sorbitol has been researched along with Autoimmune Diabetes in 49 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tolrestat disposition was characterized by first-order absorption and biexponential disposition: In normal subjects the terminal disposition half-life (t1/2) was 13 +/- 3 hours (mean +/- SD) and the apparent oral clearance (CL/F) was 48 +/- 9 ml/hr/kg, similar to the values in patients with type I diabetes mellitus (t1/2 = 14 +/- 4 hours; CL/F = 55 +/- 10 ml/hr/kg)." | 2.68 | Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes. ( Chiang, ST; Cohen, AF; Jusko, WJ; Kroon, R; Lemkes, HH; van Griensven, JM; Verhorst, CJ, 1995) |
| "Sorbinil treatment reduced the elevated sorbitol levels in the diabetic patients to normal or slightly below normal, but did not affect the erythrocyte myo-inositol concentration." | 2.65 | myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment. ( Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA, 1984) |
| " In diabetic rats with severe hyperglycemia, oral sorbinil (5 mg/kg) dramatically reduced (80-90%) sorbitol levels in tissues without affecting blood glucose; the RBC dose-response curve was similar to that in lens and sciatic nerve." | 2.65 | Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects. ( Aldinger, CE; Leavengood, H; Malone, JI; O'Brien, MM; Page, MG; Peterson, MJ, 1984) |
| "Cataracts were morphologically different and progressed more slowly in T2DC versus T1DC." | 1.40 | Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes. ( Chen, S; Ge, J; Guan, L; Leng, F; Liu, P; Su, S; Wang, C; Zhang, L, 2014) |
| " These data suggest that increasing NO bioavailability by L-arginine corrects the major biochemical abnormalities of diabetes." | 1.35 | L-Arginine prevents metabolic effects of high glucose in diabetic mice. ( Bhatnagar, A; Kaiserova, K; Ramana, KV; Srivastava, SK; West, MB, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (61.22) | 18.7374 |
| 1990's | 12 (24.49) | 18.2507 |
| 2000's | 4 (8.16) | 29.6817 |
| 2010's | 3 (6.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, S | 1 |
| Leng, F | 1 |
| Guan, L | 1 |
| Zhang, L | 1 |
| Ge, J | 1 |
| Wang, C | 1 |
| Chen, S | 1 |
| Liu, P | 1 |
| Aiello, FC | 1 |
| Trovato, FM | 1 |
| Szychlinska, MA | 1 |
| Imbesi, R | 1 |
| Castrogiovanni, P | 1 |
| Loreto, C | 1 |
| Musumeci, G | 1 |
| Wang, Y | 1 |
| Deng, GG | 1 |
| Davies, KP | 1 |
| West, MB | 1 |
| Ramana, KV | 1 |
| Kaiserova, K | 1 |
| Srivastava, SK | 1 |
| Bhatnagar, A | 1 |
| Colton, SA | 1 |
| Downs, SM | 1 |
| Morenkova, SA | 1 |
| Clarke, BF | 1 |
| Young, RJ | 1 |
| Martyn, CN | 1 |
| Ewing, DJ | 1 |
| Chylack, LT | 1 |
| Varma, SD | 1 |
| Richards, RD | 1 |
| Popp-Snijders, C | 2 |
| Lomecky-Janousek, MZ | 1 |
| Schouten, JA | 1 |
| van der Veen, EA | 2 |
| Malone, JI | 2 |
| Knox, G | 1 |
| Harvey, C | 1 |
| Ward, JD | 1 |
| Pozza, G | 1 |
| Carandente, O | 1 |
| Leavengood, H | 1 |
| Peterson, MJ | 1 |
| O'Brien, MM | 1 |
| Page, MG | 1 |
| Aldinger, CE | 1 |
| Hayashi, M | 1 |
| Ezaki, H | 1 |
