sorbitol and Cataract studies

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
" The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract."	8.02	Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021)
" In addition, sorbitol levels were estimated in the cataractous lenses of the obese rats."	7.78	Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats. ( Giridharan, NV; Reddy, GB; Reddy, PY, 2012)
" This study was performed to investigate whether high levels of myo-inositol, one of the major organic osmolytes in the lens, would lead to cataract development."	7.70	Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract. ( Cammarata, PR; Chung, SK; Chung, SS; Jiang, Z; Zhou, C, 2000)
"Lenses exposed to high concentrations of xylose in organ culture produce xylitol, and they lose transparency and exhibit other changes characteristic of cataracts."	7.70	Effects of xylose on monkey lenses in organ culture: a model for study of sugar cataracts in a primate. ( Blum, PS; Jernigan, HM; Liu, Y; Merola, LO; Stimbert, CD; Zigler, JS, 1998)
"The effect of pyruvate on the progress of galactose cataract has been studied."	7.68	Prevention of galactose cataract by pyruvate. ( Devamanoharan, PS; Henein, M; Ramachandran, S; Varma, SD, 1992)
" However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin."	5.39	Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013)
" One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more."	5.30	Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997)
"Sorbinil was added to one of each pair of selected lenses, both incubated with 13C-glucose."	5.27	Sorbitol generation and its inhibition by Sorbinil in the aging normal human and rabbit lens and human diabetic cataracts. ( Lerman, S; Moran, M, 1988)
" Development of a simple, sensitive and rapid method for sorbitol detection is of considerable significance to efficient monitoring of diabetes-associated disorders like cataract, neuropathy, and nephropathy at initial stages."	5.05	Bioengineered Polymer/Composites as Advanced Biological Detection of Sorbitol: An Application in Healthcare Sector. ( Batra, K; Minakshi, P; Rani, R; Singh, G, 2020)
"Aldose reductase (AR) appears to initiate the cataractous process in galactosemic and diabetic animals."	4.76	Aldose reductase in diabetic complications of the eye. ( Fukushi, S; Kador, P; Kinoshita, JH; Merola, LO, 1979)
"The ameliorating effects of midodrine on cataracts in the OLETF obesity rat model are exerted via the following three mechanisms: direct inhibition of the biosynthesis of sorbitol, which causes cataracts; reduction of reactive oxygen species and inflammation; and (3) stimulation of normal aerobic glycolysis."	4.12	Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors. ( Eom, Y; Han, YM; Jang, YN; Jeong, JH; Jung, TW; Kim, HM; Lee, YJ; Seo, HS; Song, JS, 2022)
" The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract."	4.02	Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021)
" A single, intraperitoneal injection of streptozotocin (STZ) (35 mg/kg) resulted in hyperglycemia, accumulation of sorbitol and formation of advanced glycation end product (AGE) in eye lens."	3.80	Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. ( Manikandan, R; Raman, T; Sai Varsha, MK, 2014)
" In addition, sorbitol levels were estimated in the cataractous lenses of the obese rats."	3.78	Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats. ( Giridharan, NV; Reddy, GB; Reddy, PY, 2012)
"We examined the effects of GP-1447 (3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]-5-methylphenyl acetic acid) on existing cataracts and sorbitol content in the lens in rats with streptozotocin-induced diabetes."	3.78	GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. ( Ishii, K; Kawakubo, K; Mori, A; Nakahara, T; Sakamoto, K, 2012)
"In sugar cataract formation in rats, aldose reductase (AR) activity is not only linked to lenticular sorbitol (diabetic) or galactitol (galactosemic) formation but also to signal transduction changes, cytotoxic signals and activation of apoptosis."	3.78	Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation. ( Blessing, K; Kador, PF; Lou, MF; Randazzo, J; Xing, K; Zhang, P, 2012)
"Studies show that the pyruvate treatment decreased the extent of several biochemical changes known to be associated with cataract formation, such as the elevation in the levels of glycated proteins, sorbitol, lipid peroxidation (MDA) and inhibition of the cation pump."	3.70	Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. ( Ali, AH; Devamanoharan, PS; Henein, M; Varma, SD; Zhao, W, 2000)
" This study was performed to investigate whether high levels of myo-inositol, one of the major organic osmolytes in the lens, would lead to cataract development."	3.70	Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract. ( Cammarata, PR; Chung, SK; Chung, SS; Jiang, Z; Zhou, C, 2000)
"The relative importance of sorbitol formation versus nonenzymatic glycosylation and advanced glycosylation end products (AGEs) on sugar cataract formation was examined in diabetic rats."	3.70	Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. ( Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF, 2000)
"Lenses exposed to high concentrations of xylose in organ culture produce xylitol, and they lose transparency and exhibit other changes characteristic of cataracts."	3.70	Effects of xylose on monkey lenses in organ culture: a model for study of sugar cataracts in a primate. ( Blum, PS; Jernigan, HM; Liu, Y; Merola, LO; Stimbert, CD; Zigler, JS, 1998)
"Galactitol and sorbitol concentrations in plasma were determined in patients (with or without cataract) in whom homo- or heterozygosity for galactokinase, galactose-1-phosphate uridyltransferase, systemic or peripheral UDP-galactose epimerase and sorbitol dehydrogenase deficiency was confirmed."	3.68	Plasma polyol levels in patients with cataract. ( Brockstedt, M; Douwes, AC; Endres, W; Jakobs, C; Shin, YS; Stellaard, F, 1990)
