sorbitol has been researched along with Diabetes Mellitus in 188 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the therapeutic effect of losartan on type 2 diabetes mellitus (DM2) with gas chromatography (GC)-based metabonomics." | 7.74 | [Assessment of therapeutic effect of losartan on diabetes mellitus with gas chromatography-based metabonomics]. ( Gao, P; Lu, X; Shi, XZ; Xu, GW; Yuan, KL, 2007) |
| "A series of in vivo and in vitro investigations was performed to examine the localisation of sorbitol pathway activity in the rat renal cortex and to investigate the possible relation that the acculumation of sorbitol pathway intermediates in renal cortical tissue may have to the pathogenesis of renal complications in diabetes mellitus." | 7.65 | The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus. ( Hollows, FC; Hutton, JC; Schofield, PJ; Williams, JF, 1975) |
| "To assess the therapeutic effect of losartan on type 2 diabetes mellitus (DM2) with gas chromatography (GC)-based metabonomics." | 3.74 | [Assessment of therapeutic effect of losartan on diabetes mellitus with gas chromatography-based metabonomics]. ( Gao, P; Lu, X; Shi, XZ; Xu, GW; Yuan, KL, 2007) |
| "Aldose reductase catalyzes the NADPH-linked reduction of hexoses to their respective sugar-alcohols, which are involved in the pathogenesis of "sugar-cataracts"." | 3.68 | Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies. ( Alvarez, A; Chávez, M; Chávez-Anaya, E; Medina, C; Medina, MD; Mendoza, R; Ramírez, MG; Sáenz, G; Vaca, G; Vargas, M, 1992) |
| "Three groups (6 patients with liver cirrhosis, 6 patients with diabetes mellitus, 6 controls) have been infused for 48 h with a 20% (w/v) glucose/sorbitol-solution (1:1)." | 3.66 | [Carbohydrate infusions in internal diseases. A comparative study in metabolically normal subjects, patients with liver diseases and diabetics. V. Infusion of a glucose-sorbitol mixture (ratio 1:1) for 48 hours]. ( Beerenfeld, A; Egberts, EH; Horbach, L; Malchow, H; Müller, PH; Prestele, H; Schmülling, R, 1982) |
| "A series of in vivo and in vitro investigations was performed to examine the localisation of sorbitol pathway activity in the rat renal cortex and to investigate the possible relation that the acculumation of sorbitol pathway intermediates in renal cortical tissue may have to the pathogenesis of renal complications in diabetes mellitus." | 3.65 | The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus. ( Hollows, FC; Hutton, JC; Schofield, PJ; Williams, JF, 1975) |
| " Insulin responses to tolbutamide, glucagon, arginine and leucine were determined and insulin resistance was measured with exogenous iv insulin." | 3.65 | Carbohydrate metabolism and insulin resistance in myotonia dystrophica. ( Hudson, AJ; Tevaarwerk, GJ, 1977) |
| "An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose." | 3.65 | Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. ( Dvornik, E; Gabbay, KH; Kinoshita, JH; Krami, M; Merola, LO; Sestanj, K; Simard-Duquesne, N; Varma, SD, 1973) |
| "Sorbinil was detected in both lens and aqueous." | 2.66 | The penetration of Sorbinil, an aldose reductase inhibitor, into lens, aqueous humour and erythrocytes of patients undergoing cataract extraction. ( Burgess, SE; Cheng, H; Crabbe, MJ; Petchey, M, 1985) |
| "Glaucoma is a leading cause of blindness." | 2.47 | Clinical and experimental links between diabetes and glaucoma. ( Bui, BV; Vingrys, AJ; Wong, VH, 2011) |
| "Mononeuritis (or mononeuritis multiplex) seems to be the result of ischaemia due to intrinsic or extrinsic (altered coagulability) vascular disease." | 2.37 | [Pathogenesis of diabetic neuropathies]. ( Arlot, S; Lalau, JD; Quichaud, J, 1985) |
| " The main objective of this study is to develop a patient complaint tablet dosage form which is sugar free, chewable and easy to use." | 1.51 | Formulation development of sugar free antacid chewable tablets for diabetes induced acidity in patients. ( Ayaz, S; Khan, M; Naveed, S; Owais, A; Qamar, F; Rehman, H; Sana, A, 2019) |
| " Single oral dosing studies were performed in rats, mice and dogs to assess the abilities of TS-071 to increase urinary glucose excretion and to lower plasma glucose levels." | 1.37 | TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity. ( Arai, M; Asami, J; Fukuhara, N; Gunji, E; Kitano, K; Kojima, N; Kozakai, A; Okumura-Kitajima, L; Takahashi, K; Takahashi, T; Tomoike, H; Toyoda, H; Uchida, S; Yamamoto, K, 2011) |
| "Fidarestat inhibited the increase with an IC50 value of 18 nmol/l." | 1.31 | Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes. ( Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K, 2001) |
| "Diabetes mellitus is an important risk factor for coronary heart disease and cerebral vascular disease." | 1.29 | [Diabetes mellitus as a risk factor for arteriosclerosis]. ( Kasuga, M; Maeda, E; Yoshino, G, 1993) |
| " Our results demonstrate the systemic bioavailability of tolrestat and its aldose reductase inhibitory activity in erythrocytes of patients with diabetes." | 1.27 | Effect of tolrestat on red blood cell sorbitol levels in patients with diabetes. ( Challis, P; Dvornik, D; Gonzalez, R; Hicks, D; Mullane, JF; Raskin, P; Rosenstock, J; Ryder, S; Smith, T, 1985) |
| " Sorbitol at a dosage of 20 g did not act as a laxative, produced the smallest BG increase, and required the least amount of insulin to return to baseline." | 1.26 | [A comparison of the blood glucose increase and insulin requirement after oral sucrose, fructose and sorbitol alone or in combination (author's transl)]. ( Irsigler, K; Kaspar, L, 1980) |
| " With respect to sorbitol and xylitol, lactic acidosis was not considered a serious side effect until now." | 1.26 | Possible side effects of glucose, fructose, sorbitol and xylitol in man. ( Förster, H, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 138 (73.40) | 18.7374 |
