sorbitol and Brain Edema studies

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

Excerpt	Relevance	Reference
" Due to its longer efficacy, glycerol provides an important supplement or alternative to sorbitol therapy, especially as the permitted maximum dosage would have to have been exceeded in a treatment consisting exclusively of sorbitol."	5.27	[Intracranial pressure-controlled treatment of brain edema with glycerin and sorbitol in intracerebral hemorrhage]. ( Brenner, M; Haass, A; Hamann, G; Harms, M; Kloss, R; Schimrigk, K, 1987)
"In seven patients with chronic renal failure in an advanced stage 17 episodes of upper abdominal pain, hypertension, vomiting and (in some of them) coma occurred during peritoneal dialysis with sorbitol-containing dialysate."	3.65	[Severe side-effects during peritoneal dialysis caused by sorbitol-containing dialysate (author's transl)]. ( Doht, B; Fernandez-Redo, E; Kubosch, J; Leititis, U; Mietzsch, G; Quellhorst, E; Scheler, F; Thorwirt, V; Volles, E, 1975)
"Volume overload may cause pulmonary edema, and water intoxication may lead to hyponatremia, hypo-osmolarity, and cerebral edema."	2.38	Complications associated with the absorption of hysteroscopic fluid media. ( Burns, WN; Olive, DL; Schenken, RS; Silverberg, KM; Witz, CA, 1993)
"The treatment of cerebral edema has changed during recent years."	2.37	[Current status of treatment of the cerebral edema]. ( Richling, B, 1987)
" Due to its longer efficacy, glycerol provides an important supplement or alternative to sorbitol therapy, especially as the permitted maximum dosage would have to have been exceeded in a treatment consisting exclusively of sorbitol."	1.27	[Intracranial pressure-controlled treatment of brain edema with glycerin and sorbitol in intracerebral hemorrhage]. ( Brenner, M; Haass, A; Hamann, G; Harms, M; Kloss, R; Schimrigk, K, 1987)
"The treatment of cerebral edema must be directed towards improving the volume regulation of the brain cell which is disturbed due to reduced blood flow and hypoxia and towards restoring the disturbed function of the blood-brain barrier."	1.25	[Osmo-oncotherapy in brain edema]. ( Gofferje, H; Landgraf, H; Schultis, K; von Schwerin, W, 1975)
"To investigate the pathophysiology of cerebral edema occurring during treatment of diabetic coma, the effects of hyperglycemia and rapid lowering of plasma glucose were evaluated in normal rabbits."	1.25	Studies on mechanisms of cerebral edema in diabetic comas. Effects of hyperglycemia and rapid lowering of plasma glucose in normal rabbits. ( Arieff, AI; Kleeman, CR, 1973)

Timeframe	Studies, this research(%)	All Research%
pre-1990	55 (91.67)	18.7374
1990's	5 (8.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
STRUCK, G	2
UMBACH, W	2
FRIED, H	1
Tzonos, T	1
Schmidt, K	3
Eife, R	1
Bökenkamp, H	1
Bremer, AM	1
Yamada, K	1
West, CR	1
Spring, A	1
Herrmann, F	2
Gaab, M	3
Pflughaupt, KW	2
Gruss, P	2
Garcia, JH	1
Conger, KA	1
Morawetz, R	1
Halsey, JH	1
Witz, CA	1
Silverberg, KM	1
Burns, WN	1
Schenken, RS	1
Olive, DL	1
Stoll, M	1
Hagen, T	1
Bartylla, K	1
Weber, M	1
Jost, V	1
Treib, J	1
Schwartz, ML	1
Dudziński, W	1
Knoblich, OE	2
Schupp, J	2
Fuhrmeister, U	2
Merrem, B	1
Niebeling, HG	1
Konovalov, AN	1
Manevitsch, AS	1
Sirovski, EB	1
