sorbitol has been researched along with Complications of Diabetes Mellitus in 86 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldose reductase (AR) appears to initiate the cataractous process in galactosemic and diabetic animals." | 4.76 | Aldose reductase in diabetic complications of the eye. ( Fukushi, S; Kador, P; Kinoshita, JH; Merola, LO, 1979) |
| "Aldose reductase catalyzes the NADPH-linked reduction of hexoses to their respective sugar-alcohols, which are involved in the pathogenesis of "sugar-cataracts"." | 3.68 | Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies. ( Alvarez, A; Chávez, M; Chávez-Anaya, E; Medina, C; Medina, MD; Mendoza, R; Ramírez, MG; Sáenz, G; Vaca, G; Vargas, M, 1992) |
| "The isolated cultured rat lens has been used to examine the effects of the aldose reductase inhibitor sorbinil on lenticular polyol accumulation and sugar cataract formation." | 3.67 | Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens. ( Beyer, TA; Hutson, NJ; Rafford, CE; Yeh, LA, 1986) |
| "An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose." | 3.65 | Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. ( Dvornik, E; Gabbay, KH; Kinoshita, JH; Krami, M; Merola, LO; Sestanj, K; Simard-Duquesne, N; Varma, SD, 1973) |
| "Sorbinil is an effective ARI, which could play therapeutic role in treating diabetes and diabetic complications." | 2.61 | Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. ( Huang, Q; Liu, Q; Ouyang, D, 2019) |
| "Glaucoma is a leading cause of blindness." | 2.47 | Clinical and experimental links between diabetes and glaucoma. ( Bui, BV; Vingrys, AJ; Wong, VH, 2011) |
| " The main objective of this study is to develop a patient complaint tablet dosage form which is sugar free, chewable and easy to use." | 1.51 | Formulation development of sugar free antacid chewable tablets for diabetes induced acidity in patients. ( Ayaz, S; Khan, M; Naveed, S; Owais, A; Qamar, F; Rehman, H; Sana, A, 2019) |
| "Recently a zwitterionic principle has been suggested as an alternative to bioisosteric replacement for increasing low bioavailability of aldose reductase inhibitors bearing an acidic function." | 1.40 | A novel zwitterionic inhibitor of aldose reductase interferes with polyol pathway in ex vivo and in vivo models of diabetic complications. ( Karasova, MJ; Prnova, MS; Stefek, M, 2014) |
| "Diabetes induced cataract is characterized by an accumulation of sorbitol which is mediated by the action of a key enzyme aldose reductase (AR)." | 1.35 | Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols. ( Chethan, S; Dharmesh, SM; Malleshi, NG, 2008) |
| "Diabetes mellitus is an important risk factor for coronary heart disease and cerebral vascular disease." | 1.29 | [Diabetes mellitus as a risk factor for arteriosclerosis]. ( Kasuga, M; Maeda, E; Yoshino, G, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (53.49) | 18.7374 |
| 1990's | 12 (13.95) | 18.2507 |
| 2000's | 9 (10.47) | 29.6817 |
| 2010's | 15 (17.44) | 24.3611 |
| 2020's | 4 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Kulkarni, SA | 1 |
| Deshpande, SK | 1 |
| Rastogi, A | 1 |
| Kashyap, K | 1 |
| Mahapatra, PP | 1 |
| Ahmed, S | 1 |
| Buyukbingol, E | 1 |
| Siddiqi, MI | 1 |
| Khan, M | 1 |
| Rehman, H | 1 |
