sorbitol and Diabetic Angiopathies studies

Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.

Research Excerpts

Excerpt	Relevance	Reference
"Glaucoma is a leading cause of blindness."	2.47	Clinical and experimental links between diabetes and glaucoma. ( Bui, BV; Vingrys, AJ; Wong, VH, 2011)
"Mononeuritis (or mononeuritis multiplex) seems to be the result of ischaemia due to intrinsic or extrinsic (altered coagulability) vascular disease."	2.37	[Pathogenesis of diabetic neuropathies]. ( Arlot, S; Lalau, JD; Quichaud, J, 1985)
"Methylguanidine was only approximately 7% as effective as aminoguanidine as an inhibitor of AGE formation from L-lysine and G6P; both compounds were poor inhibitors of AR."	1.29	Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. ( Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG, 1993)
"Diabetes mellitus is an important risk factor for coronary heart disease and cerebral vascular disease."	1.29	[Diabetes mellitus as a risk factor for arteriosclerosis]. ( Kasuga, M; Maeda, E; Yoshino, G, 1993)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (51.06)	18.7374
1990's	15 (31.91)	18.2507
2000's	5 (10.64)	29.6817
2010's	1 (2.13)	24.3611
2020's	2 (4.26)	2.80

Authors	Studies
Wang, S	1
Jiao, F	1
Border, JJ	1
Fang, X	1
Crumpler, RF	1
Liu, Y	1
Zhang, H	1
Jefferson, J	1
Guo, Y	1
Elliott, PS	1
Thomas, KN	1
Strong, LB	1
Urvina, AH	1
Zheng, B	1
Rijal, A	1
Smith, SV	1
Yu, H	1
Roman, RJ	1
Fan, F	1
Papachristoforou, E	1
Lambadiari, V	1
Maratou, E	1
Makrilakis, K	1
Wong, VH	1
Bui, BV	1
Vingrys, AJ	1
Tilton, RG	3
Hosojima, H	2
Hotta, N	1
Murphie, P	1
Nakamura, J	1
Brownlee, M	3
Cerami, A	1
Ward, JD	1
Lowe, WL	1
Florkiewicz, RZ	1
Yorek, MA	1
Spanheimer, RG	1
Albrecht, BN	1
Chang, K	4
Hasan, KS	1
Smith, SR	1
Petrash, JM	1
Misko, TP	1
Moore, WM	1
Currie, MG	1
Corbett, JA	1
McDaniel, ML	1
Yamaoka, T	1
Nishimura, C	1
Yamashita, K	1
Itakura, M	1
Yamada, T	1
Fujimoto, J	1
Kokai, Y	1
Nyengaard, JR	1
Van den Enden, M	1
Ido, Y	2
Williamson, JR	5
Guillausseau, PJ	1
Maeda, E	1
Yoshino, G	1
Kasuga, M	1
Kilo, C	4
De la Cruz, JP	1
Maximo, MA	1
Blanco, E	1
Moreno, A	1
Sánchez de la Cuesta, F	1
Daumerie-Goffinet, C	1
Lambert, AE	1
Balasse, EO	1
Tsvetanov, L	1
Ruderman, NB	1
Kawazu, S	1
Tomono, S	1
Wakasugi, M	1
Noguchi, T	1
Inoue, M	1
Tawata, M	1
Shindo, H	1
Onaya, T	1
Hasegawa, G	1
Tsutsumi, Y	1
Aoki, S	1
Sawada, M	1
Setoguchi, J	1
Nakamura, N	1
Nakano, K	1
Kondo, M	1
Kanatsuna, T	1
Ostrow, E	1
Eades, D	1
Allison, W	1
Sherman, WR	2
Kowluru, R	1
Bitensky, MW	1
Kowluru, A	1
Dembo, M	1
Keaton, PA	1
Buican, T	1
Mann, J	1
Koh, MS	1
Misch, KJ	1
Yuen, CT	1
Rhodes, EL	1
Lalau, JD	1
Arlot, S	1
Quichaud, J	1
Kador, PF	1
Kinoshita, JH	2
Sharpless, NE	1
Rowold, E	1
Marvel, J	1
Tomlinson, M	1
Ackermann, KE	1
Beaumont, P	2
Schofield, PJ	1
Hollows, FC	1
Wiows, FC	1
Steinbeck, AW	1
Williams, JF	1
Gabbay, KH	1
Wieland, OH	2
Winegrad, AI	1
Morrison, AD	1
Clements, RS	1
Lekishvili, VP	1
Mehnert, H	1
Draznin, NM	1
Fiser, RH	1
Dawidowicz, A	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes[NCT05478707]			Phase 2	64 participants (Anticipated)	Interventional	2023-10-05	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications. Journal of diabetes research, 2020, Volume: 2020 Topics: Animals; Antioxidants; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathi	2020
Clinical and experimental links between diabetes and glaucoma. Clinical & experimental optometry, 2011, Volume: 94, Issue:1 Topics: Animals; Apoptosis; Cell Death; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Di	2011
Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF. Microscopy research and technique, 2002, Jun-01, Volume: 57, Issue:5 Topics: Animals; Capillary Permeability; Cell Hypoxia; Diabetic Angiopathies; Endothelial Growth Factors; Gl	2002
[Erythrocyte sorbitol, sorbitol dehydrogenase (SDH), and glyceraldehyde reductase (GAR) in diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 8 Topics: Animals; Biomarkers; Diabetes Mellitus; Diabetic Angiopathies; Erythrocytes; Glucose; Humans; Hyperg	2002
[Risk factors for diabetic complications: Abnormality of polyol metabolism]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10 Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; F	2002
Microvascular disease aetiology in diabetic foot ulceration. Journal of wound care, 2001, Volume: 10, Issue:5 Topics: Adenosine Triphosphate; Aldehyde Reductase; Basement Membrane; Blood Flow Velocity; Diabetic Angiopa	2001
[Role of polyol pathway in pathogenesis of diabetic microangiopathy]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6 Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Fructose; Glucose; Glycation End Products, Advan	2005
The biochemistry of the complications of diabetes mellitus. Annual review of biochemistry, 1981, Volume: 50 Topics: Animals; Axonal Transport; Basement Membrane; Blood Platelets; Blood Proteins; Cataract; Diabetes Co	1981
[Preventive treatment of diabetic microangiopathy: blocking the pathogenic mechanisms]. Diabete & metabolisme, 1994, Volume: 20, Issue:2 Pt 2 Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Glucose; Glycosylation; Humans; Hyperglycemia; O	1994
[Diabetic microangiopathies]. Acta clinica Belgica, 1978, Volume: 33, Issue:4 Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies	1978
[Possibilities of preventing diabetic angiopathy (pathogenetic factors in angiopathy)]. Vutreshni bolesti, 1976, Volume: 15, Issue:2 Topics: Animals; Diabetic Angiopathies; Epinephrine; Fructose; Glucagon; Growth Hormone; Humans; Hyperglycem	1976
Glucose and diabetic vascular disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1992, Volume: 6, Issue:11 Topics: Animals; Diabetic Angiopathies; Diglycerides; Extracellular Matrix; Glucose; Humans; Hyperglycemia;	1992
Dietary advice for diabetics: a perspective from the United Kingdom. Journal of the American College of Nutrition, 1986, Volume: 5, Issue:1 Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diet, Sodium-Restricted; Dietary Carbohydra	1986
Value of glucose control in preventing complications of diabetes. The American journal of medicine, 1985, Aug-23, Volume: 79, Issue:2B Topics: Adult; Animals; Blood Glucose; Blood Pressure; Blood Vessels; Body Weight; Collagen; Diabetes Compli	1985
[Pathogenesis of diabetic neuropathies]. Annales de medecine interne, 1985, Volume: 136, Issue:6 Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Energy Metabolism; Humans;	1985
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry;	1985
[New theories of the pathogenesis of diabetic neuropathies]. Klinicheskaia meditsina, 1974, Volume: 52, Issue:11 Topics: Animals; Carbohydrate Metabolism; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic	1974
[Pathogenesis and prophylaxis of diabetic micro-angiopathy (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1974, Nov-22, Volume: 99, Issue:47 Topics: Alcohol Oxidoreductases; Animals; Basement Membrane; Cell Membrane; Collagen; Diabetes Mellitus, Exp	1974
[Diabetic cataract and modern views on the etiology and pathogenesis of vascular complications during diabetes]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1971, Mar-15, Volume: 24, Issue:6 Topics: Age Factors; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus, Type 1; Diabe	1971