| 1990's | 27 (14.36) | 18.2507 |
| 2000's | 9 (4.79) | 29.6817 |
| 2010's | 6 (3.19) | 24.3611 |
| 2020's | 8 (4.26) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, CU | 1 |
| Suryavanshi, U | 1 |
| Sontake, V | 1 |
| Reddy, PY | 1 |
| Sankhala, RS | 1 |
| Swamy, MJ | 1 |
| Reddy, GB | 1 |
| Osaka, N | 1 |
| Mori, Y | 1 |
| Terasaki, M | 1 |
| Hiromura, M | 1 |
| Saito, T | 1 |
| Yashima, H | 1 |
| Shiraga, Y | 1 |
| Kawakami, R | 1 |
| Ohara, M | 1 |
| Fukui, T | 1 |
| Yamagishi, SI | 1 |
| Kulkarni, SA | 1 |
| Deshpande, SK | 1 |
| Rastogi, A | 1 |
| Bessho, R | 1 |
| Takiyama, Y | 1 |
| Takiyama, T | 1 |
| Kitsunai, H | 1 |
| Takeda, Y | 1 |
| Sakagami, H | 1 |
| Ota, T | 1 |
| Khan, M | 1 |
| Rehman, H | 1 |
| Ayaz, S | 1 |
| Qamar, F | 1 |
| Owais, A | 1 |
| Sana, A | 1 |
| Naveed, S | 1 |
| Morava, E | 1 |
| Silva Enciso, J | 1 |
| Papachristoforou, E | 1 |
| Lambadiari, V | 1 |
| Maratou, E | 1 |
| Makrilakis, K | 1 |
| Srivastava, B | 1 |
| Sen, S | 1 |
| Sen, K | 1 |
| Niimi, N | 1 |
| Yako, H | 1 |
| Takaku, S | 1 |
| Chung, SK | 1 |
| Sango, K | 1 |
| Rusak, T | 1 |
| Misztal, T | 1 |
| Rusak, M | 1 |
| Branska-Januszewska, J | 1 |
| Tomasiak, M | 1 |
| Yuan, KL | 1 |
| Shi, XZ | 1 |
| Lu, X | 1 |
| Gao, P | 1 |
| Xu, GW | 1 |
| Matsumoto, T | 1 |
| Ono, Y | 1 |
| Kurono, M | 1 |
| Kuromiya, A | 1 |
| Nakamura, K | 1 |
| Bril, V | 1 |
| Wong, VH | 1 |
| Bui, BV | 1 |
| Vingrys, AJ | 1 |
| Yamamoto, K | 1 |
| Uchida, S | 2 |
| Kitano, K | 1 |
| Fukuhara, N | 1 |
| Okumura-Kitajima, L | 1 |
| Gunji, E | 1 |
| Kozakai, A | 1 |
| Tomoike, H | 1 |
| Kojima, N | 1 |
| Asami, J | 1 |
| Toyoda, H | 1 |
| Arai, M | 1 |
| Takahashi, T | 1 |
| Takahashi, K | 1 |
| Rivelli, JF | 1 |
| Amaiden, MR | 1 |
| Monesterolo, NE | 1 |
| Previtali, G | 1 |
| Santander, VS | 1 |
| Fernandez, A | 1 |
| Arce, CA | 1 |
| Casale, CH | 1 |
| Howard, BV | 1 |
| Wylie-Rosett, J | 1 |
| Hosojima, H | 3 |
| ALPTEKIN, N | 1 |
| ADCOCK, LH | 1 |
| GRAY, CH | 1 |
| FOSSOUL, C | 1 |
| LORTHIOIR, J | 1 |
| TAGNON, R | 1 |
| THOMAS, JJ | 1 |
| HOSHI, M | 1 |
| PIRIE, A | 2 |
| VANHEYNINGEN, R | 1 |
| KAHLENBERG, A | 1 |
| KALANT, N | 1 |
| OHKAWA, K | 1 |
| KUMAZAWA, K | 1 |
| BOGENDORFER, L | 1 |
| COHEN, EM | 1 |
| Comazzi, S | 1 |
| Bertazzolo, W | 1 |
| Bonfanti, U | 1 |
| Spagnolo, V | 1 |
| Sartorelli, P | 1 |
| Giannoukakis, N | 1 |
| Brownlee, M | 1 |
| Cerami, A | 1 |
| Tomlinson, DR | 2 |
| Mayer, JH | 1 |
| Maĭstruk, PN | 1 |
| Germaniuk, IaL | 1 |
| Varma, SD | 3 |
| Richards, RD | 2 |
| Gabbay, KH | 6 |
| Friend, J | 1 |
| Thoft, RA | 1 |
| Malaisse-Lagae, F | 1 |
| Couturier, E | 1 |
| Dufrane, SP | 1 |
| Sener, A | 1 |
| Spengler, M | 1 |
| Malaisse, WJ | 1 |
| Ward, JD | 1 |
| Popp-Snijders, C | 1 |
| Lomecky, MZ | 1 |
| de Jong, AP | 1 |
| Sherman, WR | 1 |
| Dyck, PJ | 2 |
| Guillemin, G | 1 |
| Boutroux, V | 1 |
| Paolaggi, F | 1 |
| Batellier, L | 1 |
| Segrestaa, JM | 1 |
| Rousselet, F | 1 |
| Ghigo, D | 1 |
| Bosia, A | 1 |
| Pagani, A | 1 |
| Pescarmona, GP | 1 |
| Pagano, G | 1 |
| Lenti, G | 1 |
| Todorova, S | 1 |
| Veleva, N | 1 |
| Arnaudov, I | 1 |
| Taneva, T | 1 |
| Andreev, D | 1 |
| Tarui, S | 1 |
| Kinoshita, JH | 4 |
| Kador, P | 1 |
| Catiles, M | 1 |
| Luft, D | 1 |
| Wang, YM | 1 |
| van Eys, J | 1 |
| Mayhew, JA | 1 |
| Gillon, KR | 2 |
| Hawthorne, JN | 2 |
| Winegrad, AI | 2 |
| Simmons, DA | 1 |
| Martin, DB | 1 |
| Servo, C | 4 |
| Kaspar, L | 1 |
| Irsigler, K | 1 |
| Müller, PH | 1 |
| Egberts, EH | 1 |
| Beerenfeld, A | 1 |
| Schmülling, R | 1 |
| Prestele, H | 1 |
| Horbach, L | 1 |
| Malchow, H | 1 |
| O'Malley, BC | 1 |
| Bidot-Lopez, P | 1 |
| Lee, EL | 1 |
| Robertson, S | 1 |
| Eva, PR | 1 |
| Pascoe, PT | 1 |
| Vaughan, DG | 1 |
| Woods, HF | 1 |
| Bax, ND | 1 |
| Akanuma, H | 1 |
| Ogawa, K | 1 |
| Lee, Y | 1 |
| Akanuma, Y | 1 |
| Malone, JI | 2 |
| Knox, G | 1 |
| Benford, S | 1 |
| Tedesco, TA | 1 |
| Wang, H | 1 |
| Zhang, ZB | 1 |
| Wen, RR | 1 |
| Chen, JW | 1 |
| Cox, TM | 1 |
| Lever, M | 1 |
| Sizeland, PC | 1 |
| Bason, LM | 1 |
| Hayman, CM | 1 |
| Robson, RA | 1 |
| Chambers, ST | 1 |
| Frank, RN | 1 |
| Yagihashi, S | 1 |
| Wada, R | 1 |
| Kamijo, M | 1 |
| Nagai, K | 1 |
| Maeda, E | 1 |
| Yoshino, G | 1 |
| Kasuga, M | 1 |
| Belpoliti, M | 1 |
| Maraini, G | 1 |
| Hayashi, T | 2 |
| Crabbe, MJ | 2 |
| Goode, D | 1 |
| Wolff, SP | 2 |
| Hotta, N | 3 |
| Shinohara, R | 1 |
| Ohta, Y | 1 |
| Yamauchi, M | 1 |
| Ishiguro, I | 1 |
| Sabasiński, K | 1 |
| Andrzejewska-Buczko, J | 1 |
| Kinne, RK | 1 |
| Oskarsson, HJ | 1 |
| Hofmeyer, TG | 1 |
| Coppey, L | 1 |
| Yorek, MA | 1 |
| McNutt, K | 1 |
| Sode, K | 1 |
| Sugiura, H | 1 |
| Tsugawa, W | 1 |
| Watazu, Y | 1 |
| Hamafuji, T | 1 |
| Sobajima, H | 1 |
| Aoki, T | 1 |
| Sassa, H | 1 |
| Suzuki, T | 2 |
| Taniko, K | 1 |
| Makino, M | 1 |
| Mizuno, K | 1 |
| Grimaud, D | 1 |
| Jobard, J | 1 |
| Maestracci, P | 1 |
| Schocket, SS | 1 |
| Hutton, JC | 4 |
| Schofield, PJ | 3 |
| Williams, JF | 4 |
| Hollows, FC | 4 |
| Heath, H | 1 |
| Hamlett, YC | 1 |
| Schofield, PH | 1 |
| Regtop, HL | 1 |
| Förster, H | 3 |
| Tevaarwerk, GJ | 1 |
| Hudson, AJ | 1 |
| Brunzell, JD | 1 |
| Daumerie-Goffinet, C | 1 |
| Lambert, AE | 1 |
| Kolata, GB | 1 |
| Mehnert, H | 4 |
| Héraud, G | 2 |
| Roux, E | 2 |
| Froesch, ER | 4 |
| Nyitray, L | 1 |
| Palo, J | 1 |
| Pitkänen, E | 4 |
| Lenner, RA | 1 |
| Renold, AE | 1 |
| Dubach, UC | 1 |
| Dietze, G | 1 |
| Haslbeck, M | 3 |
| Stach, JL | 1 |
| Heaf, DJ | 1 |
| Galton, DJ | 1 |
| Madhu, SV | 1 |
| Verma, NP | 1 |
| Goel, A | 1 |
| Kapoor, VK | 1 |
| Vaca, G | 1 |
| Ramírez, MG | 1 |
| Vargas, M | 1 |
| Mendoza, R | 1 |
| Chávez-Anaya, E | 1 |
| Medina, MD | 1 |
| Alvarez, A | 1 |
| Medina, C | 1 |
| Sáenz, G | 1 |
| Chávez, M | 1 |
| Sinclair, AJ | 1 |
| Lunec, J | 1 |
| Girling, AJ | 1 |
| Barnett, AH | 1 |
| Hunt, JV | 1 |
| Lowitt, S | 1 |