| Ayaz, S | 1 |
| Qamar, F | 1 |
| Owais, A | 1 |
| Sana, A | 1 |
| Naveed, S | 1 |
| Papachristoforou, E | 1 |
| Lambadiari, V | 1 |
| Maratou, E | 1 |
| Makrilakis, K | 1 |
| Srivastava, B | 1 |
| Sen, S | 1 |
| Sen, K | 1 |
| Kajal, A | 1 |
| Singh, R | 1 |
| Samukawa, Y | 2 |
| Haneda, M | 1 |
| Seino, Y | 1 |
| Sasaki, T | 1 |
| Fukatsu, A | 1 |
| Kubo, Y | 1 |
| Sato, Y | 1 |
| Sakai, S | 1 |
| Huang, Q | 1 |
| Liu, Q | 1 |
| Ouyang, D | 1 |
| Kimura, T | 1 |
| Obata, A | 1 |
| Shimoda, M | 1 |
| Okauchi, S | 1 |
| Kanda-Kimura, Y | 1 |
| Nogami, Y | 1 |
| Moriuchi, S | 1 |
| Hirukawa, H | 1 |
| Kohara, K | 1 |
| Nakanishi, S | 1 |
| Mune, T | 1 |
| Kaku, K | 1 |
| Kaneto, H | 1 |
| Higashi, Y | 1 |
| Higashi, K | 1 |
| Mori, A | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 2 |
| Nakahara, T | 1 |
| Snow, A | 1 |
| Shieh, B | 1 |
| Chang, KC | 1 |
| Pal, A | 1 |
| Lenhart, P | 1 |
| Ammar, D | 1 |
| Ruzycki, P | 1 |
| Palla, S | 1 |
| Reddy, GB | 2 |
| Petrash, JM | 2 |
| Karasova, MJ | 1 |
| Prnova, MS | 1 |
| Stefek, M | 1 |
| Gessei, T | 1 |
| Arakawa, T | 1 |
| Kudo, H | 1 |
| Mitsubayashi, K | 1 |
| Luo, J | 1 |
| Huang, L | 1 |
| Chen, Z | 1 |
| Zeng, Z | 1 |
| Miyamoto, T | 1 |
| Wu, H | 1 |
| Zhang, Z | 1 |
| Pan, Z | 1 |
| Fujita, N | 1 |
| Hikata, T | 1 |
| Iwanami, A | 1 |
| Tsuji, T | 1 |
| Nakamura, M | 1 |
| Matsumoto, M | 1 |
| Watanabe, K | 1 |
| Cao, K | 1 |
| Kojima, N | 1 |
| Takahashi, T | 1 |
| Kato, A | 2 |
| Minoshima, Y | 1 |
| Yamamoto, J | 1 |
| Adachi, I | 2 |
| Watson, AA | 1 |
| Nash, RJ | 2 |
| Chethan, S | 1 |
| Dharmesh, SM | 1 |
| Malleshi, NG | 1 |
| Saraswat, M | 1 |
| Muthenna, P | 1 |
| Suryanarayana, P | 1 |
| Lee, YS | 2 |
| Kim, SH | 1 |
| Jung, SH | 1 |
| Kim, JK | 2 |
| Pan, CH | 1 |
| Lim, SS | 2 |
| Wong, VH | 1 |
| Bui, BV | 1 |
| Vingrys, AJ | 1 |
| Bae, YS | 1 |
| Won, MH | 1 |
| Kang, IJ | 1 |
| Liu, QS | 1 |
| Pang, ZR | 1 |
| Liu, R | 1 |
| He, GR | 1 |
| Cui, J | 1 |
| Yin, XY | 1 |
| Yamada, N | 1 |
| Kumeda, Y | 1 |
| Inaba, M | 1 |
| Nishizawa, Y | 1 |
| Yono, M | 1 |
| Latifpour, J | 1 |
| Yoshida, M | 1 |
| Ueda, S | 1 |
| Huang, P | 1 |
| Jiang, Z | 1 |
| Teng, S | 1 |
| Wong, YC | 1 |
| Frohman, MA | 1 |
| Chung, SK | 1 |
| Chung, SS | 1 |
| Yasuko, H | 1 |
| Goto, H | 1 |
| Hollinshead, J | 1 |
| Giannoukakis, N | 1 |
| Brownlee, M | 1 |
| Cerami, A | 1 |
| Kennedy, A | 1 |
| Frank, RN | 2 |
| Varma, SD | 4 |
| Richards, RD | 1 |
| Gabbay, KH | 4 |
| Friend, J | 1 |
| Thoft, RA | 2 |
| Ward, JD | 1 |
| Crabbe, MJ | 2 |
| Wolff, S | 1 |
| Halder, AB | 1 |
| Ting, HH | 1 |
| Eva, PR | 1 |
| Pascoe, PT | 1 |
| Vaughan, DG | 1 |
| Weber, DO | 1 |
| Yarnoz, MD | 1 |
| Anaja, HP | 1 |
| Yagihashi, S | 1 |
| Wada, R | 1 |
| Kamijo, M | 1 |
| Nagai, K | 1 |
| Maeda, E | 1 |
| Yoshino, G | 1 |
| Kasuga, M | 1 |
| Goode, D | 1 |
| Wolff, SP | 2 |
| Kotani, T | 1 |
| Nagaki, Y | 1 |
| Ishii, A | 1 |
| Konishi, Y | 1 |
| Yago, H | 1 |
| Suehiro, S | 1 |
| Okukado, N | 1 |
| Okamoto, K | 1 |
| Hotta, N | 1 |
| Sabasiński, K | 1 |
| Andrzejewska-Buczko, J | 1 |
| Steiner, G | 1 |
| Wilson, D | 1 |
| Vranic, M | 1 |
| Kinoshita, JH | 6 |
| Fukushi, S | 1 |
| Kador, P | 1 |
| Merola, LO | 2 |
| Chylack, LT | 1 |
| Henriques, HF | 1 |
| Cheng, HM | 2 |
| Tung, WH | 1 |