Article	Year
Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals. American journal of physiology. Heart and circulatory physiology, 2022, 02-01, Volume: 322, Issue:2 Topics: Animals; Arterioles; Blood-Brain Barrier; Cells, Cultured; Cerebrovascular Circulation; Cognition; D	2022
[The problem of the complications of diabetes]. Journees annuelles de diabetologie de l'Hotel-Dieu, 1984 Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellit	1984
Regulation of growth factor mRNA levels in the eyes of diabetic rats. Metabolism: clinical and experimental, 1995, Volume: 44, Issue:8 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retino	1995
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes, 1993, Volume: 42, Issue:2 Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; B	1993
Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Diabetologia, 1995, Volume: 38, Issue:3 Topics: Aldehyde Reductase; Animals; Base Sequence; Blotting, Southern; Blotting, Western; Diabetic Angiopat	1995
Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats. Diabetes, 1995, Volume: 44, Issue:2 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Eye; Fructos	1995
[Diabetes mellitus as a risk factor for arteriosclerosis]. Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:8 Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Glycosylation; H	1993
Interactions between the sorbitol pathway, non-enzymatic glycation, and diabetic vascular dysfunction. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11 Suppl 5 Topics: Animals; Blood Flow Velocity; Blood Glucose; Capillary Permeability; Cattle; Diabetes Mellitus, Expe	1996
Effect of erythrocytes and prostacyclin production in the effect of fructose and sorbitol on platelet activation in human whole blood in vitro. Thrombosis research, 1997, Jun-15, Volume: 86, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adenosine Diphosphate; Adult; Animals; Aorta; Blood Glucose	1997
[Physiopathology of chronic complications in diabetes: therapeutic implications]. Bruxelles medical, 1979, Volume: 59, Issue:10 Topics: Adult; Aged; Arteriosclerosis; Blood Platelets; Diabetes Complications; Diabetic Angiopathies; Diabe	1979
Glycosylation of proteins and microangiopathy. Hospital practice (Office ed.), 1992, Volume: 27 Suppl 1 Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dogs; Gl	1992
[Diabetic microangiopathy--its biochemical bases]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Animals; Basement Membrane; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Glu	1991
Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes. Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 44, Issue:4 Topics: Aldehyde Reductase; Animals; Aorta, Thoracic; Blood Glucose; Chalcone; Chalcones; Diabetes Mellitus,	1991
[Clinical significance of erythrocyte sorbitol, sorbitol dehydrogenase and glyceraldehyde reductase in diabetic complications]. Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48 Suppl Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Humans; L-Iditol 2-Dehydrogenase; Sorbitol;	1990
Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor. The Journal of clinical investigation, 1990, Volume: 85, Issue:4 Topics: Aldehyde Reductase; Animals; Capillary Permeability; Diabetic Angiopathies; Glucose; Glycosylation;	1990
Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:9 Topics: Adenosine Triphosphate; Animals; Cytosol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Er	1989
Accumulation of sorbitol in endothelial cells--a possible cause of diabetic microangiopathy. Diabetes research (Edinburgh, Scotland), 1986, Volume: 3, Issue:4 Topics: Cells, Cultured; Diabetic Angiopathies; Endothelium; Female; Glucose; Humans; Kinetics; Muscle, Smoo	1986
Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Adolescent; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Angiopathies;	1986
Growth hormone, sorbitol, and diabetic capillary disease. Lancet (London, England), 1971, Mar-20, Volume: 1, Issue:7699 Topics: Capillaries; Diabetic Angiopathies; Diabetic Retinopathy; Fatty Acids; Glucose; Growth Hormone; Huma	1971
Growth hormone, sorbitol, and diabetic capillary disease. Lancet (London, England), 1971, May-01, Volume: 1, Issue:7705 Topics: Blood Glucose; Diabetic Angiopathies; Glucose; Growth Hormone; Humans; Osmotic Fragility; Sorbitol	1971
[Pathobiochemistry of the late-onset diabetic syndrome]. Therapie der Gegenwart, 1974, Volume: 113, Issue:9 Topics: Age Factors; Alcohol Oxidoreductases; Animals; Basement Membrane; Cataract; Diabetes Mellitus; Diabe	1974
Polyol pathway activity in aorta. Advances in metabolic disorders, 1973, Volume: 2 Topics: Animals; Aorta; Arteriosclerosis; Diabetic Angiopathies; Fructose; Fructose-Bisphosphate Aldolase; G	1973
[Pathobiochemistry of the late-onset diabetic syndrome]. Medizinische Klinik, 1974, Sep-06, Volume: 69, Issue:36 Topics: Animals; Carbohydrates; Cataract; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complicatio	1974
[Pathogenesis of angio- and neuropathies in patients with diabetes mellitus]. Sovetskaia meditsina, 1973, Volume: 36, Issue:12 Topics: Blood Vessels; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic	1973
Lipid metabolism, the polyol pathway and vascular complications. California medicine, 1973, Volume: 119, Issue:4 Topics: Diabetes Mellitus; Diabetic Angiopathies; Female; Glucose; Humans; Infant, Newborn; Infant, Newborn,	1973
Glucose-dependent changes in aortic wall metabolism. JAMA, 1970, Mar-30, Volume: 211, Issue:13 Topics: Animals; Aorta; Blood Glucose; Diabetic Angiopathies; Humans; Hyperglycemia; Rabbits; Sorbitol	1970
Factors in diabetic microangiopathy. Transactions of the Australian College of Ophthalmologists, 1970, Volume: 2 Topics: Diabetic Angiopathies; Diabetic Retinopathy; Fatty Acids, Nonesterified; Humans; Retinal Vessels; So	1970

sorbitol and Diabetic Angiopathies

Research Excerpts

Research

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Clinical Trials (1)

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