| Kakuta, H | 1 |
| Koh, N | 1 |
| Fukasawa, H | 1 |
| Yasuma, T | 1 |
| Awaya, S | 1 |
| Sakamoto, N | 3 |
| Hamada, Y | 1 |
| Kitoh, R | 1 |
| Raskin, P | 2 |
| Yoneta, T | 1 |
| Tagashira, E | 1 |
| Kuzuya, T | 1 |
| Oberrieder, HK | 1 |
| Fryer, EB | 1 |
| Gülzow, HJ | 1 |
| Kary, H | 1 |
| Schiffner, U | 1 |
| Vicario, PP | 1 |
| Slater, EE | 1 |
| Saperstein, R | 1 |
| Airey, CM | 1 |
| Price, DE | 1 |
| Kemp, JV | 1 |
| Perkins, CM | 2 |
| Wales, JK | 1 |
| Suarez, G | 1 |
| Vinson, JA | 1 |
| Staretz, ME | 1 |
| Bose, P | 1 |
| Kassm, HM | 1 |
| Basalyga, BS | 1 |
| Nagasaka, Y | 2 |
| Fujii, S | 2 |
| Kaneko, T | 2 |
| Greene, DA | 2 |
| Sima, AA | 1 |
| Lattimer, SA | 2 |
| Kador, PF | 4 |
| Mann, J | 1 |
| Sarges, R | 1 |
| Peterson, MJ | 2 |
| Pitts, NE | 1 |
| Vreeland, F | 1 |
| Shaw, GL | 1 |
| Mehta, DJ | 1 |
| Collier, J | 1 |
| Gundersen, K | 1 |
| Bagnasco, SM | 1 |
| Balaban, RS | 1 |
| Burg, MB | 2 |
| Zimmerman, BR | 1 |
| Vilen, TH | 1 |
| Minnerath, SR | 1 |
| Karnes, JL | 1 |
| Yao, JK | 1 |
| Poduslo, JF | 1 |
| Whiteley, SJ | 1 |
| Taylor, R | 1 |
| Agius, L | 1 |
| Vertommen, J | 1 |
| Rillaerts, E | 1 |
| Gysels, M | 1 |
| De Leeuw, I | 1 |
| Funasako, M | 1 |
| Samukawa, A | 1 |
| Nishio, K | 1 |
| Tanichi, M | 1 |
| Sunda, N | 1 |
| Nakai, Y | 1 |
| Kobayashi, S | 1 |
| Kakutani, A | 1 |
| Nishikawa, O | 1 |
| Sunda, H | 1 |
| Hale, PJ | 1 |
| Nattrass, M | 1 |
| Silverman, SH | 1 |
| Sennit, C | 1 |
| Uden, A | 1 |
| Sundkvist, G | 1 |
| Kilo, C | 1 |
| Lalau, JD | 1 |
| Arlot, S | 1 |
| Quichaud, J | 1 |
| Petchey, M | 1 |
| Burgess, SE | 1 |
| Cheng, H | 1 |
| Sharpless, NE | 1 |
| Srivastava, SK | 1 |
| Hair, GA | 1 |
| Das, B | 1 |
| Rosenstock, J | 1 |
| Challis, P | 1 |
| Ryder, S | 1 |
| Mullane, JF | 1 |
| Gonzalez, R | 1 |
| Hicks, D | 1 |
| Smith, T | 1 |
| Dvornik, D | 1 |
| Drasnin, N | 1 |
| Stock, SL | 1 |
| Aloia, JF | 2 |
| Nilakantan, S | 1 |
| Holcomb, GN | 1 |
| Klemm, LA | 1 |
| Dulin, WE | 1 |
| Keller, U | 2 |
| Zapf, J | 1 |
| Oelz, O | 1 |
| Bässler, KH | 1 |
| Brinkrolf, H | 1 |
| Dvornik, E | 1 |
| Simard-Duquesne, N | 1 |
| Krami, M | 1 |
| Sestanj, K | 1 |
| Merola, LO | 1 |
| Wieland, OH | 2 |
| Steiner, G | 1 |
| O'Sullivan, JB | 2 |
| Panksepp, J | 1 |
| Tonge, D | 1 |
| Oatley, K | 1 |
| Macdonald, I | 1 |
| Birnesser, H | 1 |
| Reinauer, H | 1 |
| Hollmann, S | 1 |
| Keller, JT | 1 |
| Zviagintseva, TD | 1 |
| Draznin, NM | 1 |
| Butturini, U | 1 |
| Fiser, RH | 1 |
| Goto, Y | 1 |
| Suslov, VS | 1 |
| Karamishev, AM | 1 |
| Khadzhaĭ, IaI | 1 |
| Kharchenko, MS | 1 |
| Lang, K | 1 |
| Irving, MH | 1 |
| Rushman, GB | 1 |
| Geser, CA | 1 |
| De Neef, J | 1 |
| Morrison, AD | 1 |
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| Lesnichiĭ, AV | 1 |
| Friedburg, D | 1 |
| Mayer, U | 1 |
| Brennan, E | 1 |
| Griswell, B | 1 |
| Shattuck, L | 1 |
| Dehner, N | 1 |
| Klostermeier, M | 1 |
| Hartman, M | 1 |
| Bass, B | 1 |
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| Ruiz, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes[NCT05478707] | Phase 2 | 64 participants (Anticipated) | Interventional | 2023-10-05 | Recruiting | ||
| Influence of Food Liking of Adding Spices to Replace Dietary Sugar Using Sequential Monadic CLT Methodology[NCT03139552] | 150 participants (Actual) | Interventional | 2016-10-17 | Completed | |||
| Influence on Food Liking of Adding Spices to Replace Dietary Sugar[NCT03134079] | 160 participants (Actual) | Interventional | 2015-09-10 | Completed | |||
| Refinement of the Magnetic Resonance Imaging Technique for the Study of the Normal Eye, Particularly the Lens and Cataract[NCT00005911] | 20 participants | Observational | 2000-06-30 | Completed | |||
| Targeted Proteomic Analysis in the Plasma of Children With Diabetes Type 1 and Its Association With Peripheral Diabetic Neuropathy[NCT04257877] | 50 participants (Anticipated) | Observational | 2018-11-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Overall liking of apple crisp with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: Day of taste testing
| Intervention | score on likert rating scale (Mean) |
|---|---|
| Full Sugar Recipe | 7.31 |
| Reduced Sugar Recipe | 6.83 |
| Reduced Sugar Plus Spice Recipe | 7.22 |
Overall liking of oatmeal with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing
| Intervention | score on a likert rating scale (Mean) |
|---|---|
| Full Sugar Recipe | 6.84 |
| Reduced Sugar Recipe | 5.70 |
| Reduced Sugar Plus Spice Recipe | 6.15 |
Overall liking of tea with a 9-point hedonic rating scale instrument (whereby 0 = dislike extremely and 9 = like extremely ) (NCT03139552)
Timeframe: day of taste testing
| Intervention | score on a likert rating scale (Mean) |
|---|---|
| Full Sugar Recipe | 6.00 |
| Reduced Sugar Recipe | 5.62 |
| Reduced Sugar Plus Spice Recipe | 5.85 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 54 |
| Second Place Ranking | 63 |
| Third Place Ranking | 33 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 88 |
| Second Place Ranking | 39 |
| Third Place Ranking | 21 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 66 |
| Second Place Ranking | 41 |
| Third Place Ranking | 42 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 48 |
| Second Place Ranking | 60 |
| Third Place Ranking | 40 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 63 |
| Second Place Ranking | 44 |
| Third Place Ranking | 43 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 49 |
| Second Place Ranking | 50 |
| Third Place Ranking | 50 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 33 |
| Second Place Ranking | 43 |
| Third Place Ranking | 74 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: day of taste testing
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 12 |
| Second Place Ranking | 49 |
| Third Place Ranking | 87 |