| Kojitsu, N | 1 |
| Hayashi, F | 1 |
| Yamashita, F | 1 |
| Vaaler, S | 2 |
| Hanssen, KF | 2 |
| Aagenaes, O | 2 |
| Vadot, E | 1 |
| Guibal, JP | 1 |
| Dyck, PJ | 1 |
| Sherman, WR | 2 |
| Hallcher, LM | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Grina, LA | 1 |
| Palumbo, PJ | 1 |
| Swanson, CJ | 1 |
| Dayhaw-Barker, P | 1 |
| Whikehart, DR | 1 |
| Ishida, Y | 1 |
| Okamoto, R | 1 |
| Mino, M | 1 |
| Konishi, K | 1 |
| Cunningham, JJ | 1 |
| Mearkle, PL | 1 |
| Brown, RG | 1 |
| van Griensven, JM | 1 |
| Jusko, WJ | 1 |
| Lemkes, HH | 1 |
| Kroon, R | 1 |
| Verhorst, CJ | 1 |
| Chiang, ST | 1 |
| Cohen, AF | 1 |
| Ramasamy, R | 2 |
| Oates, PJ | 1 |
| Schaefer, S | 2 |
| Anaja, HP | 1 |
| Hayashi, R | 1 |
| Hayakawa, N | 1 |
| Makino, M | 1 |
| Nagata, M | 1 |
| Kakizawa, H | 1 |
| Uchimura, K | 1 |
| Hamada, M | 1 |
| Aono, T | 1 |
| Fujita, T | 1 |
| Shinohara, R | 1 |
| Nagasaka, A | 1 |
| Itoh, M | 1 |
| Trueblood, N | 1 |
| Fountain, WC | 1 |
| Requena, JR | 1 |
| Jenkins, AJ | 1 |
| Lyons, TJ | 1 |
| Smyth, B | 1 |
| Baynes, JW | 1 |
| Thorpe, SR | 1 |
| Sundkvist, G | 1 |
| Dahlin, LB | 1 |
| Nilsson, H | 1 |
| Eriksson, KF | 1 |
| Lindgärde, F | 1 |
| Rosén, I | 1 |
| Lattimer, SA | 1 |
| Sima, AA | 2 |
| Sullivan, K | 1 |
| Greene, DA | 1 |
| Schatz, H | 1 |
| Winkler, G | 1 |
| Pfeiffer, EF | 1 |
| Loy, A | 1 |
| Lurie, KG | 1 |
| Ghosh, A | 1 |
| Wilson, JM | 1 |
| MacGregor, LC | 1 |
| Matschinsky, FM | 1 |
| Barr, CC | 1 |
| Airey, CM | 1 |
| Price, DE | 1 |
| Kemp, JV | 1 |
| Perkins, CM | 1 |
| Wales, JK | 1 |
| Bareford, D | 1 |
| Jennings, PE | 1 |
| Stone, PC | 1 |
| Baar, S | 1 |
| Barnett, AH | 1 |
| Stuart, J | 1 |
| Williamson, JR | 1 |
| Chang, K | 1 |
| Tilton, RG | 1 |
| Prater, C | 1 |
| Jeffrey, JR | 1 |
| Weigel, C | 1 |
| Eades, DM | 1 |
| Kilo, C | 1 |
| Kowluru, A | 1 |
| Kowluru, R | 1 |
| Bitensky, MW | 1 |
| Corwin, EJ | 1 |
| Solomon, SS | 1 |
| Johnson, JD | 1 |
| Averbuch, M | 1 |
| Weintraub, M | 1 |
| Liao, JC | 1 |
| Brazzell, RK | 1 |
| Dobbs, RE | 1 |
| Bjørneklett, A | 1 |
| Jelling, I | 1 |
| Skrede, G | 1 |
| Fausa, O | 1 |
| Rillaerts, EG | 1 |
| Vertommen, JJ | 1 |
| De Leeuw, IH | 1 |
| Wambua, PP | 1 |
| Juma, FD | 1 |
| Gitau, W | 1 |
| Bertelsmann, FW | 1 |
| Heimans, JJ | 1 |
| van Rooy, JC | 1 |
| Chantelau, E | 1 |
| Nakayama, H | 1 |
| Taneda, S | 1 |
| Aoki, S | 1 |
| Komori, K | 1 |
| Kuroda, Y | 1 |
| Misawa, K | 1 |
| Tsushima, S | 1 |
| Nakagawa, S | 1 |
| Akgün, S | 1 |
| Ertel, NH | 1 |
| Kemp, FW | 1 |
| Lapolla, A | 1 |
| Poli, T | 1 |
| Valerio, A | 1 |
| Fedele, D | 1 |
| Sharkey, TP | 1 |
| Talke, H | 1 |
| Maier, KP | 1 |
| Dawidowicz, A | 1 |
7 reviews available for sorbitol and Autoimmune Diabetes
| Article | Year |
|---|---|
Molecular Links Between Diabetes and Osteoarthritis: The Role of Physical Activity.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diglycerides; Disease Progression; Exercise; G | 2017 |
[Recent advances in the assessment of diabetic control--the clinical parameters as the indices of control].
