sorbitol has been researched along with Diabetes Mellitus, Type 1 in 49 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tolrestat disposition was characterized by first-order absorption and biexponential disposition: In normal subjects the terminal disposition half-life (t1/2) was 13 +/- 3 hours (mean +/- SD) and the apparent oral clearance (CL/F) was 48 +/- 9 ml/hr/kg, similar to the values in patients with type I diabetes mellitus (t1/2 = 14 +/- 4 hours; CL/F = 55 +/- 10 ml/hr/kg)." | 2.68 | Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes. ( Chiang, ST; Cohen, AF; Jusko, WJ; Kroon, R; Lemkes, HH; van Griensven, JM; Verhorst, CJ, 1995) |
| "Sorbinil treatment reduced the elevated sorbitol levels in the diabetic patients to normal or slightly below normal, but did not affect the erythrocyte myo-inositol concentration." | 2.65 | myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment. ( Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA, 1984) |
| " In diabetic rats with severe hyperglycemia, oral sorbinil (5 mg/kg) dramatically reduced (80-90%) sorbitol levels in tissues without affecting blood glucose; the RBC dose-response curve was similar to that in lens and sciatic nerve." | 2.65 | Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects. ( Aldinger, CE; Leavengood, H; Malone, JI; O'Brien, MM; Page, MG; Peterson, MJ, 1984) |
| "Cataracts were morphologically different and progressed more slowly in T2DC versus T1DC." | 1.40 | Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes. ( Chen, S; Ge, J; Guan, L; Leng, F; Liu, P; Su, S; Wang, C; Zhang, L, 2014) |
| " These data suggest that increasing NO bioavailability by L-arginine corrects the major biochemical abnormalities of diabetes." | 1.35 | L-Arginine prevents metabolic effects of high glucose in diabetic mice. ( Bhatnagar, A; Kaiserova, K; Ramana, KV; Srivastava, SK; West, MB, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (61.22) | 18.7374 |
| 1990's | 12 (24.49) | 18.2507 |
| 2000's | 4 (8.16) | 29.6817 |
| 2010's | 3 (6.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, S | 1 |
| Leng, F | 1 |
| Guan, L | 1 |
| Zhang, L | 1 |
| Ge, J | 1 |
| Wang, C | 1 |
| Chen, S | 1 |
| Liu, P | 1 |
| Aiello, FC | 1 |
| Trovato, FM | 1 |
| Szychlinska, MA | 1 |
| Imbesi, R | 1 |
| Castrogiovanni, P | 1 |
| Loreto, C | 1 |
| Musumeci, G | 1 |
| Wang, Y | 1 |
| Deng, GG | 1 |
| Davies, KP | 1 |
| West, MB | 1 |
| Ramana, KV | 1 |
| Kaiserova, K | 1 |
| Srivastava, SK | 1 |
| Bhatnagar, A | 1 |
| Colton, SA | 1 |
| Downs, SM | 1 |
| Morenkova, SA | 1 |
| Clarke, BF | 1 |
| Young, RJ | 1 |
| Martyn, CN | 1 |
| Ewing, DJ | 1 |
| Chylack, LT | 1 |
| Varma, SD | 1 |
| Richards, RD | 1 |
| Popp-Snijders, C | 2 |
| Lomecky-Janousek, MZ | 1 |
| Schouten, JA | 1 |
| van der Veen, EA | 2 |
| Malone, JI | 2 |
| Knox, G | 1 |
| Harvey, C | 1 |
| Ward, JD | 1 |
| Pozza, G | 1 |
| Carandente, O | 1 |
| Leavengood, H | 1 |
| Peterson, MJ | 1 |
| O'Brien, MM | 1 |
| Page, MG | 1 |
| Aldinger, CE | 1 |
| Hayashi, M | 1 |
| Ezaki, H | 1 |