| Brunzell, JD | 1 |
| Berger, W | 1 |
| Kolata, GB | 1 |
| Foulks, GN | 1 |
| Perry, HD | 1 |
| Tolentino, FI | 1 |
| Balasse, EO | 1 |
| van Heyningen, R | 1 |
| Madhu, SV | 1 |
| Verma, NP | 1 |
| Goel, A | 1 |
| Kapoor, VK | 1 |
| Vaca, G | 1 |
| Ramírez, MG | 1 |
| Vargas, M | 1 |
| Mendoza, R | 1 |
| Chávez-Anaya, E | 1 |
| Medina, MD | 1 |
| Alvarez, A | 1 |
| Medina, C | 1 |
| Sáenz, G | 1 |
| Chávez, M | 1 |
| Hunt, JV | 1 |
| Badiga, MS | 1 |
| Jain, NK | 1 |
| Casanova, C | 1 |
| Pitchumoni, CS | 1 |
| Greene, DA | 3 |
| Sima, AA | 2 |
| Lattimer, SA | 3 |
| Kador, PF | 5 |
| González, RG | 1 |
| Sarges, R | 1 |
| Peterson, MJ | 1 |
| Akagi, Y | 1 |
| Yeh, LA | 1 |
| Rafford, CE | 1 |
| Beyer, TA | 1 |
| Hutson, NJ | 1 |
| Bagnasco, SM | 1 |
| Uchida, S | 1 |
| Balaban, RS | 1 |
| Burg, MB | 3 |
| Williams, WF | 1 |
| Odom, JD | 1 |
| Kilo, C | 1 |
| Sharpless, NE | 1 |
| Dvornik, E | 1 |
| Simard-Duquesne, N | 1 |
| Krami, M | 1 |
| Sestanj, K | 1 |
| Kleinknecht, D | 1 |
| Jungers, P | 1 |
| Michel, JR | 1 |
| Wieland, OH | 1 |
| Ismail, AM | 1 |
| Keller, JT | 1 |
| Draznin, NM | 1 |
| Butturini, U | 1 |
| Fisherman, EW | 1 |
| Cohen, GN | 1 |
| Dawidowicz, A | 1 |
| Friedburg, D | 1 |
| Mayer, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes[NCT05478707] | Phase 2 | 64 participants (Anticipated) | Interventional | 2023-10-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
26 reviews available for sorbitol and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathi | 2020 |
Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Enzyme Inhibit | 2019 |
Clinical and experimental links between diabetes and glaucoma.
Topics: Animals; Apoptosis; Cell Death; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Di | 2011 |
[Molecular mechanisms of diabetic atherosclerosis].
Topics: Arteriosclerosis; Diabetes Complications; Glycation End Products, Advanced; Humans; Hyperinsulinism; | 2002 |
[Diabetes mellitus and osteoporosis].
Topics: Animals; Bone and Bones; Chronic Disease; Diabetes Complications; Diagnosis, Differential; Humans; H | 2002 |
Ranirestat as a therapeutic aldose reductase inhibitor for diabetic complications.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; En | 2008 |
The biochemistry of the complications of diabetes mellitus.
Topics: Animals; Axonal Transport; Basement Membrane; Blood Platelets; Blood Proteins; Cataract; Diabetes Co | 1981 |
[The biochemical basis of the complications of diabetes].
Topics: Aldehyde Reductase; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Fruc | 1984 |
The aldose reductase controversy.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimen | 1994 |
New concepts and insights on pathogenesis and treatment of diabetic complications: polyol pathway and its inhibition.
Topics: Animals; Diabetes Complications; Diabetic Neuropathies; Humans; Sorbitol | 1997 |
[The role of polyol pathways in formation of diabetic cataracts].
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Glucose; Humans; L | 1997 |
Aldose reductase in diabetic complications of the eye.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Chromans; Cornea; Diabetes Complications; Diabetic Re | 1979 |
Hyperglycemia, polyol metabolism, and complications of diabetes mellitus.