Dietrich, K	1
Fuchs, EC	1
Müller-Busch, HC	1
Goblet, W	1
Quellhorst, E	1
Mietzsch, G	1
Doht, B	1
Fernandez-Redo, E	1
Kubosch, J	1
Leititis, U	1
Volles, E	1
Thorwirt, V	1
Scheler, F	1
Diemath, HE	1
Gofferje, H	1
Landgraf, H	1
von Schwerin, W	1
Schultis, K	1
Nisch, G	1
Gaab, MR	1
Seegers, K	1
Smedema, RJ	1
Heissler, HE	1
Goetz, C	1
Fritz, W	1
Richling, B	1
Haass, A	1
Kloss, R	1
Brenner, M	1
Hamann, G	1
Harms, M	1
Schimrigk, K	1
Brachmann, J	2
Steinhausen, F	1
Goldhahn, WE	1
Dietrich, J	1
Geikler, M	1
Clements, RS	4
Prockop, LD	4
Winegrad, AI	2
Klose, R	1
Neundörfer, B	1
Peter, K	1
Tornow, K	1
Hutschenreuter, K	1
Racenberg, E	1
Dietzel, W	1
Gundlach, K	1
Wiedemann, K	1
Göpel, W	1
Eberle, H	1
Arieff, AI	2
Kleeman, CR	2
Metzel, E	1
Hu, KH	1
Friede, RL	1
Thilman, J	1
Zeumer, H	1
Schädlich, M	1
Baethmann, A	1
Lanksch, W	1
Schmiedek, P	1
Winegard, AI	2
Thiele, G	1
Klimpel, L	1
Blumenthal, SA	1
Morrison, AD	1
Alter, H	1
Franke, K	1
Paul, B	2
Braun, W	1
Gutjahr, L	1
Hemmer, R	1
Grossberger, D	1
Weller, D	1
Berg, U	1
Sandmann, F	1
Janik, B	1
Schulze, R	1
Weber, HE	1
Roesner, J	1
Krasemann, PH	1
Steps, HJ	1

Article	Year
Complications associated with the absorption of hysteroscopic fluid media. Fertility and sterility, 1993, Volume: 60, Issue:5 Topics: Absorption; Anaphylaxis; Blood Coagulation Disorders; Brain Edema; Dextrans; Diuretics; Female; Glyc	1993
[Current status of treatment of the cerebral edema]. Der Anaesthesist, 1987, Volume: 36, Issue:5 Topics: Adrenal Cortex Hormones; Barbiturates; Bed Conversion; Brain Edema; Carbon Dioxide; Combined Modalit	1987

Article	Year
[On changes in oxygen transport capacity following osmo- and oncotherapy]. Der Anaesthesist, 1967, Volume: 16, Issue:11 Topics: Adult; Blood Volume; Brain Edema; Craniotomy; Dextrans; Humans; Infusions, Parenteral; Mathematics;	1967
Changes of cerebral perfusion after osmotherapy in acute cerebral edema assessed with perfusion weighted MRI. Neurological research, 1998, Volume: 20, Issue:6 Topics: Aged; Blood Flow Velocity; Blood Volume; Brain Edema; Cerebral Hemorrhage; Cerebral Infarction; Cere	1998
A comparative analysis of THAM (Tris-buffer) in traumatic brain oedema. Acta neurochirurgica. Supplementum, 1990, Volume: 51 Topics: Adolescent; Animals; Body Water; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cold Temp	1990
[Clinical observations of Rheomacrodex and Rheomacrodex with sorbite in cerebrovascular circulation disorders]. Die Medizinische Welt, 1970, Feb-14, Volume: 7 Topics: Brain Edema; Cerebrovascular Disorders; Dextrans; Female; Humans; Male; Sorbitol	1970

Article	Year
[COMPARATIVE ELECTRONOPTIC STUDIES ON THE HUMAN CEREBRAL CORTEX BEFORE AND AFTER EDEMA THERAPY]. Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin, 1964, Feb-27, Volume: 337 Topics: Brain Edema; Brain Neoplasms; Cerebral Cortex; Edema; Electrons; Humans; Intracranial Pressure; Micr	1964
[THE ELECTRONOPTIC PICTURE OF BRAIN EDEMA IN THE CORTEX AND MEDULLA OF THE SAME PATIENT BEFORE AND AFTER MEDICAL DEHYDRATION]. Neurochirurgia, 1964, Volume: 7 Topics: Brain Edema; Cerebral Cortex; Dehydration; Drug Therapy; Electrons; Humans; Intracranial Pressure; M	1964
[DRUG TREATMENT OF CEREBRAL PRESSURE]. Psychiatrie, Neurologie, und medizinische Psychologie, 1964, Volume: 16 Topics: Brain Edema; Drug Therapy; Humans; Intracranial Pressure; Pressure; Sorbitol; Urea	1964