"The effect of pyruvate on the progress of galactose cataract has been studied."	3.68	Prevention of galactose cataract by pyruvate. ( Devamanoharan, PS; Henein, M; Ramachandran, S; Varma, SD, 1992)
"Aldose reductase catalyzes the NADPH-linked reduction of hexoses to their respective sugar-alcohols, which are involved in the pathogenesis of "sugar-cataracts"."	3.68	Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies. ( Alvarez, A; Chávez, M; Chávez-Anaya, E; Medina, C; Medina, MD; Mendoza, R; Ramírez, MG; Sáenz, G; Vaca, G; Vargas, M, 1992)
"The relationship between red blood cell sorbitol content and diabetic complications (cataract, retinopathy, neuropathy, and nephropathy) was examined in 23 non-insulin-dependent diabetic (NIDD) patients."	3.68	Studies on clinical markers of diabetes mellitus. 6. Red blood cell sorbitol and diabetic complications. ( Aro, T; Fuda, H; Hatano, M; Hiyoshi, S; Katsu, K; Maruyama, S; Sugiura, M; Taguchi, H, 1990)
"It has been suggested that sugar cataracts associated with diabetes mellitus result from the accumulation of excess sorbitol within lens fibrils."	3.68	Nonosmotic diabetic cataracts. ( Cook, WR; Lowitt, S; Malone, JI, 1990)
"Circulating glycosylated hemoglobin (Hb A1) and/or fasting blood glucose (FBG) levels, measures of the extent to which diabetes is clinically controlled, were correlated with the contents of fructose, sorbitol, glucose, and inositol in 27 cataracts removed by intracapsular extraction."	3.67	Polyol pathway metabolites in human cataracts. Correlation of circulating glycosylated hemoglobin content and fasting blood glucose levels. ( Lerner, BC; Richards, RD; Varma, SD, 1984)
"The cataractogenic effect of a galactose diet was studied in male and female pigs in relation to the daily galactose intake."	3.67	The effects of 5% and 25% galactose diets on lens polyols, glutathione and protein glycation in male and female pigs. ( Alloussi, S; Birlouez-Aragon, I; Fevrier, C; Morawiec, M, 1989)
"Rat lenses with experimentally induced cataract (either by naphthalene or by streptozotocin) were analyzed biochemically."	3.67	Alterations of lens metabolism with experimentally induced cataract in rats. ( Bours, J; Hockwin, O; Korte, I; Wegener, A, 1988)
"The isolated cultured rat lens has been used to examine the effects of the aldose reductase inhibitor sorbinil on lenticular polyol accumulation and sugar cataract formation."	3.67	Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens. ( Beyer, TA; Hutson, NJ; Rafford, CE; Yeh, LA, 1986)
"Heretofore, the intracellular accumulation of sorbitol has been associated exclusively with deleterious (cataractogenic) changes in the lens."	3.67	Sorbitol production in the lens: a means of counteracting glucose-derived osmotic stress. ( Chylack, LT; Harding, R; Tung, W, 1986)
"NADPH and NADP+ levels were measured in rat lens from normal controls, from galactose-fed and diabetic rats during the first week of cataract formation."	3.67	Aldose reductase, NADPH and NADP+ in normal, galactose-fed and diabetic rat lens. ( Doughty, CC; Lee, SM; Schade, SZ, 1985)
"In this report we demonstrate that 13C-nuclear magnetic resonance spectroscopy may be used to monitor the sorbitol and glycolytic pathways in a single, intact, crystalline lens of the rabbit, thereby providing a new, noninvasive method for the study of sugar cataractogenesis."	3.66	13C-nuclear magnetic resonance studies of sugar cataractogenesis in the single intact rabbit lens. ( Aguayo, J; Campbell, P; Chylack, LT; González, RG; Schleich, T; Willis, J, 1982)
"An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose."	3.65	Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. ( Dvornik, E; Gabbay, KH; Kinoshita, JH; Krami, M; Merola, LO; Sestanj, K; Simard-Duquesne, N; Varma, SD, 1973)
"Aldose reductase (AR) and sorbitol dehydrogenase (SDH) make up the sorbitol pathway, which has been implicated in the pathogenesis of sugar cataracts."	3.65	Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens. ( Collins, JG; Corder, CN, 1977)
"Diabetic retinopathy is similarly related to sorbitol accumulation and may be prevented or reversed by inhibition of aldose reductase."	2.37	NIH conference. Aldose reductase and complications of diabetes. ( Cobo, LM; Cogan, DG; Datilis, MB; Kador, PF; Kinoshita, JH; Kupfer, C; Robison, G, 1984)
"Cataracts were morphologically different and progressed more slowly in T2DC versus T1DC."	1.40	Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes. ( Chen, S; Ge, J; Guan, L; Leng, F; Liu, P; Su, S; Wang, C; Zhang, L, 2014)
" However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin."	1.39	Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013)
"Diabetes induced cataract is characterized by an accumulation of sorbitol which is mediated by the action of a key enzyme aldose reductase (AR)."	1.35	Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols. ( Chethan, S; Dharmesh, SM; Malleshi, NG, 2008)
"No lens opacities were detected."	1.32	High-resolution magic angle spinning 1H NMR spectroscopy of metabolic changes in rabbit lens after treatment with dexamethasone combined with UVB exposure. ( Cejková, J; Krane, J; Midelfart, A; Risa, O; Saether, O, 2004)
" One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more."	1.30	Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997)
" In accordance with the polyol theory, the chronic administration of SDI 157 to diabetic rats accelerated the cataract development and depleted the lens of total and oxidized glutathione."	1.29	Sorbitol-accumulating pyrimidine derivatives. ( Geisen, K; Grötsch, H; Lang, HJ; Nimmesgern, H; Utz, R, 1994)
"Lens galactose accumulation was low (3 mumol/g wet wt) up to 7 days; however, it was rapidly increased after 7 days."	1.28	Myo-inositol transport in the lens of galactose-maintained rats. ( Beyer-Mears, A; Cruz, E; Diecke, FP; Mistry, K, 1992)
"Inositol was not detectable from stage I."	1.27	Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. ( Fukuda, M; Kuriyama, H; Sasaki, K, 1983)
