sorbitol and Anemia, Hypochromic studies

Anemia, Hypochromic: Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)

Research Excerpts

Excerpt	Relevance	Reference
"An investigation has been performed with a new parenteral iron preparation, iron-poly-(sorbitol-gluconic acid) complex (Ferastral) in the treatment with iron deficiency anaemia associated with inflammatory diseases, mainly rheumatoid arthritis."	5.04	Ferastral in the treatment of patients with inflammatory anaemia. ( Strandberg, O; Wijnbladh, E, 1977)
"The treatment of iron-deficiency anaemia in pregnancy with a new intramuscular iron preparation, iron-poly (sorbitol-gluconic acid) complex (Ferastral), has been assessed and compared with oral iron therapy."	5.04	The treatment of iron-deficiency anaemia with a new intramuscular iron preparation (Ferastral). ( Ayeni, O; Ogunbode, O; Oluboyede, OA, 1977)
"One hundred and twenty-eight patients with iron deficiency anemia were treated with a new intramuscular iron preparation, iron-sorbitol-citric acid."	3.64	PRELIMINARY REPORT ON AN IRON-SORBITOL-CITRIC ACID COMPLEX (JECTOFER), A NEW INTRAMUSCULAR IRON PREPARATION. ( LEY, DC; ROBINSON, SC, 1964)
"Mebendazole-treated subjects remained worm-free and the hookworm egg counts of the controls decreased during the study period."	1.26	The relationship of hookworm infection, anaemia and iron status in a Papua New Guinea highland population and the response to treatment with iron and mebendazole. ( Blunden, RW; Casey, GJ; Kimber, RJ; Kutkaite, D; Payne, R; Shield, JM; Vaterlaws, AL, 1981)
" Thereafter, the absorption rate is slower, and 32 days after the injection 94% has been absorbed from the injection site."	1.26	Studies on an iron-poly(sorbitol-gluconic acid) complex for parenteral treatment of iron deficiency anaemia. ( Domeij, K; Hellström, V; Högberg, KG; Lindvall, S; Ortengren, B; Rydell, G; Wichman, U, 1977)

Timeframe	Studies, this research(%)	All Research%
pre-1990	61 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
ANDERSSON, NS	2
JORDAL, R	1
KRISTENSEN, MB	1
PRINGLE, A	1
GOLDBER, GA	1
MACDONALD, E	1
JOHNSTON, S	1
SCOTT, JM	1
CHANEY, CH	1
BARNHART, CE	1
GALLOWAY, R	1
GATENBY, PB	1
LEY, DC	1
ROBINSON, SC	1
SHALABY, ES	1
ABDEL-SALAM, R	1
MCCURDY, PR	2
MAIER, C	1
REZAKOVIC, D	1
STRANDBERG, O	3
Scott, DE	1
Saltin, AS	1
Pritchard, JA	1
Bernát, SI	1
Soós, G	1
Shield, JM	1
Vaterlaws, AL	1
Kimber, RJ	1
Payne, R	1
Casey, GJ	1
Blunden, RW	1
Kutkaite, D	1
Oluboyede, OA	3
Ogunbode, O	2
Ayeni, O	2
Callender, ST	1
Campbell, BC	1
Lawrence, JR	1
Sumner, DJ	1
Kelman, A	1
Smith, A	1
Elliott, HL	1
Goldberg, A	1
Abdulkadyrov, KM	1
Beliakova, TA	1
Andrianova, IG	2
Lake-Bakaar, DM	1
Lindvall, S	3
Reizenstein, P	1
Domeij, K	1
Hellström, V	1
Högberg, KG	1
Rydell, G	1
Wichman, U	1
Ortengren, B	1
Sundin, T	1
Ploem, JE	1
Bloem, JA	1
Eriksson, H	1
Svärd, PO	1
Simonsson, B	1
Birgegård, G	1
Killander, A	1
Levander, H	1
Grafford, K	1
Swedberg, B	1
Norrby, A	1
Sölvell, L	1
Evers, JE	2
Lockner, D	1
Paul, C	1
Wijnbladh, E	1
Esan, GJ	1
Salako, LA	1
Akande, EO	1
Ezem, BU	1
Fleming, AF	2
Werblińska, B	2
Knight, R	1
Svanberg, B	1
Rybo, G	1
Dujardin, M	1
Ricci-Bitti, ML	1
Marti, HR	1
Barbotin, M	1
Charles, D	1
Darracq, R	1
Olsson, KS	1
Dube, SK	1
Walia, BN	1
Perkash, A	1
Mehta, BC	1
Bhatt, PD	1
Gandhi, SG	1
Patel, JC	1
Blekta, M	1
Komanec, J	1
Andrásová, V	1
Jarý, J	1
Hlavatý, V	1
Hermanská, Z	1
Homolka, J	1
Carlsson, H	1
Thafvelin, B	1
Nakao, K	1
Maekawa, T	1
Horiuchi, H	1
Shirakura, T	1
Ebara, H	1
Colin, C	1
Lejeune, P	1
Alekseev, NA	1
Ivanova, NA	1
Mikhaĭlova, MS	1
Abazid, MA	1
Ostroukhova, TM	1
Cochrane, JC	1
Verhave, TH	1
Nohemí Akemi, M	1
Fröhlich, E	1
Siubaeva, NI	1
Dygin, VP	1
Antonov, VB	1
Segal, J	2
Galal, EE	1
Nasr, A	1
Kandil, A	1
Nabil, M	1
Awad, K	1
el Far, N	1

Article	Year
