sorbitol has been researched along with Alloxan Diabetes in 356 studies
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract." | 8.02 | Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 7.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| " However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin." | 5.39 | Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013) |
| " One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more." | 5.30 | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997) |
| "Sorbinil treatment completely prevented renal cortical sorbital accumulation, but did not abolish kidney enlargement or the increase in ultrafiltration pressure and glomerular filtration rate." | 5.28 | Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats. ( Aperia, A; Celsi, G; Eklöf, AC; Körner, A; Linné, T; Persson, B, 1992) |
| " This study intends to examine the effects of sea buckthorn and metformin on body weight, water and feed intake, glycaemia, insulinemia, sorbitol accumulation and cataract development in Zucker diabetic fatty rats, which represent an animal model of type 2 Diabetes mellitus, as well as to characterize the individual content of bioactive substances and the antioxidant activity of sea buckthorn." | 4.12 | The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats. ( Brindza, J; Capcarova, M; Dupak, R; Hrnkova, J; Ivanisova, E; Kalafova, A; Kovac, J; Prnova, MS; Schneidgenova, M; Simonova, N; Tokarova, K, 2022) |
| " The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract." | 4.02 | Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021) |
| "On SAC administration in the rats with diabetes, the levels of blood glucose, insulin resistance, glycated hemoglobin, AR, SDH, sorbitol, fructose, TBARS and hydroperoxide increased significantly (p<0." | 3.83 | Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes. ( Begum, MS; Meriga, B; Munipally, PK; Naidu, PB; Naik, RR; Pandiyan, R; Pothani, S; Saravanan, G; Sathibabu Uddandrao, VV; Varatharaju, C, 2016) |
| " A single, intraperitoneal injection of streptozotocin (STZ) (35 mg/kg) resulted in hyperglycemia, accumulation of sorbitol and formation of advanced glycation end product (AGE) in eye lens." | 3.80 | Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. ( Manikandan, R; Raman, T; Sai Varsha, MK, 2014) |
| "In sugar cataract formation in rats, aldose reductase (AR) activity is not only linked to lenticular sorbitol (diabetic) or galactitol (galactosemic) formation but also to signal transduction changes, cytotoxic signals and activation of apoptosis." | 3.78 | Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation. ( Blessing, K; Kador, PF; Lou, MF; Randazzo, J; Xing, K; Zhang, P, 2012) |
| "We examined the effects of GP-1447 (3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]-5-methylphenyl acetic acid) on existing cataracts and sorbitol content in the lens in rats with streptozotocin-induced diabetes." | 3.78 | GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. ( Ishii, K; Kawakubo, K; Mori, A; Nakahara, T; Sakamoto, K, 2012) |
| "To study aldose reductase and the sorbitol pathway in periodontitis and diabetes, rats with experimental periodontitis with or without diabetes were treated with three structurally diverse aldose reductase inhibitors (ARIs)." | 3.77 | Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats. ( Blessing, K; Kador, PF; Marx, DB; O'Meara, JD; Reinhardt, RA, 2011) |
| " Serum-advanced glycation end-products level, malonaldehyde level, sorbitol concentration of red blood cell, 24 h albuminuria excretion were significantly decreased, whereas activity of serum superoxide dismutase and glutathione peroxidase and creatinine clearance rate were increased by mangiferin." | 3.76 | Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats. ( Cui, X; Li, W; Li, X; Sun, X; Zhu, Q, 2010) |
| "Oral administration of fidarestat attenuated leukocyte accumulation in the retina of STZ induced-diabetic rats, suggesting that fidarestat may have a therapeutic role in preventing the progression of diabetic retinopathy." | 3.76 | Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. ( Hattori, T; Matsubara, A; Ogura, Y; Taniguchi, K, 2010) |
| "Peripheral hyperglycemia was associated with significant increases in brain sorbitol (7." | 3.74 | Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. ( Chong, L; Diamond, DM; Hanna, S; Malone, JI; Mervis, RF; Park, CR; Saporta, S, 2008) |
| "Studies show that the pyruvate treatment decreased the extent of several biochemical changes known to be associated with cataract formation, such as the elevation in the levels of glycated proteins, sorbitol, lipid peroxidation (MDA) and inhibition of the cation pump." | 3.70 | Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. ( Ali, AH; Devamanoharan, PS; Henein, M; Varma, SD; Zhao, W, 2000) |
| "The relative importance of sorbitol formation versus nonenzymatic glycosylation and advanced glycosylation end products (AGEs) on sugar cataract formation was examined in diabetic rats." | 3.70 | Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. ( Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF, 2000) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 3.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| "To study the influence of the course of diabetes, aging, and glycemia on the sorbitol accumulation in diabetic rats." | 3.69 | Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods. ( Batista, MR; Bazotte, RB; Brunaldi, K; Ferraz, M; Ishii-Iwamoto, EL, 1997) |
| "It has been suggested that sugar cataracts associated with diabetes mellitus result from the accumulation of excess sorbitol within lens fibrils." | 3.68 | Nonosmotic diabetic cataracts. ( Cook, WR; Lowitt, S; Malone, JI, 1990) |
| "NADPH and NADP+ levels were measured in rat lens from normal controls, from galactose-fed and diabetic rats during the first week of cataract formation." | 3.67 | Aldose reductase, NADPH and NADP+ in normal, galactose-fed and diabetic rat lens. ( Doughty, CC; Lee, SM; Schade, SZ, 1985) |
| "Aldose reductase (AR) and sorbitol dehydrogenase (SDH) make up the sorbitol pathway, which has been implicated in the pathogenesis of sugar cataracts." | 3.65 | Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens. ( Collins, JG; Corder, CN, 1977) |
| " In diabetic rats with severe hyperglycemia, oral sorbinil (5 mg/kg) dramatically reduced (80-90%) sorbitol levels in tissues without affecting blood glucose; the RBC dose-response curve was similar to that in lens and sciatic nerve." | 2.65 | Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects. ( Aldinger, CE; Leavengood, H; Malone, JI; O'Brien, MM; Page, MG; Peterson, MJ, 1984) |
| "Sorbinil is an effective ARI, which could play therapeutic role in treating diabetes and diabetic complications." | 2.61 | Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. ( Huang, Q; Liu, Q; Ouyang, D, 2019) |
| "Cataracts were morphologically different and progressed more slowly in T2DC versus T1DC." | 1.40 | Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes. ( Chen, S; Ge, J; Guan, L; Leng, F; Liu, P; Su, S; Wang, C; Zhang, L, 2014) |
| "Recently a zwitterionic principle has been suggested as an alternative to bioisosteric replacement for increasing low bioavailability of aldose reductase inhibitors bearing an acidic function." | 1.40 | A novel zwitterionic inhibitor of aldose reductase interferes with polyol pathway in ex vivo and in vivo models of diabetic complications. ( Karasova, MJ; Prnova, MS; Stefek, M, 2014) |
| " However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin." | 1.39 | Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013) |
| "Fidarestat treatment did not affect diabetes-induced increase in glucose concentrations, but normalized sorbitol and fructose concentrations (enzymatic spectrofluorometric assays) as well as 12(S)-hydroxyeicosatetraenoic concentration (ELISA), a measure of 12/15-lipoxygenase activity, in the sciatic nerve and spinal cord." | 1.38 | Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. ( Hirooka, H; Nadler, JL; Obrosova, IG; Shevalye, H; Stavniichuk, R, 2012) |
| " Single oral dosing studies were performed in rats, mice and dogs to assess the abilities of TS-071 to increase urinary glucose excretion and to lower plasma glucose levels." | 1.37 | TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity. ( Arai, M; Asami, J; Fukuhara, N; Gunji, E; Kitano, K; Kojima, N; Kozakai, A; Okumura-Kitajima, L; Takahashi, K; Takahashi, T; Tomoike, H; Toyoda, H; Uchida, S; Yamamoto, K, 2011) |
| " Owing to aldose reductase pharmacophore requirements for an acidic proton, most aldose reductase inhibitors contain an acetic acid moiety, ionized at physiological pH, resulting in poor bioavailability of the drugs." | 1.37 | (2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature. ( Juskova, M; Milackova, I; Snirc, V; Stefek, M; Triantos, N; Tsantili-Kakoulidou, A, 2011) |
