sorbitol has been researched along with Chemical and Drug Induced Liver Injury in 46 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, DDB therapeutic effectiveness is restricted by its low oral bioavailability that arises from its poor solubility and dissolution." | 1.38 | Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation. ( Abdelbary, GA; Aburahma, MH, 2012) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (82.61) | 18.7374 |
| 1990's | 2 (4.35) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Tong, W | 1 |
| Kehinde, AJ | 1 |
| Aburahma, MH | 1 |
| Abdelbary, GA | 1 |
| WATTS, C | 1 |
| GRIFFITHS, HE | 1 |
| VULLIEMOZ, P | 1 |
| FAVEZ, G | 1 |
| Sachs, M | 1 |
| Asskali, F | 1 |
| Förster, H | 3 |
| Encke, A | 1 |
| Funakoshi, T | 1 |
| Ueda, K | 1 |
| Shimada, H | 1 |
| Kojima, S | 1 |
| Schuchhardt, C | 1 |
| Reutter, W | 2 |
| Lesch, R | 2 |
| Carlson, GP | 1 |
| Hütteroth, TH | 1 |
| Wagner, R | 1 |
| Knolle, J | 1 |
| Imoto, S | 1 |
| Sutherland, LR | 1 |
| Edwards, LA | 1 |
| Medline, A | 1 |
| Wilkinson, RW | 1 |
| Connon, JJ | 1 |
| Kurysheva, NG | 1 |
| Ekshtat, BIa | 1 |
| Kazanina, SS | 1 |
| Vogel, G | 1 |
| Trost, W | 1 |
| Braatz, R | 1 |
| Odenthal, KP | 1 |
| Brüsewitz, G | 1 |
| Antweiler, H | 1 |
| Seeger, R | 1 |
| Jaeger, RJ | 1 |
| Conolly, RB | 1 |
| Reynolds, ES | 1 |
| Murphy, SD | 1 |
| Galaske, RG | 1 |
| Burdelski, M | 1 |
| Brodehl, J | 1 |
| Harvey, DG | 1 |
| Hoe, CM | 1 |
| Hoffmann, H | 1 |
| Bode, JC | 2 |
| Thorpe, E | 1 |
| Gopinath, C | 2 |
| Jones, RS | 1 |
| Ford, EJ | 1 |
| Stillman, AE | 1 |
| Henry, MC | 1 |
| Marlow, M | 1 |
| Rauen, HM | 7 |
| Schriewer, H | 7 |
| Gebauer, B | 3 |
| Abu Tair, M | 3 |
| Rüther, N | 2 |
| The, LG | 2 |
| Rahmede, D | 1 |
| Riese, B | 1 |
| Kopp, O | 1 |
| Peters, U | 1 |
| Badde, R | 2 |
| Roth, G | 2 |
| Keppler, DO | 1 |
| Hübner, G | 1 |
| Ishmael, J | 1 |
| Iturriaga, H | 1 |
| Vaisman, S | 1 |
| Eugenia PINO, ME | 1 |
| Pereda, T | 1 |
| Poggioli, R | 4 |
| Baggio, G | 2 |
| Tamiso, R | 1 |
| Greggia, A | 1 |
| Heine, W | 1 |
| Schill, H | 1 |
| Tessmann, D | 1 |
| Kupatz, H | 1 |
| Bauer, C | 1 |
| Fowler, JS | 1 |
| Gromashevskaia, LL | 2 |
| Demchenko, VN | 2 |
| Mironova, EM | 1 |
| Gette, ZP | 1 |
| Gusovskiĭ, IaM | 1 |
2 reviews available for sorbitol and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Repeated perioperative administration of fructose and sorbitol in a female patient with hereditary fructose intolerance [HFI)].