Subjects ranked each recipe in order of likability as first, second or third. (NCT03139552)
Timeframe: Day of taste testings
| Intervention | Participants (Count of Participants) |
|---|---|
| First Place Ranking | 34 |
| Second Place Ranking | 58 |
| Third Place Ranking | 57 |
41 reviews available for sorbitol and Diabetes Mellitus
| Article | Year |
|---|---|
Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathi | 2020 |
Aldose Reductase and the Polyol Pathway in Schwann Cells: Old and New Problems.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Enzyme Inhibitors; Glucose; Humans; Metabolic Networ | 2021 |
Clinical and experimental links between diabetes and glaucoma.
Topics: Animals; Apoptosis; Cell Death; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Di | 2011 |
[Erythrocyte sorbitol, sorbitol dehydrogenase (SDH), and glyceraldehyde reductase (GAR) in diabetes mellitus].
Topics: Animals; Biomarkers; Diabetes Mellitus; Diabetic Angiopathies; Erythrocytes; Glucose; Humans; Hyperg | 2002 |
Ranirestat as a therapeutic aldose reductase inhibitor for diabetic complications.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; En | 2008 |
The biochemistry of the complications of diabetes mellitus.
Topics: Animals; Axonal Transport; Basement Membrane; Blood Platelets; Blood Proteins; Cataract; Diabetes Co | 1981 |
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy.
Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1984 |
[Sorbitol and its role in nutrition].
Topics: Animals; Blood Glucose; Cataract; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, Diabetic | 1983 |
[The biochemical basis of the complications of diabetes].
Topics: Aldehyde Reductase; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Fruc | 1984 |
[Metabolic alterations and diabetic complications (author's transl)].
Topics: Biological Transport, Active; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Hemoglobins; | 1980 |
Nutritional significance of fructose and sugar alcohols.
Topics: Adult; Dental Caries; Diabetes Mellitus; Dietary Carbohydrates; Dose-Response Relationship, Drug; Fr | 1981 |
The aldose reductase controversy.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimen | 1994 |
[Sorbitol].
Topics: Diabetes Mellitus; Humans; Sorbitol | 1995 |
[Metabolic disorder of polyol pathway].
Topics: Diabetes Mellitus; Diabetic Neuropathies; Fructose; Glucose; Humans; NAD; NADP; Sorbitol | 1997 |
[Erythrocyte sorbitol, sorbitol dehydrogenase (SDH) and glyceraldehyde reductase (GAR) in diabetes mellitus].
Topics: Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus; Enzyme-Linked Immunosorbent Ass | 1998 |
[The role of polyol pathways in formation of diabetic cataracts].
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Glucose; Humans; L | 1997 |
Mechanisms of osmolyte release.
Topics: Animals; Betaine; Calcium Signaling; Cell Membrane Permeability; Cell Polarity; Diabetes Mellitus; G | 1998 |
Use of fructose, sorbitol, or xylitol as a sweetener in diabetes mellitus.
Topics: Arteriosclerosis; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Dietary Carbohydrates; D | 1978 |
[Diabetic microangiopathies].
Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies | 1978 |
[Sugar substitutes in the diabetic diet].
Topics: Adult; Animals; Carbohydrates; Diabetes Mellitus; Diarrhea; Disaccharides; Energy Metabolism; Fatty | 1976 |
[Recent acquisitions on sweetening agents. Applications to the diabetic diet].
Topics: Amino Acids; Cyclamates; Diabetes Mellitus; Diet, Diabetic; Diterpenes; Flavonoids; Glycyrrhiza; Hum | 1976 |
Polyol pathway in the pathogenesis of diabetic complications and aldose reductase inhibitors.
Topics: Aldehyde Reductase; Diabetes Complications; Diabetes Mellitus; Humans; L-Iditol 2-Dehydrogenase; Sor | 1992 |
Modulators of free radical activity in diabetes mellitus: role of ascorbic acid.
Topics: Animals; Antioxidants; Ascorbic Acid; Diabetes Mellitus; Diabetes Mellitus, Experimental; Free Radic | 1992 |
Nonenzymatic browning of proteins and the sorbitol pathway.
Topics: Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus; Fructose; Maillard Reaction; Proteins; So | 1989 |
[Sorbitol, phosphoinositides and Na K-ATPase in the pathogenesis of diabetic complications].
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Human | 1988 |
Dietary advice for diabetics: a perspective from the United Kingdom.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diet, Sodium-Restricted; Dietary Carbohydra | 1986 |
Biochemical alterations and complications in diabetes.
Topics: Biological Transport; Diabetes Complications; Diabetes Mellitus; Energy Metabolism; Glucose; Humans; | 1986 |
Sorbitol, osmoregulation, and the complications of diabetes.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Kidney | 1988 |
The biochemistry of diabetes.
Topics: Animals; Diabetes Mellitus; Glucose; Hormones; Humans; Insulin; Lipid Metabolism; Sorbitol | 1988 |
Value of glucose control in preventing complications of diabetes.
Topics: Adult; Animals; Blood Glucose; Blood Pressure; Blood Vessels; Body Weight; Collagen; Diabetes Compli | 1985 |
[Pathogenesis of diabetic neuropathies].
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Energy Metabolism; Humans; | 1985 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; | 1985 |
The sorbitol pathway and the complications of diabetes.
Topics: Alcohol Oxidoreductases; Animals; Carbohydrate Metabolism; Cataract; Central Nervous System; Diabete | 1973 |
Diabetes mellitus: current concepts of the hormonal and metabolic defects.
Topics: Amino Acids; Carbohydrate Metabolism; Diabetes Mellitus; Drug Resistance; Fatty Acids; Glucagon; Glu | 1972 |
Beta cells and glucose in diabetes.
Topics: Adenylyl Cyclases; Animals; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Gluc | 1973 |
Dietary carbohydrates. Their indications and contraindications in clinical medicine.
