Compounds > sorbitol
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sorbitol and Aging

sorbitol has been researched along with Aging in 36 studies

D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"To study the influence of the course of diabetes, aging, and glycemia on the sorbitol accumulation in diabetic rats."3.69Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods. ( Batista, MR; Bazotte, RB; Brunaldi, K; Ferraz, M; Ishii-Iwamoto, EL, 1997)
" 230 l), and the half-life was slightly increased (19."2.68Influence of age, frailty and liver function on the pharmacokinetics of brofaromine. ( Antonin, KH; Bergmann, W; Bieck, P; Degel, F; Fuchs, L; Platt, D; Zeeh, J, 1996)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199017 (47.22)18.7374
1990's12 (33.33)18.2507
2000's6 (16.67)29.6817
2010's0 (0.00)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Tonoki, A1
Ogasawara, M1
Yu, Z1
Itoh, M1
Chan, AW1
Ho, YS1
Chung, SK1
Chung, SS1
Hagopian, K1
Ramsey, JJ1
Weindruch, R1
KUCK, JF1
PIRIE, A2
VANHEYNINGEN, R1
Yono, M1
Latifpour, J1
Yoshida, M1
Ueda, S1
Bauchart, D1
Schiffman, SS1
Gatlin, LA1
Sattely-Miller, EA1
Graham, BG1
Heiman, SA1
Stagner, WC1
Erickson, RP1
Bechensteen, AG1
Halvorsen, S1
Skottner, A1
Malo, C1
Hirano, F1
Tanaka, H1
Okamoto, K1
Makino, Y1
Inaba, M1
Nomura, Y1
Fukawa, E1
Miura, T1
Tani, T1
Makino, I1
Zeeh, J1
Fuchs, L1
Bergmann, W1
Antonin, KH1
Degel, F1
Bieck, P1
Platt, D1
Martel, F1
Martins, MJ1
Calhau, C1
Hipólito-Reis, C1
Azevedo, I1
Ferraz, M1
Ishii-Iwamoto, EL1
Batista, MR1
Brunaldi, K1
Bazotte, RB1
Fountain, WC1
Requena, JR1
Jenkins, AJ1
Lyons, TJ1
Smyth, B1
Baynes, JW1
Thorpe, SR1
Kirk, CJ1
Miller, RA1
Regenold, WT1
Kling, MA1
Hauser, P1
Tabata, H1
Ikegami, H1
Kariya, K1
Kost'ál, V1
Slachta, M1
Simek, P1
van Heyningen, R1
Hunt, JV2
Wolff, SP2
Suzuki, K2
Yen-Chung, H1
Toyota, T2
Goto, Y2
Hirata, Y1
Okada, K1
Saito, N1
Sakata, Y1
Bessems, GJ1
Dragomirescu, V1
Möller, B1
Korte, I1
Hockwin, O2
Dean, RT1
Kowluru, A1
Kowluru, R1
Bitensky, MW1
Corwin, EJ1
Solomon, SS1
Johnson, JD1
Funasako, M1
Samukawa, A1
Nishio, K1
Tanichi, M1
Sunda, N1
Nakai, Y1
Kobayashi, S1
Kakutani, A1
Nishikawa, O1
Sunda, H1
Drasnin, N1
Stock, SL1
Murray, RK1
Gadacz, I1
Bach, M1
Hardin, S1
Morris, HP1
Hodgen, GD1
Sherins, RJ1
Takaku, I1
Hasegawa, K1
Kimura, R1
Watanabe, Y1
Enerbäck, L1
Lundin, PM1

Reviews

1 review available for sorbitol and Aging

ArticleYear
Age changes of lens metabolism.
    Altern und Entwicklung. Aging and development, 1971, Volume: 1

    Topics: Aging; Animals; Cattle; Chickens; Citric Acid Cycle; Enzymes; Eye Proteins; Glucose; Glucosephosphat

1971

Trials

1 trial available for sorbitol and Aging

ArticleYear
Influence of age, frailty and liver function on the pharmacokinetics of brofaromine.
    European journal of clinical pharmacology, 1996, Volume: 49, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Caffeine; Chromatography, Gas; Cross-Ov

1996

Other Studies

34 other studies available for sorbitol and Aging

ArticleYear
Appetitive Memory with Survival Benefit Is Robust Across Aging in
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 03-11, Volume: 40, Issue:11

    Topics: Aging; Animals; Arabinose; Conditioning, Classical; Dietary Sugars; Dopaminergic Neurons; Drosophila