| " These data suggest that increasing NO bioavailability by L-arginine corrects the major biochemical abnormalities of diabetes." | 1.35 | L-Arginine prevents metabolic effects of high glucose in diabetic mice. ( Bhatnagar, A; Kaiserova, K; Ramana, KV; Srivastava, SK; West, MB, 2008) |
| "In magnolol-treated GK rats, fasting blood glucose and plasma insulin were significantly decreased, and the pancreatic islets also showed strong insulin antigen positivity." | 1.34 | Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. ( Jang, DS; Jung, DH; Kim, CS; Kim, JS; Kim, YS; Lee, YM; Sohn, EJ, 2007) |
| " In rats, its oral bioavailability is 98% and it has a favorable plasma t(1/2) (26 +/- 3 h)." | 1.33 | A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners. ( Armento, SJ; Beebe, DA; Conn, EL; Coutcher, JB; Dina, MS; Linhares, MC; Martin, WH; Mylari, BL; O'Gorman, MT; Oates, PJ; Tess, DA; Withbroe, GJ; Zembrowski, WJ, 2005) |
| "Fidarestat did not cause direct inhibition of PARP activity in a cell-free system containing PARP and NAD(+) but did counteract high-glucose-induced PARP activation in Schwann cells." | 1.33 | Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. ( Hirooka, H; Obrosova, IG; Pacher, P; Stevens, MJ; Szabó, C; Yorek, MA; Zsengeller, Z, 2005) |
| " Based on these observations, we suggest that NO regulates the vascular synthesis of polyols by S-thiolating AR; therefore, increasing NO synthesis or bioavailability may be useful in preventing diabetes-induced changes in the polyol pathway." | 1.32 | Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells. ( Bhatnagar, A; Chandra, D; Ramana, KV; Srivastava, S; Srivastava, SK, 2003) |
| " It is well absorbed in rats (oral bioavailability, 98%) and has a long plasma t(1/2) (26 +/- 3 h)." | 1.32 | A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one. ( Armento, SJ; Beebe, DA; Conn, EL; Coutcher, JB; Dina, MS; Linhares, MC; Martin, WH; Mylari, BL; O'Gorman, MT; Oates, PJ; Tess, DA; Withbroe, GJ; Zembrowski, WJ, 2003) |
| "Fidarestat inhibited the increase with an IC50 value of 18 nmol/l." | 1.31 | Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes. ( Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K, 2001) |
| "Sorbinil treatment essentially corrected diabetes-induced sorbitol and fructose accumulation, myo-inositol depletion, decrease in free cytosolic NAD+:NADH ratio and energy deficiency." | 1.31 | Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study. ( Fathallah, L; Obrosova, IG, 2000) |
| "After 6 weeks of untreated streptozotocin diabetes, rats were treated for 2 weeks." | 1.30 | Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. ( Basso, M; Cameron, NE; Cotter, MA; Hohman, TC, 1997) |
| " One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more." | 1.30 | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997) |
| "Methylguanidine was only approximately 7% as effective as aminoguanidine as an inhibitor of AGE formation from L-lysine and G6P; both compounds were poor inhibitors of AR." | 1.29 | Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. ( Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG, 1993) |
| " In accordance with the polyol theory, the chronic administration of SDI 157 to diabetic rats accelerated the cataract development and depleted the lens of total and oxidized glutathione." | 1.29 | Sorbitol-accumulating pyrimidine derivatives. ( Geisen, K; Grötsch, H; Lang, HJ; Nimmesgern, H; Utz, R, 1994) |
| "Myo-inositol levels were 18% decreased by diabetes." | 1.28 | Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats. ( Cameron, NE; Cotter, MA; Dines, K; Love, A, 1992) |
| "Sorbinil treatment completely prevented renal cortical sorbital accumulation, but did not abolish kidney enlargement or the increase in ultrafiltration pressure and glomerular filtration rate." | 1.28 | Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats. ( Aperia, A; Celsi, G; Eklöf, AC; Körner, A; Linné, T; Persson, B, 1992) |
| "Iloprost was administered intraperitoneally to streptozotocin-induced diabetic rats at a dose of 10 micrograms/kg/day for a month." | 1.28 | Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats. ( Ito, H; Kanazawa, A; Miwa, T; Ohno, A; Tanaka, A, 1992) |
| "Diaminoguanidine was a stronger inhibitor than monoaminoguanidine." | 1.28 | Inhibition of diabetes-associated complications by nucleophilic compounds. ( Bansal, V; Kumari, K; Sahib, MK; Umar, S, 1991) |
| " These results demonstrated that the chronic administration of monotard insulin may decrease AR activity and sorbitol content in the lens of STZ-diabetic rats without lowering glucose levels." | 1.28 | [Effect of insulin on aldose reductase activity in the lens of rats with streptozotocin-induced diabetes]. ( Nishigami, T, 1990) |
| "Inositol was diminished in diabetes to 0." | 1.28 | Myocardial inositol and sodium in diabetes. ( Beyer-Mears, A; Fusilli, LD; Regan, TJ; Torres, R, 1992) |
| "Myo-inositol was reduced approximately 50%." | 1.28 | [Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats]. ( Lu, KM; Zhong, XL; Zhu, QY; Zhu, XX, 1990) |
| "With ponalrestat treatment, the increase in contraction time was only 11%, and relaxation was only slowed by 4% (p less than 0." | 1.28 | Contractile properties of cardiac papillary muscle in streptozotocin-diabetic rats and the effects of aldose reductase inhibition. ( Cameron, NE; Cotter, MA; Robertson, S, 1989) |
| "Myo-inositol treatment did not affect nerve levels." | 1.28 | The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats. ( Cameron, NE; Cotter, MA; Robertson, S, 1989) |
| " In the retinas of controls, dosage with ICI 105552 reduced the concentration of sorbitol by 36% without other effects." | 1.27 | The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats. ( Earl, DC; Heath, H; Mirrlees, DJ; Poulsom, R, 1983) |
| "Sorbinil treatment at 20 mg ." | 1.27 | Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition. ( Gillon, KR; Hawthorne, JN; Tomlinson, DR, 1983) |
| "This study examined the effect of streptozotocin diabetes of 5 weeks duration on the profile of slow orthogradely transported radiolabelled protein in rat sciatic motoneurones." | 1.27 | Slow orthograde axonal transport of radiolabelled protein in sciatic motoneurones of rats with short-term experimental diabetes: effects of treatment with an aldose reductase inhibitor or myo-inositol. ( Mayer, JH; McLean, WG; Tomlinson, DR, 1984) |
| "Inositol was not detectable from stage I." | 1.27 | Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. ( Fukuda, M; Kuriyama, H; Sasaki, K, 1983) |
| "To test the possible involvement of the sorbitol pathway in the pathogenesis of retinopathy in long-term experimentally-diabetic rats, streptozotocin-diabetic and normal rats were dosed orally (50 mg/kg body weight daily) for up to 373 days with an aldose reductase inhibitor (ICI 105552) or a placebo." | 1.27 | The effects of long-term treatment of streptozotocin-diabetic rats with an aldose reductase inhibitor. ( Boot-Handford, RP; Heath, H; Poulsom, R, 1983) |
| "Two new potent aldose reductase inhibitors, AL-1567 (DL-spiro(2-fluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione) and AL-1576 (spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)2',5'-dione), have been characterized with respect to in vitro activity toward rat lens and human placental aldose reductase and in vivo activity in uncontrolled, severely diabetic rats dosed acutely with the compounds." | 1.27 | Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats. ( Chandler, ML; Griffin, BW; McNatt, LG; York, BM, 1987) |
| "Sorbinil treatment, initiated after 8 weeks of diabetes, and without effect on sciatic nerve glucose levels, normalized sorbitol concentrations following 4, 8, or 12 weeks of treatment but only partially reversed the accumulation of fructose by 368, 161 and 199%, compared to age-matched non-diabetic control values, at the above times, respectively." | 1.27 | Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil. ( Ross, IS; Whiting, PH, 1988) |
| "Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave." | 1.27 | The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988) |
| "Treatment with Sorbinil (25 mg/kg/day, p." | 1.27 | Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. ( Mayer, JH; Moriarty, RJ; Tomlinson, DR, 1984) |
| "Acute alloxan diabetes was associated with decreased AR in small arteries, but not glomeruli." | 1.26 | Aldose reductase and sorbitol dehydrogenase distribution in rat kidney. ( Brannan, TS; Collins, JG; Corder, CN; Sharma, J, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 156 (43.82) | 18.7374 |
| 1990's | 116 (32.58) | 18.2507 |
| 2000's | 48 (13.48) | 29.6817 |