Topics: Arteriosclerosis; Carbohydrate Metabolism, Inborn Errors; Contraceptives, Oral; Dental Caries; Diabe | 1974 |
[Metabolism of various carbohydrates in diabetes mellitus].
Topics: Adult; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; Glucose; Humans; Middle Aged; S | 1967 |
[Sorbit and its application in medicine (review of literature)].
Topics: Adult; Animals; Biliary Tract Diseases; Child; Diabetes Mellitus; Female; Humans; Hyperglycemia; Int | 1969 |
[Pharmacological action and the use of sorbit].
Topics: Acid-Base Equilibrium; Animals; Blood Glucose; Brain; Depression, Chemical; Diabetes Mellitus; Dogs; | 1969 |
[Xylitol, metabolism and clinical use].
Topics: Adrenal Glands; Alcohols; Animal Feed; Animals; Carbohydrate Metabolism; Diabetes Mellitus; Diet, Di | 1971 |
Parenteral nutrition for the surgical patient. A review of indications and current practice.
Topics: Amino Acids; Anemia; Burns; Carbohydrate Metabolism; Diabetes Mellitus; Ethanol; Fats; Fructose; Gas | 1971 |
5 trials available for sorbitol and Diabetes Mellitus
| Article | Year |
|---|---|
Experimental and clinical studies on the reduction of erythrocyte sorbitol-glucose ratios by ascorbic acid in diabetes mellitus.
Topics: Adolescent; Adult; Ascorbic Acid; Blood Glucose; Child; Diabetes Mellitus; Erythrocytes; Female; Hum | 1995 |
Abnormal glycine betaine content of the blood and urine of diabetic and renal patients.
Topics: Adult; Albuminuria; Betaine; Chromatography, High Pressure Liquid; Creatinine; Diabetes Mellitus; Fe | 1994 |
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1989 |
Clinical experience with sorbinil--an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Blood Glucose; Clinical Trials as To | 1986 |
The penetration of Sorbinil, an aldose reductase inhibitor, into lens, aqueous humour and erythrocytes of patients undergoing cataract extraction.
Topics: Aged; Aldehyde Reductase; Aqueous Humor; Cataract Extraction; Chromatography, High Pressure Liquid; | 1985 |
142 other studies available for sorbitol and Diabetes Mellitus
| Article | Year |
|---|---|
Effect of Sorbitol on Alpha-Crystallin Structure and Function.
Topics: alpha-Crystallins; Animals; Cataract; Diabetes Mellitus; Lens, Crystalline; Molecular Chaperones; Ra | 2022 |
Luseogliflozin inhibits high glucose-induced TGF-
Topics: Animals; Cardiomegaly; Diabetes Mellitus; Glucose; Humans; Male; Mice; Myocytes, Cardiac; RNA, Messe | 2022 |
Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Endothelial Cells; Fibroblas | 2022 |
Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy.
Topics: Animals; Cell Hypoxia; Diabetes Mellitus; Diabetic Nephropathies; Hypoglycemic Agents; Hypoxia-Induc | 2019 |
Formulation development of sugar free antacid chewable tablets for diabetes induced acidity in patients.
Topics: Antacids; Anti-Ulcer Agents; Chemistry, Pharmaceutical; Diabetes Complications; Diabetes Mellitus; D | 2019 |
Elevated sorbitol underlies a heritable neuropathy.
Topics: Diabetes Mellitus; Humans; Mutation; Sorbitol | 2020 |
Natriuresis, Diuresis, and Volume Changes in Diabetics With Heart Failure With Preserved Ejection Fraction: Impact of Sodium-Glucose Cotransporter 2 Inhibitors on Natriuretic Peptides.
Topics: Diabetes Mellitus; Diuresis; Glucose; Heart Failure; Humans; Natriuresis; Natriuretic Peptides; Sodi | 2020 |
Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy.
Topics: Caffeine; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Humans; Sorbitol; Spectr | 2022 |
Involvement of hyperglycemia in the development of platelet procoagulant response: the role of aldose reductase and platelet swelling.
Topics: Adolescent; Adult; Aldehyde Reductase; Blood Coagulation; Blood Platelets; Cell Size; Diabetes Melli | 2017 |
[Assessment of therapeutic effect of losartan on diabetes mellitus with gas chromatography-based metabonomics].
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Biomarkers; Chromatography, Gas; Creatinine; Deoxyguanosin | 2007 |
Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Diabetic Neuropathies; Enzyme Inhibitors; Male; Neur | 2008 |
TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity.
Topics: Animals; Blood Glucose; CHO Cells; Cricetinae; Cricetulus; Deoxyglucose; Diabetes Mellitus; Diabetes | 2011 |
High glucose levels induce inhibition of Na,K-ATPase via stimulation of aldose reductase, formation of microtubules and formation of an acetylated tubulin/Na,K-ATPase complex.
Topics: Acetylation; Adult; Aldehyde Reductase; Animals; Brain; Cell Line, Tumor; Chlorocebus aethiops; COS | 2012 |
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca | 2002 |
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca | 2002 |
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca | 2002 |
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association.
Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Diet; Dietary Sucrose; Fructose; Glyca | 2002 |
[Effects of sorbitol on blood sugar and glycosuria in diabetes].
Topics: Blood Glucose; Diabetes Mellitus; Glycosuria; Humans; Sorbitol | 1953 |
The metabolism of sorbitol in the human subject.
Topics: Carbohydrate Metabolism; Diabetes Mellitus; Humans; Inactivation, Metabolic; Sorbitol | 1957 |
[Effect of intravenous sorbitol on blood sugar of normal and diabetic subjects before and after administration of ACTH].
Topics: Adrenocorticotropic Hormone; Blood Glucose; Diabetes Mellitus; Humans; Pharmaceutical Preparations; | 1958 |
CLINICAL APPLICATION OF SORBITOL IN PATIENTS WITH DIABETES MELLITUS AND IN PATIENTS WITH LIVER DISEASE.
Topics: Biomedical Research; Blood Chemical Analysis; Blood Glucose; Carbohydrate Metabolism; Diabetes Melli | 1963 |
THE EFFECT OF DIABETES ON THE CONTENT OF SORBITOL, GLUCOSE, FRUCTOSE AND INOSITOL IN THE HUMAN LENS.
Topics: Aging; Cataract; Diabetes Mellitus; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalli | 1964 |
THE EFFECT OF INSULIN ON HUMAN ADIPOSE TISSUE.
Topics: Adipose Tissue; Carbohydrate Metabolism; Diabetes Mellitus; Glucose; Insulin; Lipid Metabolism; Olig | 1964 |
HISTOCHEMICAL STUDY ON THE ACTIVITY OF SORBITOL DEHYDROGENASE IN RATS WITH EXPERIMENTAL DIABETES MELLITUS.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Histocytochemistry; L-Iditol 2-Dehydrog | 1964 |
EPIDEMIOLOGICAL AND BIOCHEMICAL STUDIES OF CATARACT AND DIABETES.
Topics: Carbohydrate Metabolism; Cataract; Cataract Extraction; Diabetes Mellitus; England; Epidemiology; Fr | 1965 |
[Use of sionon chocolate in diabetes].
Topics: Animals; Cacao; Diabetes Mellitus; Humans; Lepidoptera; Sorbitol | 1950 |
On the influence of sorbitol on the carbohydrate metabolism in alloxan diabetic rats.
Topics: Alloxan; Animals; Carbohydrate Metabolism; Carbohydrates; Diabetes Mellitus; Diabetes Mellitus, Expe | 1950 |
Advanced glycation end products and sorbitol in blood from differently compensated diabetic dogs.