"Sorbinil was added to one of each pair of selected lenses, both incubated with 13C-glucose."	1.27	Sorbitol generation and its inhibition by Sorbinil in the aging normal human and rabbit lens and human diabetic cataracts. ( Lerman, S; Moran, M, 1988)
"Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave."	1.27	The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988)
"It is proposed that the observed lens opacities are due to the presence of sugar alcohols in the culture medium and not to hyperosmolar shock."	1.27	Study of experimental cataract produced by sugar alcohols in the organ-cultured mammalian ocular lens. ( Bagchi, M; Barret, R; Caporale, MJ; Hazlett, L; Kiessling, B, 1988)
"After 160 days, no cataract is revealed in the T and P groups."	1.26	[Reactions in the rats from prolonged consumption of lactose or hydrolyzed lactose. 3. Crystalline lens]. ( Adrian, J; David, C; Frangne, R; Manent, PJ; Poiffait, A, 1982)
"A case of diabetic ketoacidosis treated by the usual methods is described."	1.25	Coincidental changes in conscious level and lens translucency during treatment of diabetic ketoacidosis. ( Corrall, RJ, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	83 (60.58)	18.7374
1990's	30 (21.90)	18.2507
2000's	10 (7.30)	29.6817
2010's	10 (7.30)	24.3611
2020's	4 (2.92)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Refinement of the Magnetic Resonance Imaging Technique for the Study of the Normal Eye, Particularly the Lens and Cataract[NCT00005911]				20 participants	Observational	2000-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Bioengineered Polymer/Composites as Advanced Biological Detection of Sorbitol: An Application in Healthcare Sector. Current topics in medicinal chemistry, 2020, Volume: 20, Issue:11 Topics: Biosensing Techniques; Cataract; Diabetic Nephropathies; Diabetic Neuropathies; Electrochemical Tech	2020
The biochemistry of the complications of diabetes mellitus. Annual review of biochemistry, 1981, Volume: 50 Topics: Animals; Axonal Transport; Basement Membrane; Blood Platelets; Blood Proteins; Cataract; Diabetes Co	1981
NIH conference. Aldose reductase and complications of diabetes. Annals of internal medicine, 1984, Volume: 101, Issue:1 Topics: Aldehyde Reductase; Animals; Axonal Transport; Cataract; Corneal Diseases; Diabetic Neuropathies; Di	1984
[Sorbitol and its role in nutrition]. Voprosy pitaniia, 1983, Issue:1 Topics: Animals; Blood Glucose; Cataract; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, Diabetic	1983
[The biochemical basis of the complications of diabetes]. Journees annuelles de diabetologie de l'Hotel-Dieu, 1984 Topics: Aldehyde Reductase; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Fruc	1984
[The role of polyol pathways in formation of diabetic cataracts]. Klinika oczna, 1997, Volume: 99, Issue:6 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Glucose; Humans; L	1997
Aldose reductase in diabetic complications of the eye. Metabolism: clinical and experimental, 1979, Volume: 28, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Chromans; Cornea; Diabetes Complications; Diabetic Re	1979
Hyperglycemia, polyol metabolism, and complications of diabetes mellitus. Annual review of medicine, 1975, Volume: 26 Topics: Animals; Blood Glucose; Body Fluids; Cataract; Chemical Phenomena; Chemistry; Diabetes Complications	1975
Sugar alcohols in the pathogenesis of galactose and diabetic cataracts. Birth defects original article series, 1976, Volume: 12, Issue:3 Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism, Inborn Errors; Cataract; Chemical Phenomena; C	1976
Review: pathogenesis, progression, and therapeutic intervention of diabetic neuropathy. Journal of ocular pharmacology, 1992,Summer, Volume: 8, Issue:2 Topics: Aldehyde Reductase; Animals; Axons; Cataract; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Huma	1992
Role of aldose reductase and sorbitol in maintaining the medullary intracellular milieu. Kidney international, 1988, Volume: 33, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Galactosemias; Humans; Kidney Medulla	1988
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry;	1985
The sorbitol pathway and the complications of diabetes. The New England journal of medicine, 1973, Apr-19, Volume: 288, Issue:16 Topics: Alcohol Oxidoreductases; Animals; Carbohydrate Metabolism; Cataract; Central Nervous System; Diabete	1973
Mechanisms initiating cataract formation. Proctor Lecture. Investigative ophthalmology, 1974, Volume: 13, Issue:10 Topics: Acetates; Adenosine Triphosphatases; Aged; Alcohol Oxidoreductases; Animals; Biological Transport; C	1974
Alterations in the composition and metabolism of the inner aortic wall associated with increased polyol pathway activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1974, Volume: Suppl 4 Topics: Alcohol Oxidoreductases; Animals; Aorta, Thoracic; Cataract; Fructose; Glucose; Glycolysis; Hexokina	1974
[Diabetic cataract and modern views on the etiology and pathogenesis of vascular complications during diabetes]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1971, Mar-15, Volume: 24, Issue:6 Topics: Age Factors; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus, Type 1; Diabe	1971
Galactose cataract: a review. Experimental eye research, 1971, Volume: 11, Issue:3 Topics: Age Factors; Alcohol Oxidoreductases; Aminoisobutyric Acids; Animals; Cataract; Dairy Products; Gala	1971

Article	Year
Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors. Endocrinology and metabolism (Seoul, Korea), 2022, Volume: 37, Issue:2 Topics: Animals; Cataract; Glycolysis; Midodrine; Obesity; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Recep	2022
Effect of Sorbitol on Alpha-Crystallin Structure and Function. Biochemistry. Biokhimiia, 2022, Volume: 87, Issue:2 Topics: alpha-Crystallins; Animals; Cataract; Diabetes Mellitus; Lens, Crystalline; Molecular Chaperones; Ra	2022
Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. Current eye research, 2021, Volume: 46, Issue:1 Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental;	2021
Anti-cataract Effect of Resveratrol in High-Glucose-Treated Streptozotocin-Induced Diabetic Rats. Biological & pharmaceutical bulletin, 2018, Volume: 41, Issue:10 Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Crystallins; Diabetes Complicati	2018
Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol. IUBMB life, 2013, Volume: 65, Issue:5 Topics: Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Galactose; Glucose; Hot Temperature	2013
Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PloS one, 2013, Volume: 8, Issue:10 Topics: Aldehyde Reductase; Animals; Antioxidants; Biocompatible Materials; Biodegradation, Environmental; B	2013
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. Experimental eye research, 2014, Volume: 128 Topics: Animals; Blood Glucose; Calcium; Calcium-Transporting ATPases; Cataract; Diabetes Mellitus, Experime	2014
Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes. Investigative ophthalmology & visual science, 2014, Nov-18, Volume: 55, Issue:12 Topics: Adenosine Triphosphate; Aldehyde Reductase; Analysis of Variance; Animals; Cataract; Diabetes Mellit	2014
Aldose reductase expression as a risk factor for cataract. Chemico-biological interactions, 2015, Jun-05, Volume: 234 Topics: Aldehyde Reductase; Animals; Apoptosis; Cataract; Diabetes Complications; Diabetes Mellitus, Experim	2015
Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation. Experimental eye research, 2008, Volume: 87, Issue:5 Topics: Aging; Aldehyde Reductase; Animals; Antioxidants; Cataract; Diabetes Mellitus, Experimental; Disease	2008
Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols. Bioorganic & medicinal chemistry, 2008, Dec-01, Volume: 16, Issue:23 Topics: Aldehyde Reductase; Biphenyl Compounds; Cataract; Diabetes Complications; Eleusine; Flavonoids; Free	2008
Modelling and analysis of the sugar cataract development process using stochastic hybrid systems. IET systems biology, 2009, Volume: 3, Issue:3 Topics: Algorithms; Biochemical Phenomena; Cataract; Computer Simulation; Models, Biological; Models, Chemic	2009
Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats. Molecular vision, 2012, Volume: 18 Topics: Age Factors; Animals; Antioxidants; Cataract; Disease Models, Animal; Disease Susceptibility; Eye Pr	2012
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:6 Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibi	2012
Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation. Experimental eye research, 2012, Volume: 101 Topics: Aldehyde Reductase; Animals; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Electroph	2012
Rhizome of Anemarrhena asphodeloides counteracts diabetic ophthalmopathy progression in streptozotocin-induced diabetic rats. Phytotherapy research : PTR, 2013, Volume: 27, Issue:8 Topics: Anemarrhena; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy	2013
The sorbital pathway in the lens. Experimental eye research, 1962, Volume: 1 Topics: Cataract; Hexoses; Lens, Crystalline; Oxidoreductases; Sorbitol	1962
INHIBITION OF ACTION OF LENS MUTAROTASE ON GLUCOSE BY CATARACTOGENIC SUGARS AND CORRESPONDING POLYOLS. Archives of biochemistry and biophysics, 1963, Volume: 102 Topics: Alcohols; Animals; Arabinose; Carbohydrate Epimerases; Carbohydrates; Cataract; Cattle; Dogs; Enzyme	1963
LENS CELL MEMBRANE PERMEABILITY AND CATARACT FORMATION. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 115 Topics: Adenosine Triphosphate; Alcohols; Animals; Biological Transport; Cataract; Cell Biology; Cell Membra	1964
THE EFFECT OF DIABETES ON THE CONTENT OF SORBITOL, GLUCOSE, FRUCTOSE AND INOSITOL IN THE HUMAN LENS. Experimental eye research, 1964, Volume: 3 Topics: Aging; Cataract; Diabetes Mellitus; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalli	1964
LENS ASSAYS ON DIABETIC AND GALACTOSEMIC RATS RECEIVING DIETS THAT MODIFY CATARACT DEVELOPMENT. Investigative ophthalmology, 1965, Volume: 4 Topics: Amino Acids; Animals; Caseins; Cataract; Diabetes Mellitus, Experimental; Diet; Dietary Carbohydrate	1965
CHANGES ASSOCIATED WITH THE APPEARANCE OF MATURE SUGAR CATARACTS. Investigative ophthalmology, 1965, Volume: 4 Topics: Adenosine Triphosphate; Alcohols; Animals; Carbohydrates; Cataract; Diabetes Mellitus, Experimental;	1965
EPIDEMIOLOGICAL AND BIOCHEMICAL STUDIES OF CATARACT AND DIABETES. Investigative ophthalmology, 1965, Volume: 4 Topics: Carbohydrate Metabolism; Cataract; Cataract Extraction; Diabetes Mellitus; England; Epidemiology; Fr	1965
CARBOHYDRATES OF THE LENS IN NORMAL AND PRECATARACTOUS STATES. Investigative ophthalmology, 1965, Volume: 4 Topics: Animals; Carbohydrate Metabolism; Cataract; Fructose; Glucose; Humans; Lens, Crystalline; Sorbitol;	1965
High-resolution magic angle spinning 1H NMR spectroscopy of metabolic changes in rabbit lens after treatment with dexamethasone combined with UVB exposure. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004, Volume: 242, Issue:12 Topics: Administration, Topical; Animals; Cataract; Combined Modality Therapy; Dexamethasone; Glucocorticoid	2004
Prevention of cataract by pyruvate in experimentally diabetic mice. Molecular and cellular biochemistry, 2005, Volume: 269, Issue:1-2 Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Glycosylation; Lens, Crystalline; Mice; Mice, In	2005
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress. Experimental eye research, 2006, Volume: 83, Issue:4 Topics: Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Progression; Dis	2006
Galactitol and galactose-1-phosphate in the lens of a galactosemic infant. Experimental eye research, 1967, Volume: 6, Issue:1 Topics: Alcohols; Cataract; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Female;	1967
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. Ophthalmic research, 1983, Volume: 15, Issue:4 Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Fructose; Inositol; Lens, Crystalline; Male; Pot	1983