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Electrolytes; Female; Fructose; Fructos | 1993 |
44 other studies available for sorbitol and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Functional Oil from Black Seed Differentially Inhibits Aldose-reductase and Ectonucleotidase Activities by Up-regulating Cellular Energy in Haloperidol-induced Hepatic Toxicity in Rat Liver.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Aldehyde Reductase; Animals; Chemical and Drug I | 2017 |
Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Calori | 2012 |
BIOCHEMICAL STUDIES OF SEVERE LIVER DAMAGE CAUSED BY P-AMINOSALICYLIC ACID.
Topics: Alanine Transaminase; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransferases; Biliru | 1964 |
[ENZYMATIC STUDY OF THE LIVER IN PULMONARY TUBERCULOSIS. RESEARCH ON A POSSIBLE HEPATOTOXIC EFFECT OF ANTIBACTERIAL MEDICATIONS].
Topics: Alanine Transaminase; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Aspartate Am | 1964 |
Effects of dithiocarbamates on toxicity of cadmium in rat primary hepatocyte cultures.
Topics: Animals; Cadmium; Cadmium Poisoning; Cells, Cultured; Chelating Agents; Chemical and Drug Induced Li | 1997 |
Investigations on d-galactosamine hepatitis after pretreatment with alpha-hexachlorocyclohexane.
Topics: Alcohol Oxidoreductases; Animals; Chemical and Drug Induced Liver Injury; DNA; Female; Galactosamine | 1976 |
Potentiation of carbon tetrachloride hepatotoxicity in rats by pretreatment with polychlorinated biphenyls.
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Body Weight; Ca | 1975 |
[Severe toxic liver injury after overdosage of parenteral administered carbohydrates: a case report (author's transl)].
Topics: Adult; Anorexia Nervosa; Biopsy; Chemical and Drug Induced Liver Injury; Female; Fructose; Glucose; | 1977 |
Meglumine hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Meglumine; Middle Aged; Sorbitol | 1978 |
Meglumine iodipamide (Cholografin) hepatotoxicity.
Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Cholangiography; Female; Humans; Iodipamide; | 1977 |
[Mechanism of the hepatotropic action of 1,1,2,3-tetrachlorpropene].
Topics: Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; Chemical and Dru | 1977 |
[Pharmacodynamics, site and mechanism of action of silymarin, the antihepatoxic principle from Silybum mar. (L) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) pharmacology].
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Amanitins; Anesthetics, Local; Animals; Aspartate Ami | 1975 |
Biochemical toxicology of unsaturated halogenated monomers.
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Animals; Butadienes; Chemical and Drug Induced Liver | 1975 |
[Primary polyuric kidney failure and acute yellow liver dystrophy following infusion of glucose substitutes in children].
Topics: Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cr | 1986 |
The application of some liver function tests to sheep dosed with carbon tetrachloride and hexachlorphene.
Topics: Alkaline Phosphatase; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Car | 1971 |
[Biochemical considerations of the use of carbohydrates in parenteral feeding].
Topics: Animals; Carbohydrates; Chemical and Drug Induced Liver Injury; Fatty Acids, Nonesterified; Fructose | 1974 |
[Undesirable metabolic effects following the administration of higher doses of fructose and sorbitol].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Chemical and Drug I | 1974 |
[Undesirable metabolic effects following the administration of larger doses of fructose and sorbitol].
Topics: Acute Disease; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Drug Interac | 1974 |
The effect of chloroform on the liver and the activity of serum enzymes in the horse.
Topics: Adenosine Triphosphatases; Animals; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced L | 1969 |
Hepatotoxic reaction to iodipamide meglumine injection.
Topics: Acute Disease; Aged; Amino Sugars; Aspartate Aminotransferases; Chemical and Drug Induced Liver Inju | 1974 |
[Genuine adverse effects following the infusion of sugar-exchange substances?].