Topics: Animals; Diabetes Mellitus; Dog Diseases; Dogs; Female; Glycation End Products, Advanced; Hyperglyce | 2008 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di | 1984 |
The diabetic cornea.
Topics: Adult; Aged; Animals; Basement Membrane; Blood Glucose; Cornea; Corneal Diseases; Diabetes Complicat | 1984 |
Effect of a sorbitol-rich diet on plasma and erythrocyte sorbitol concentrations in normal and diabetic subjects.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Dietary Carbohydrates; Erythrocytes; Female; Humans; Male; | 1984 |
[The problem of the complications of diabetes].
Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellit | 1984 |
Determination of sorbitol in erythrocytes of diabetic and healthy subjects by capillary gas chromatography.
Topics: Chromatography, Gas; Diabetes Mellitus; Erythrocytes; Gas Chromatography-Mass Spectrometry; Humans; | 1983 |
Free inositol, sorbitol and fructose levels in sciatic nerve.
Topics: Diabetes Mellitus; Fructose; Humans; Inositol; Reference Values; Sciatic Nerve; Sorbitol | 1983 |
[Determination of erythrocyte sorbitol].
Topics: Adult; Diabetes Mellitus; Erythrocytes; Female; Humans; Male; Sorbitol | 1983 |
[Changes in erythrocyte deformability following changes in oxido-reductive metabolism in diabetes mellitus].
Topics: Adult; Aged; Diabetes Mellitus; Erythrocytes; Glutathione; Humans; Middle Aged; NADP; Osmotic Fragil | 1983 |
[Effect of dietetic fruit products prepared with sorbitol and pectin on the blood sugar and insulin levels in diabetic patients].
Topics: Blood Glucose; Diabetes Mellitus; Diet, Diabetic; Fruit; Humans; Insulin; Pectins; Sorbitol; Sweeten | 1982 |
Aldose reductase in diabetic cataracts.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus; Humans; Imidazoles; Imidazolidines; L-Idit | 1981 |
[Carbohydrate infusion in internal diseases. A comparative study in metabolically healthy patients, patients with liver diseases and diabetic patients. I. Physiopathologic aspects in the parenteral administration of monosaccharides].
Topics: Blood Glucose; Diabetes Mellitus; Fructose; Humans; Liver Cirrhosis; Monosaccharides; Parenteral Nut | 1981 |
Free and lipid inositol, sorbitol and sugars in sciatic nerve obtained post-mortem from diabetic patients and control subjects.
Topics: Aged; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; Glucose; Humans; Inositol; Lipid | 1983 |
Sorbitol, inositol and nerve conduction in diabetes.
Topics: Animals; Diabetes Mellitus; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Mice; Mic | 1983 |
Has one diabetic complication been explained?
Topics: Animals; Axons; Diabetes Mellitus; Diabetic Neuropathies; Fructose; Humans; Imidazoles; Imidazolidin | 1983 |
Sorbitol and myoinositol levels in the cerebrospinal fluid of diabetic patients.
Topics: Diabetes Mellitus; Humans; Inositol; Reference Values; Sorbitol | 1980 |
[A comparison of the blood glucose increase and insulin requirement after oral sucrose, fructose and sorbitol alone or in combination (author's transl)].
Topics: Aged; Blood Glucose; Diabetes Mellitus; Female; Fructose; Humans; Insulin; Male; Middle Aged; Sorbit | 1980 |
[Carbohydrate infusions in internal diseases. A comparative study in metabolically normal subjects, patients with liver diseases and diabetics. V. Infusion of a glucose-sorbitol mixture (ratio 1:1) for 48 hours].
Topics: Diabetes Mellitus; Glucose; Humans; Infusions, Parenteral; Liver Cirrhosis; Sorbitol; Triglycerides | 1982 |
Sorbitol accumulation in human normal and diabetic platelets.
Topics: Adult; Blood Platelets; Diabetes Mellitus; Humans; Male; Middle Aged; Platelet Function Tests; Sorbi | 1982 |
Refractive change in hyperglycaemia: hyperopia, not myopia.
Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Female; Glucose; Humans; Hyperglycemia; Hype | 1982 |
Sweetness in the diabetic diet.
Topics: Diabetes Mellitus; Diet, Diabetic; Dietary Carbohydrates; Fructose; Humans; Saccharin; Sorbitol; Swe | 1982 |
Reduced levels of plasma 1,5-anhydroglucitol in diabetic patients.
Topics: Blood Glucose; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes Mellitus; Glycerol; Huma | 1981 |
Red cell sorbitol: an indicator of diabetic control.
Topics: Blood Glucose; Chromatography, Gas; Diabetes Mellitus; Erythrocytes; Humans; Reference Values; Sorbi | 1980 |
Therapeutic use of fructose: professional freedom, 'pharmacovigilance' and Europe.
Topics: Culture; Diabetes Mellitus; Europe; Fructose; Fructose Intolerance; Germany; Humans; Infusions, Intr | 1995 |
Peripheral neuropathy in the WBN/Kob rat with chronic pancreatitis and spontaneous diabetes.
Topics: Action Potentials; Animals; Axons; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; | 1993 |
[Diabetes mellitus as a risk factor for arteriosclerosis].
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Glycosylation; H | 1993 |
Sugar alcohols in the lens epithelium of age-related cataract.
Topics: Aged; Blood Glucose; Cataract; Diabetes Mellitus; Epithelium; Female; Humans; Inositol; Lens, Crysta | 1993 |
Aldose reductase: black sheep or skeleton in the cupboard?
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, | 1996 |
Improved fluorometric enzymatic sorbitol assay in human blood.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Erythrocytes; Female; Fluorometry; Glycated Hemoglobin; Hum | 1998 |
Effect of protein kinase C and phospholipase A2 inhibitors on the impaired ability of human diabetic platelets to cause vasodilation.
Topics: Adolescent; Adult; Aged; Animals; Blood Platelets; Diabetes Mellitus; Diglycerides; Female; Glucose; | 1999 |
What clients need to know about sugar replacers.
Topics: Diabetes Mellitus; Disaccharides; Erythritol; Humans; Maltose; Mannitol; Patient Education as Topic; | 2000 |
Enzyme electrochemical preparation of a 3-keto derivative of 1,5-anhydro-D-glucitol using glucose-3-dehydrogenase.
Topics: Biomarkers; Deoxyglucose; Diabetes Mellitus; Electrochemistry; Glucose 1-Dehydrogenase; Glucose Dehy | 2000 |
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Me | 2001 |
[Metabolism of glucides and polyols and disorders of their utilization].
Topics: Blood Glucose; Diabetes Mellitus; Fructose; Galactose; Glucose; Glycerol; Hexoses; Humans; Insulin; | 1977 |
Implications of aldose reductase in cataracts in human diabetes.
Topics: Aldehyde Reductase; Blood Glucose; Cataract; Diabetes Mellitus; Fructose; Glucose; Humans; Inositol; | 1979 |
The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus.
Topics: Animals; Chromatography, Gas; Diabetes Mellitus; Diabetic Nephropathies; Fructose; Glucose; Inositol | 1975 |
The sorbitol pathway: effect of streptozotocin induced diabetes and the feeding of a sucrose-rich diet on glucose, sorbitol and fructose in the retina, blood and liver of rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Dietary Carbohydrates; Glucose; Liver; Male; Rats; Retina | 1976 |
The effect of an unsaturated-fat diet on cataract formation in streptozotocin-induced diabetic rats.
Topics: Animals; Aqueous Humor; Carbohydrate Metabolism; Cataract; Diabetes Mellitus; Dietary Fats; Eye; Fat | 1976 |
Possible side effects of glucose, fructose, sorbitol and xylitol in man.