Mechanisms of senile cataract formation. Ophthalmology, 1984, Volume: 91, Issue:6 Topics: Aged; Aldehyde Reductase; Aqueous Humor; Blood Glucose; Cataract; Crystallins; Diabetes Mellitus, Ty	1984
Etiology of cataracts in diabetics. International ophthalmology clinics, 1984,Winter, Volume: 24, Issue:4 Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di	1984
Polyol pathway metabolites in human cataracts. Correlation of circulating glycosylated hemoglobin content and fasting blood glucose levels. Archives of ophthalmology (Chicago, Ill. : 1960), 1984, Volume: 102, Issue:6 Topics: Blood Glucose; Carbohydrates; Cataract; Fructose; Glucose; Glycated Hemoglobin; Humans; Inositol; Le	1984
Altering the course of cataracts in diabetic rats. Investigative ophthalmology & visual science, 1980, Volume: 19, Issue:3 Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Fructose; Len	1980
Aldose reductase in diabetic cataracts. JAMA, 1981, Jul-17, Volume: 246, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus; Humans; Imidazoles; Imidazolidines; L-Idit	1981
Diabetic cataracts- is aldose reductase important? Metabolic and pediatric ophthalmology, 1981, Volume: 5, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Complications; Erythrocytes; Humans; Kinetic	1981
Aldose reductase and the etiology of diabetic cataracts. Current topics in eye research, 1980, Volume: 3 Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Cataract; Child; Child, Preschool; Diabetes Complica	1980
[Effects of M79175, an aldose reductase inhibitor, on experimental sugar cataracts]. Nippon Ganka Gakkai zasshi, 1982, Volume: 86, Issue:9 Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Imidazoles; Imidazol	1982
13C-nuclear magnetic resonance studies of sugar cataractogenesis in the single intact rabbit lens. Investigative ophthalmology & visual science, 1982, Volume: 22, Issue:6 Topics: Animals; Cataract; Glucose; In Vitro Techniques; Lens, Crystalline; Magnetic Resonance Spectroscopy;	1982
Modelling cortical cataractogenesis: 3. In vivo effects of vitamin E on cataractogenesis in diabetic rats. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1982, Volume: 17, Issue:2 Topics: Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Fructose; Glucose; Lens, Crystall	1982
[Reactions in the rats from prolonged consumption of lactose or hydrolyzed lactose. 3. Crystalline lens]. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1982, Volume: 52, Issue:4 Topics: Animals; Cataract; Crystallins; Galactitol; Galactosephosphates; Hydrolysis; Inositol; Lactose; Lens	1982
[Pathogenesis of the diabetic cataract]. Bulletin des societes d'ophtalmologie de France, 1982, Volume: 82, Issue:12 Topics: Adult; Aged; Cataract; Diabetes Mellitus, Type 1; Fructose; Humans; Lens, Crystalline; Sorbitol	1982
[Sugars, polyols and electrolytes in human cataractous lens (author's transl)]. Nippon Ganka Gakkai zasshi, 1980, Oct-10, Volume: 84, Issue:10 Topics: Aged; Cataract; Glucose; Humans; Inositol; Lens, Crystalline; Middle Aged; Potassium; Sodium; Sorbit	1980
Modelling cortical cataractogenesis: 1. In vitro effects of glucose, sorbitol and fructose on intact rat lenses in medium 199. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1980, Volume: 15, Issue:4 Topics: Animals; Carbohydrates; Cataract; Fructose; Glucose; In Vitro Techniques; Lens, Crystalline; Microsc	1980
Modelling cortical cataractogenesis: 2. In vitro effects on the lens of agents preventing glucose- and sorbitol-induced cataracts. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1981, Volume: 16, Issue:1 Topics: Animals; Antioxidants; Cataract; Glucose; In Vitro Techniques; Lens, Crystalline; Male; Microscopy,	1981
Sorbitol-accumulating pyrimidine derivatives. Arzneimittel-Forschung, 1994, Volume: 44, Issue:9 Topics: Animals; Behavior, Animal; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Dose-Response R	1994
Trolox protects hyperglycemia-induced cataractogenesis in cultured rat lens. Research communications in chemical pathology and pharmacology, 1994, Volume: 84, Issue:1 Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Cataract; Cells, Cultured; Chromans; Drug Interacti	1994
Increased lenticular aldose reductase activity and high incidence of congenital cataract in the offspring of diabetic rats. Acta ophthalmologica, 1993, Volume: 71, Issue:5 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Female; Fetus; Incidence; Le	1993
Sugar alcohols in the lens epithelium of age-related cataract. Experimental eye research, 1993, Volume: 56, Issue:1 Topics: Aged; Blood Glucose; Cataract; Diabetes Mellitus; Epithelium; Female; Humans; Inositol; Lens, Crysta	1993
Membrane-bound sorbitol dehydrogenase in human red blood cells. Studies in normal subjects and in enzyme-deficient subjects with congenital cataracts. Journal of inherited metabolic disease, 1993, Volume: 16, Issue:1 Topics: Cataract; Erythrocyte Membrane; Female; Humans; Isoenzymes; Kinetics; L-Iditol 2-Dehydrogenase; Male	1993
Aldose reductase: black sheep or skeleton in the cupboard? Nature structural biology, 1996, Volume: 3, Issue:8 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus,	1996
Effects of a novel potent aldose reductase inhibitor, GP-1447, on aldose reductase activity in vitro and on diabetic neuropathy and cataract formation in rats. Japanese journal of pharmacology, 1997, Volume: 73, Issue:2 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental;	1997
Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. Toxicology, 1997, Dec-05, Volume: 123, Issue:3 Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Me	1997
Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice. Diabetes, 1998, Volume: 47, Issue:6 Topics: Animals; Brain; Cataract; Diabetes Mellitus, Experimental; Fructose; Glucose; Inositol; Introns; Kid	1998
Effects of xylose on monkey lenses in organ culture: a model for study of sugar cataracts in a primate. Experimental eye research, 1998, Volume: 67, Issue:1 Topics: Animals; Cataract; Disease Models, Animal; Galactitol; Galactose; Glucose; Lens, Crystalline; Macaca	1998