| 2010's | 32 (8.99) | 24.3611 |
| 2020's | 4 (1.12) | 2.80 |
| Authors | Studies |
|---|---|
| Gessei, T | 1 |
| Monkawa, A | 1 |
| Arakawa, T | 1 |
| Mitsubayashi, K | 1 |
| Dupak, R | 1 |
| Hrnkova, J | 1 |
| Simonova, N | 1 |
| Kovac, J | 1 |
| Ivanisova, E | 1 |
| Kalafova, A | 1 |
| Schneidgenova, M | 1 |
| Prnova, MS | 2 |
| Brindza, J | 1 |
| Tokarova, K | 1 |
| Capcarova, M | 1 |
| Singh, A | 1 |
| Bodakhe, SH | 1 |
| Daniels, LJ | 1 |
| Annandale, M | 1 |
| Koutsifeli, P | 1 |
| Li, X | 5 |
| Bussey, CT | 1 |
| van Hout, I | 1 |
| Bunton, RW | 1 |
| Davis, PJ | 1 |
| Coffey, S | 1 |
| Katare, R | 1 |
| Lamberts, RR | 1 |
| Delbridge, LMD | 1 |
| Mellor, KM | 1 |
| Nakatsu, Y | 1 |
| Kokubo, H | 1 |
| Bumdelger, B | 1 |
| Yoshizumi, M | 1 |
| Yamamotoya, T | 1 |
| Matsunaga, Y | 1 |
| Ueda, K | 1 |
| Inoue, Y | 1 |
| Inoue, MK | 1 |
| Fujishiro, M | 1 |
| Kushiyama, A | 1 |
| Ono, H | 3 |
| Sakoda, H | 1 |
| Asano, T | 1 |
| Huang, Q | 1 |
| Liu, Q | 3 |
| Ouyang, D | 1 |
| Kimura, T | 1 |
| Obata, A | 1 |
| Shimoda, M | 1 |
| Okauchi, S | 1 |
| Kanda-Kimura, Y | 1 |
| Nogami, Y | 1 |
| Moriuchi, S | 1 |
| Hirukawa, H | 1 |
| Kohara, K | 1 |
| Nakanishi, S | 1 |
| Mune, T | 1 |
| Kaku, K | 1 |
| Kaneto, H | 2 |
| Higashi, Y | 1 |
| Higashi, K | 1 |
| Mori, A | 2 |
| Sakamoto, K | 2 |
| Ishii, K | 3 |
| Nakahara, T | 2 |
| Io, F | 1 |
| Gunji, E | 2 |
| Koretsune, H | 1 |
| Kato, K | 3 |
| Sugisaki-Kitano, M | 1 |
| Okumura-Kitajima, L | 2 |
| Kimura, K | 1 |
| Uchida, S | 2 |
| Yamamoto, K | 2 |
| Reddy, PY | 1 |
| Giridharan, NV | 1 |
| Balakrishna, N | 2 |
| Validandi, V | 1 |
| Pullakhandam, R | 1 |
| Reddy, GB | 3 |
| Grama, CN | 1 |
| Suryanarayana, P | 1 |
| Patil, MA | 1 |
| Raghu, G | 1 |
| Kumar, MN | 1 |
| Wang, ZH | 2 |
| Hsieh, CH | 1 |
| Liu, WH | 1 |
| Yin, MC | 3 |
| Sai Varsha, MK | 1 |
| Raman, T | 1 |
| Manikandan, R | 1 |
| Su, S | 1 |
| Leng, F | 1 |
| Guan, L | 1 |
| Zhang, L | 1 |
| Ge, J | 1 |
| Wang, C | 1 |
| Chen, S | 1 |
| Liu, P | 1 |
| Snow, A | 1 |
| Shieh, B | 1 |
| Chang, KC | 2 |
| Pal, A | 1 |
| Lenhart, P | 1 |
| Ammar, D | 1 |
| Ruzycki, P | 1 |
| Palla, S | 1 |
| Petrash, JM | 2 |
| Karasova, MJ | 1 |
| Stefek, M | 3 |
| Hao, W | 2 |
| Tashiro, S | 1 |
| Hasegawa, T | 1 |
| Sato, Y | 1 |
| Kobayashi, T | 1 |
| Tando, T | 1 |
| Katsuyama, E | 1 |
| Fujie, A | 1 |
| Watanabe, R | 1 |
| Morita, M | 1 |
| Miyamoto, K | 1 |
| Morioka, H | 1 |
| Nakamura, M | 1 |
| Matsumoto, M | 1 |
| Amizuka, N | 1 |
| Toyama, Y | 1 |
| Miyamoto, T | 1 |
| Soltesova Prnova, M | 1 |
| Ballekova, J | 1 |
| Gajdosikova, A | 1 |
| Gajdosik, A | 1 |
| Freeman, OJ | 1 |
| Unwin, RD | 1 |
| Dowsey, AW | 1 |
| Begley, P | 1 |
| Ali, S | 1 |
| Hollywood, KA | 1 |
| Rustogi, N | 1 |
| Petersen, RS | 1 |
| Dunn, WB | 1 |
| Cooper, GJ | 1 |
| Gardiner, NJ | 1 |
| Wang, Y | 1 |
| Deng, GG | 1 |
| Davies, KP | 1 |
| Naidu, PB | 1 |
| Sathibabu Uddandrao, VV | 1 |
| Naik, RR | 1 |
| Pothani, S | 1 |
| Munipally, PK | 1 |
| Meriga, B | 1 |
| Begum, MS | 1 |
| Varatharaju, C | 1 |
| Pandiyan, R | 1 |
| Saravanan, G | 1 |
| West, MB | 1 |
| Ramana, KV | 4 |
| Kaiserova, K | 1 |
| Srivastava, SK | 4 |
| Bhatnagar, A | 4 |
| Kato, A | 1 |
| Minoshima, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Protein Profile of Immunoregulatory Factors in Diabetic Cataract[NCT01832311] | Phase 4 | 61 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.[NCT00846092] | Phase 1 | 4 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for sorbitol and Alloxan Diabetes
| Article | Year |
|---|---|
Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Enzyme Inhibit | 2019 |
The biochemistry of the complications of diabetes mellitus.
Topics: Animals; Axonal Transport; Basement Membrane; Blood Platelets; Blood Proteins; Cataract; Diabetes Co | 1981 |
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy.
Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1984 |
[Sorbitol and its role in nutrition].
Topics: Animals; Blood Glucose; Cataract; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, Diabetic | 1983 |
The aldose reductase controversy.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimen | 1994 |
Limitations of the polyol hypothesis in the pathobiology of experimental diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Humans; Models, Ne | 1993 |
Does neuropathy develop in animal models?
Topics: Animals; Axotomy; Biological Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dise | 1997 |
Modulators of free radical activity in diabetes mellitus: role of ascorbic acid.
Topics: Animals; Antioxidants; Ascorbic Acid; Diabetes Mellitus; Diabetes Mellitus, Experimental; Free Radic | 1992 |
The link between hyperglycaemia and diabetic nephropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; Glyco | 1992 |
Cardiomyopathy associated with noninsulin-dependent diabetes.
Topics: Animals; Animals, Newborn; Calcium; Cardiomyopathies; Carrier Proteins; Diabetes Mellitus, Experimen | 1991 |
The anomeric malaise: a manifestation of B-cell glucotoxicity.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glycogen; Glycosylatio | 1991 |
[Diabetic neuropathy--a review of pathological studies].
Topics: Adolescent; Adult; Aged; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mo | 1991 |
Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice.
Topics: Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Female; Fru | 1988 |
Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and (Na,K)-ATPase regulation in diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves | 1986 |
Sorbitol, osmoregulation, and the complications of diabetes.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Kidney | 1988 |
[New theories of the pathogenesis of diabetic neuropathies].
Topics: Animals; Carbohydrate Metabolism; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic | 1974 |
[Pathogenesis and prophylaxis of diabetic micro-angiopathy (author's transl)].
Topics: Alcohol Oxidoreductases; Animals; Basement Membrane; Cell Membrane; Collagen; Diabetes Mellitus, Exp | 1974 |
[The role of carbohydrates in parenteral feeding].
Topics: Alcohols; Animals; Carbohydrate Metabolism; Carbohydrates; Diabetes Mellitus, Experimental; Fructose | 1971 |
2 trials available for sorbitol and Alloxan Diabetes
| Article | Year |
|---|---|
Aldose reductase inhibition in diabetes.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mel | 1984 |
Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects.
Topics: Administration, Oral; Adolescent; Adult; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Di | 1984 |
336 other studies available for sorbitol and Alloxan Diabetes
| Article | Year |
|---|---|
Blood sorbitol measurement in diabetic rats treated with an aldose reductase inhibitor using an improved fiber-optic sorbitol biosensor.
Topics: Aldehyde Reductase; Animals; Biosensing Techniques; Blood Glucose; Diabetes Mellitus, Experimental; | 2022 |
The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Frui | 2022 |
Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract.
Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; | 2021 |
Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fructokinases; F | 2021 |
The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cell Adhesion Molecules; Cytokines; Diabetes Mel | 2017 |
Protective effects of the SGLT2 inhibitor luseogliflozin on pancreatic β-cells in db/db mice: The earlier and longer, the better.
Topics: Animals; Cells, Cultured; Cytoprotection; Diabetes Complications; Diabetes Mellitus, Experimental; D | 2018 |
Anti-cataract Effect of Resveratrol in High-Glucose-Treated Streptozotocin-Induced Diabetic Rats.
Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Crystallins; Diabetes Complicati | 2018 |
SGL5213, a novel and potent intestinal SGLT1 inhibitor, suppresses intestinal glucose absorption and enhances plasma GLP-1 and GLP-2 secretion in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose; | 2019 |
Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol.
Topics: Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Galactose; Glucose; Hot Temperature | 2013 |
Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model.
Topics: Aldehyde Reductase; Animals; Antioxidants; Biocompatible Materials; Biodegradation, Environmental; B | 2013 |
Glycyrrhizic acid attenuated glycative stress in kidney of diabetic mice through enhancing glyoxalase pathway.
Topics: Aldehyde Reductase; Animals; Chemokine CCL2; Diabetes Mellitus, Experimental; Dose-Response Relation | 2014 |
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis.
Topics: Animals; Blood Glucose; Calcium; Calcium-Transporting ATPases; Cataract; Diabetes Mellitus, Experime | 2014 |
Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Analysis of Variance; Animals; Cataract; Diabetes Mellit | 2014 |
Aldose reductase expression as a risk factor for cataract.