Topics: Acidosis; Animals; Chemical and Drug Induced Liver Injury; Fructose; Humans; Lactates; Oxalates; Par | 1973 |
Serum enzymes in hepatotoxicity induced by chloroethylcyclohexyl nitrosourea and arabinofuranosyl-6-mercaptopurine.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents; Arabinose; Aspartate Ami | 1973 |
[Multivariant analysis of experimental liver damage: normal parameters of the rat serum].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Barbiturates; Chem | 1973 |
[Duration of enzyme activities, free fatty acids and lipids in the rat serum following carbon tetrachloride intoxication].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1973 |
[The hepatotoxic effect of deoxycholate. A multivariant analysis model of experimental liver damage].
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Barbiturates; Bile | 1973 |
[Biochemical problems of the environment. I. The hepatotoxic effect of tensides: dodecyl sulfate].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Membrane; Chemical and Drug Induced | 1973 |
[Pharmacokinetics of the anti-hepatotoxic effect of silymarin in CCl4-and deoxycholate-induced liver damage in the rat].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Carbon Tetrachlori | 1973 |
[The anti-hepatotoxic effect of silymarin on thioacetamide-induced liver damage].
Topics: Acetamides; Alanine Transaminase; Alcohols; Animals; Aspartate Aminotransferases; Chemical and Drug | 1973 |
Liver injury induced by 2-deoxy-D-galactose.
Topics: Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced | 1973 |
Effect of a single small dose of inorganic copper on the liver of sheep.
Topics: Animals; Appetite; Aspartate Aminotransferases; Behavior, Animal; Bilirubin; Blood Urea Nitrogen; Ch | 1972 |
[Correlations of enzyme activities in serum after experimental liver damage in rats].
Topics: Acetamides; Alanine Transaminase; Alcohol Oxidoreductases; Alcoholic Intoxication; Alkaline Phosphat | 1971 |
Lysosomal injury and hepatic necrosis. Effects of triton WR-1339 on liver cells in the rat.
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Inju | 1971 |
[Hepatoprotective activity in the rat of 2,4-monofurfurylidene-tetra-O-methyl-sorbitol (MSF). I. Protection from acute poisoning with CCl 4', dl-ethionine and allyl alcohol].
Topics: Alcohols; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethionine | 1969 |
[Hepatoprotective activity in the rat of 2,4-monofurfurylidene-tetra-O-methyl-sorbitol (MSF). II. Influence of phenobarbital on sleep in animals with carbon tetrachloride poisoning].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Furans; Phenobarbit | 1969 |
[Hepatoprotective activity in the rat of 2,4-monofurfurylidene-tetra-O-methyl-sorbitol (MSF). 3. Influence on choleresis in animals with carbon tetrachloride poisoning].
Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Furans; Rats; | 1969 |
[Hepatoprotective activity of 2,4-monofurfuryliden-tetra-o-methyl sorbitol (MSF) in rats. VII. Comparison between the protective activity of MSF and 2 of its analogs against CC1-4 poisoning].
Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Liver | 1969 |
[Fatal liver dystrophy in 3 siblings with hereditary fructose intolerance after long-lasting infusion with sorbitol solutions].
Topics: Autopsy; Carbohydrate Metabolism, Inborn Errors; Chemical and Drug Induced Liver Injury; Fatty Liver | 1969 |
On the mechanism of action of galactosamine: different response to D-galactosamine of rat liver during development.
Topics: Age Factors; Alcohol Oxidoreductases; Amines; Animals; Animals, Newborn; Aspartate Aminotransferases | 1970 |
Toxicity of carbon tetrachloride and other fasciocidal drugs in sheep and chickens.
Topics: Administration, Oral; Alcohol Oxidoreductases; Animals; Anthelmintics; Aspartate Aminotransferases; | 1971 |
[Enzyme activity of the serum and liver of animals with parenchymatous lesion of the liver at different amounts of protein in the diet].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical | 1967 |
[Serum and liver enzyme activity in experimental cirrhosis of the liver at various stages in its development].
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Carbon Tetrachl | 1968 |