sophoricoside and Edema

sophoricoside has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for sophoricoside and Edema

Article	Year
Anti-inflammatory action of legume isoflavonoid sophoricoside through inhibition on cyclooxygenase-2 activity. Planta medica, 2003, Volume: 69, Issue:5 Soy is a main source of isoflavonoids which are of high dietary intake for the oriental population. In this study, the anti-inflammatory action of sophoricoside, an isoflavone glycoside isolated from immature fruits of Sophora japonica L. (Leguminosae), has been demonstrated. When administered orally at > 100 mg/kg or injected intravenously at > 10 mg/kg, sophoricoside showed significant reduction of carrageenin-induced paw edema in mice. Sophoricoside has been identified as a selective inhibitor of cyclooxygenase (COX)-2 activity with an IC50 value of 3.3 microM. Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Inhibitory Concentration 50; Injections, Intravenous; Isoenzymes; Isoflavones; Lipopolysaccharides; Macrophages; Mice; Phytotherapy; Prostaglandin-Endoperoxide Synthases; Sophora	2003

Article

Year

Anti-inflammatory action of legume isoflavonoid sophoricoside through inhibition on cyclooxygenase-2 activity.

Planta medica, 2003, Volume: 69, Issue:5

Soy is a main source of isoflavonoids which are of high dietary intake for the oriental population. In this study, the anti-inflammatory action of sophoricoside, an isoflavone glycoside isolated from immature fruits of Sophora japonica L. (Leguminosae), has been demonstrated. When administered orally at > 100 mg/kg or injected intravenously at > 10 mg/kg, sophoricoside showed significant reduction of carrageenin-induced paw edema in mice. Sophoricoside has been identified as a selective inhibitor of cyclooxygenase (COX)-2 activity with an IC50 value of 3.3 microM.

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Inhibitory Concentration 50; Injections, Intravenous; Isoenzymes; Isoflavones; Lipopolysaccharides; Macrophages; Mice; Phytotherapy; Prostaglandin-Endoperoxide Synthases; Sophora

2003