Interaction between osmotic and oxidative stress in diabetic precataractous lens: studies with a sorbitol dehydrogenase inhibitor. Biochemical pharmacology, 1999, Dec-15, Volume: 58, Issue:12 Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Glutathione; L-Idito	1999
Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:6 Topics: Aldehyde Reductase; Animals; Blotting, Northern; Carrier Proteins; Cataract; Dietary Carbohydrates;	2000
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:2 Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibito	2000
Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. Diabetes, obesity & metabolism, 2000, Volume: 2, Issue:3 Topics: Adenosine Triphosphate; Animals; Body Weight; Cataract; Crystallins; Diabetes Mellitus, Experimental	2000
Biochemical and morphological changes during development of sugar cataract in Otsuka Long-Evans Tokushima fatty (OLETF) rat. Experimental eye research, 2001, Volume: 73, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Type 2; Disease Models, Animal; L-Iditol 2	2001
Implications of aldose reductase in cataracts in human diabetes. Investigative ophthalmology & visual science, 1979, Volume: 18, Issue:3 Topics: Aldehyde Reductase; Blood Glucose; Cataract; Diabetes Mellitus; Fructose; Glucose; Humans; Inositol;	1979
Efficacy of Alrestatin, an aldose reductase inhibitor, in human diabetic and nondiabetic lenses. Ophthalmology, 1979, Volume: 86, Issue:9 Topics: Aldehyde Reductase; Cataract; Cataract Extraction; Diabetes Complications; Glucose; Humans; Isoquino	1979
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats. Metabolism: clinical and experimental, 1979, Volume: 28, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Benzopyrans; Cataract; Chromans; Diabetes Mellitus, Experimental; Galac	1979
The effect of an unsaturated-fat diet on cataract formation in streptozotocin-induced diabetic rats. The British journal of nutrition, 1976, Volume: 36, Issue:2 Topics: Animals; Aqueous Humor; Carbohydrate Metabolism; Cataract; Diabetes Mellitus; Dietary Fats; Eye; Fat	1976
Absorption, metabolism, and tolerance of polyol sugar substitutes. Pharmacology and therapeutics in dentistry, 1978, Volume: 3, Issue:2-4 Topics: Absorption; Cataract; Chemical Phenomena; Chemistry; Diarrhea; Glucuronates; Humans; Intestinal Abso	1978
Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens. Investigative ophthalmology & visual science, 1977, Volume: 16, Issue:3 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Epi	1977
[Do sorbit and fructose aggravate the diabetic lento- and neuropathy?]. Deutsche medizinische Wochenschrift (1946), 1978, Feb-10, Volume: 103, Issue:6 Topics: Age Factors; Blood Glucose; Cataract; Diabetic Neuropathies; Diet, Diabetic; Fructose; Humans; Sorbi	1978
Coincidental changes in conscious level and lens translucency during treatment of diabetic ketoacidosis. The British journal of ophthalmology, 1975, Volume: 59, Issue:4 Topics: Cataract; Diabetic Coma; Diabetic Ketoacidosis; Female; Humans; Lens, Crystalline; Middle Aged; Sorb	1975
Experimental studies on cataract. Investigative ophthalmology & visual science, 1976, Volume: 15, Issue:9 Topics: Aging; Animals; Ascorbic Acid; Cataract; Crystallins; Diabetic Retinopathy; Humans; Lens, Crystallin	1976
Hyperinsulinemia, insulin resistance and cataract formation in sand rats. Israel journal of medical sciences, 1975, Volume: 11, Issue:7 Topics: Adipose Tissue; Animals; Cataract; Diet; Disease Models, Animal; Galactitol; Glucose; Hyperglycemia;	1975
Sorbitol and other polyols in lens, adipose tissue and urine in diabetes mellitus. Clinica chimica acta; international journal of clinical chemistry, 1975, Aug-18, Volume: 63, Issue:1 Topics: Adipose Tissue; Cataract; Chromatography, Gas; Diabetes Mellitus; Fructose; Glucose; Humans; Inosito	1975
Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity. In vitro and in vivo studies. Archives of medical research, 1992,Spring, Volume: 23, Issue:1 Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Aldehyde Reductase; Animals; Black People	1992
Effect of D-myo-inositol on platelet function and composition and on cataract development in streptozotocin-induced diabetic rats. Biochemical medicine and metabolic biology, 1992, Volume: 48, Issue:1 Topics: Animals; Blood Platelets; Cataract; Diabetes Mellitus, Experimental; Fatty Acids; In Vitro Technique	1992
Anti-oxidant status in an in vitro model for hyperglycaemic lens cataract formation: competition for available nicotinamide adenine dinucleotide phosphate between glutathione reduction and the polyol pathway. Biochemistry international, 1992, Volume: 27, Issue:5 Topics: Animals; Binding, Competitive; Cataract; Esters; Glutathione; Hydrogen Peroxide; Hyperglycemia; In V	1992
Effects of some natural products on sugar cataract studied with nuclear magnetic resonance spectroscopy. Journal of ocular pharmacology, 1992,Summer, Volume: 8, Issue:2 Topics: Animals; Carbon Isotopes; Cataract; Drugs, Chinese Herbal; Flavins; Glucose; Lens, Crystalline; Magn	1992
Myo-inositol transport in the lens of galactose-maintained rats. Current eye research, 1992, Volume: 11, Issue:1 Topics: Animals; Biological Transport, Active; Carbohydrate Metabolism; Cataract; Cell Membrane Permeability	1992
Prevention of galactose cataract by pyruvate. Lens and eye toxicity research, 1992, Volume: 9, Issue:1 Topics: Adenosine Triphosphate; Animals; Cataract; Crystallins; Diet; Disease Models, Animal; Galactitol; Ga	1992
Effects of a new aldose reductase inhibitor on diabetic complications in rats. Arzneimittel-Forschung, 1991, Volume: 41, Issue:11 Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Electrophores	1991
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract. Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:12 Topics: Administration, Topical; Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Len	1991
