somatostatin--trp(8)-cys(14)- and Amnesia

somatostatin--trp(8)-cys(14)- has been researched along with Amnesia* in 1 studies

Other Studies

1 other study(ies) available for somatostatin--trp(8)-cys(14)- and Amnesia

Article	Year
Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats. Psychoneuroendocrinology, 1986, Volume: 11, Issue:1 In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats. (D-Trp8, D-Cys14)-somatostatin (as did the somatostatin molecule itself) delayed the extinction of active avoidance behavior, antagonized ECS-induced amnesia, and did not modify spatial-discrimination learning. Des-Asn5-(D-Trp8, D-Ser13) somatostatin and des-AA1,2,4,5,12,13,-(D-Trp8) somatostatin did not influence these behaviors. The data suggest that certain parts of the somatostatin molecule are important for its behavioral actions. Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Discrimination Learning; Extinction, Psychological; Male; Peptide Fragments; Rats; Somatostatin; Space Perception; Structure-Activity Relationship	1986

Article

Year

Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats.

Psychoneuroendocrinology, 1986, Volume: 11, Issue:1

In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats. (D-Trp8, D-Cys14)-somatostatin (as did the somatostatin molecule itself) delayed the extinction of active avoidance behavior, antagonized ECS-induced amnesia, and did not modify spatial-discrimination learning. Des-Asn5-(D-Trp8, D-Ser13) somatostatin and des-AA1,2,4,5,12,13,-(D-Trp8) somatostatin did not influence these behaviors. The data suggest that certain parts of the somatostatin molecule are important for its behavioral actions.

Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Discrimination Learning; Extinction, Psychological; Male; Peptide Fragments; Rats; Somatostatin; Space Perception; Structure-Activity Relationship

1986