Iron deficiency anaemia during pregnancy a comparative trial of treatment by iron-poly (sorbitol-gluconic acid) complex Ferastral given intramuscularly and iron dextran (Imferon) by total dose infusion. East African medical journal, 1980, Volume: 57, Issue:9 Topics: Anemia, Hypochromic; Clinical Trials as Topic; Female; Gluconates; Humans; Infusions, Parenteral; In	1980
A pharmacokinetic and clinical evaluation of iron poly (sorbitol-gluconic acid) complex. Pharmatherapeutica, 1980, Volume: 2, Issue:7 Topics: Anemia, Hypochromic; Drug Evaluation; Female; Gluconates; Hematinics; Humans; Injections, Intramuscu	1980
Ferastral treatment of three healthy phlebotomized males. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adult; Anemia, Hypochromic; Bloodletting; Clinical Trials as Topic; Drug Combinations; Gluconates; H	1977
Studies on an iron-poly (sorbitol-gluconic acid) complex for parenteral use in man. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adult; Anemia, Hypochromic; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Electrocar	1977
A clinical investigation of an iron-poly (sorbitol-gluconic acid) complex, Ferastral, for the treatment of iron deficiency anaemia. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Clinical Trials as Topic; Drug Combinations; Drug Eval	1977
Haemoglobin synthesis following injection of iron-poly (sorbitol-gluconic acid) complex, Ferastral. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adult; Anemia, Hypochromic; Bone Marrow; Clinical Trials as Topic; Dose-Response Relationship, Drug;	1977
Iron-poly (sorbitol-gluconic acid) complex and iron-dextran in the treatment of severe iron deficiency anaemia. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Anemia, Hypochromic; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Drug Hypersensiti	1977
Clinical trial of a new intramuscular iron preparation in iron deficiency anaemia. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adult; Aged; Anemia, Hypochromic; Bone Marrow; Clinical Trials as Topic; Dose-Response Relationship,	1977
Ferastral in the treatment of patients with inflammatory anaemia. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Anemia, Hypochromic; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Combinations; Drug Evalua	1977
Clinical trial of Ferastral in iron-deficient, non-pregnant patients in Ibadan, Nigeria. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Anemia, Hypochromic; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Gluconate	1977
Treatment of severe iron-deficiency anaemia of hookworm infestation with Ferastral, a new intramuscular iron preparation. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adolescent; Adult; Anemia, Hypochromic; Bephenium Compounds; Clinical Trials as Topic; Drug Combinat	1977
The use of Ferastral in iron-deficient, non-pregnant Gambian adults. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Clinical Trials as Topic; Drug Combinations; Drug Eval	1977
Side-effects and placental function in six pregnant women treated with Ferastral. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Anemia, Hypochromic; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Estrogens; Female	1977
The treatment of iron-deficiency anaemia with a new intramuscular iron preparation (Ferastral). Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Administration, Oral; Anemia, Hypochromic; Bone Marrow; Clinical Trials as Topic; Drug Combinations;	1977
Ferastral, an iron-poly (sorbitol-gluconic acid) complex, in the treatment of severe iron-deficiency anaemia in pregnancy. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adolescent; Adult; Amniotic Fluid; Anemia, Hypochromic; Clinical Trials as Topic; Drug Combinations;	1977