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat. Metabolism: clinical and experimental, 1991, Volume: 40, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Neuropathies; Diabetic Retinopathy; Female; Kinetics	1991
Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil. Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:6 Topics: Aldehyde Reductase; Animals; Benzofurans; Cataract; Cattle; Diabetic Neuropathies; Hydantoins; Imida	1991
Analysis of diabetic cataractogenesis using chemical-shift nuclear magnetic resonance microscopy. Magnetic resonance in medicine, 1991, Volume: 17, Issue:1 Topics: Animals; Carbon; Cataract; Diabetes Mellitus, Experimental; Female; Glucose; Lactates; Lens, Crystal	1991
In vivo activities of aldose reductase inhibitors having a 1-(arylsulfonyl)hydantoin structure. Biochemical pharmacology, 1990, Jul-15, Volume: 40, Issue:2 Topics: Aldehyde Reductase; Animals; Body Weight; Cataract; Diabetes Mellitus, Experimental; Galactosemias;	1990
In vitro study of aldose reductase inhibitor concentrations in the lens and inhibitory effect on sugar alcohol accumulation. Current eye research, 1990, Volume: 9, Issue:5 Topics: Aldehyde Reductase; Animals; Cataract; Culture Media; Lens, Crystalline; Male; Organ Culture Techniq	1990
Plasma polyol levels in patients with cataract. Journal of inherited metabolic disease, 1990, Volume: 13, Issue:4 Topics: Carbohydrate Epimerases; Cataract; Child, Preschool; Galactitol; Galactokinase; Galactose; Heterozyg	1990
Studies on clinical markers of diabetes mellitus. 6. Red blood cell sorbitol and diabetic complications. Meikai Daigaku shigaku zasshi = The Journal of Meikai University School of Dentistry, 1990, Volume: 19, Issue:2 Topics: Biomarkers; Cataract; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Eryth	1990
Nonosmotic diabetic cataracts. Pediatric research, 1990, Volume: 27, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines;	1990
[Detection of sorbitol content in crystalline lens of normal rats and rats with diabetic cataract by 1H-NMR]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1990, Volume: 21, Issue:2 Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Lens, Crystalline; Magnetic Resonance Spectrosco	1990
The effects of 5% and 25% galactose diets on lens polyols, glutathione and protein glycation in male and female pigs. Current eye research, 1989, Volume: 8, Issue:5 Topics: Animals; Cataract; Chromatography, Gas; Chromatography, High Pressure Liquid; Diet; Female; Galactit	1989
Lens hexitols and cataract formation during lactation in a woman heterozygote for galactosaemia. Journal of inherited metabolic disease, 1989, Volume: 12 Suppl 2 Topics: Adult; Cataract; Female; Galactitol; Galactokinase; Galactosemias; Genetic Carrier Screening; Humans	1989
Photographic and spectroscopic correlations of human cataracts. Ophthalmic research, 1989, Volume: 21, Issue:1 Topics: Aged; Aged, 80 and over; Cataract; Fluorescence; Humans; Lens, Crystalline; Magnetic Resonance Spect	1989
The identification of aldose reductase in the pathogenesis of diabetic complications: the background. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Complications; Diabetes Mellitus; Dia	1985
Lens metabolism and cellular effects of aldose reductase. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazo	1985
Diabetic cataracts in animal models: prevention and reversibility with aldose reductase inhibitors. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Lens, Crystalline; Rats; Sor	1985
Alterations of lens metabolism with experimentally induced cataract in rats. Ophthalmic research, 1988, Volume: 20, Issue:3 Topics: Animals; Cataract; Eye Proteins; Fructose; Glucose; Lens, Crystalline; Naphthalenes; Rats; Solubilit	1988
The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cataract; Cell Membrane; Diabetes Complications	1986
The effect of aldose reductase and its inhibition on sugar cataract formation. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Imid	1986
Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Hyperglycemia; Imidazoles; Imidazolid	1986
The study of diabetic cataractogenesis in the intact rabbit lens by deuterium NMR spectroscopy. Biochemical and biophysical research communications, 1987, Jan-30, Volume: 142, Issue:2 Topics: Aldehyde Reductase; Animals; Cataract; Deuterium; Diabetic Retinopathy; Glucose; In Vitro Techniques	1987
The utilization of 13C and 31P nuclear magnetic resonance spectroscopy in the study of the sorbitol pathway and aldose reductase inhibition in intact rabbit lenses. Experimental eye research, 1987, Volume: 44, Issue:6 Topics: Aldehyde Reductase; Animals; Cataract; Culture Media; Diabetes Complications; Diabetes Mellitus, Exp	1987
Study of experimental cataract produced by sugar alcohols in the organ-cultured mammalian ocular lens. Ophthalmic research, 1988, Volume: 20, Issue:4 Topics: Animals; Aquaporins; Autoradiography; Cataract; Culture Media; Eye Proteins; Lens, Crystalline; Mann	1988
Sorbitol generation and its inhibition by Sorbinil in the aging normal human and rabbit lens and human diabetic cataracts. Ophthalmic research, 1988, Volume: 20, Issue:6 Topics: Adolescent; Adult; Aged; Animals; Cataract; Child; Child, Preschool; Humans; Imidazoles; Imidazolidi	1988
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. Metabolism: clinical and experimental, 1988, Volume: 37, Issue:5 Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias;	1988
[Contents of glucose, sorbitol and fructose in the human lens]. Yan ke xue bao = Eye science, 1986, Volume: 2, Issue:3 Topics: Adult; Aged; Cataract; Female; Fructose; Glucose; Humans; Lens, Crystalline; Male; Reference Values;	1986
Sorbitol production in the lens: a means of counteracting glucose-derived osmotic stress. Ophthalmic research, 1986, Volume: 18, Issue:5 Topics: Animals; Cataract; Glucose; In Vitro Techniques; Lens, Crystalline; Osmotic Pressure; Rabbits; Sorbi	1986
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes, 1985, Volume: 34, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazo	1985
Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat. Metabolism: clinical and experimental, 1985, Volume: 34, Issue:4 Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Dogs; Erythrocytes;	1985
Aldose reductase, NADPH and NADP+ in normal, galactose-fed and diabetic rat lens. Biochimica et biophysica acta, 1985, Sep-06, Volume: 841, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Lens, Crystalline; Male; NAD	1985
[Prevention and reversal of rat galactosemic cataract with aldose reductase inhibitor--immunohistochemical study]. Nippon Ganka Gakkai zasshi, 1985, Volume: 89, Issue:11 Topics: Aldehyde Reductase; Animals; Cataract; Galactose; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcoho	1985
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. Science (New York, N.Y.), 1973, Dec-14, Volume: 182, Issue:4117 Topics: Acetates; Administration, Oral; Alcohol Oxidoreductases; Animals; Cataract; Culture Techniques; Diab	1973
[Pathobiochemistry of the late-onset diabetic syndrome]. Therapie der Gegenwart, 1974, Volume: 113, Issue:9 Topics: Age Factors; Alcohol Oxidoreductases; Animals; Basement Membrane; Cataract; Diabetes Mellitus; Diabe	1974
[Studies of the pentose-phosphate cycle in human cataract lenses]. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1968, Volume: 174, Issue:4 Topics: Cataract; Eye Proteins; Female; Glucose; Glucosephosphate Dehydrogenase; Humans; Lens, Crystalline;	1968
[Pathobiochemistry of the late-onset diabetic syndrome]. Medizinische Klinik, 1974, Sep-06, Volume: 69, Issue:36 Topics: Animals; Carbohydrates; Cataract; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complicatio	1974
[Pathogenesis of angio- and neuropathies in patients with diabetes mellitus]. Sovetskaia meditsina, 1973, Volume: 36, Issue:12 Topics: Blood Vessels; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic	1973
The interaction of the lens and the vitreous. I. The high glucose cataract in a lens-vitreous preparation. Experimental eye research, 1972, Volume: 14, Issue:1 Topics: Animals; Cataract; Culture Media; Fructose; Glucose; Lens, Crystalline; Organ Culture Techniques; Or	1972
Xylose cataract: a comparison between the weanling and the older rat. Experimental eye research, 1969, Volume: 8, Issue:4 Topics: Age Factors; Alcohol Oxidoreductases; Animals; Animals, Newborn; Blood Glucose; Cataract; Cecum; Die	1969
[Biochemical studies on the etiology of cataract in diabetes]. Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1970, Volume: 70 Topics: Alcohol Oxidoreductases; Animals; Cataract; Cattle; Diabetes Complications; Diabetes Mellitus; Fruct	1970
[Biochemical characteristics of the cataract lens. 1. Comparison of water content and concentration of sorbitol, inositol, glutathione and sialic acid in the young and adult rat lens]. Nippon Ganka Gakkai zasshi, 1967, Volume: 71, Issue:7 Topics: Aging; Animals; Cataract; Glutathione; Inositol; Lens, Crystalline; Neuraminic Acids; Rats; Sorbitol	1967
[Effect of glucose and galactose on protein synthesis in the lens]. Ceskoslovenska oftalmologie, 1968, Volume: 24, Issue:4 Topics: Animals; Cataract; Crystallins; Galactose; Glucose; Guinea Pigs; Lens, Crystalline; Rats; Sorbitol	1968
A biochemical evaluation of a cataract induced in a high-glucose medium. Investigative ophthalmology, 1969, Volume: 8, Issue:4 Topics: Animals; Biological Transport, Active; Carbon Isotopes; Cataract; Cell Membrane Permeability; Fructo	1969

sorbitol and Cataract

Research Excerpts

Research

Studies (137)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Lee, YJ	1
Jang, YN	1
Kim, HM	1
Han, YM	1
Seo, HS	1
Eom, Y	1
Song, JS	1
Jeong, JH	1
Jung, TW	1
Kumar, CU	1
Suryavanshi, U	1
Sontake, V	1
Reddy, PY	3
Sankhala, RS	1
Swamy, MJ	1
Reddy, GB	5
Rani, R	1
Singh, G	1
Batra, K	1
Minakshi, P	1
Singh, A	1
Bodakhe, SH	1
Higashi, Y	1
Higashi, K	1
Mori, A	2
Sakamoto, K	2
Ishii, K	2
Nakahara, T	2
Giridharan, NV	2
Balakrishna, N	2
Validandi, V	1
Pullakhandam, R	1
Grama, CN	1
Suryanarayana, P	1
Patil, MA	1
Raghu, G	1
Kumar, MN	1
Sai Varsha, MK	1
Raman, T	1
Manikandan, R	1
Su, S	1
Leng, F	1
Guan, L	1
Zhang, L	1
Ge, J	1
Wang, C	1
Chen, S	1
Liu, P	1
Snow, A	1
Shieh, B	1
Chang, KC	1
Pal, A	1
Lenhart, P	1
Ammar, D	1
Ruzycki, P	1
Palla, S	1
Petrash, JM	1
Chan, AW	1
Ho, YS	1
Chung, SK	4
Chung, SS	4
Chethan, S	1
Dharmesh, SM	1
Malleshi, NG	1
Riley, D	1
Koutsoukos, X	1
Riley, K	1
Kawakubo, K	1
Zhang, P	1
Xing, K	1
Randazzo, J	1
Blessing, K	2
Lou, MF	2
Kador, PF	8
Li, X	2
Cui, X	1
Wang, J	1
Yang, J	1
Sun, X	1
Zhu, Q	1
Li, W	1
VAN HAYNINGEN, R	1
KESTON, AS	1
PATTERSON, JW	3
BUNTING, KW	2
PIRIE, A	2
VANHEYNINGEN, R	1
PATTERSON, ME	1
KINSEY, VE	1
REDDY, DV	1
KUCK, JF	1
Saether, O	1
Risa, O	1
Cejková, J	1
Krane, J	1
Midelfart, A	1
Hegde, KR	1
Varma, SD	8
Huang, P	1
Jiang, Z	2
Teng, S	1
Wong, YC	1
Frohman, MA	1
Gitzelmann, R	1
Curtius, HC	1
Schneller, I	1
Brownlee, M	1
Cerami, A	1
Cogan, DG	1
Kinoshita, JH	13
Robison, G	1
Datilis, MB	1
Cobo, LM	1
Kupfer, C	1
Kuriyama, H	1
Sasaki, K	1
Fukuda, M	1
Maĭstruk, PN	1
Germaniuk, IaL	1
Chylack, LT	6
Richards, RD	3
Gabbay, KH	4
Lerner, BC	1
Fukushi, S	2
Merola, LO	4
Kador, P	2
Catiles, M	1
Crabbe, MJ	2
Wolff, S	1
Halder, AB	1
Ting, HH	1
Ono, H	2
Nozawa, Y	1
Hayano, S	2
González, RG	2
Willis, J	1
Aguayo, J	1
Campbell, P	1
Schleich, T	1
Ross, WM	3
Creighton, MO	3
Stewart-DeHaan, PJ	3
Sanwal, M	3
Hirst, M	1
Trevithick, JR	3
Poiffait, A	1
Frangne, R	1
David, C	1
Manent, PJ	1
Adrian, J	1
Vadot, E	1
Guibal, JP	1
Funahashi, M	1
Komori, T	1
Geisen, K	1
Utz, R	1
Grötsch, H	1
Lang, HJ	2
Nimmesgern, H	1
Ansari, NH	1
Bhatnagar, A	1
Fulep, E	1
Khanna, P	1
Srivastava, SK	1
Simán, CM	1
Naeser, P	1
Eriksson, UJ	1
Belpoliti, M	1
Maraini, G	1
Alvarez, A	2
Martínez, A	1
Ibarra, B	1
Medina, C	2
Bracamontes, M	1
Perea, J	1
Vaca, G	2
Goode, D	1
Wolff, SP	1
Ashizawa, N	1
Yoshida, M	1
Sugiyama, Y	1
Akaike, N	1
Ohbayashi, S	1
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Lee, LW	1
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