Compounds > soman
Page last updated: 2024-08-18

soman and Status Epilepticus

soman has been researched along with Status Epilepticus in 48 studies

*Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30) [MeSH]

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (10.42)18.2507
2000's7 (14.58)29.6817
2010's23 (47.92)24.3611
2020's13 (27.08)2.80

Authors

AuthorsStudies
Gage, M; Kannurpatti, SS; Meyer, CM; Rao, NS; Thedens, DR; Thippeswamy, T; Vasanthi, SS1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Rossetti, K1
Almanza, A; Bryant, E; Carlo, AM; Corson, BE; Gage, M; Kharate, M; Mafuta, C; Massey, N; Meyer, C; Ostrander, M; Rao, NS; Samidurai, M; Showman, L; Thippeswamy, T; Trevino, L; Vasanthi, SS; Wachter, L; Wang, C; Wohlgemuth, M1
Baldwin, R; Estrada, IBF; Furtado, MA; Lumley, L; Naylor, D; Niquet, J; Rossetti, F; Schultz, M; Suchomelova, L; Wasterlain, CG1
de Araujo Furtado, M; Kundrick, E; Lee-Stubbs, RB; Lumley, LA; Marrero-Rosado, B; Schultz, C; Stone, M; Walker, K1
Ardinger, CE; Beske, PH; Bodner, PM; Dubée, PB; Dunn, EN; Eisen, MR; Haines, KM; Honnold, CL; McCarren, HS; McDonough, JH; McNutt, PM; Nguyen, DL; Ondeck, CA; Santoro, AN1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MFM; De Araujo Furtado, M; Figueiredo, TH1
de Araujo Furtado, M; Kundrick, ER; Lumley, LA; Marrero-Rosado, BM; Nguyen, DA; Schultz, CR; Stone, MF; Walker, KA1
Abreu-Melon, J; Dingledine, R; McCarren, HS; McDonough, JH; Rojas, A; Wang, J; Wang, S; Wang, W1
He, H; Lin, G; Long, J; Luo, Y; Sui, X; Wang, Q; Wang, S; Wang, Y; Yang, J1
Acon-Chen, C; Loughery, TN; Shih, TM; Whitten, KA1
Kuruba, R; Reddy, DS; Wu, X; Zaayman, M1
Chandler, JK; Ferrara-Bowens, TM; Guignet, MA; Irwin, JF; Johnson, EA; Laitipaya, K; McCabe, JT; Palmer, DD; Shumway, LJ; Tucker, LB; Wegner, MD1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MFM; Figueiredo, TH; Pidoplichko, VI; Rossetti, K1
Lee, RB; Lumley, LA; Marrero-Rosado, B; Moffett, MC; Rice, MW; Rossetti, F; Stone, MF1
de Araujo Furtado, M; Du, F; Kundrick, E; Lumley, LA; Marrero-Rosado, B; O'Brien, S; Schultz, CR; Stone, M; Walker, K1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH1
Almeida-Suhett, CP; Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Prager, EM1
Bialer, M; Finnell, RH; Hen, N; McDonough, JH; Shekh-Ahmad, T; Wlodarczyk, B; Yagen, B1
Almeida-Suhett, CP; Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Olsen, CH; Prager, EM; Rossetti, F1
Chen, C; Chen, J; Greig, NH; He, J; Iskandar, K; Jacobowitz, DM; Marini, AM; McDonough, JH; Pan, H; Piermartiri, T; Wu, W; Yu, QS1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Pidoplichko, VI; Prager, EM1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F1
Almeida-Suhett, CP; Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Prager, EM1
Apland, JP; Chen, J; Grunberg, N; Marini, AM; McDonough, J; Pan, H; Piermartiri, TC1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Krishnan, JK; Miller, SL; Pidoplichko, VI1
Carpentier, P; Dorandeu, F; Fauvelle, F; Foquin, A; Graveron-Demilly, D; Rabeson, H; Testylier, G; van Ormondt, D1
Arvers, P; Carpentier, P; Dorandeu, F; Fauvelle, F; Foquin, A; Graveron-Demilly, D; Rabeson, H; Testylier, G1
de Araujo Furtado, M; Lichtenstein, S; Lumley, LA; Robison, C; Tong, LC; Yourick, DL1
Campbell, AJ; Clarkson, ED; Demar, JC; Evans, SA; Gordon, RK; Herdman, CA; Khan, FA; Ku, TC; Leader, H; Marek, E; Medynets, MA; Nambiar, MP; Owens, RR; Ratcliffe, RH; Schulz, SM; Thangavelu, SG1
Johnson, EA; Kan, RK1
Ling, EA; Loke, WK; Tang, FR1
Dao, TL; Geddes, CE; Guignet, MA; Johnson, EA; Kan, RK; Koemeter-Cox, AI1
Carpentier, P; Dorandeu, F; Foquin, A1
Baille, V; Barbier, L; Beaup, C; Carpentier, P; Dhote, F; Dorandeu, F; Foquin, A; Peinnequin, A; Pernot, F; Testylier, G1
Carpentier, P; Dorandeu, F; Fauvelle, F; Foquin, A; Testylier, G1
Barbier, L; Carpentier, P; Dhote, F; Dorandeu, F; Testylier, G1
Adams, JD; Cross, R; Klaidman, LK; Pazdernik, TL; Samson, F1
Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM1
Bhagat, YA; Hamilton, MG; Kendall, EJ; Mikler, J; Obenaus, A1
Baubichon, D; Bernabé, D; Burckhart, MF; Carpentier, P; Dorandeu, F; Four, E; Lallement, G1
Gordon, RK; Nambiar, MP; Ratcliffe, RH; Rezk, PE; Steele, KE; Tetz, LM1
Baille, V; Carpentier, P; Dorandeu, F; Lallement, G; Mikler, J; Sawyer, T; Testylier, G1
Blanchet, G; Carpentier, P; Lallement, G; Sentenac-Roumanou, H1
Beers, ET; Brennecke, LH; Sparenborg, S1
Koplovitz, I; Skvorak, JP1
Ballough, GP; Cann, FJ; Filbert, MG; Forster, JS; Kling, CE; Smith, CD1
Braitman, DJ; Brennecke, LH; Jaax, NK; Sparenborg, S1