Topics: Acidosis; Adult; Animals; Bilirubin; Blood Glucose; Diabetes Mellitus; Fructose; Glucose; Humans; In | 1976 |
Carbohydrate metabolism and insulin resistance in myotonia dystrophica.
Topics: Adult; Aged; Arginine; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; | 1977 |
Blood sugar and the complications of diabetes.
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Glucose; Glycoproteins; Hemoglobi | 1979 |
Saccharin substitutes for diabetics.
Topics: Diabetes Mellitus; Fructose; Humans; Sorbitol; Sweetening Agents; Xylitol | 1979 |
[Turnover and utilization of glucose and glucose substitutes in human and animals].
Topics: Adipose Tissue; Animals; Blood Glucose; Brain; Diabetes Mellitus; Diaphragm; Fructose; Glucagon; Glu | 1975 |
[Analysis of antitussive syrup for the use of diabetics].
Topics: Antitussive Agents; Chlorides; Codeine; Cough; Diabetes Mellitus; Drug Stability; Humans; Sorbitol | 1977 |
Polyols in the cerebrospinal fluid and plasma of neurological, diabetic and uraemic patients.
Topics: Diabetes Mellitus; Humans; Inositol; Ischemic Attack, Transient; Kidney Failure, Chronic; Mannitol; | 1977 |
Specially designed sweeteners and food for diabetics--a real need?
Topics: Aged; Blood Glucose; Diabetes Mellitus; Diet, Diabetic; Dietary Carbohydrates; Evaluation Studies as | 1976 |
Quantitatively minor areas of metabolism of both sugar alcohols and sugars.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus; Glucosamine; Glucose; Inositol; Sorbitol; Sugar | 1976 |
Metabolism of glucose substitutes compared to that of glucose.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Fructose; Glucose; Lactates; | 1976 |
[Comparative study of i.v. administration of xylitol and sorbitol to diabetics].
Topics: Adult; Aged; Bilirubin; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Humans | 1976 |
[Sugar and sugar substitutes in the dietetics of carbohydrate metabolism disorders].
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Fructose; Glucose; Humans; Insul | 1975 |
[Letter: Practical importance of sorbitol in diabetology].
Topics: Blood Glucose; Diabetes Mellitus; Humans; Nutritional Physiological Phenomena; Sorbitol | 1975 |
Sorbitol and other polyols in lens, adipose tissue and urine in diabetes mellitus.
Topics: Adipose Tissue; Cataract; Chromatography, Gas; Diabetes Mellitus; Fructose; Glucose; Humans; Inosito | 1975 |
Variation in polyol levels in cerebrospinal fluid and serum in diabetic patients.
Topics: Aged; Blood Glucose; Creatinine; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Ethers, Cy | 1975 |
Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aldehyde Reductase; Animals; Black People | 1992 |
Oxidative glycation and free radical production: a causal mechanism of diabetic complications.
Topics: Aging; Aldehydes; Animals; Benzoates; Benzoic Acid; Cattle; Chelating Agents; Chromatography, Affini | 1991 |
Measurements of tissue sorbitol in diabetes mellitus: enzyme method versus gas-liquid chromatography.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Chromatography, Gas; Diabetes Mellitus; Diabetes | 1992 |
In vitro retinal and erythrocyte polyol pathway regulation by hormones and an aldose reductase inhibitor.
Topics: Aged; Aldehyde Reductase; Animals; Diabetes Mellitus; Epinephrine; Erythrocytes; Fructose; Glucose; | 1991 |
Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients.
Topics: Adult; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Erythrocytes; Female; Humans; Male; Mid | 1991 |
[Aldose reductase inhibitors].
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Flavonoids; Fructose; Glucose; Glutarates; Humans; I | 1991 |
[Etiology of chronic complications diabetes mellitus and the plan for their management].
Topics: Arteriosclerosis; Blood Glucose; Collagen; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glycosylati | 1991 |
College students' knowledge and consumption of sorbitol.
Topics: Adult; Colic; Diabetes Mellitus; Diarrhea; Energy Intake; Female; Flatulence; Humans; Male; Sorbitol | 1991 |
[Clinical significance of erythrocyte sorbitol, sorbitol dehydrogenase and glyceraldehyde reductase in diabetic complications].
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Humans; L-Iditol 2-Dehydrogenase; Sorbitol; | 1990 |
[The adaptive responses of human oral microorganisms to sorbitol].
Topics: Adaptation, Physiological; Adolescent; Adult; Bacteria; Diabetes Mellitus; Female; Humans; Male; Mou | 1990 |
The effect of ponalrestat on sorbitol levels in the lens of obese and diabetic mice.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Insu | 1989 |
[New diagnostic tests for diabetes mellitus. Sorbitol].
Topics: Blood Glucose; Diabetes Mellitus; Erythrocytes; Humans; Polymers; Sorbitol | 1989 |
[Clinical significance of erythrocyte sorbitol analysis].
Topics: Diabetes Mellitus; Erythrocytes; Humans; Reference Values; Sorbitol; Spectrometry, Fluorescence | 1989 |
[Causes and treatment of diabetic complications].
Topics: Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Glycosylatio | 1989 |
In vitro and in vivo reduction of erythrocyte sorbitol by ascorbic acid.
Topics: Adolescent; Adult; Ascorbic Acid; Diabetes Mellitus; Erythrocytes; Female; Food, Fortified; Humans; | 1989 |
Effects of high glucose and sorbitol pathway on lipid peroxidation of erythrocytes.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Erythrocytes; Glutathione; Humans; Lipid Peroxidation; Midd | 1989 |
The identification of aldose reductase in the pathogenesis of diabetic complications: the background.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Complications; Diabetes Mellitus; Dia | 1985 |
Sorbinil: a member of the novel class of spirohydantoin aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Complications; Diabetes Mellitu | 1986 |
Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.
Topics: Aldehyde Reductase; Animals; Cell Line; Diabetes Complications; Diabetes Mellitus; Extracellular Spa | 1987 |
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus; Diabetic Neuropathies; Erythrocytes; | 1988 |
Motor nerve conduction velocity and nerve polyols in mice with short-term genetic or streptozotocin-induced diabetes.
Topics: Acute Disease; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Fructose; Glucos | 1985 |
Human erythrocyte sorbitol metabolism and the role of sorbitol dehydrogenase.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Erythrocytes; Humans; Kinetics; L-Iditol 2-Dehydrogenase; M | 1988 |
Erythrocyte sorbitol content in diabetic patients: relation to metabolic control.
Topics: Adult; Aged; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus; Erythrocytes; Female; Humans | 1987 |
[Aging and erythrocyte sorbitol].
Topics: Aged; Aged, 80 and over; Aging; Diabetes Mellitus; Female; Humans; Male; Sex Factors; Sorbitol | 1987 |
Peripheral nerve concentrations of glucose, fructose, sorbitol and myoinositol in diabetic and non-diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; Glucos | 1987 |
Activated and unactivated forms of human erythrocyte aldose reductase.
Topics: Aldehyde Reductase; Diabetes Mellitus; Enzyme Activation; Erythrocytes; Glucose; Glyceraldehyde; Hum | 1985 |
Effect of tolrestat on red blood cell sorbitol levels in patients with diabetes.
Topics: Administration, Oral; Adult; Biological Availability; Blood Glucose; Chromatography, High Pressure L | 1985 |
Is more really better?
Topics: Aging; Animals; Diabetes Mellitus; Glucose; Humans; Rats; Sorbitol | 1973 |
Sorbitol accumulation.