[The influence of low-molecular dextran with sorbital and tris-buffer in experimental brain edema after microembolism]. Acta neurochirurgica, 1967, Volume: 16, Issue:1 Topics: Animals; Brain; Brain Edema; Buffers; Cats; Dextrans; Intracranial Embolism and Thrombosis; Sorbitol	1967
[On the behavior of the electroencephalogram after osmo-oncotherapy in brain pressure and brain edema]. Acta neurochirurgica, 1967, Volume: 17, Issue:1 Topics: Adult; Blood Pressure; Brain; Brain Edema; Brain Neoplasms; Cerebrovascular Circulation; Dextrans; E	1967
Ischemic cerebral edema in primates: effects of acetazolamide, phenytoin, sorbitol, dexamethasone, and methylprednisolone on brain water and electrolytes. Neurosurgery, 1980, Volume: 6, Issue:2 Topics: Acetazolamide; Animals; Brain; Brain Edema; Brain Ischemia; Cerebral Cortex; Dexamethasone; Haplorhi	1980
[Blood-level changes of lactate and pyruvate after osmotherapy with mannitol and sorbitol (author's transl)]. Neurochirurgia, 1980, Volume: 23, Issue:5 Topics: Acidosis; Adolescent; Adult; Aged; Brain Edema; Brain Neoplasms; Child; Humans; Lactates; Mannitol;	1980
[Medical treatment in experimental brain oedema (author's transl)]. Neurochirurgia, 1981, Volume: 24, Issue:2 Topics: Animals; Brain Chemistry; Brain Edema; Cold Temperature; Dexamethasone; Furosemide; Glycerol; Humans	1981
Postischemic brain edema: quantitation and evolution. Advances in neurology, 1980, Volume: 28 Topics: Blood-Brain Barrier; Body Fluid Compartments; Brain Edema; Brain Ischemia; Caudate Nucleus; Cerebral	1980
Distention fluid complication in hysteroscopic surgery. The Journal of the American Association of Gynecologic Laparoscopists, 1999, Volume: 6, Issue:3 Topics: Animals; Brain Edema; Female; Glycine; Humans; Hyponatremia; Hysteroscopy; Mannitol; Monitoring, Int	1999
[Brain edema as a complication of diabetic ketoacidosis]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1976, Dec-20, Volume: 31, Issue:51 Topics: Blood; Blood Viscosity; Brain; Brain Edema; Cerebrospinal Fluid; Diabetic Ketoacidosis; Glucose; Hum	1976
Effect of furosemide (lasix) on acute severe experimental cerebral edema. Journal of neurology, 1979, May-02, Volume: 220, Issue:3 Topics: Albumins; Animals; Brain Chemistry; Brain Edema; Cats; Dexamethasone; Electroencephalography; Furose	1979
[The influence on water-electrolyte balance through osmotherapy for decreasing intracranial pressure]. Zentralblatt fur Neurochirurgie, 1979, Volume: 40, Issue:3 Topics: Brain Edema; Diuretics, Osmotic; Glycerol; Humans; Intracranial Pressure; Mannitol; Sorbitol; Water-	1979
[The effect of pyritinol on human brain circulation]. Fortschritte der Medizin, 1979, Dec-13, Volume: 97, Issue:47 Topics: Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dextrans; Female; Furosemide; Humans; Male	1979
[The effect of different types of osmotic or oncotic therapy on intracranial pressure and electrical activity of the brain in experimental brain edema]. Acta neurochirurgica, 1978, Volume: 40, Issue:3-4 Topics: Albumins; Animals; Brain Edema; Cats; Central Venous Pressure; Dextrans; Electroencephalography; Gly	1978