Topics: Adolescent; Age Factors; Blood Glucose; Blood Proteins; Diabetes Mellitus, Type 1; Diphosphoglyceric | 1982 |
Mechanisms of pathogenesis in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Histocompatibilit | 1995 |
Review: pathogenesis, progression, and therapeutic intervention of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Cataract; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Huma | 1992 |
Diabetic retinopathy.
Topics: Adult; Aldehyde Reductase; Aneurysm; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 1986 |
Diabetes mellitus--present problems and new research. VI. Nephropathy and neuropathy.
Topics: Adult; Alcohol Oxidoreductases; Animals; Cerebrospinal Fluid; Child; Diabetes Mellitus, Type 1; Diab | 1971 |
[Diabetic cataract and modern views on the etiology and pathogenesis of vascular complications during diabetes].
Topics: Age Factors; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus, Type 1; Diabe | 1971 |
8 trials available for sorbitol and Autoimmune Diabetes
| Article | Year |
|---|---|
Aldose reductase inhibition in diabetes.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mel | 1984 |
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment.
Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1984 |
Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects.
Topics: Administration, Oral; Adolescent; Adult; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Di | 1984 |
Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus.
Topics: Adult; Aldehyde Reductase; Ascorbic Acid; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocytes; Fe | 1994 |
Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Erythrocy | 1995 |
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1989 |
Red blood cell sorbitol lowering effects and tolerance of single doses of AL 1576 (HOE 843) in diabetic patients.
Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Double-B | 1988 |
Sorbitol as a sweetener in the diet of insulin-dependent diabetes.
Topics: Adolescent; Adult; Blood Glucose; Breath Tests; Clinical Trials as Topic; Diabetes Mellitus, Type 1; | 1987 |
34 other studies available for sorbitol and Autoimmune Diabetes
| Article | Year |
|---|---|
Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Analysis of Variance; Animals; Cataract; Diabetes Mellit | 2014 |
Novel insights into development of diabetic bladder disorder provided by metabolomic analysis of the rat nondiabetic and diabetic detrusor and urothelial layer.
Topics: Amino Acids, Branched-Chain; Animals; Bile Acids and Salts; Case-Control Studies; Citric Acid Cycle; | 2016 |
L-Arginine prevents metabolic effects of high glucose in diabetic mice.
Topics: Aldehyde Reductase; Animals; Aortitis; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2008 |
Potential role for the sorbitol pathway in the meiotic dysfunction exhibited by oocytes from diabetic mice.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Carbon Isotopes; Cells, Cultured; Crosses, Geneti | 2004 |
[Comparative analysis of dependence of saliva sorbitol and fructosamine levels on blood glucose level in patients with diabetes].
Topics: Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female | 2004 |
Mechanisms of senile cataract formation.
Topics: Aged; Aldehyde Reductase; Aqueous Humor; Blood Glucose; Cataract; Crystallins; Diabetes Mellitus, Ty | 1984 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di | 1984 |
Sorbitol accumulation is altered in type 1 (insulin-dependent) diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Child; Diabetes Mellitus, Type 1; Erythrocytes; Female; Glucose; G | 1984 |
[The problem of the complications of diabetes].
Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellit | 1984 |
[Erythrocyte changes in diabetes].