Topics: Aging; Animals; Diabetes Mellitus; Diet; Humans; Rats; Sorbitol | 1973 |
[Review on the balance of energy substances with special reference to the metabolism of glucose, fructose, sorbitol and xylitol and their therapeutic utilization].
Topics: Adipose Tissue; Diabetes Mellitus; Fructose; Glucose; Humans; Insulin; Liver; Parenteral Nutrition; | 1972 |
The cerebrospinal fluid in uncontrolled diabetes mellitus.
Topics: Adolescent; Adult; Aged; Alcohol Oxidoreductases; Blood Glucose; Diabetes Mellitus; Diabetic Ketoaci | 1973 |
The polyol pathway for glucose metabolism in tissues from normal, diabetic, and ketotic Chinese hamsters.
Topics: Animals; Blood Glucose; Cricetinae; Diabetes Mellitus; Diabetic Ketoacidosis; Disease Models, Animal | 1974 |
[The significance of carbohydrates in parenteral feeding].
Topics: Adult; Animals; Carbohydrates; Diabetes Mellitus; Fructose; Glucose; Humans; Kidney; Liver; Liver Di | 1974 |
[Parenteral administration of sugar substitutes with special reference to diabetes mellitus].
Topics: Animals; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Fructose; Glucose; Humans; In | 1974 |
Metabolism and oxidation of U- 14 C-glucose, xylitol, fructose and sorbitol in the fasted and in the streptozotocin-diabetic rat.
Topics: Amino Sugars; Animals; Anti-Bacterial Agents; Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus; Fa | 1971 |
Comparative study of the metabolism of U- 14 C-fructose, U- 14 C-sorbitol and U- 14 C-xylitol in the normal and in the streptozotocin-diabetic rat.
Topics: Adipose Tissue; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus; Fructose; Glucose; Homeo | 1971 |
[The role of oxaloacetate in increased ketogenesis and in Antiketogenic action].
Topics: Animals; Biodegradation, Environmental; Blood Glucose; Carboxy-Lyases; Citrates; Diabetes Mellitus; | 1971 |
Role of sorbitol pathway in neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Disease Models, Animal; Fructose; | 1973 |
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.
Topics: Acetates; Administration, Oral; Alcohol Oxidoreductases; Animals; Cataract; Culture Techniques; Diab | 1973 |
Sorbitol metabolism in the retina: accumulation of pathway intermediates in streptozotocin induced diabetes in the rat.
Topics: Animals; Aqueous Humor; Blood Glucose; Chromatography, Gas; Diabetes Mellitus; Fatty Acids, Nonester | 1974 |
The failure of aldose reductase inhibitor 3,3'-tetramethylene glutaric acid to inhibit in vivo sorbitol accumulation in lens and retina in diabetes.
Topics: Administration, Oral; Alcohol Oxidoreductases; Animals; Aqueous Humor; Carbohydrates; Chromatography | 1974 |
[Pathobiochemistry of the late-onset diabetic syndrome].
Topics: Age Factors; Alcohol Oxidoreductases; Animals; Basement Membrane; Cataract; Diabetes Mellitus; Diabe | 1974 |
The sorbitol pathway. Enzyme localization and content in normal and diabetic nerve and cord.
Topics: Animals; Axons; Blood Glucose; Cauda Equina; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1968 |
[Pathobiochemistry of the late-onset diabetic syndrome].
Topics: Animals; Carbohydrates; Cataract; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complicatio | 1974 |
Insulin and glucostatic control of feeding.
Topics: Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus; Drinking Behavior; Feeding Behavior; Gl | 1972 |
Cerebrospinal fluid polyols in patients with diabetes mellitus.
Topics: Blood Glucose; Chromatography, Gas; Diabetes Mellitus; Sorbitol; Sugar Alcohols | 1973 |
Comparative study of enzyme activities degrading sorbitol, ribitol, xylitol and gluconate in guinea pig tissues.
Topics: Adipose Tissue; Animals; Brain; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, | 1973 |
Monosaccharides and polyols in diabetes mellitus and uremia.
Topics: Adult; Aged; Blood Glucose; Chromatography, Gas; Diabetes Mellitus; Female; Fructose; Humans; Inosit | 1973 |
Occurrence of I,5-anhydroglucitol in human cerebrospinal fluid.
Topics: Adult; Aged; Chromatography, Gas; Chromatography, Ion Exchange; Chromatography, Paper; Diabetes Mell | 1973 |
Letter: Hyperopia in diabetes.
Topics: Diabetes Complications; Diabetes Mellitus; Fructose; Humans; Hyperopia; Lens, Crystalline; Sorbitol; | 1973 |
[Effect of sorbitol on the liver function in diabetes mellitus].
Topics: Animals; Diabetes Mellitus; Female; Humans; Liver; Liver Function Tests; Male; Rats; Sorbitol | 1973 |
[Pathogenesis of angio- and neuropathies in patients with diabetes mellitus].
Topics: Blood Vessels; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic | 1973 |
[Diabetes mellitus, uricemia and gout].
Topics: Diabetes Complications; Diabetes Mellitus; Fructose; Glucose; Gout; Humans; Nucleoproteins; Nutritio | 1973 |
Lipid metabolism, the polyol pathway and vascular complications.
Topics: Diabetes Mellitus; Diabetic Angiopathies; Female; Glucose; Humans; Infant, Newborn; Infant, Newborn, | 1973 |
[Letter: Glucose exchange in diabetes].
Topics: Diabetes Mellitus; Diet, Diabetic; Dietary Carbohydrates; Fructose; Humans; Sorbitol; Xylitol | 1974 |
[Clinical use of xylitol].
Topics: Acidosis; Diabetes Mellitus; Fructose; Glucose; Glycosuria; Humans; Liver Cirrhosis; Parenteral Nutr | 1971 |
Quantitative determination of mixtures of monosaccharides, disaccharides and alditols as their trimethylsilyl ether derivatives by gas-liquid chromatography.
Topics: Blood Glucose; Chemical Phenomena; Chemistry; Chromatography, Gas; Diabetes Mellitus; Disaccharides; | 1969 |
Glucose utilization by the polyol pathway in human erythrocytes.
Topics: Alcohol Oxidoreductases; Diabetes Mellitus; Erythrocytes; Fructose; Glucose; Humans; Male; Sorbitol | 1970 |
[Effect of sorbit on the functional status of the liver in patients with diabetes mellitus].
Topics: Diabetes Mellitus; Humans; Liver; Sorbitol | 1970 |
[Biochemical studies on the etiology of cataract in diabetes].
Topics: Alcohol Oxidoreductases; Animals; Cataract; Cattle; Diabetes Complications; Diabetes Mellitus; Fruct | 1970 |
Sorbitol and mannitol for diabetic patients?
Topics: Diabetes Mellitus; Diet Therapy; Humans; Mannitol; Sorbitol; Sweetening Agents | 1971 |
[Studies on tolerance to sorbitol-chocolate].
Topics: Blood Glucose; Cacao; Diabetes Mellitus; Humans; Sorbitol | 1967 |
The sorbitol pathway in diabetes and galactosemia: enzyme and sobstrate localization and changes in kidney.
Topics: Alcohol Oxidoreductases; Animals; Diabetes Mellitus; Galactose; Galactosemias; Kidney; Nerve Tissue; | 1968 |
Sorbiline in diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Choline; Citrates; Diabetes Mellitus; Humans; Middle Aged; Sorbito | 1968 |
[Studies on the nutrition of sugar-alcohols. 4. Metabolism of sorbitol in the alloxan diabetic rats].
Topics: Animals; Chromatography; Diabetes Mellitus; In Vitro Techniques; Rats; Sorbitol | 1965 |