2020
Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation.
    Experimental eye research, 2008, Volume: 87, Issue:5

    Topics: Aging; Aldehyde Reductase; Animals; Antioxidants; Cataract; Diabetes Mellitus, Experimental; Disease

2008
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
    Biogerontology, 2009, Volume: 10, Issue:4

    Topics: Age Factors; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Fructose; Glucose; L-Iditol 2-

2009
SUGAR AND SUGAR ALCOHOL LEVELS IN THE AGING RAT LENS.
    Investigative ophthalmology, 1963, Volume: 2

    Topics: Aging; Aqueous Humor; Carbohydrate Metabolism; Carbon Isotopes; Fructose; Glucose; Lens, Crystalline

1963
THE EFFECT OF DIABETES ON THE CONTENT OF SORBITOL, GLUCOSE, FRUCTOSE AND INOSITOL IN THE HUMAN LENS.
    Experimental eye research, 1964, Volume: 3

    Topics: Aging; Cataract; Diabetes Mellitus; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalli

1964
Age-related alterations in the biochemical and functional properties of the bladder in type 2 diabetic GK rats.
    Journal of receptor and signal transduction research, 2005, Volume: 25, Issue:3

    Topics: Acetylcholine; Adenosine Triphosphate; Aging; Animals; Body Weight; Carbachol; Diabetes Complication

2005
Difference in swelling and opacity formation between young and old lenses.
    Nature, 1967, Nov-04, Volume: 216, Issue:5114

    Topics: Aging; Animals; Diet; Galactose; Lens, Crystalline; Proteins; Rats; Sorbitol

1967
[Evolution of postprandial cholesterolemia and triglyceridemia with age in the preruminant calf; the effect of sorbitol ingestion].
    Reproduction, nutrition, developpement, 1983, Volume: 23, Issue:1

    Topics: Aging; Animals; Body Weight; Cattle; Cholesterol; Cholesterol Esters; Feeding Behavior; Free Radical

1983
The effects of lifetime feeding studies on patterns of senile lesions in mice and rats.
    Drug and chemical toxicology, 1980, Volume: 3, Issue:1

    Topics: Adrenal Glands; Aging; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Kidney

1980
The effect of sweeteners on bitter taste in young and elderly subjects.
    Brain research bulletin, 1994, Volume: 35, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Female; Humans; Male; Sorbitol; Sucrose

1994
Recombinant human insulin-like growth factor 1 (rh-IGF-1) stimulates erythropoiesis in adult, but not in newborn mice.
    Acta physiologica Scandinavica, 1994, Volume: 151, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Citrates; Citric Acid; Drug Combinations; Erythroid Precursor Cell

1994
Ontogeny of Na+/D-glucose cotransport in guinea-pig jejunal vesicles: only one system is involved at both 20 degrees C and 35 degrees C.
    Biochimica et biophysica acta, 1993, Dec-12, Volume: 1153, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Biological Transport, Active; Buffers; Female; Fetus; Guinea Pigs;

1993
Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters.
    Diabetes research and clinical practice, 1995, Volume: 28, Issue:3

    Topics: Aging; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrophy

1995
Postnatal development of organic cation transport in the rat liver.
    Pharmacological research, 1998, Volume: 37, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Aging; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1

1998
Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:4

    Topics: Aging; Animals; Diabetes Mellitus, Experimental; Lens, Crystalline; Male; Rats; Rats, Wistar; Sciati

1997
Quantification of N-(glucitol)ethanolamine and N-(carboxymethyl)serine: two products of nonenzymatic modification of aminophospholipids formed in vivo.
    Analytical biochemistry, 1999, Jul-15, Volume: 272, Issue:1

    Topics: Aging; Amines; Diabetes Mellitus, Type 1; Erythrocyte Membrane; Gas Chromatography-Mass Spectrometry

1999
Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells.
    Cellular immunology, 1999, Nov-01, Volume: 197, Issue:2

    Topics: Aging; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Ceramides; Colforsin; Cyclosporine; Dim

1999
Elevated sorbitol concentration in the cerebrospinal fluid of patients with mood disorders.
    Psychoneuroendocrinology, 2000, Volume: 25, Issue:6

    Topics: Adult; Aging; Bipolar Disorder; Black People; Female; Humans; Linear Models; Male; Middle Aged; Mood

2000
Spontaneous age-related peripheral neuropathy in B6C3F1 mice.
    The Journal of toxicological sciences, 2000, Volume: 25, Issue:2