Topics: Animals; Blood Glucose; Body Fluids; Cataract; Chemical Phenomena; Chemistry; Diabetes Complications | 1975 |
Use of fructose, sorbitol, or xylitol as a sweetener in diabetes mellitus.
Topics: Arteriosclerosis; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Dietary Carbohydrates; D | 1978 |
Sugar alcohols in the pathogenesis of galactose and diabetic cataracts.
Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism, Inborn Errors; Cataract; Chemical Phenomena; C | 1976 |
Polyol pathway in the pathogenesis of diabetic complications and aldose reductase inhibitors.
Topics: Aldehyde Reductase; Diabetes Complications; Diabetes Mellitus; Humans; L-Iditol 2-Dehydrogenase; Sor | 1992 |
[Sorbitol, phosphoinositides and Na K-ATPase in the pathogenesis of diabetic complications].
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Human | 1988 |
Biochemical alterations and complications in diabetes.
Topics: Biological Transport; Diabetes Complications; Diabetes Mellitus; Energy Metabolism; Glucose; Humans; | 1986 |
Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications.
Topics: Animals; Diabetes Complications; Humans; Inositol; Phosphatidylinositols; Protein Kinase C; Rats; So | 1987 |
Role of aldose reductase and sorbitol in maintaining the medullary intracellular milieu.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Galactosemias; Humans; Kidney Medulla | 1988 |
Sorbitol, osmoregulation, and the complications of diabetes.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Kidney | 1988 |
Value of glucose control in preventing complications of diabetes.
Topics: Adult; Animals; Blood Glucose; Blood Pressure; Blood Vessels; Body Weight; Collagen; Diabetes Compli | 1985 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; | 1985 |
The sorbitol pathway and the complications of diabetes.
Topics: Alcohol Oxidoreductases; Animals; Carbohydrate Metabolism; Cataract; Central Nervous System; Diabete | 1973 |
Mechanisms initiating cataract formation. Proctor Lecture.
Topics: Acetates; Adenosine Triphosphatases; Aged; Alcohol Oxidoreductases; Animals; Biological Transport; C | 1974 |
[Diabetic cataract and modern views on the etiology and pathogenesis of vascular complications during diabetes].
Topics: Age Factors; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus, Type 1; Diabe | 1971 |
1 trial available for sorbitol and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Pharmacokinetics and Pharmacodynamics of Luseogliflozin, a Selective SGLT2 Inhibitor, in Japanese Patients With Type 2 Diabetes With Mild to Severe Renal Impairment.
Topics: Adult; Aged; Asian People; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Type 2; Female; | 2018 |
59 other studies available for sorbitol and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Endothelial Cells; Fibroblas | 2022 |
Identification of Potential Aldose Reductase Inhibitors Using Convolutional Neural Network-Based in Silico Screening.
Topics: Aldehyde Reductase; Diabetes Complications; Enzyme Inhibitors; Humans; Molecular Docking Simulation; | 2023 |
Formulation development of sugar free antacid chewable tablets for diabetes induced acidity in patients.
Topics: Antacids; Anti-Ulcer Agents; Chemistry, Pharmaceutical; Diabetes Complications; Diabetes Mellitus; D | 2019 |
Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy.
Topics: Caffeine; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Humans; Sorbitol; Spectr | 2022 |
Modulation of Advanced Glycation End Products, Sorbitol, and Aldose Reductase by Hydroalcohol Extract of Lagenaria siceraria Mol Standl in Diabetic Complications: An In Vitro Approach.
Topics: Aldehyde Reductase; Animals; Antioxidants; Biomarkers; Cucurbitaceae; Diabetes Complications; Erythr | 2018 |
Protective effects of the SGLT2 inhibitor luseogliflozin on pancreatic β-cells in db/db mice: The earlier and longer, the better.
Topics: Animals; Cells, Cultured; Cytoprotection; Diabetes Complications; Diabetes Mellitus, Experimental; D | 2018 |
Anti-cataract Effect of Resveratrol in High-Glucose-Treated Streptozotocin-Induced Diabetic Rats.
Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Crystallins; Diabetes Complicati | 2018 |
Aldose reductase expression as a risk factor for cataract.
Topics: Aldehyde Reductase; Animals; Apoptosis; Cataract; Diabetes Complications; Diabetes Mellitus, Experim | 2015 |
A novel zwitterionic inhibitor of aldose reductase interferes with polyol pathway in ex vivo and in vivo models of diabetic complications.