[What is achieved by the therapy of brain edema?]. Der Internist, 1976, Volume: 17, Issue:12 Topics: Adrenal Cortex Hormones; Barbiturates; Brain Edema; Carbon Dioxide; Diuretics; Glycerol; Humans; Hyp	1976
Monitoring of intracranial pressure in patients with severe head injury. Neurochirurgia, 1977, Volume: 20, Issue:2 Topics: Adult; Brain Edema; Brain Injuries; Child; Dexamethasone; Humans; Intracranial Pressure; Mannitol; S	1977
[Severe side-effects during peritoneal dialysis caused by sorbitol-containing dialysate (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1975, Jun-27, Volume: 100, Issue:26 Topics: Adult; Brain Edema; Coma; Female; Glucose; Humans; Hypertension; Kidney Failure, Chronic; Male; Midd	1975
[Treatment of traumatic brain edema]. Zeitschrift fur Allgemeinmedizin, 1975, Jul-10, Volume: 51, Issue:19 Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Child; Child, Preschool; Dexamethasone; Diuret	1975
[Osmo-oncotherapy in brain edema]. Infusionstherapie und klinische Ernahrung, 1975, Volume: 2, Issue:5 Topics: Biological Transport; Blood-Brain Barrier; Brain Edema; Fructose; Glucose; Glycerol; Humans; Hyperna	1975
[Prevention of brain edema and dehydrating therapy in acute brain injury]. Zentralblatt fur Chirurgie, 1975, Volume: 100, Issue:13 Topics: Brain; Brain Edema; Brain Injuries; Fructose; Glucose; Mannitol; Osmolar Concentration; Oxygen; Sorb	1975
[Transcranial Doppler ultrasound monitoring of osmo-oncotherapy in neurosurgical patients with brain edema]. Neurochirurgia, 1990, Volume: 33, Issue:6 Topics: Blood Flow Velocity; Brain Diseases; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Criti	1990
[Intracranial pressure-controlled treatment of brain edema with glycerin and sorbitol in intracerebral hemorrhage]. Der Nervenarzt, 1987, Volume: 58, Issue:1 Topics: Administration, Oral; Brain Edema; Cerebral Hemorrhage; Drug Therapy, Combination; Female; Glycerol;	1987
[Optimization of osmotherapy using an intracranial pressure-dependent automatic control system in the postoperative phase following cerebral interventions]. Zentralblatt fur Neurochirurgie, 1987, Volume: 48, Issue:1 Topics: Brain Edema; Dose-Response Relationship, Drug; Humans; Infusion Pumps; Intracranial Pressure; Postop	1987
[Long-term behavior of ventricular fluid pressure in automatically controlled infusion therapy with sorbitol and relation to clinical and paraclinical parameters]. Zentralblatt fur Neurochirurgie, 1987, Volume: 48, Issue:1 Topics: Brain Edema; Brain Neoplasms; Dose-Response Relationship, Drug; Humans; Infusion Pumps; Intracranial	1987
Acute cerebral oedema during treatment of hyperglycaemia. An experimentsl model. Lancet (London, England), 1968, Aug-17, Volume: 2, Issue:7564 Topics: Animals; Blood Glucose; Brain Chemistry; Brain Edema; Dogs; Fructose; Glucose; Hyperglycemia; Intrac	1968
[Conservative treatment of severe craniocerebral injuries]. Zeitschrift fur praktische Anasthesie und Wiederbelebung, 1971, Volume: 6, Issue:2 Topics: Brain; Brain Edema; Brain Injuries; Electroencephalography; Fructose; Humans; Intensive Care Units;	1971
[Problems of anesthesia in brain surgery]. Zeitschrift fur praktische Anasthesie und Wiederbelebung, 1971, Volume: 6, Issue:6 Topics: Anesthesia; Anesthetics; Blood Pressure Determination; Brain; Brain Edema; Cerebrospinal Fluid; Cere	1971