Availability of iron sorbitol for hemoglobin formation as studied with phlebotomy. Acta medica Scandinavica, 1972, Volume: 192, Issue:6 Topics: Administration, Oral; Adult; Anemia, Hypochromic; Blood Volume; Bloodletting; Bone Marrow; Bone Marr	1972

Article	Year
Clinical investigations on a new intramuscular haematinic. British medical journal, 1961, Jul-29, Volume: 2, Issue:5247 Topics: Anemia; Anemia, Hypochromic; Citrates; Hematinics; Hematologic Diseases; Humans; Injections, Intramu	1961
[Iron therapy. A survey of iron-deficiency diseases together with experiences with Jectofer treatment]. Maanedsskrift for praktisk laegegerning og social Medicin, 1962, Volume: 40 Topics: Anemia; Anemia, Hypochromic; Citric Acid; Drug Combinations; Ferric Compounds; Humans; Iron; Sorbito	1962
59Fe iron sorbitol citric-acid complex in iron-deficiency anaemia. Lancet (London, England), 1962, Oct-13, Volume: 2, Issue:7259 Topics: Anemia, Hypochromic; Anemia, Iron-Deficiency; Citrates; Citric Acid; Drug Combinations; Ferric Compo	1962
Iron-sorbitol-citrate in pregnancy anaemia. British medical journal, 1963, Aug-10, Volume: 2, Issue:5353 Topics: Anemia, Hypochromic; Citrates; Citric Acid; Drug Combinations; Female; Ferric Compounds; Humans; Iro	1963
THE EFFECT OF IRON SUPPLEMENTATION ON THE PREVENTION OF ANEMIA IN BABY PIGS. American journal of veterinary research, 1964, Volume: 25 Topics: Anemia; Anemia, Hypochromic; Animals; Animals, Newborn; Ascorbic Acid; Blood Volume Determination; D	1964
IRON-SORBITOL COMPLEX IN THE TREATMENT OF IRON DEFICIENCY IN PREGNANCY. Journal of the Irish Medical Association, 1964, Volume: 54 Topics: Anemia, Hypochromic; Citric Acid; Drug Combinations; Female; Ferric Compounds; Humans; Iron; Iron-De	1964
PRELIMINARY REPORT ON AN IRON-SORBITOL-CITRIC ACID COMPLEX (JECTOFER), A NEW INTRAMUSCULAR IRON PREPARATION. Canadian Medical Association journal, 1964, Aug-08, Volume: 91 Topics: Anemia; Anemia, Hypochromic; Anemia, Iron-Deficiency; Citrates; Citric Acid; Drug Combinations; Drug	1964
RE-EVALUATION OF PARENTERAL IRON THERAPY. The Journal of the Egyptian Medical Association, 1964, Volume: 47 Topics: Anemia; Anemia, Hypochromic; Biomedical Research; Citrates; Drug Therapy; Injections; Injections, In	1964
PARENTERAL IRON THERAPY. II. A NEW IRON-SORBITOL CITRIC ACID COMPLEX FOR INTRA-MUSCULAR INJECTION. Annals of internal medicine, 1964, Volume: 61 Topics: Anemia; Anemia, Hypochromic; Biomedical Research; Citrates; Citric Acid; Drug Combinations; Drug The	1964
[JECTOFER, A NEW PREPARATION FOR INTRAMUSCULAR IRON INJECTION]. Schweizerische medizinische Wochenschrift, 1964, May-09, Volume: 94 Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Pernicious; Citric Acid; Drug Combinations;	1964
ORAL AND PARENTERAL IRON THERAPY: A COMPARISON. JAMA, 1965, Mar-08, Volume: 191 Topics: Anemia; Anemia, Hypochromic; Biomedical Research; Dosage Forms; Drug Therapy; Humans; Injections; In	1965
[JECTOFER IN THE TREATMENT OF IRON-DEFICIENCY ANEMIAS]. Medicinski glasnik, 1964, Volume: 18 Topics: Anemia; Anemia, Hypochromic; Anemia, Iron-Deficiency; Citric Acid; Drug Combinations; Drug Therapy;	1964
ISOTOPE STUDIES OF THE DISTRIBUTION OF JECTOFER IN PATIENTS WITH RHEUMATOID ARTHRITIS AND IN HEALTH SUBJECTS. Acta rheumatologica Scandinavica, 1965, Volume: 11 Topics: Anemia; Anemia, Hypochromic; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Blood; Citrates;	1965
Iron sorbitex for treating iron-deficiency anemia. Obstetrics and gynecology, 1967, Volume: 30, Issue:5 Topics: Anemia, Hypochromic; Citrates; Dextrans; Female; Genital Diseases, Female; Hemoglobinometry; Humans;	1967
[A new method for the determination of iron concentration in urine and its use in intramuscular iron load for the reliable and early detection of iron deficiency conditions]. Folia haematologica (Leipzig, Germany : 1928), 1983, Volume: 110, Issue:3 Topics: Adult; Aged; Anemia, Hypochromic; Citrates; Citric Acid; Drug Combinations; Female; Ferric Compounds	1983
