sorbitan-monooleate and Psoriasis

Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types.. The nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values.. The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

Topics: Administration, Topical; Adult; Antioxidants; Castor Oil; Chemistry, Pharmaceutical; Drug Stability; Electric Conductivity; Emulsions; Female; Hexoses; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Nanotechnology; Particle Size; Plant Oils; Psoriasis; Rice Bran Oil; Skin; Skin Absorption; Water; Young Adult

Tamoxifen is a nonsteroidal estrogen receptor modulator indicated in the treatment of breast cancer. Apoptosis has been reported to be a major mechanism for its antitumor effect. Tamoxifen has also shown significant potential in treating various dermatological disorders including psoriasis, characterized by hyperproliferation of epidermal keratinocytes. An endeavor was made in the current studies to investigate the potency of vesicle-encapsulated tamoxifen on human epidermal keratinocyte cell lines.. Drug was encapsulated in the phospholipid-based vesicular systems, namely, conventional liposomes and flexible-membrane liposomes. In vitro cytotoxicity evaluation of the formulations was carried out employing MTT cell proliferation assay.. A composition-dependent strong inhibition in the viability of epidermal keratinocyte cells was observed.. The encouraging findings of this work construe immense potential of the tamoxifen-encapsulated vesicular systems in the management of psoriasis.

Topics: Administration, Cutaneous; Cell Line; Cell Proliferation; Cell Survival; Cholesterol; Drug Carriers; Hexoses; Humans; Inhibitory Concentration 50; Keratinocytes; Liposomes; Membrane Fluidity; Phosphatidylcholines; Psoriasis; Selective Estrogen Receptor Modulators; Surface-Active Agents; Tamoxifen