Topics: Aldehyde Reductase; Animals; Apoptosis; Cataract; Diabetes Complications; Diabetes Mellitus, Experim | 2015 |
A novel zwitterionic inhibitor of aldose reductase interferes with polyol pathway in ex vivo and in vivo models of diabetic complications.
Topics: Aldehyde Reductase; Animals; Biological Availability; Diabetes Complications; Diabetes Mellitus, Exp | 2014 |
Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation.
Topics: Aldehyde Reductase; Animals; Calcitriol; Cell Dedifferentiation; Cells, Cultured; Demyelinating Dise | 2015 |
A novel carboxymethylated mercaptotriazinoindole inhibitor of aldose reductase interferes with the polyol pathway in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Male; Polymers; Rats; Rats, Wistar; Si | 2015 |
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; | 2016 |
Novel insights into development of diabetic bladder disorder provided by metabolomic analysis of the rat nondiabetic and diabetic detrusor and urothelial layer.
Topics: Amino Acids, Branched-Chain; Animals; Bile Acids and Salts; Case-Control Studies; Citric Acid Cycle; | 2016 |
Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes.
Topics: Aldehyde Reductase; Animals; Biomarkers; Blood Glucose; Cysteine; Diabetes Mellitus, Experimental; F | 2016 |
L-Arginine prevents metabolic effects of high glucose in diabetic mice.
Topics: Aldehyde Reductase; Animals; Aortitis; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2008 |
Protective effects of dietary chamomile tea on diabetic complications.
Topics: Aldehyde Reductase; alpha-Amylases; Animals; Beverages; Blood Glucose; Diabetes Complications; Diabe | 2008 |
Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation.
Topics: Aging; Aldehyde Reductase; Animals; Antioxidants; Cataract; Diabetes Mellitus, Experimental; Disease | 2008 |
Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Dendrites; Dendritic Spines; Diabetes Mellitus, Experimen | 2008 |
Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Fructose; In Vitro Techn | 2009 |
Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation.
Topics: Animals; Blood Vessels; Diabetes Mellitus, Experimental; Male; NAD; Nervous System; Oxidation-Reduct | 2010 |
Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice.
Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Caffeic Acids; Cyt | 2010 |
Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats.
Topics: Albuminuria; Animals; Blood Glucose; Cell Proliferation; Cells, Cultured; Collagen Type IV; Creatini | 2010 |
Skeletal muscle sorbitol levels in diabetic rats with and without insulin therapy and endurance exercise training.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Exercise Test; Hypoglycemic Agents; Insulin | 2009 |
Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo.
Topics: Acridine Orange; Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus | 2010 |
Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
Topics: Aldehyde Reductase; Alveolar Bone Loss; Animals; Antioxidants; Citric Acid Cycle; Diabetes Mellitus, | 2011 |
Polyol profile as an early diagnostic and prognostic marker in natural product chemoprevention of hepatocellular carcinoma in diabetic rats.
Topics: Aldehyde Reductase; Allyl Compounds; alpha-Fetoproteins; Animals; Ascorbic Acid; Blood Glucose; Carc | 2011 |
TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity.
Topics: Animals; Blood Glucose; CHO Cells; Cricetinae; Cricetulus; Deoxyglucose; Diabetes Mellitus; Diabetes | 2011 |
Protective effects of an aqueous extract from pepino (Solanum muricatum Ait.) in diabetic mice.
Topics: Aldehyde Reductase; Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Catalase; Chemokine CCL2; D | 2011 |
Effective compounds group of Mongolian prescriptions BAIMAI-SAN protect against peripheral neuropathy in lower limbs of rats through neuro protective effect.
Topics: Animals; Brain; Cell Culture Techniques; Cell Survival; Cells, Cultured; Diabetes Complications; Dia | 2011 |
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.
Topics: Acetates; Aldehyde Reductase; Animals; Antioxidants; Diabetes Mellitus, Experimental; Disease Models | 2011 |
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
Topics: Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Gluco | 2012 |
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibi | 2012 |
Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation.
Topics: Aldehyde Reductase; Animals; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Electroph | 2012 |
Rhizome of Anemarrhena asphodeloides counteracts diabetic ophthalmopathy progression in streptozotocin-induced diabetic rats.
Topics: Anemarrhena; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy | 2013 |
Polyol pathway mediates enhanced degradation of extracellular matrix via p38 MAPK activation in intervertebral disc of diabetic rats.
Topics: ADAM Proteins; Aggrecans; Aldehyde Reductase; Animals; Blood Glucose; Blotting, Western; Body Weight | 2013 |
Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Flavonoids; Iridace | 2002 |
[Effect of gui xin tong on sorbitol and nerve conduction velocity in diabetic rats].
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Drug Combinations; Drugs, Chinese Herb | 1999 |
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Glucose; Imidazoles; Imi | 2002 |
Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes.
Topics: Aldehyde Reductase; Animals; Blood-Retinal Barrier; Capillary Permeability; Cattle; Cells, Cultured; | 2002 |
Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Angiogenesis Inducing Agents; Animals; Cattle; Cells, Cultured; Diabetes Mellitu | 2003 |
Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Aorta; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Mic | 2003 |
A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Biological Availability; Caco-2 Cells; Combinator | 2003 |
The metabolism of sorbitol in diseased states. I. In vitro study of the metabolism of sorbitol, fructose and glucose in alloxandiabetic and CC14-poisoning rats.
Topics: Animals; Carbohydrate Metabolism; Carbon Tetrachloride; Diabetes Mellitus, Experimental; Fructose; G | 1961 |
[Formation of liver and muscle glycogen from xylitol, sorbitol and glucose in healthy and alloxan-diabetic rats].
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glucose; Glycogen; Liver; Liver Glycogen; Muscles | 1963 |
[Experimental and clinical studies on serum sorbitol dehydrogenase activity].
Topics: Animals; Diabetes Mellitus, Experimental; Humans; L-Iditol 2-Dehydrogenase; Liver Diseases; Oxidatio | 1962 |
THE METABOLISM OF C14-LABELED GLUCOSE, FRUCTOSE AND SORBITOL IN ALLOXAN DIABETIC AND CCL4-POISONING ANIMALS.
Topics: Alloxan; Animals; Carbohydrate Metabolism; Carbon Isotopes; Carbon Tetrachloride Poisoning; Diabetes | 1963 |
LENS CELL MEMBRANE PERMEABILITY AND CATARACT FORMATION.
Topics: Adenosine Triphosphate; Alcohols; Animals; Biological Transport; Cataract; Cell Biology; Cell Membra | 1964 |
HISTOCHEMICAL STUDY ON THE ACTIVITY OF SORBITOL DEHYDROGENASE IN RATS WITH EXPERIMENTAL DIABETES MELLITUS.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Histocytochemistry; L-Iditol 2-Dehydrog | 1964 |
LENS ASSAYS ON DIABETIC AND GALACTOSEMIC RATS RECEIVING DIETS THAT MODIFY CATARACT DEVELOPMENT.
Topics: Amino Acids; Animals; Caseins; Cataract; Diabetes Mellitus, Experimental; Diet; Dietary Carbohydrate | 1965 |
CHANGES ASSOCIATED WITH THE APPEARANCE OF MATURE SUGAR CATARACTS.
Topics: Adenosine Triphosphate; Alcohols; Animals; Carbohydrates; Cataract; Diabetes Mellitus, Experimental; | 1965 |
The antiketogenic action of sorbitol in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Rats; Sorbitol | 1954 |
The metabolism of sorbitol in diseased states. II. In vivo study on the metabolism of sorbitol, fructose and glucose in alloxan-diabetic and CCL4-poisoning animals.
Topics: Alloxan; Animals; Carbohydrate Metabolism; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Dia | 1961 |
Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Fructos | 2003 |
On the influence of sorbitol on the carbohydrate metabolism in alloxan diabetic rats.
Topics: Alloxan; Animals; Carbohydrate Metabolism; Carbohydrates; Diabetes Mellitus; Diabetes Mellitus, Expe | 1950 |
Metabolism of sorbitol and glucose compared in normal and alloxan-diabetic rats.
Topics: Alloxan; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Glucose; Rats; Sorbitol | 1951 |
Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.
Topics: Animals; Benzamides; Cell Hypoxia; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inh | 2004 |
A study on the effects to diabetic nephropathy of Hachimi-jio-gan in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Creatinine; Diabetes Mellitus, Experiment | 2004 |
Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diureti | 2004 |
Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications.
Topics: Acetic Acid; Aldehyde Reductase; Animals; Chronic Disease; Diabetes Mellitus, Experimental; Drug Des | 2004 |
Effects of ellagic acid and 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid on sorbitol accumulation in vitro and in vivo.
Topics: Aldehyde Reductase; Animals; Caesalpinia; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2004 |
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.
Topics: Aldehyde Reductase; Animals; Aorta; Arterioles; Cattle; Diabetes Mellitus, Experimental; Endothelium | 2005 |
Prevention of cataract by pyruvate in experimentally diabetic mice.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Glycosylation; Lens, Crystalline; Mice; Mice, In | 2005 |
Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.