The relationship of hookworm infection, anaemia and iron status in a Papua New Guinea highland population and the response to treatment with iron and mebendazole. Papua and New Guinea medical journal, 1981, Volume: 24, Issue:1 Topics: Anemia, Hypochromic; Benzimidazoles; Drug Therapy, Combination; Ethnicity; Female; Ferritins; Folic	1981
[Treatment of iron deficiency anemia and the prevention of its recurrences using Soviet iron-containing preparations]. Klinicheskaia meditsina, 1980, Volume: 58, Issue:4 Topics: Adult; Anemia, Hypochromic; Drug Evaluation; Female; Ferrous Compounds; Humans; Iron; Male; Middle A	1980
Distribution of 59Fe-labelled iron-poly(soribitol-gluconic acid) complex in normal and anaemic rats. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Anemia, Hypochromic; Animals; Bone and Bones; Diet; Drug Combinations; Feces; Gluconates; Injections	1977
Metabolic studies of iron-poly (sorbitol-gluconic acid) complex, Ferastral. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adult; Aged; Anemia, Hypochromic; Drug Combinations; Drug Evaluation; Erythrocytes; Female; Gluconat	1977
Studies on an iron-poly(sorbitol-gluconic acid) complex for parenteral treatment of iron deficiency anaemia. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Absorption; Anemia, Hypochromic; Animals; Cats; Chemical Phenomena; Chemistry; Dogs; Drug Combinatio	1977
Kinetic studies on an intramuscular iron-poly (sorbitol-gluconic acid) complex. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adult; Aged; Anemia, Hypochromic; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluati	1977
Compensation for blood loss in plastic surgery with ferastral and autologous blood transfusion. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Adolescent; Adult; Anemia, Hypochromic; Blood Transfusion, Autologous; Breast; Female; Gluconates; H	1977
Pharmacological studies on an iron-poly-(sorbitol-gluconic acid) complex for parenteral treatment of iron deficiency anaemia. Scandinavian journal of haematology. Supplementum, 1977, Volume: 32 Topics: Acetylcholine; Anemia, Hypochromic; Animals; Blood Coagulation; Blood Pressure; Cardiovascular Syste	1977
Treatment of iron deficiency in Nigerians with daily intramuscular Ferastral. Annals of tropical medicine and parasitology, 1979, Volume: 73, Issue:2 Topics: Adolescent; Adult; Anemia, Hypochromic; Child; Female; Gluconates; Hemoglobinometry; Hookworm Infect	1979
Anemia in rheumatoid arthritis. Acta medica Scandinavica. Supplementum, 1966, Volume: 454 Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aged; Anemia, Hypochromic;	1966
[Intestinal absorption of iron]. Il Policlinico. Sezione pratica, 1968, Aug-12, Volume: 75, Issue:33 Topics: Adult; Age Factors; Anemia, Hypochromic; Ascorbic Acid; Diphosphates; Female; Humans; Intestinal Abs	1968
[Diagnosis and therapy of iron deficiency]. La Clinica terapeutica, 1974, Jul-15, Volume: 70, Issue:1 Topics: Administration, Oral; Anemia, Hypochromic; Humans; Injections, Intravenous; Iron; Iron-Dextran Compl	1974
[Treatment of iron deficiency anemia in African women. Use of an injectable ferric complex]. Bulletin de la Societe medicale d'Afrique noire de langue francaise, 1974, Volume: 19, Issue:2 Topics: Adult; Anemia, Hypochromic; Citrates; Drug Combinations; Female; Humans; Iron; Middle Aged; Sorbitol	1974
Tolerance and response to a high single dose of iron sorbitol citrate complex in children with iron deficiency anaemia. The Indian journal of medical research, 1972, Volume: 60, Issue:3 Topics: Anemia, Hypochromic; Child; Child, Preschool; Female; Humans; Infant; Iron; Male; Sorbitol	1972