Topics: Aldehyde Reductase; Animals; Biological Availability; Diabetes Complications; Diabetes Mellitus, Exp | 2014 |
A fiber-optic sorbitol biosensor based on NADH fluorescence detection toward rapid diagnosis of diabetic complications.
Topics: Animals; Biosensing Techniques; Diabetes Complications; NAD; Optical Fibers; Sheep; Sorbitol; Spectr | 2015 |
Increased sorbitol levels in the hypertrophic ligamentum flavum of diabetic patients with lumbar spinal canal stenosis.
Topics: Aged; Aged, 80 and over; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Case-Cont | 2017 |
SGLT2 inhibitor (Luseogliflozin): a new mechanism for treating type 2 diabetes mellitus and therapeutic potential to prevent the progression of diabetic complications.
Topics: Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus, Type 2; Disease Progression; Hu | 2016 |
Protective effects of dietary chamomile tea on diabetic complications.
Topics: Aldehyde Reductase; alpha-Amylases; Animals; Beverages; Blood Glucose; Diabetes Complications; Diabe | 2008 |
Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols.
Topics: Aldehyde Reductase; Biphenyl Compounds; Cataract; Diabetes Complications; Eleusine; Flavonoids; Free | 2008 |
Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications.
Topics: Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Complications; Diabetic Retinopathy; | 2008 |
Aldose reductase inhibitory compounds from Glycyrrhiza uralensis.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Enzyme Inhibitors; Flavonoids; Glucose; Glycyrr | 2010 |
Inhibitory effect of glucodistylin from the bark of Quercus acutissima on human recombinant aldose reductase and sorbitol accumulation.
Topics: Aldehyde Reductase; Catechin; Diabetes Complications; Drug Evaluation, Preclinical; Flavonoids; Flav | 2011 |
Effective compounds group of Mongolian prescriptions BAIMAI-SAN protect against peripheral neuropathy in lower limbs of rats through neuro protective effect.
Topics: Animals; Brain; Cell Culture Techniques; Cell Survival; Cells, Cultured; Diabetes Complications; Dia | 2011 |
Age-related alterations in the biochemical and functional properties of the bladder in type 2 diabetic GK rats.
Topics: Acetylcholine; Adenosine Triphosphate; Aging; Animals; Body Weight; Carbachol; Diabetes Complication | 2005 |
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress.
Topics: Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Progression; Dis | 2006 |
Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity.
Topics: Aldehyde Reductase; Carbolines; Diabetes Complications; Enzyme Inhibitors; Erythrocytes; Evodia; Fem | 2009 |
Galactitol accumulation by glucose-6-phosphate deficient fibroblasts: a cellular model for resistance to the complications of diabetes mellitus.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Child; Child, Preschool; Diabetes Complications; Fibrob | 1983 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di | 1984 |
The diabetic cornea.
Topics: Adult; Aged; Animals; Basement Membrane; Blood Glucose; Cornea; Corneal Diseases; Diabetes Complicat | 1984 |
[The problem of the complications of diabetes].
Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellit | 1984 |
Diabetic cataracts- is aldose reductase important?
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Complications; Erythrocytes; Humans; Kinetic | 1981 |
Aldose reductase and the etiology of diabetic cataracts.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Cataract; Child; Child, Preschool; Diabetes Complica | 1980 |
Refractive change in hyperglycaemia: hyperopia, not myopia.
Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Female; Glucose; Humans; Hyperglycemia; Hype | 1982 |
Hyperkalemia complicating cardiopulmonary bypass: analysis of risk factors.
Topics: Adult; Aged; Aspartic Acid; Blood Glucose; Cardiopulmonary Bypass; Diabetes Complications; Drug Comb | 1982 |
Effect of short-term hyperglycaemia of oral glucose on red cell sorbitol and plasma glucose concentrations in diabetic and non-diabetic Nigerians.
Topics: Adult; Aged; Aldehyde Reductase; Black People; Blood Glucose; Case-Control Studies; Diabetes Complic | 1995 |
Peripheral neuropathy in the WBN/Kob rat with chronic pancreatitis and spontaneous diabetes.
Topics: Action Potentials; Animals; Axons; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; | 1993 |
[Diabetes mellitus as a risk factor for arteriosclerosis].
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Glycosylation; H | 1993 |
Aldose reductase: black sheep or skeleton in the cupboard?
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, | 1996 |
Highly selective aldose reductase inhibitors. 3. Structural diversity of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids.