Reviews

4 review(s) available for soman and Status Epilepticus

ArticleYear
Rational polytherapy in the treatment of cholinergic seizures.
    Neurobiology of disease, 2020, Volume: 133

    Topics: Animals; Anticonvulsants; Cholinesterase Inhibitors; Drug Therapy, Combination; Ketamine; Male; Midazolam; Muscarinic Agonists; Nerve Agents; Pilocarpine; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus; Valproic Acid

2020
Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy.
    Neurobiology of disease, 2020, Volume: 133

    Topics: Animals; Anticonvulsants; Cholinesterase Inhibitors; Humans; Isoquinolines; Nerve Agents; Neuroprotective Agents; Organophosphate Poisoning; Rats; Receptors, AMPA; Receptors, Kainic Acid; Soman; Status Epilepticus; Tetrazoles

2020
Comparison of status epilepticus models induced by pilocarpine and nerve agents - a systematic review of the underlying aetiology and adopted therapeutic approaches.
    Current medicinal chemistry, 2011, Volume: 18, Issue:6

    Topics: Animals; Brain; Chemical Warfare Agents; Humans; Pilocarpine; Sarin; Soman; Status Epilepticus

2011
Ketamine combinations for the field treatment of soman-induced self-sustaining status epilepticus. Review of current data and perspectives.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dizocilpine Maleate; Guinea Pigs; Humans; Ketamine; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Soman; Status Epilepticus; Time Factors

2013

Other Studies

44 other study(ies) available for soman and Status Epilepticus

ArticleYear
Sex-based structural and functional MRI outcomes in the rat brain after soman (GD) exposure-induced status epilepticus.
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Animals; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Nerve Agents; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus

2023
Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure.
    Experimental biology and medicine (Maywood, N.J.), 2023, Volume: 248, Issue:7

    Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Female; Male; Midazolam; Nerve Agents; Rats; Seizures; Soman; Status Epilepticus

2023
Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy.
    Journal of neuroinflammation, 2023, Jul-12, Volume: 20, Issue:1

    Topics: Animals; Atropine; Cytokines; Enzyme Inhibitors; Epilepsy; Gliosis; Male; Midazolam; Neuroglia; Nitric Oxide Synthase Type II; Parvalbumins; Rats; Rats, Sprague-Dawley; Seizures; Soman; Status Epilepticus

2023
Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice.
    Annals of the New York Academy of Sciences, 2020, Volume: 1479, Issue:1

    Topics: Animals; Carboxylesterase; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Knockout; Midazolam; Nerve Agents; Sex Characteristics; Soman; Status Epilepticus

2020
Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.
    Epilepsy research, 2020, Volume: 162

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Levetiracetam; Mice; Nerve Agents; Phenobarbital; Soman; Status Epilepticus; Valproic Acid