[Methods of anesthesia in intracranial surgery]. Zeitschrift fur praktische Anasthesie und Wiederbelebung, 1971, Volume: 6, Issue:6 Topics: Acidosis; Adolescent; Adult; Aged; Anesthesia; Basal Metabolism; Blood Gas Analysis; Blood Pressure	1971
[Acute AH 3 intoxication with neurologic focal symptoms and pathological EEG in a 13-year-old child]. Zeitschrift fur arztliche Fortbildung, 1972, Dec-01, Volume: 66, Issue:23 Topics: Adolescent; Bees; Brain Edema; Electroencephalography; Histamine H1 Antagonists; Humans; Hypnotics a	1972
[Intensive care of patients with skull and brain injuries]. Helvetica chirurgica acta, 1972, Volume: 39, Issue:5 Topics: Brain Edema; Brain Injuries; Cerebral Angiography; Cerebrovascular Circulation; Humans; Intensive Ca	1972
Studies on mechanisms of cerebral edema in diabetic comas. Effects of hyperglycemia and rapid lowering of plasma glucose in normal rabbits. The Journal of clinical investigation, 1973, Volume: 52, Issue:3 Topics: Amino Acids; Animals; Blood; Blood Glucose; Body Water; Brain; Brain Edema; Cerebrospinal Fluid; Chl	1973
[Urgent diagnostic and therapeutic measures in craniocerebral injuris]. Zeitschrift fur Allgemeinmedizin, 1973, Feb-28, Volume: 49, Issue:6 Topics: Brain Edema; Brain Injuries; Cerebral Angiography; Humans; Injections, Intravenous; Skull Fractures;	1973
Effect of osmolarity of CSF and temperature on the extracellular space of fish brain in vitro. Journal of neuropathology and experimental neurology, 1973, Volume: 32, Issue:4 Topics: Animals; Body Temperature; Brain; Brain Edema; Cerebrospinal Fluid; Extracellular Space; Fishes; Osm	1973
Cerebral edema in diabetic comas. II. Effects of hyperosmolality, hyperglycemia and insulin in diabetic rabbits. The Journal of clinical endocrinology and metabolism, 1974, Volume: 38, Issue:6 Topics: Amino Acids; Animals; Blood; Body Water; Brain Chemistry; Brain Edema; Cerebrospinal Fluid; Chloride	1974
[Treatment of cerebral oedema with high doses of furosemide (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1974, Volume: 99, Issue:18 Topics: Brain Edema; Cerebrospinal Fluid; Diuresis; Electroencephalography; Female; Furosemide; Humans; Inje	1974
[1st aid in life-endangering conditions. Basic problems and therapy]. Zeitschrift fur arztliche Fortbildung, 1974, Feb-15, Volume: 68, Issue:4 Topics: Asparagine; Brain Edema; Electric Countershock; First Aid; Glucose; Heart Arrest; Heart Massage; Hum	1974
Formation and treatment of cerebral edema. Neurochirurgia, 1974, Volume: 17, Issue:2 Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexamethasone; Ethacrynic Ac	1974
A mechanism to explain acute cerebral edema during the treatment of diabetic acidosis. Diabetes, 1968, Volume: 17 Topics: Animals; Blood Glucose; Brain Edema; Carbohydrates; Diabetic Ketoacidosis; Dogs; Electrolytes; Fruct	1968
Hyperglycemia, polyol accumulation, and increased intracranial pressure. Archives of neurology, 1971, Volume: 25, Issue:2 Topics: Animals; Brain; Brain Edema; Cerebrospinal Fluid Proteins; Diabetic Ketoacidosis; Disease Models, An	1971
[Use of sorbitol solutions in anesthesia and resuscitation]. Zeitschrift fur arztliche Fortbildung, 1970, Apr-15, Volume: 64, Issue:8 Topics: Adult; Aged; Anesthesia; Blood Glucose; Brain Edema; Cerebrovascular Circulation; Female; Glucose; H	1970