| Kojitsu, N | 1 |
| Hayashi, F | 1 |
| Yamashita, F | 1 |
| Vaaler, S | 2 |
| Hanssen, KF | 2 |
| Aagenaes, O | 2 |
| Vadot, E | 1 |
| Guibal, JP | 1 |
| Dyck, PJ | 1 |
| Sherman, WR | 2 |
| Hallcher, LM | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Grina, LA | 1 |
| Palumbo, PJ | 1 |
| Swanson, CJ | 1 |
| Dayhaw-Barker, P | 1 |
| Whikehart, DR | 1 |
| Ishida, Y | 1 |
| Okamoto, R | 1 |
| Mino, M | 1 |
| Konishi, K | 1 |
| Cunningham, JJ | 1 |
| Mearkle, PL | 1 |
| Brown, RG | 1 |
| van Griensven, JM | 1 |
| Jusko, WJ | 1 |
| Lemkes, HH | 1 |
| Kroon, R | 1 |
| Verhorst, CJ | 1 |
| Chiang, ST | 1 |
| Cohen, AF | 1 |
| Ramasamy, R | 2 |
| Oates, PJ | 1 |
| Schaefer, S | 2 |
| Anaja, HP | 1 |
| Hayashi, R | 1 |
| Hayakawa, N | 1 |
| Makino, M | 1 |
| Nagata, M | 1 |
| Kakizawa, H | 1 |
| Uchimura, K | 1 |
| Hamada, M | 1 |
| Aono, T | 1 |
| Fujita, T | 1 |
| Shinohara, R | 1 |
| Nagasaka, A | 1 |
| Itoh, M | 1 |
| Trueblood, N | 1 |
| Fountain, WC | 1 |
| Requena, JR | 1 |
| Jenkins, AJ | 1 |
| Lyons, TJ | 1 |
| Smyth, B | 1 |
| Baynes, JW | 1 |
| Thorpe, SR | 1 |
| Sundkvist, G | 1 |
| Dahlin, LB | 1 |
| Nilsson, H | 1 |
| Eriksson, KF | 1 |
| Lindgärde, F | 1 |
| Rosén, I | 1 |
| Lattimer, SA | 1 |
| Sima, AA | 2 |
| Sullivan, K | 1 |
| Greene, DA | 1 |
| Schatz, H | 1 |
| Winkler, G | 1 |
| Pfeiffer, EF | 1 |
| Loy, A | 1 |
| Lurie, KG | 1 |
| Ghosh, A | 1 |
| Wilson, JM | 1 |
| MacGregor, LC | 1 |
| Matschinsky, FM | 1 |
| Barr, CC | 1 |
| Airey, CM | 1 |
| Price, DE | 1 |
| Kemp, JV | 1 |
| Perkins, CM | 1 |
| Wales, JK | 1 |
| Bareford, D | 1 |
| Jennings, PE | 1 |
| Stone, PC | 1 |
| Baar, S | 1 |
| Barnett, AH | 1 |
| Stuart, J | 1 |
| Williamson, JR | 1 |
| Chang, K | 1 |
| Tilton, RG | 1 |
| Prater, C | 1 |
| Jeffrey, JR | 1 |
| Weigel, C | 1 |
| Eades, DM | 1 |
| Kilo, C | 1 |
| Kowluru, A | 1 |
| Kowluru, R | 1 |
| Bitensky, MW | 1 |
| Corwin, EJ | 1 |
| Solomon, SS | 1 |
| Johnson, JD | 1 |
| Averbuch, M | 1 |
| Weintraub, M | 1 |
| Liao, JC | 1 |
| Brazzell, RK | 1 |
| Dobbs, RE | 1 |
| Bjørneklett, A | 1 |
| Jelling, I | 1 |
| Skrede, G | 1 |
| Fausa, O | 1 |
| Rillaerts, EG | 1 |
| Vertommen, JJ | 1 |
| De Leeuw, IH | 1 |
| Wambua, PP | 1 |
| Juma, FD | 1 |
| Gitau, W | 1 |
| Bertelsmann, FW | 1 |
| Heimans, JJ | 1 |
| van Rooy, JC | 1 |
| Chantelau, E | 1 |
| Nakayama, H | 1 |
| Taneda, S | 1 |
| Aoki, S | 1 |
| Komori, K | 1 |
| Kuroda, Y | 1 |
| Misawa, K | 1 |
| Tsushima, S | 1 |
| Nakagawa, S | 1 |
| Akgün, S | 1 |
| Ertel, NH | 1 |
| Kemp, FW | 1 |
| Lapolla, A | 1 |
| Poli, T | 1 |
| Valerio, A | 1 |
| Fedele, D | 1 |
| Sharkey, TP | 1 |
| Talke, H | 1 |
| Maier, KP | 1 |
| Dawidowicz, A | 1 |
7 reviews available for sorbitol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Molecular Links Between Diabetes and Osteoarthritis: The Role of Physical Activity.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diglycerides; Disease Progression; Exercise; G | 2017 |
[Recent advances in the assessment of diabetic control--the clinical parameters as the indices of control].