Topics: 2,3-Diphosphoglycerate; Blood Glucose; Diabetes Mellitus, Type 1; Diphosphoglyceric Acids; Erythrocy | 1983 |
Sucrose and sorbitol as sweeteners in the diet of insulin-dependent diabetics.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diet, Diabetic; Dietary Carbohydrates; | 1980 |
[Pathogenesis of the diabetic cataract].
Topics: Adult; Aged; Cataract; Diabetes Mellitus, Type 1; Fructose; Humans; Lens, Crystalline; Sorbitol | 1982 |
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Fructose; Humans; Inositol; Middle Aged; Periphera | 1980 |
The inhibition of sodium, potassium-stimulated ATPase and corneal swelling: the role played by polyols.
Topics: Animals; Cattle; Cells, Cultured; Corneal Edema; Diabetes Mellitus, Type 1; Endothelium, Corneal; Ga | 1995 |
Red blood cell sorbitol in diabetic children.
Topics: Adolescent; Blood Glucose; Child; Child, Preschool; Diabetes Mellitus, Type 1; Erythrocytes; Female; | 1994 |
Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Benzothiazoles; Blood Glucose; Diabetes Mellitu | 1997 |
Diagnostic performance of red cell sorbitol assay in a Nigerian teaching hospital.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Child; Confidence Intervals; Diabetes Mel | 1997 |
Changes in erythrocyte sorbitol concentrations measured using an improved assay system in patients with diabetic complications and treated with aldose reductase inhibitor.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Blood Glucose; Child; Diabetes Mellitus, Type 1; Diabet | 1998 |
Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cytosol; Diabetes Mellitus, Type 1; Enzyme Inhibitors; | 1998 |
Quantification of N-(glucitol)ethanolamine and N-(carboxymethyl)serine: two products of nonenzymatic modification of aminophospholipids formed in vivo.
Topics: Aging; Amines; Diabetes Mellitus, Type 1; Erythrocyte Membrane; Gas Chromatography-Mass Spectrometry | 1999 |
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Human | 2000 |
[Sweetening agents and sugar substituting agents in the diet of juvenile diabetic patients].
Topics: Adolescent; Child; Child, Institutionalized; Child, Preschool; Cyclamates; Diabetes Mellitus, Type 1 | 1977 |
Diabetes and the myo-inositol paradox.
Topics: Animals; Aqueous Humor; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 1990 |
Effects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus.
Topics: Adult; Aged; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability | 1986 |
Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes. Prevention by aldose reductase inhibitors and castration.
Topics: Aldehyde Reductase; Animals; Aorta; Blood Glucose; Body Weight; Capillary Permeability; Castration; | 1987 |
Suggested mechanism for the selective excretion of glucosylated albumin. The effects of diabetes mellitus and aging on this process and the origins of diabetic microalbuminuria.
Topics: Adolescent; Adult; Aging; Albuminuria; Animals; Cations; Child; Diabetes Mellitus, Experimental; Dia | 1987 |
Effect of statil (ICI 128436) on erythrocyte viscosity in vitro.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Erythrocytes; Female; Hu | 1988 |
Sorbitol levels in normal Africans and in insulin dependent diabetics.
Topics: Africa; Black People; Diabetes Mellitus, Type 1; Humans; Reference Values; Sorbitol | 1988 |
Peripheral nerve function in relation to quality of metabolic control in diabetes.
Topics: Adolescent; Adult; Aged; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythrocytes; Female; Hum | 1987 |
[Sugar substitutes in the diet therapy of type I diabetes mellitus].
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Diet, Diabetic; Fructose; Glucose; Humans; Sorbitol; Sweet | 1986 |
Antibodies to nonenzymatically glucosylated albumin in the human serum.
Topics: Adult; Antigens; Autoantibodies; Binding, Competitive; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1985 |
Red cell sorbitol and diabetic control.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocytes; Humans; Male; Middle Aged; Sorbitol; | 1985 |
Is red cell sorbitol content a good marker of glycemic control in diabetic patients?
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocytes; Female; Glycated Hemoglobin; Hu | 1985 |
[Glucose, fructose, sorbitol and xylitol metabolism in man].
Topics: Acidosis; Adenine Nucleotides; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Fructose; Glucose; | 1973 |