somatostatin--trp(8)-cys(14)- and Diabetes-Mellitus--Type-1

somatostatin--trp(8)-cys(14)- has been researched along with Diabetes-Mellitus--Type-1* in 1 studies

Other Studies

1 other study(ies) available for somatostatin--trp(8)-cys(14)- and Diabetes-Mellitus--Type-1

Article	Year
D-Trp8-D-Cys14-somatostatin--demonstration of its differential suppressive activity in juvenile diabetics. Hormone and metabolic research. Supplement series, 1979, Issue:8 In 8 insulin-dependent diabetics, the effect of D-Trp8-D-Cys14-somatostatin on blood glucose, growth hormone, and glucagon levels as well as on insulin requirements from an artificial endocrine pancreas was studied during a balanced meal. The somatostatin analogue was infused at a rate of 25 microgram/h preceeded by a bolus injection of 25 microgram 30 minutes before ingestion of the meal. At this dose the analogue had no effect on glucagon levels and insulin requirements from the artificial pancreas. On the other hand, there was a significant lowering effect on fasting blood glucose levels, possibly indicating a direct inhibition of hepatic glucose production. Furthermore, there might be a slight effect on growth hormone levels, as was demonstrated by a rebound increase after termination of analogue infusion. Topics: Adolescent; Adult; Artificial Organs; Blood Glucose; Diabetes Mellitus, Type 1; Glucagon; Growth Hormone; Humans; Infusions, Parenteral; Insulin; Islets of Langerhans; Somatostatin	1979

Article

Year

D-Trp8-D-Cys14-somatostatin--demonstration of its differential suppressive activity in juvenile diabetics.

Hormone and metabolic research. Supplement series, 1979, Issue:8

In 8 insulin-dependent diabetics, the effect of D-Trp8-D-Cys14-somatostatin on blood glucose, growth hormone, and glucagon levels as well as on insulin requirements from an artificial endocrine pancreas was studied during a balanced meal. The somatostatin analogue was infused at a rate of 25 microgram/h preceeded by a bolus injection of 25 microgram 30 minutes before ingestion of the meal. At this dose the analogue had no effect on glucagon levels and insulin requirements from the artificial pancreas. On the other hand, there was a significant lowering effect on fasting blood glucose levels, possibly indicating a direct inhibition of hepatic glucose production. Furthermore, there might be a slight effect on growth hormone levels, as was demonstrated by a rebound increase after termination of analogue infusion.

Topics: Adolescent; Adult; Artificial Organs; Blood Glucose; Diabetes Mellitus, Type 1; Glucagon; Growth Hormone; Humans; Infusions, Parenteral; Insulin; Islets of Langerhans; Somatostatin

1979