Topics: Adolescent; Age Factors; Blood Glucose; Blood Proteins; Diabetes Mellitus, Type 1; Diphosphoglyceric | 1982 |
Mechanisms of pathogenesis in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Histocompatibilit | 1995 |
Review: pathogenesis, progression, and therapeutic intervention of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Cataract; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Huma | 1992 |
Diabetic retinopathy.
Topics: Adult; Aldehyde Reductase; Aneurysm; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 1986 |
Diabetes mellitus--present problems and new research. VI. Nephropathy and neuropathy.
Topics: Adult; Alcohol Oxidoreductases; Animals; Cerebrospinal Fluid; Child; Diabetes Mellitus, Type 1; Diab | 1971 |
[Diabetic cataract and modern views on the etiology and pathogenesis of vascular complications during diabetes].
Topics: Age Factors; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus, Type 1; Diabe | 1971 |
8 trials available for sorbitol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Aldose reductase inhibition in diabetes.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mel | 1984 |
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment.
Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1984 |
Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects.
Topics: Administration, Oral; Adolescent; Adult; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Di | 1984 |
Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus.
Topics: Adult; Aldehyde Reductase; Ascorbic Acid; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocytes; Fe | 1994 |
Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Erythrocy | 1995 |
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1989 |
Red blood cell sorbitol lowering effects and tolerance of single doses of AL 1576 (HOE 843) in diabetic patients.
Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Double-B | 1988 |
Sorbitol as a sweetener in the diet of insulin-dependent diabetes.
Topics: Adolescent; Adult; Blood Glucose; Breath Tests; Clinical Trials as Topic; Diabetes Mellitus, Type 1; | 1987 |
34 other studies available for sorbitol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Analysis of Variance; Animals; Cataract; Diabetes Mellit | 2014 |
Novel insights into development of diabetic bladder disorder provided by metabolomic analysis of the rat nondiabetic and diabetic detrusor and urothelial layer.
Topics: Amino Acids, Branched-Chain; Animals; Bile Acids and Salts; Case-Control Studies; Citric Acid Cycle; | 2016 |
L-Arginine prevents metabolic effects of high glucose in diabetic mice.
Topics: Aldehyde Reductase; Animals; Aortitis; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2008 |
Potential role for the sorbitol pathway in the meiotic dysfunction exhibited by oocytes from diabetic mice.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Carbon Isotopes; Cells, Cultured; Crosses, Geneti | 2004 |
[Comparative analysis of dependence of saliva sorbitol and fructosamine levels on blood glucose level in patients with diabetes].
Topics: Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female | 2004 |
Mechanisms of senile cataract formation.
Topics: Aged; Aldehyde Reductase; Aqueous Humor; Blood Glucose; Cataract; Crystallins; Diabetes Mellitus, Ty | 1984 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di | 1984 |
Sorbitol accumulation is altered in type 1 (insulin-dependent) diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Child; Diabetes Mellitus, Type 1; Erythrocytes; Female; Glucose; G | 1984 |
[The problem of the complications of diabetes].
Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellit | 1984 |
[Erythrocyte changes in diabetes].