Topics: 3-Iodobenzylguanidine; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Heart; Male; Me | 2005 |
Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.
Topics: Aldehyde Reductase; Animals; Chenopodiaceae; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fla | 2005 |
Regulation of lens aldose reductase activity by nitric oxide.
Topics: Aldehyde Reductase; Animals; Cell Line, Transformed; Cells, Cultured; Crystallins; Diabetes Mellitus | 2005 |
A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.
Topics: Animals; Blood Glucose; Cell Culture Techniques; Cell Line; Cyclic AMP; Diabetes Mellitus, Experimen | 2005 |
Inhibitory effects of Ganoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; E | 2005 |
Restoration of ultrastructural and biochemical changes in alloxan-induced diabetic rat sciatic nerve on treatment with Na3VO4 and Trigonella--a promising antidiabetic agent.
Topics: Aldehyde Reductase; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Fructo | 2005 |
A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Biological Availability; Caco-2 Cells; Diabetes M | 2005 |
Age-related alterations in the biochemical and functional properties of the bladder in type 2 diabetic GK rats.
Topics: Acetylcholine; Adenosine Triphosphate; Aging; Animals; Body Weight; Carbachol; Diabetes Complication | 2005 |
Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.
Topics: 3-Iodobenzylguanidine; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Heart; Male; Me | 2005 |
Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues.
Topics: Aldehyde Reductase; Animals; Antioxidants; Diabetes Mellitus, Experimental; Female; Glucose; Glucose | 2006 |
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress.
Topics: Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Progression; Dis | 2006 |
Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; DNA Damage; Enzyme Activation; Fructos | 2006 |
Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Anim | 2006 |
Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats.
Topics: Animals; Biphenyl Compounds; Blood Glucose; Collagen Type IV; Creatinine; Diabetes Mellitus, Experim | 2007 |
Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia.
Topics: Animals; Blood Glucose; Brain; Chromatography, Gas; Diabetes Mellitus, Experimental; Female; Fluorom | 1967 |
[Studies on metabolism of sugar alcohol. (V). Effect of sorbitol loading on carbohydrate metabolism].
Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Fructose; Liver Glycogen; Male; Rats; Sor | 1967 |
Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Diabe | 1983 |
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Exper | 1984 |
Slow orthograde axonal transport of radiolabelled protein in sciatic motoneurones of rats with short-term experimental diabetes: effects of treatment with an aldose reductase inhibitor or myo-inositol.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Carbohydrate Metabolism; Diabetes Mellitus, Experimen | 1984 |
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Fructose; Inositol; Lens, Crystalline; Male; Pot | 1983 |
The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructosephosphates; In Vitro Technique | 1983 |
Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; I | 1983 |
Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Gluco | 1983 |
Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazo | 1983 |
Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Male; Motor Neu | 1984 |
N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Galactitol; Isoquinolines; Len | 1984 |
The effects of long-term treatment of streptozotocin-diabetic rats with an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Kidney; Male; Organ | 1983 |
Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; | 1984 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di | 1984 |
The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Galactosemias; I | 1984 |
The diabetic cornea.
Topics: Adult; Aged; Animals; Basement Membrane; Blood Glucose; Cornea; Corneal Diseases; Diabetes Complicat | 1984 |
Determination of sorbitol and galactitol at the nanogram level in biological samples by high-performance liquid chromatography.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Ery | 1984 |
Prevention of some electrophysiologic and biochemical abnormalities with oxygen supplementation in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetic Neuropath | 1984 |
Altering the course of cataracts in diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Fructose; Len | 1980 |
Aldose reductase and the etiology of diabetic cataracts.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Cataract; Child; Child, Preschool; Diabetes Complica | 1980 |
[Effects of M79175, an aldose reductase inhibitor, on experimental sugar cataracts].
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Imidazoles; Imidazol | 1982 |
Sorbitol pathway in lenses of normal and diabetic rabbits.
Topics: Animals; Diabetes Mellitus, Experimental; Lens, Crystalline; Rabbits; Sorbitol | 1983 |
Transport of myo-inositol into endoneurial preparations of sciatic nerve from normal and streptozotocin-diabetic rats.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Body Weight; Diabetes Mellitus, Exper | 1983 |
Beneficial effects of low-carbohydrate--high-protein diets in long-term diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diet, Diabetic; Dietary Carboh | 1980 |
Modelling cortical cataractogenesis: 3. In vivo effects of vitamin E on cataractogenesis in diabetic rats.
Topics: Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Fructose; Glucose; Lens, Crystall | 1982 |
Corneal epithelial changes in diabetic rats.
Topics: Animals; Cornea; Corneal Diseases; Diabetes Mellitus, Experimental; Epithelium; Female; Fructose; Gl | 1982 |
Diabetes mellitus and the rabbit corneal epithelium.
Topics: Animals; Cornea; Corneal Diseases; Corneal Injuries; Diabetes Mellitus, Experimental; Disease Models | 1981 |
Neurotropin prevents neurophysiological abnormalities and ADP-induced hyperaggregability in rats with streptozotocin-induced diabetes.
Topics: Adenosine Diphosphate; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Electrocardiography; | 1995 |
Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetic Neuro | 1995 |
Effect of a potent new aldose reductase inhibitor, (5-(3-thienyltetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1995 |
Regulation of growth factor mRNA levels in the eyes of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retino | 1995 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; B | 1993 |
Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta.
Topics: Acetylcholine; Adenosine Diphosphate; Aldehyde Reductase; Animals; Aorta; Blood Glucose; Body Weight | 1993 |
The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat.
Topics: Albuminuria; Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Body Weight; Butylated Hydrox | 1995 |
Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats.
Topics: Aldehyde Reductase; Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Female; | 1994 |
Effects of acute, subacute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve. Relation to mechanisms of peripheral neuropathy.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Carbohydrate Metabolism; Chronic Disease; Diabetes M | 1995 |
Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Eye; Fructos | 1995 |
Transphosphatidylation of sugar alcohols and its implications for the pathogenesis of diabetic complications.
Topics: Aldehyde Reductase; Animals; Brain; Cell Line; Cells, Cultured; Chromatography, Gas; Chromatography, | 1994 |
Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Ca(2+) Mg(2+)-ATPase; Carnitine; Diabetes Mellitus, Experimental; Diabetic | 1994 |
1H-NMR analysis of nerve edema in the streptozotocin-induced diabetic rat.
Topics: Aldehyde Reductase; Animals; Body Water; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ede | 1994 |
Sorbitol-accumulating pyrimidine derivatives.
Topics: Animals; Behavior, Animal; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Dose-Response R | 1994 |
Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cattle; Diabetes Mellitus, Experimental; Diabetic Neuro | 1994 |
Increased lenticular aldose reductase activity and high incidence of congenital cataract in the offspring of diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Female; Fetus; Incidence; Le | 1993 |
Is sorbitol dehydrogenase gene expression affected by streptozotocin-diabetes in the rat?
Topics: Aldehyde Reductase; Animals; Base Sequence; Brain; Diabetes Mellitus, Experimental; Gene Expression; | 1994 |
Sorbitol content and ultrastructure of the aortic tissues of streptozotocin diabetic rats: relation to plasma glucose, glycated hemoglobin and blood sorbitol.
Topics: Animals; Aorta; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gly | 1993 |
Control of sorbitol metabolism in renal inner medulla of diabetic rats: regulation by substrate, cosubstrate and products of the aldose reductase reaction.
Topics: Aldehyde Reductase; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; In Vitro Techniques; | 1993 |
[Effects of vanadate on glucose metabolism of the streptozotocin-diabetic rat lens].
Topics: Administration, Oral; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucos | 1993 |
Acetyl-L-carnitine corrects electroretinographic deficits in experimental diabetes.
Topics: Acetylcarnitine; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; | 1993 |
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1993 |
Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats.
Topics: Action Potentials; Animals; Butylated Hydroxytoluene; Capillaries; Diabetes Mellitus, Experimental; | 1993 |
Effects of propionyl-L-carnitine and insulin on the electroretinogram, nerve conduction and nerve blood flow in rats with streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Body Weight; Cardiotonic Agents; Carnitine; Diabetes Mellitus, Experimental; | 1996 |
Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats.
Topics: Acetanilides; Aldehyde Reductase; Analysis of Variance; Animals; Arginine; Blood Glucose; Body Weigh | 1996 |
Impaired myelinated fiber regeneration following freeze-injury in rats with streptozotocin-induced diabetes: involvement of the polyol pathway.
Topics: Acetanilides; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Di | 1995 |
An aldose reductase inhibitor, TAT, prevents electroretinographic abnormalities and ADP-induced hyperaggregability in streptozotocin-induced diabetic rats.
Topics: Adenosine Diphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Retino | 1995 |
Aldose reductase: black sheep or skeleton in the cupboard?
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, | 1996 |
Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats.
Topics: Animals; Base Sequence; Blotting, Northern; Diabetes Mellitus, Experimental; DNA Primers; Fructose; | 1996 |
Effect of an aldose reductase inhibitor on glomerular basement membrane anionic sites in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Albuminuria; Aldehyde Reductase; Animals; Anions; Basement Membrane; Blood Glu | 1995 |
Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats.