Iron sorbitol: study of utilization and excretion using Fe-59. Indian journal of medical sciences, 1973, Volume: 27, Issue:5 Topics: Anemia, Hypochromic; Humans; Iron; Iron Radioisotopes; Sorbitol; Thalassemia	1973
[Administration of Jectofer in the treatment of hypochromic sideropenic anaemia during pregnancy (author's transl)]. Ceskoslovenska gynekologie, 1973, Volume: 38, Issue:9 Topics: Anemia, Hypochromic; Citrates; Drug Combinations; Female; Humans; Iron; Pregnancy; Pregnancy Complic	1973
Properties of a complex of iron and a sorbitol-gluconic acid polymer for treatment of piglet anaemia. Acta veterinaria Scandinavica, 1974, Volume: 15, Issue:1 Topics: Anemia, Hypochromic; Animals; Drug Combinations; Drug Tolerance; Gluconates; Hemoglobins; Iron; Iron	1974
Studies on the metabolism of iron sorbitol. Acta haematologica, 1967, Volume: 37, Issue:5 Topics: Adolescent; Adult; Anemia, Hypochromic; Animals; Erythrocyte Count; Female; Hemoglobinometry; Humans	1967
[A new parenteral iron preparation for the treatment of post-partum anemia]. Ginecologia y obstetricia de Mexico, 1972, Volume: 31, Issue:185 Topics: Anemia, Hypochromic; Drug Combinations; Female; Folic Acid; Humans; Injections, Intramuscular; Iron;	1972
[Ferbitol treatment of hypoferric anemia in children]. Voprosy okhrany materinstva i detstva, 1971, Volume: 16, Issue:7 Topics: Adolescent; Anemia, Hypochromic; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; I	1971
[Study of the speed of absorption of ferbitol from the muscles]. Problemy gematologii i perelivaniia krovi, 1970, Volume: 15, Issue:3 Topics: Absorption; Anemia, Hypochromic; Animals; Humans; Injections, Intramuscular; Iron; Muscles; Rabbits;	1970
Fatality associated with injection of Jectofer. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1970, Nov-14, Volume: 44, Issue:45 Topics: Anemia, Hypochromic; Citrates; Drug Hypersensitivity; Female; Humans; Infant; Iron; Iron-Dextran Com	1970
[Treatment of anemias of pregnancy and the puerperium with iron-sorbitol complex]. Ginecologia y obstetricia de Mexico, 1970, Volume: 28, Issue:170 Topics: Anemia, Hypochromic; Female; Folic Acid; Humans; Iron; Pregnancy; Pregnancy Complications, Hematolog	1970
[Pharmacological and toxicological studies with a new organic iron complex for intramuscular application]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:11 Topics: Absorption; Anemia, Hypochromic; Animals; Delayed-Action Preparations; Drug Compounding; Drug Stabil	1970
[Experience in the use of an iron preparation, ferbitol, for intramuscular administration in iron deficiency anemias]. Terapevticheskii arkhiv, 1971, Volume: 43, Issue:1 Topics: Anemia, Hypochromic; Female; Humans; Injections, Intramuscular; Iron; Male; Sorbitol	1971
[Clinical observations on the use of ferro-sorbitol in the treatment of iron-deficiency anemias]. Revista brasileira de medicina, 1965, Volume: 22, Issue:7 Topics: Adolescent; Adult; Anemia, Hypochromic; Child, Preschool; Citrates; Female; Humans; Iron; Male; Midd	1965
[Clinical observations on the use of ferro-sorbitol in the treatment of iron-deficiency anemias]. Revista brasileira de medicina, 1965, Volume: 22, Issue:7 Topics: Adolescent; Adult; Anemia, Hypochromic; Child, Preschool; Citrates; Female; Humans; Iron; Male; Midd	1965
Assessment of a new iron intramuscular compound in animals and human beings. The Journal of the Egyptian Medical Association, 1965, Volume: 48 Topics: Anemia, Hypochromic; Animals; Citrates; Humans; Injections, Intramuscular; Iron; Iron-Dextran Comple	1965
Evaluation of an iron preparation for intramuscular use. Iron sorbitex (jectofer). JAMA, 1966, Jul-11, Volume: 197, Issue:2 Topics: Anemia, Hypochromic; Citrates; Humans; Injections, Intramuscular; Iron; Sorbitol	1966

sorbitol and Anemia, Hypochromic

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