Topics: 2,3-Diphosphoglycerate; Blood Glucose; Diabetes Mellitus, Type 1; Diphosphoglyceric Acids; Erythrocy | 1983 |
Sucrose and sorbitol as sweeteners in the diet of insulin-dependent diabetics.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diet, Diabetic; Dietary Carbohydrates; | 1980 |
[Pathogenesis of the diabetic cataract].
Topics: Adult; Aged; Cataract; Diabetes Mellitus, Type 1; Fructose; Humans; Lens, Crystalline; Sorbitol | 1982 |
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Fructose; Humans; Inositol; Middle Aged; Periphera | 1980 |
The inhibition of sodium, potassium-stimulated ATPase and corneal swelling: the role played by polyols.
Topics: Animals; Cattle; Cells, Cultured; Corneal Edema; Diabetes Mellitus, Type 1; Endothelium, Corneal; Ga | 1995 |
Red blood cell sorbitol in diabetic children.
Topics: Adolescent; Blood Glucose; Child; Child, Preschool; Diabetes Mellitus, Type 1; Erythrocytes; Female; | 1994 |
Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Benzothiazoles; Blood Glucose; Diabetes Mellitu | 1997 |
Diagnostic performance of red cell sorbitol assay in a Nigerian teaching hospital.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Child; Confidence Intervals; Diabetes Mel | 1997 |
Changes in erythrocyte sorbitol concentrations measured using an improved assay system in patients with diabetic complications and treated with aldose reductase inhibitor.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Blood Glucose; Child; Diabetes Mellitus, Type 1; Diabet | 1998 |
Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cytosol; Diabetes Mellitus, Type 1; Enzyme Inhibitors; | 1998 |
Quantification of N-(glucitol)ethanolamine and N-(carboxymethyl)serine: two products of nonenzymatic modification of aminophospholipids formed in vivo.
Topics: Aging; Amines; Diabetes Mellitus, Type 1; Erythrocyte Membrane; Gas Chromatography-Mass Spectrometry | 1999 |
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Human | 2000 |
[Sweetening agents and sugar substituting agents in the diet of juvenile diabetic patients].
Topics: Adolescent; Child; Child, Institutionalized; Child, Preschool; Cyclamates; Diabetes Mellitus, Type 1 | 1977 |
Diabetes and the myo-inositol paradox.
Topics: Animals; Aqueous Humor; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 1990 |
Effects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus.
Topics: Adult; Aged; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability | 1986 |
Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes. Prevention by aldose reductase inhibitors and castration.
Topics: Aldehyde Reductase; Animals; Aorta; Blood Glucose; Body Weight; Capillary Permeability; Castration; | 1987 |
Suggested mechanism for the selective excretion of glucosylated albumin. The effects of diabetes mellitus and aging on this process and the origins of diabetic microalbuminuria.
Topics: Adolescent; Adult; Aging; Albuminuria; Animals; Cations; Child; Diabetes Mellitus, Experimental; Dia | 1987 |
Effect of statil (ICI 128436) on erythrocyte viscosity in vitro.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Erythrocytes; Female; Hu | 1988 |
Sorbitol levels in normal Africans and in insulin dependent diabetics.
Topics: Africa; Black People; Diabetes Mellitus, Type 1; Humans; Reference Values; Sorbitol | 1988 |
Peripheral nerve function in relation to quality of metabolic control in diabetes.
Topics: Adolescent; Adult; Aged; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythrocytes; Female; Hum | 1987 |
[Sugar substitutes in the diet therapy of type I diabetes mellitus].
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Diet, Diabetic; Fructose; Glucose; Humans; Sorbitol; Sweet | 1986 |
Antibodies to nonenzymatically glucosylated albumin in the human serum.
Topics: Adult; Antigens; Autoantibodies; Binding, Competitive; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1985 |
Red cell sorbitol and diabetic control.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocytes; Humans; Male; Middle Aged; Sorbitol; | 1985 |
Is red cell sorbitol content a good marker of glycemic control in diabetic patients?
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocytes; Female; Glycated Hemoglobin; Hu | 1985 |
[Glucose, fructose, sorbitol and xylitol metabolism in man].
Topics: Acidosis; Adenine Nucleotides; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Fructose; Glucose; | 1973 |