Topics: 3-O-Methylglucose; Aldehyde Reductase; Animals; Base Sequence; Blood Glucose; Carrier Proteins; Diab | 1996 |
Effect of propionyl-L-carnitine on oscillatory potentials in electroretinogram in streptozotocin-diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; | 1996 |
Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats.
Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Electroretino | 1995 |
Endothelial dysfunction in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Capillary Permeability; Coloring Agents; Diabetes Mellitus, Experimenta | 1996 |
Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation.
Topics: Aldehyde Reductase; Animals; Arachidonic Acids; Cell Membrane; Diabetes Mellitus, Experimental; Digl | 1997 |
Interactions between the sorbitol pathway, non-enzymatic glycation, and diabetic vascular dysfunction.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Capillary Permeability; Cattle; Diabetes Mellitus, Expe | 1996 |
Effects of a novel potent aldose reductase inhibitor, GP-1447, on aldose reductase activity in vitro and on diabetic neuropathy and cataract formation in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; | 1997 |
Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Ex | 1997 |
Hepatic glucose production from L-alanine is absent in perfused liver of diabetic rats.
Topics: Alanine; Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Gluconeogenesis; | 1997 |
In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Chromatography, High Pressure Liquid; Diabetes Mell | 1996 |
Effects of ONO-2235, an aldose reductase inhibitor, on muscarinic receptors and contractile response of the urinary bladder in rats with streptozotocin-induced diabetes.
Topics: Acetylcholine; Aldehyde Reductase; Analysis of Variance; Animals; Binding, Competitive; Blood Glucos | 1997 |
Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Me | 1997 |
Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts.
Topics: Administration, Oral; Ampholyte Mixtures; Animals; Chromatography, High Pressure Liquid; Cohort Stud | 1997 |
Electroretinogram in sucrose-fed diabetic rats treated with an aldose reductase inhibitor or an anticoagulant.
Topics: 2,3-Diphosphoglycerate; Aldehyde Reductase; Animals; Anticoagulants; Blood Glucose; Body Weight; Cil | 1997 |
Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice.
Topics: Animals; Brain; Cataract; Diabetes Mellitus, Experimental; Fructose; Glucose; Inositol; Introns; Kid | 1998 |
Amelioration of neurovascular deficits in diabetic rats by a novel aldose reductase inhibitor, GP-1447: minor contribution of nitric oxide.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1998 |
Effects of two aldose reductase inhibitors upon sorbitol output, D-glucose metabolism and insulin release in islets from normal and hereditarily diabetic rats.
Topics: Aldehyde Reductase; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fe | 1998 |
Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners.
Topics: Aldehyde Reductase; Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Enzyme Inhibit | 1998 |
Effects of thyroid hormone on the sorbitol pathway in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hyperthyro | 1998 |
Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid.
Topics: Adenine Nucleotides; Animals; Antioxidants; Diabetes Mellitus, Experimental; Energy Metabolism; Fruc | 1998 |
Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods.
Topics: Aging; Animals; Diabetes Mellitus, Experimental; Lens, Crystalline; Male; Rats; Rats, Wistar; Sciati | 1997 |
Biological evaluation of the nitric oxide-trapping agent, N-methyl-D-glucamine dithiocarbamate-Fe2+, as a probe of nitric oxide activity released from control and diabetic rat endothelium.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Chelating Agents; Diabetes Mell | 1999 |
Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relati | 1999 |
A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, C | 1999 |
Interaction between osmotic and oxidative stress in diabetic precataractous lens: studies with a sorbitol dehydrogenase inhibitor.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Glutathione; L-Idito | 1999 |
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibito | 2000 |
Evaluation of alpha(1)-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Blood Glucose; Blood Pressure; Body Weight; Cre | 2000 |
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 2000 |
Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Aldehyde Reductase; Animals; Antioxidants; Ca(2+) Mg | 2000 |
Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate.
Topics: Adenosine Triphosphate; Animals; Body Weight; Cataract; Crystallins; Diabetes Mellitus, Experimental | 2000 |
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.
Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, | 2001 |
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Me | 2001 |
Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.
Topics: Aldehyde Reductase; Animals; Chalcone; Diabetes Mellitus, Experimental; Flavonoids; Free Radical Sca | 2001 |
Streptozotocin-induced diabetes causes metabolic changes and alterations in neurotrophin content and retrograde transport in the cervical vagus nerve.
Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Fructose; Glucose; Hyperglycemia; Insuli | 2001 |
Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve.
Topics: Acetylcholine; Animals; Arterioles; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 2000 |
Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve.
Topics: Animals; Antioxidants; Aorta; Arterioles; Diabetes Mellitus, Experimental; Dietary Supplements; Inos | 2001 |
Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Vessels; Body Weight; Diabetes Mellitus, Experimental; | 2001 |
Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats.
Topics: Alternative Splicing; Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Dehydroascorbic Acid; Dia | 2001 |
Role of sorbitol in the up-regulation of urinary bladder M(2) muscarinic receptors in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Autoradiography; Blotting, Northern; Blotting, Western; Diabetes Mellit | 2002 |
Inhibition of polyol pathway activity in diabetic and galactosemic rats by the aldose reductase inhibitor CP-45,634.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cattle; Diabetes Mellitus, Experimental; Galactitol; Gal | 1979 |
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Benzopyrans; Cataract; Chromans; Diabetes Mellitus, Experimental; Galac | 1979 |
Effect of experimental diabetes and insulin onphosphatidyl-inositol synthesis in rat sciatic nerve.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Galactitol; Galactose; Glucose; Inositol; Insulin | 1979 |
Relationship of endogenous to dietary sorbitol. A study in normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Female; Insulin; Islets of Langerha | 1979 |
Aldose reductase and sorbitol dehydrogenase distribution in rat kidney.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glu | 1977 |
Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Epi | 1977 |
Initial changes in the free carbohydrate profile of rat lens and retina following streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Fructose; Glucose; Inositol; Kineti | 1979 |
Diabetic retinopathy and carbohydrate metabolism.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dietary Car | 1979 |
Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetic Neuropath | 1992 |
Erythrocyte sodium-potassium ATPase activity and thiol metabolism in genetically hyperglycemic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocyte Membrane; Erythrocytes; Glutathione; Glycated | 1992 |
A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.alpha CD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.
Topics: Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hy | 1992 |
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1992 |
Myocardial inositol and sodium in diabetes.
Topics: Animals; Biopsy; Body Fluid Compartments; Chromatography, Gas; Diabetes Mellitus, Experimental; Dise | 1992 |
Amelioration of dermal lesions in streptozotocin-induced diabetic rats by aminoguanidine.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamid | 1992 |
Glycosylation of proteins and microangiopathy.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dogs; Gl | 1992 |
The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Diabetes Me | 1992 |
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Expe | 1992 |
Effect of D-myo-inositol on platelet function and composition and on cataract development in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Platelets; Cataract; Diabetes Mellitus, Experimental; Fatty Acids; In Vitro Technique | 1992 |
Effect of aldose reductase inhibitor on the inhibition of platelet aggregation induced by diabetic rat plasma.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Erythrocytes; | 1992 |
Increase in cardiac muscle fructose content in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Gas Chromatography-Mass Spec | 1992 |
Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Glycation End Products, Advanced; Guanidines; In | 1992 |
Renal sorbitol, myo-inositol and glycerophosphorylcholine in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Di | 1992 |
Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats.
Topics: Albuminuria; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Glo | 1992 |
Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructos | 1992 |
Effect of vitamin C on sorbitol in the lens of guinea-pigs made diabetic with streptozotocin.
Topics: Adenosine Triphosphate; Animals; Aqueous Humor; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Gluco | 1992 |
Potential aldose reductase inhibitors: 1,2,4-triazolidine-3,5-diones and 2-(3,4,5-trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione .
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Isoxazole | 1992 |
Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.
Topics: Acetates; Aldehyde Reductase; Animals; Benzothiazoles; Binding Sites; Diabetes Mellitus, Experimenta | 1992 |
Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Chromans; Diabetes Mellitus, Experimental; Dose-Response Relationship, | 1992 |
Effect of vanadate administration on polyol pathway in diabetic rat kidney.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Kidney; Kidney | 1992 |
Amelioration of nerve Na(+)-K(+)-ATPase activity independently of myo-inositol level by PGE1 analogue OP-1206.alpha-CD in streptozocin-induced diabetic rats.
Topics: Alprostadil; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inositol; Male; M | 1991 |
Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats.
Topics: Action Potentials; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Exper | 1991 |
Measurements of tissue sorbitol in diabetes mellitus: enzyme method versus gas-liquid chromatography.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Chromatography, Gas; Diabetes Mellitus; Diabetes | 1992 |
Effects of a new aldose reductase inhibitor on diabetic complications in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Electrophores | 1991 |
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract.
Topics: Administration, Topical; Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Len | 1991 |
Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes.
Topics: Aldehyde Reductase; Animals; Aorta, Thoracic; Blood Glucose; Chalcone; Chalcones; Diabetes Mellitus, | 1991 |
Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Ca | 1991 |
Effect of vanadate on renal hypertrophy and sorbitol accumulation in streptozotocin induced diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypertrophy; Inosit | 1991 |
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.
Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Mellitus | 1991 |
Inhibition of diabetes-associated complications by nucleophilic compounds.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Reti | 1991 |
Polyol pathway in tissues of spontaneously diabetic Chinese hamsters (Cricetulus griseus) and the effect of an aldose reductase inhibitor, ONO-2235.
Topics: Aldehyde Reductase; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Fructo | 1991 |
Monoaminoguanidine prevents sorbitol accumulation, nonenzymatic protein glycosylation and development of kidney lesions in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycos | 1991 |
Analysis of diabetic cataractogenesis using chemical-shift nuclear magnetic resonance microscopy.
Topics: Animals; Carbon; Cataract; Diabetes Mellitus, Experimental; Female; Glucose; Lactates; Lens, Crystal | 1991 |
Effects of islet isografts on hemodynamic and vascular filtration changes in diabetic rats.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Hemodynamics; | 1990 |
Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones.
Topics: Aldehyde Reductase; Animals; Aza Compounds; Benzopyrans; Chromans; Diabetes Mellitus, Experimental; | 1990 |
[Effect of insulin on aldose reductase activity in the lens of rats with streptozotocin-induced diabetes].
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Insulin; Lens, Crys | 1990 |
In vivo activities of aldose reductase inhibitors having a 1-(arylsulfonyl)hydantoin structure.
Topics: Aldehyde Reductase; Animals; Body Weight; Cataract; Diabetes Mellitus, Experimental; Galactosemias; | 1990 |
Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix.
Topics: Aldehyde Reductase; Animals; Chalcone; Chalcones; Diabetes Mellitus, Experimental; Drugs, Chinese He | 1990 |
Permeability changes at blood-retinal barrier in diabetes and effect of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Exper | 1990 |
Studies on WE-3681, a novel aldose reductase inhibitor. III. Effects of WF-3681 and its derivatives on sorbitol accumulation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Furans; Male; | 1990 |
The significance of nerve sugar levels for the peripheral nerve impairment of spontaneously diabetic GK (Goto-Kakizaki) rats.
Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fructose; Glucose; Inos | 1990 |
Nonosmotic diabetic cataracts.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; | 1990 |
Effects of long-term aldose reductase inhibition on development of experimental diabetic neuropathy. Ultrastructural and morphometric studies of sural nerve in streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Male; | 1990 |
Correction of altered metabolic activities in sciatic nerves of streptozocin-induced diabetic rats. Effect of ganglioside treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Gangliosides; Inositol; Male; Myelin Proteins; O | 1990 |
[Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glucose; Inositol; Male; Ouabain; R | 1990 |
Diabetes and the myo-inositol paradox.
Topics: Animals; Aqueous Humor; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 1990 |
A new prostaglandin E1 analogue (TFC-612) improves the reduction in motor nerve conduction velocity in spontaneously diabetic GK (Goto-Kakizaki) rats.
Topics: Aging; Alprostadil; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabeti | 1990 |
[Effects of baicalin and liquid extract of licorice on sorbitol level in red blood cells of diabetic rats].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Erythrocytes; Flavon | 1990 |
Regulation and localization of organic osmolytes in mammalian kidney.
Topics: Animals; Betaine; Diabetes Insipidus; Diabetes Mellitus, Experimental; Glycerylphosphorylcholine; In | 1990 |
Modulation of hemodynamic and vascular filtration changes in diabetic rats by dietary myo-inositol.
Topics: Animals; Diabetes Mellitus, Experimental; Diet; Dose-Response Relationship, Drug; Glomerular Filtrat | 1990 |
[Detection of sorbitol content in crystalline lens of normal rats and rats with diabetic cataract by 1H-NMR].
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Lens, Crystalline; Magnetic Resonance Spectrosco | 1990 |
Reversal of deficits in axonal transport and nerve conduction velocity by treatment of streptozotocin-diabetic rats with myo-inositol.
Topics: Administration, Oral; Animals; Axonal Transport; Blood Glucose; Body Weight; Diabetes Mellitus, Expe | 1985 |
Prevention of defective axonal transport in streptozocin-diabetic rats by treatment with "Statil" (ICI 128436), an aldose reductase inhibitor.
Topics: Animals; Autonomic Fibers, Preganglionic; Axonal Transport; Blood Glucose; Choline O-Acetyltransfera | 1985 |
Slow component-a of axonal transport, nerve myo-inositol, and aldose reductase inhibition in streptozocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Fructose; Ganglia, S | 1986 |
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Humans; Imidazol | 1986 |
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Topics: Animals; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Diabetes Mellitus, Experiment | 1986 |
Fast anterograde axonal transport in wasted and non-wasted diabetic rats; effects of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Body Temperature; Diabetes Mellitus, E | 1986 |
Defects of axonal transport in experimental diabetes that are unrelated to the sorbitol pathway.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Fruct | 1987 |
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathie | 1987 |
Studies on peripheral nerve and lens in long-term experimental diabetes: effects of the aldose reductase inhibitor statil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Body Weight; Carbohydrates; Choline O-Acetyltransfera | 1988 |
Essential fatty acid treatment--effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats.
Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fatty Acids, Esse | 1989 |
Ascorbic acid metabolism and polyol pathway in diabetes.
Topics: Aldehyde Reductase; Animals; Ascorbic Acid; Diabetes Mellitus, Experimental; Dietary Carbohydrates; | 1989 |
Effects of aldose reductase inhibitor sorbinil on neuroaxonal dystrophy and levels of myo-inositol and sorbitol in sympathetic autonomic ganglia of streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactos | 1989 |
Comparison of glucose, sorbitol and fructose accumulation in lens and liver of diabetic and insulin-treated rats and mice.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Insulin; L-Iditol 2 | 1989 |
Sorbinil suppresses glomerular prostaglandin production in the streptozotocin diabetic rat.
Topics: 6-Ketoprostaglandin F1 alpha; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mell | 1989 |
Contractile properties of cardiac papillary muscle in streptozotocin-diabetic rats and the effects of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Heart Ventricles | 1989 |
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.
Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes | 1989 |
The effect of ponalrestat on sorbitol levels in the lens of obese and diabetic mice.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Insu | 1989 |
The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Kinet | 1989 |
Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; D | 1989 |
Effects of sorbinil on glomerular structure and function in long-term-diabetic rats.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Diabetes Mellitus, Experimental; Diab | 1989 |
Oral baicalin and liquid extract of licorice reduce sorbitol levels in red blood cell of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Erythrocytes; Flavanones; Flavonoid | 1989 |
Sorbitol metabolism in inner medullary collecting duct cells of diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cell Membrane Permeability; Diabetes Mellitus, Experimen | 1989 |
Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy.
Topics: Adenosine Triphosphate; Animals; Cytosol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Er | 1989 |
Sorbitol accumulation in heart: implication for diabetic cardiomyopathy.
Topics: Animals; Cardiomyopathies; Diabetes Mellitus, Experimental; Male; Myocardium; Rats; Rats, Inbred Str | 1989 |
Carbon tetrachloride and the sorbitol pathway in the diabetic mouse.
Topics: Animals; Blood Glucose; Body Weight; Carbon Tetrachloride; Diabetes Mellitus, Experimental; Fructose | 1989 |
Identification of D-sorbitol 3-phosphate in the normal and diabetic mammalian lens.
Topics: Animals; Cattle; Diabetes Mellitus, Experimental; Hexosephosphates; Lens, Crystalline; Magnetic Reso | 1989 |
Two-step high-performance liquid chromatography method for the determination of myo-inositol and sorbitol.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Female; Fructose; In | 1989 |
Polyol pathway activity in streptozotocin-diabetic rat lens.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Glycerophosphates; Kinetics; Lens, Crys | 1989 |
Polyols and myo-inositol in diabetic neuropathy--of mice and men.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactitol; Inositol; Mice; Periphe | 1989 |
Nerve glucose, sorbitol, fructose, and myo-inositol at various time after feeding in streptozotocin-induced diabetes in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Food; Fructose; Glucose; Hexoses; Inositol; Male; Peroneal | 1989 |
Organic solute profiles and transport in the rat renal medulla.
Topics: Animals; Betaine; Biological Transport; Diabetes Mellitus, Experimental; Glycerylphosphorylcholine; | 1989 |
Hyperglycemia and development of glomerular pathology: diabetes compared with galactosemia.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dogs; Galactitol; Galactosemias; H | 1989 |
Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glutathione; I | 1987 |
Effect of a new aldose reductase inhibitor, 8'-chloro-2',3'-dihydrospiro [pyrrolidine-3,6'(5'H)-pyrrolo[1,2,3-de] [1,4]benzoxazine]-2,5,5'- trione (ADN-138), on delayed motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; I | 1988 |
Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing.