Increased cerebrospinal fluid pressure during therapy for diabetic acidosis. Transactions of the Association of American Physicians, 1971, Volume: 84 Topics: Adult; Alcohol Oxidoreductases; Animals; Blood Glucose; Brain; Brain Edema; Carbon Dioxide; Cerebros	1971
[Prevention and treatment of brain edema using mannit, sorbit and other diuretics]. Hefte zur Unfallheilkunde, 1972, Volume: 111 Topics: Brain Edema; Diuresis; Diuretics; Humans; Mannitol; Sorbitol	1972
[Diagnostic and therapeutic problems following closed craniocerebral injuries]. Zeitschrift fur arztliche Fortbildung, 1971, Jul-15, Volume: 65, Issue:14 Topics: Blood Pressure; Brain Concussion; Brain Edema; Brain Injuries; Cerebral Angiography; Cerebral Hemorr	1971
[Lead encephalopathy with intracranial pressure elevation in adults]. Zentralblatt fur Neurochirurgie, 1971, Volume: 32, Issue:3 Topics: Adult; Brain Edema; Brain Neoplasms; Calcium; Dextrans; Diagnosis, Differential; Environmental Expos	1971
[Therapy of space-occupying intracranial processes (brain edema, brain tumor) and low cerebrospinal fluid pressure]. Bibliotheca psychiatrica et neurologica, 1969, Volume: 139 Topics: Adrenal Cortex Hormones; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Cerebrospinal Fluid Shun	1969
[Encephalitic brain edema with special regard to therapy]. Zeitschrift fur arztliche Fortbildung, 1970, Volume: 64, Issue:7 Topics: Adrenal Cortex Hormones; Analgesics; Anticonvulsants; Brain Edema; Dextrans; Electroencephalography;	1970
[Brain diseases and dextrose infusions]. Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:6 Topics: Brain Edema; Brain Neoplasms; Child; Glucose; Humans; Hypertonic Solutions; Infant; Infusions, Paren	1970
[Diagnosis and therapy of posttraumatic brain edema]. Die Medizinische Welt, 1971, Mar-20, Volume: 12 Topics: Brain Edema; Brain Injuries; Contusions; Dextrans; Humans; Skull Fractures; Sorbitol	1971
[Modern therapy of brain edema]. Zeitschrift fur arztliche Fortbildung, 1971, Jan-15, Volume: 65, Issue:2 Topics: Aminophylline; Aspartic Acid; Brain Edema; Buffers; Dextrans; Fructose; Glucose; Humans; Hypertonic	1971
["Rheomacrodex 10 per cent with Sorbit 20 per cent" in acute brain and spinal cord edema]. Medizinische Klinik, 1967, May-12, Volume: 62, Issue:19 Topics: Acute Disease; Blood Pressure; Blood Viscosity; Brain Edema; Brain Injuries; Dextrans; Diuretics; Ed	1967
Polyol metabolism and the development of elevated cerebrospinal fluid pressure following sustained hyperglycemia. Neurology, 1968, Volume: 18, Issue:3 Topics: Alcohols; Animals; Brain Edema; Dogs; Fructose; Glucose; Humans; Hyperglycemia; Hypertonic Solutions	1968
[Urea therapy and hemorrhagic diathesis]. Medizinische Klinik, 1966, Apr-08, Volume: 61, Issue:14 Topics: Brain Edema; Calcium; Cerebral Hemorrhage; Hemorrhagic Disorders; Humans; Infusions, Parenteral; Int	1966
[On osmotherapy with urea and sorbitol in the ENT specialty]. HNO, 1966, Volume: 14, Issue:3 Topics: Adolescent; Adult; Brain Abscess; Brain Edema; Humans; Male; Skull Fractures; Sorbitol; Urea	1966

sorbitol and Brain Edema

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