    Topics: Aging; Animals; Axons; Blood Glucose; Body Temperature; Cell Division; Female; Glycated Hemoglobin;

2000
Cryoprotective role of polyols independent of the increase in supercooling capacity in diapausing adults of Pyrrhocoris apterus (Heteroptera: Insecta).
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2001, Volume: 130, Issue:3

    Topics: Adaptation, Physiological; Aging; Animals; Cold Temperature; Cryoprotective Agents; Gas Chromatograp

2001
Experimental studies on cataract.
    Investigative ophthalmology & visual science, 1976, Volume: 15, Issue:9

    Topics: Aging; Animals; Ascorbic Acid; Cataract; Crystallins; Diabetic Retinopathy; Humans; Lens, Crystallin

1976
Oxidative glycation and free radical production: a causal mechanism of diabetic complications.
    Free radical research communications, 1991, Volume: 12-13 Pt 1

    Topics: Aging; Aldehydes; Animals; Benzoates; Benzoic Acid; Cattle; Chelating Agents; Chromatography, Affini

1991
The significance of nerve sugar levels for the peripheral nerve impairment of spontaneously diabetic GK (Goto-Kakizaki) rats.
    Diabetes research (Edinburgh, Scotland), 1990, Volume: 14, Issue:1

    Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fructose; Glucose; Inos

1990
A new prostaglandin E1 analogue (TFC-612) improves the reduction in motor nerve conduction velocity in spontaneously diabetic GK (Goto-Kakizaki) rats.
    Prostaglandins, 1990, Volume: 40, Issue:5

    Topics: Aging; Alprostadil; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabeti

1990
Biochemical analysis of bovine lens sections obtained by a new sectioning device.
    Lens and eye toxicity research, 1989, Volume: 6, Issue:1-2

    Topics: Aging; Animals; Cattle; Crystallins; Equipment Design; Frozen Sections; Fructose; Glucose; Lens Cort

1989
Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing.
    The Biochemical journal, 1988, Nov-15, Volume: 256, Issue:1

    Topics: Aging; Animals; Copper; Diabetes Mellitus, Experimental; Free Radicals; Glucose; Glycosylation; Hydr

1988
Suggested mechanism for the selective excretion of glucosylated albumin. The effects of diabetes mellitus and aging on this process and the origins of diabetic microalbuminuria.
    The Journal of experimental medicine, 1987, Nov-01, Volume: 166, Issue:5

    Topics: Adolescent; Adult; Aging; Albuminuria; Animals; Cations; Child; Diabetes Mellitus, Experimental; Dia

1987
[Aging and erythrocyte sorbitol].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1987, Volume: 24, Issue:5

    Topics: Aged; Aged, 80 and over; Aging; Diabetes Mellitus; Female; Humans; Male; Sex Factors; Sorbitol

1987
Is more really better?
    Lancet (London, England), 1973, May-26, Volume: 1, Issue:7813

    Topics: Aging; Animals; Diabetes Mellitus; Glucose; Humans; Rats; Sorbitol

1973
Sorbitol accumulation.
    Lancet (London, England), 1973, Jul-14, Volume: 2, Issue:7820

    Topics: Aging; Animals; Diabetes Mellitus; Diet; Humans; Rats; Sorbitol

1973
Metabolic and electrophoretic studies of rat liver sorbitol dehydrogenase.
    Canadian journal of biochemistry, 1969, Volume: 47, Issue:6

    Topics: Adrenal Glands; Adrenalectomy; Aging; Alcohol Oxidoreductases; Animals; Borates; Buffers; Carcinoma,

1969
Enzymes as markers of testicular growth and development in the rat.
    Endocrinology, 1973, Volume: 93, Issue:4

    Topics: Acyltransferases; Age Factors; Aging; Animals; Cell Division; Colorimetry; Electrophoresis, Polyacry

1973
[Biochemical characteristics of the cataract lens. 1. Comparison of water content and concentration of sorbitol, inositol, glutathione and sialic acid in the young and adult rat lens].
    Nippon Ganka Gakkai zasshi, 1967, Volume: 71, Issue:7

    Topics: Aging; Animals; Cataract; Glutathione; Inositol; Lens, Crystalline; Neuraminic Acids; Rats; Sorbitol

1967
Mast cells and storage of iron.
    Pathologia Europaea, 1969, Volume: 4, Issue:2

    Topics: Aging; Animals; Injections, Intravenous; Iron; Iron-Dextran Complex; Liver; Lymph Nodes; Mast Cells;

1969