Topics: Acetates; Aldehyde Reductase; Animals; Benzothiazoles; Diabetes Complications; Enzyme Inhibitors; Hu | 1997 |
Studies of glucose turnover and renal function in an unusual case of hereditary fructose intolerance.
Topics: Administration, Oral; Carbohydrate Metabolism, Inborn Errors; Diabetes Complications; Fructose; Fruc | 1977 |
Efficacy of Alrestatin, an aldose reductase inhibitor, in human diabetic and nondiabetic lenses.
Topics: Aldehyde Reductase; Cataract; Cataract Extraction; Diabetes Complications; Glucose; Humans; Isoquino | 1979 |
[Lactic acidosis (author's transl)].
Topics: Acidosis; Alcoholic Intoxication; Bicarbonates; Biguanides; Diabetes Complications; Fructose; Hepati | 1978 |
Blood sugar and the complications of diabetes.
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Glucose; Glycoproteins; Hemoglobi | 1979 |
Factors related to corneal epithelial complications after closed vitrectomy in diabetics.
Topics: Cornea; Corneal Diseases; Diabetes Complications; Epithelium; Female; Fructose; Humans; Intraocular | 1979 |
[Physiopathology of chronic complications in diabetes: therapeutic implications].
Topics: Adult; Aged; Arteriosclerosis; Blood Platelets; Diabetes Complications; Diabetic Angiopathies; Diabe | 1979 |
Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aldehyde Reductase; Animals; Black People | 1992 |
Oxidative glycation and free radical production: a causal mechanism of diabetic complications.
Topics: Aging; Aldehydes; Animals; Benzoates; Benzoic Acid; Cattle; Chelating Agents; Chromatography, Affini | 1991 |
Diarrhea in diabetics: the role of sorbitol.
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Breath Tests; Diabetes Complications; Diarrhea; Drug | 1990 |
The identification of aldose reductase in the pathogenesis of diabetic complications: the background.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Complications; Diabetes Mellitus; Dia | 1985 |
The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cataract; Cell Membrane; Diabetes Complications | 1986 |
Sorbinil: a member of the novel class of spirohydantoin aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Complications; Diabetes Mellitu | 1986 |
The effect of aldose reductase and its inhibition on sugar cataract formation.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Imid | 1986 |
Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Hyperglycemia; Imidazoles; Imidazolid | 1986 |
Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.
Topics: Aldehyde Reductase; Animals; Cell Line; Diabetes Complications; Diabetes Mellitus; Extracellular Spa | 1987 |
The utilization of 13C and 31P nuclear magnetic resonance spectroscopy in the study of the sorbitol pathway and aldose reductase inhibition in intact rabbit lenses.
Topics: Aldehyde Reductase; Animals; Cataract; Culture Media; Diabetes Complications; Diabetes Mellitus, Exp | 1987 |
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.
Topics: Acetates; Administration, Oral; Alcohol Oxidoreductases; Animals; Cataract; Culture Techniques; Diab | 1973 |
[Anuric complications after perfusion urography in patients with renal failure, myeloma excepted].
Topics: Adult; Aged; Amino Sugars; Anuria; Dehydration; Diabetes Complications; Diatrizoate; Female; Humans; | 1972 |
[Pathobiochemistry of the late-onset diabetic syndrome].
Topics: Animals; Carbohydrates; Cataract; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complicatio | 1974 |
Refractive changes in diabetes.
Topics: Cell Membrane Permeability; Diabetes Complications; Glucose; Hyperopia; Myopia; Refractive Errors; S | 1972 |
Letter: Hyperopia in diabetes.
Topics: Diabetes Complications; Diabetes Mellitus; Fructose; Humans; Hyperopia; Lens, Crystalline; Sorbitol; | 1973 |
[Pathogenesis of angio- and neuropathies in patients with diabetes mellitus].
Topics: Blood Vessels; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic | 1973 |
[Diabetes mellitus, uricemia and gout].
Topics: Diabetes Complications; Diabetes Mellitus; Fructose; Glucose; Gout; Humans; Nucleoproteins; Nutritio | 1973 |
Tween 80 exacerbated intrinsic rhinitis and asthma in non-aspirin-sensitive patients.
Topics: Aspirin; Asthma; Blood Vessels; Chemical Phenomena; Chemistry; Cholestyramine Resin; Diabetes Compli | 1974 |
[Biochemical studies on the etiology of cataract in diabetes].
Topics: Alcohol Oxidoreductases; Animals; Cataract; Cattle; Diabetes Complications; Diabetes Mellitus; Fruct | 1970 |