Topics: Aging; Animals; Copper; Diabetes Mellitus, Experimental; Free Radicals; Glucose; Glycosylation; Hydr | 1988 |
The identification of aldose reductase in the pathogenesis of diabetic complications: the background.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Cataract; Diabetes Complications; Diabetes Mellitus; Dia | 1985 |
Lens metabolism and cellular effects of aldose reductase.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazo | 1985 |
Diabetic cataracts in animal models: prevention and reversibility with aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Lens, Crystalline; Rats; Sor | 1985 |
Axonal transport and nerve conduction velocity in animal models of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazol | 1985 |
The effect of aldose reductase inhibitor Statil (ICI 128436) on the glucose over-utilization in kidney of diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glucuronates; Kidney; Lactates; Orga | 1988 |
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Glucose; Imidaz | 1986 |
Effect of aldose reductase inhibitor ONO 2235 on reduced sympathetic nervous system activity and peripheral nerve disorders in STZ-induced diabetic rats.
Topics: Aldehyde Reductase; alpha-Methyltyrosine; Animals; Autonomic Nervous System Diseases; Diabetes Melli | 1987 |
Aldose reductase inhibition, glomerular metabolism, and diabetic nephropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazoles; Im | 1985 |
Role of sorbitol accumulation and myo-inositol depletion in paranodal swelling of large myelinated nerve fibers in the insulin-deficient spontaneously diabetic bio-breeding rat. Reversal by insulin replacement, an aldose reductase inhibitor, and myo-inosi
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electrophysiology; Inositol; Insulin; | 1987 |
Sorbinil: a member of the novel class of spirohydantoin aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Complications; Diabetes Mellitu | 1986 |
The effect of aldose reductase and its inhibition on sugar cataract formation.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Imid | 1986 |
Studies of aldose reductase using neuronal cell culture and ligated rat sciatic nerve.
Topics: Aldehyde Reductase; Animals; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic N | 1986 |
Prevention of neural myoinositol depletion in diabetic rats by aldose reductase inhibition with tolrestat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose; I | 1986 |
Evidence for existence of polyol pathway in cultured rat mesangial cells.
Topics: Aldehyde Reductase; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Galactitol; Glomerula | 1987 |
Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Fluorenes; Humans; Hydantoins; | 1987 |
Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes. Prevention by aldose reductase inhibitors and castration.
Topics: Aldehyde Reductase; Animals; Aorta; Blood Glucose; Body Weight; Capillary Permeability; Castration; | 1987 |
Development of potent aldose reductase inhibitors having a hydantoin structure.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Hydantoins; Inositol; Lens, Crystallin | 1987 |
The utilization of 13C and 31P nuclear magnetic resonance spectroscopy in the study of the sorbitol pathway and aldose reductase inhibition in intact rabbit lenses.
Topics: Aldehyde Reductase; Animals; Cataract; Culture Media; Diabetes Complications; Diabetes Mellitus, Exp | 1987 |
Suggested mechanism for the selective excretion of glucosylated albumin. The effects of diabetes mellitus and aging on this process and the origins of diabetic microalbuminuria.
Topics: Adolescent; Adult; Aging; Albuminuria; Animals; Cations; Child; Diabetes Mellitus, Experimental; Dia | 1987 |
Spiro hydantoin aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Hydantoins; Indicators and Rea | 1988 |
Statil-sensitive polyol formation in nerve of galactose-fed mice.
Topics: Aldehyde Reductase; Animals; Carbohydrates; Diabetes Mellitus, Experimental; Galactitol; Galactose; | 1988 |
Glutathione depletion in the lens of galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Aminoisobutyric Acids; Animals; Cell Membrane Permeability; Diabetes Mellitus, E | 1988 |
Effect of aldose reductase inhibition on nerve conduction velocity and resistance to ischemic conduction block in experimental diabetes.
Topics: Action Potentials; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Inositol; Insulin; | 1988 |
Specific radioimmunoassay of glucitol-lysine--application to lens proteins in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Crystallins; Diabetes Mellitus, Experimental; Lysine; Male; Rad | 1988 |
Renal sorbitol accumulation and associated enzyme activities in diabetes.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Kidney Cortex; Kidney Medulla; L-Idito | 1988 |
AL-1576, an aldose reductase inhibitor (ARI), did not prevent the decrease of norepinephrine turnover in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Fluorenes; Hydantoins; Lens, C | 1988 |
Sorbitol metabolism in the retina, optic nerve, and sural nerve of diabetic rats treated with an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; L-Iditol 2-Dehydrogenase; Opti | 1988 |
Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazo | 1988 |
Motor nerve conduction velocity and nerve polyols in mice with short-term genetic or streptozotocin-induced diabetes.
Topics: Acute Disease; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Fructose; Glucos | 1985 |
Analysis of sorbitol, galactitol, and myo-inositol in lens and sciatic nerve by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Galactitol; Galactos | 1988 |
Methylcobalamin improves nerve conduction in streptozotocin-diabetic rats without affecting sorbitol and myo-inositol contents of sciatic nerve.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inositol; Male; Neural Conduct | 1988 |
Sorbitol in aortic endothelium of diabetic rats.
Topics: Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; L-Iditol 2-Dehydrogenase; Ra | 1988 |
Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cells, Cultured; Cerebrovascular Circulation | 1988 |
A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats.
Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Insulin; Mal | 1988 |
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias; | 1988 |
Effects of diabetes and insulin treatment on sorbitol and water of rat lenses.
Topics: Alloxan; Animals; Body Water; Diabetes Mellitus, Experimental; Female; Insulin; Lens, Crystalline; O | 1986 |
Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Body Weight; Creatine; Diabetes Mellitus, Ex | 1988 |
The sorbitol shunt in the retina and the optic nerve of mice with inherited and STZ-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose-Bisphosphate Aldolase; Hexokinase; L-Iditol 2-Deh | 1987 |
Changes in sorbitol, myo-inositol and lipid inositol in dorsal root and sympathetic ganglia from streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Ganglia, Spinal; Ganglia, Sympathetic; Inositol; | 1986 |
Sorbinil partially prevents decreased erythrocyte deformability in experimental diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocyte Deformability; Erythrocytes; Imidazoles; Imida | 1987 |
Increased accumulation of sorbitol in offspring of manifest diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Embryo, Mammalian; Female; Fetal Growth Retardation; Fetus | 1986 |
[Effect of trapidil on neuropathy in diabetic mice].
Topics: Animals; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Experimental; Diabetic Neuropathies; In | 1986 |
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazo | 1985 |
Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Dogs; Erythrocytes; | 1985 |
Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dietary Carbohy | 1985 |
Sorbitol determination by liquid chromatography: application to red blood cells of diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Carbohydrates; Chromatography, Liquid; Diabetes Mellitus | 1985 |
Aldose reductase, NADPH and NADP+ in normal, galactose-fed and diabetic rat lens.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Lens, Crystalline; Male; NAD | 1985 |
Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electrophysiology; Imidazoles; Imidazo | 1985 |
The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Animals; Cattle; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dr | 1985 |
Sex steroid dependency of diabetes-induced changes in polyol metabolism, vascular permeability, and collagen cross-linking.
Topics: Animals; Blood Glucose; Capillary Permeability; Collagen; Diabetes Mellitus, Experimental; Female; G | 1986 |
Altered retinal metabolism in diabetes. I. Microanalysis of lipid, glucose, sorbitol, and myo-inositol in the choroid and in the individual layers of the rabbit retina.
Topics: Animals; Choroid Plexus; Diabetes Mellitus, Experimental; Glucose; Inositol; Ischemia; Lipids; Male; | 1986 |
Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil.
Topics: Adolescent; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Angiopathies; | 1986 |
The sorbitol pathway. Enzyme localization and content in normal and diabetic nerve and cord.
Topics: Animals; Axons; Blood Glucose; Cauda Equina; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1968 |
[Pathobiochemistry of the late-onset diabetic syndrome].
Topics: Animals; Carbohydrates; Cataract; Cell Membrane; Chemical Phenomena; Chemistry; Diabetes Complicatio | 1974 |
Effects of elevated glucose concentrations on the metabolism of the aortic wall.
Topics: Alcohol Oxidoreductases; Animals; Aorta, Thoracic; Blood Glucose; Diabetes Mellitus, Experimental; F | 1972 |
Comparative study of enzyme activities degrading sorbitol, ribitol, xylitol and gluconate in guinea pig tissues.
Topics: Adipose Tissue; Animals; Brain; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, | 1973 |
Cerebral edema in diabetic comas. II. Effects of hyperosmolality, hyperglycemia and insulin in diabetic rabbits.
Topics: Amino Acids; Animals; Blood; Body Water; Brain Chemistry; Brain Edema; Cerebrospinal Fluid; Chloride | 1974 |
[Hyperglycemic and glycogenetic effect of sorbitol, fructose and glucose in diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Glycogen; Hyperglycemia; Rats; Sorbitol | 1972 |
Sorbitol pathway in the ciliary body in relation to accumulation of amino acids in the aqueous humor of alloxan-diabetic rabbits.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Aqueous Humor; Ciliary Body; Diabetes Mellitus, Exper | 1971 |
Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; In Vitro Techniq | 1966 |
Free sugars in alloxan diabetic rat nerve.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; In Vitro Techniq | 1966 |
[Inhibition of fatty acid oxidation as a factor in the antiketogenic effect of sugars and polyalcohols].
Topics: Alcohols; Animals; Carbohydrates; Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus, Experimental; | 1966 |