somatomedin-b has been researched along with Hypopituitarism* in 2 studies
2 other study(ies) available for somatomedin-b and Hypopituitarism
| Article | Year |
|---|---|
Immunoreactive somatomedin B in the human foetus and in women during pregnancy.
Immunoreactive somatomedin B (RIA-B) was identified in foetal organ extracts, amniotic fluid and foetal serum in the second trimester. After separation using a G-200 neutral Sephadex column, the RIA-B activity in the cytosol prepared from foetal organs eluted after the void volume, suggesting the dominance of activity with the molecular weight of approximately 200 K. In contrast, the majority of the RIA-B activity in amniotic fluid eluted around the elution volume, suggesting dominance of activity with a molecular weight of approximately 5 K. Cord blood RIA-B levels were examined and found to be significantly lower than adult levels. A significant correlation between cord blood RIA-B levels, and neonatal weight was found. A longitudinal study during pregnancy showed that RIA-B is increased in both healthy women and in women suffering from hypopituitarism suggesting a pituitary-independent production of RIA-B during pregnancy. Topics: Adolescent; Adult; Amniotic Fluid; Cytosol; Female; Fetal Blood; Fetus; Humans; Hypopituitarism; Middle Aged; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Radioimmunoassay; Somatomedins; Tissue Distribution | 1987 |
A screening method for measuring somatomedin B protein binding in serum from children with growth retardation.
A simple method which uses 100 microliter serum has been developed to measure the binding of somatomedin B (SMB) to protein in serum from normal children, adults, and patients with growth hormone deficiency. 125I-labelled SMB was used as binding ligand. The correlation between the binding of label by the proposed procedure and by an immunoelectrophoretic technique was acceptable (r = 0.73; P less than 0.02). The mean percentage of label bound to protein in serum from patients with deficiencies of growth hormone or other trophic hormones was significantly (P less than 0.001) lower than that for controls. The physicochemical characteristics of a specific binding-protein suggested that a protein with low capacity (160 pmol/l) and low Ka (4.37 X 10(6) l/mol was present in serum, in addition to a high concentration of alpha globulin(s) which also bound 125I SMB. Topics: Adolescent; Carrier Proteins; Child; Child, Preschool; Female; Growth Hormone; Humans; Hypopituitarism; Insulin-Like Growth Factor Binding Proteins; Male; Somatomedins | 1982 |