 |
[Do sorbit and fructose aggravate the diabetic lento- and neuropathy?].
Topics: Age Factors; Blood Glucose; Cataract; Diabetic Neuropathies; Diet, Diabetic; Fructose; Humans; Sorbi | 1978 |
Cerebrospinal fluid sorbitol and myoinositol in diabetic polyneuropathy.
Topics: Adult; Aged; Blood Glucose; Diabetic Neuropathies; Dietary Carbohydrates; Humans; Hypoglycemic Agent | 1977 |
Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetic Neuropath | 1992 |
A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.alpha CD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.
Topics: Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hy | 1992 |
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1992 |
The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Diabetes Me | 1992 |
Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetic Neuropathies; Fructose; Hypoglycem | 1992 |
Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructos | 1992 |
[Diabetic neuropathy--pathogenesis and precipitating factors].
Topics: Alcohol Drinking; Animals; Diabetic Neuropathies; Energy Metabolism; Fructose; Glucose; Humans; Imid | 1991 |
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Neuropathies; Diabetic Retinopathy; Female; Kinetics | 1991 |
Studies on WF-3681, a novel aldose reductase inhibitor. IV. Effect of FR-62765, a derivative of WF-3681, on the diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Furans; Kinetics; Male; Motor Neurons; Neural Co | 1991 |
Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil.
Topics: Aldehyde Reductase; Animals; Benzofurans; Cataract; Cattle; Diabetic Neuropathies; Hydantoins; Imida | 1991 |
[Diabetic complication].
Topics: Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetic Nephropathies; Diabe | 1991 |
Effects of long-term aldose reductase inhibition on development of experimental diabetic neuropathy. Ultrastructural and morphometric studies of sural nerve in streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Male; | 1990 |
[Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glucose; Inositol; Male; Ouabain; R | 1990 |
A new prostaglandin E1 analogue (TFC-612) improves the reduction in motor nerve conduction velocity in spontaneously diabetic GK (Goto-Kakizaki) rats.
Topics: Aging; Alprostadil; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabeti | 1990 |
Clinical significance of erythrocyte sorbitol-blood glucose ratios in type II diabetes mellitus.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; E | 1990 |
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Humans; Imidazol | 1986 |
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Topics: Animals; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Diabetes Mellitus, Experiment | 1986 |
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathie | 1987 |
Essential fatty acid treatment--effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats.
Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fatty Acids, Esse | 1989 |
Effects of aldose reductase inhibitor sorbinil on neuroaxonal dystrophy and levels of myo-inositol and sorbitol in sympathetic autonomic ganglia of streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactos | 1989 |
The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Kinet | 1989 |
Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; D | 1989 |
[Recent advances in the pathogenesis of diabetic neuropathy].
Topics: Animals; Axons; Diabetic Neuropathies; Humans; Inositol; Phosphocreatine; Sorbitol | 1989 |
[Causes and treatment of diabetic complications].
Topics: Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Glycosylatio | 1989 |
Polyols and myo-inositol in diabetic neuropathy--of mice and men.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactitol; Inositol; Mice; Periphe | 1989 |
The pathogenesis and prevention of diabetic neuropathy and nephropathy.
Topics: Aldehyde Reductase; Diabetic Nephropathies; Diabetic Neuropathies; Glucose; Humans; Phosphatidylinos | 1988 |
Pathogenesis of diabetic neuropathy.
Topics: Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves; Sorbitol | 1989 |
Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Electrophysiology; Glycated Hemoglobin; Hexo | 1986 |
Axonal transport and nerve conduction velocity in animal models of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazol | 1985 |
Recent advances in the therapy of diabetic peripheral neuropathy by means of an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Biological Transport; Diabetic Neuropathies; Humans; Imidazoles; Imidaz | 1985 |
Effect of aldose reductase inhibitor ONO 2235 on reduced sympathetic nervous system activity and peripheral nerve disorders in STZ-induced diabetic rats.
Topics: Aldehyde Reductase; alpha-Methyltyrosine; Animals; Autonomic Nervous System Diseases; Diabetes Melli | 1987 |
The polyol pathway in dysfunction of diabetic peripheral nerve.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Humans; Inositol; Neural Conduction; Peripheral | 1985 |
Studies of aldose reductase using neuronal cell culture and ligated rat sciatic nerve.
Topics: Aldehyde Reductase; Animals; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic N | 1986 |
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus; Diabetic Neuropathies; Erythrocytes; | 1988 |
A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats.
Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Insulin; Mal | 1988 |
Peripheral nerve function in relation to quality of metabolic control in diabetes.
Topics: Adolescent; Adult; Aged; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythrocytes; Female; Hum | 1987 |
[Effect of trapidil on neuropathy in diabetic mice].
Topics: Animals; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Experimental; Diabetic Neuropathies; In | 1986 |
Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dietary Carbohy | 1985 |
Role of sorbitol pathway in neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Disease Models, Animal; Fructose; | 1973 |
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.
Topics: Acetates; Administration, Oral; Alcohol Oxidoreductases; Animals; Cataract; Culture Techniques; Diab | 1973 |
[Pathobiochemistry of the late-onset diabetic syndrome].
Topics: Age Factors; Alcohol Oxidoreductases; Animals; Basement Membrane; Cataract; Diabetes Mellitus; Diabe | 1974 |
The sorbitol pathway. Enzyme localization and content in normal and diabetic nerve and cord.
Topics: Animals; Axons; Blood Glucose; Cauda Equina; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1968 |
Aetiogenesis of diabetic neuropathy.
Topics: Animals; Demyelinating Diseases; Diabetic Neuropathies; Humans; Nerve Degeneration; Peripheral Nerve | 1972 |
[Pathogenesis of angio- and neuropathies in patients with diabetes mellitus].
Topics: Blood Vessels; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic | 1973 |
[Diabetic neuropathy and the sorbitol cycle].
Topics: Animals; Blood Glucose; Brain; Diabetic Neuropathies; Glucose; Humans; In Vitro Techniques; Nervous | 1969 |
Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; In Vitro Techniq | 1966 |
Free sugars in alloxan diabetic rat nerve.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; In Vitro Techniq | 1966 |