2020
Electroencephalographic analysis in soman-exposed 21-day-old rats and the effects of midazolam or LY293558 with caramiphen.
    Annals of the New York Academy of Sciences, 2020, Volume: 1479, Issue:1

    Topics: Animals; Antidotes; Cyclopentanes; Electrocardiography; Isoquinolines; Male; Midazolam; Nerve Agents; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus; Tetrazoles

2020
Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice.
    Epilepsy & behavior : E&B, 2020, Volume: 111

    Topics: Animals; Anticonvulsants; Brain; Carboxylesterase; Drug Therapy, Combination; Electroencephalography; Female; Ketamine; Male; Mice; Mice, Knockout; Midazolam; Seizures; Soman; Status Epilepticus

2020
Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman.
    Neurotoxicology, 2021, Volume: 83

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Waves; Cell Death; Cyclooxygenase 2; Disease Models, Animal; Electroencephalography; Encephalitis; Gliosis; Isoflurophate; Male; Rats, Sprague-Dawley; Soman; Status Epilepticus; Time Factors; Weight Loss

2021
TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NLRP3 Inflammasome.
    Neuroscience bulletin, 2021, Volume: 37, Issue:7

    Topics: Animals; Brain; Brain Injuries; Inflammasomes; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Receptors, N-Methyl-D-Aspartate; Soman; Status Epilepticus; TRPV Cation Channels

2021
Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for organophosphorus nerve agent-induced Status Epilepticus.
    Toxicology and applied pharmacology, 2021, 05-15, Volume: 419

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Anticonvulsants; Brain; Deoxyadenosines; Disease Models, Animal; Drug Administration Schedule; Injections, Intramuscular; Male; Neuroprotective Agents; Norbornanes; Rats, Sprague-Dawley; Sarin; Soman; Status Epilepticus; Time Factors

2021
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
    Neuropharmacology, 2021, 06-15, Volume: 191

    Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons; Organophosphates; Pilocarpine; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus

2021
Neuropathological and behavioral sequelae in IL-1R1 and IL-1Ra gene knockout mice after soman (GD) exposure.
    Neurotoxicology, 2017, Volume: 63

    Topics: Animals; Brain; Convulsants; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Interleukin 1 Receptor Antagonist Protein; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interleukin-1 Type I; Signal Transduction; Soman; Spatial Learning; Status Epilepticus

2017
Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 365, Issue:2

    Topics: Animals; Anticonvulsants; Anxiety; Basolateral Nuclear Complex; Behavior, Animal; Child; Cyclopentanes; Diazepam; Disease Models, Animal; Drug Interactions; Humans; Isoquinolines; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus; Tetrazoles

2018
Age-Related Susceptibility to Epileptogenesis and Neuronal Loss in Male Fischer Rats Exposed to Soman and Treated With Medical Countermeasures.
    Toxicological sciences : an official journal of the Society of Toxicology, 2018, 07-01, Volume: 164, Issue:1

    Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Brain; Cell Count; Chemical Warfare Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Lethal Dose 50; Male; Medical Countermeasures; Neurons; Rats, Inbred F344; Seizures; Soman; Status Epilepticus; Telemetry; Time Factors

2018
Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.
    Epilepsia, 2018, Volume: 59, Issue:12

    Topics: Animals; Anticonvulsants; Carboxylesterase; Cell Count; Chemical Warfare Agents; Cholinesterase Reactivators; Electroencephalography; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Nerve Degeneration; Seizures; Soman; Status Epilepticus

2018
Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure.
    Neurotoxicology, 2013, Volume: 38

    Topics: Amygdala; Animals; Brain; Cholinesterase Inhibitors; Hippocampus; Male; Nerve Degeneration; Olfactory Pathways; Rats; Soman; Status Epilepticus

2013
Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus.
    Journal of medicinal chemistry, 2013, Aug-22, Volume: 56, Issue:16

    Topics: Acetamides; Amides; Animals; Anticonvulsants; Disease Models, Animal; Rats; Soman; Status Epilepticus; Stereoisomerism; Teratogens; Valproic Acid

2013
The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: relation to anxiety-like behavior.
    Neuropharmacology, 2014, Volume: 81

    Topics: Acetylcholinesterase; Animals; Anxiety; Basolateral Nuclear Complex; Cholinesterase Inhibitors; Disease Models, Animal; Disease Progression; Exploratory Behavior; Fluoresceins; Gene Expression Regulation, Enzymologic; Glutamate Decarboxylase; Long-Term Potentiation; Male; Rats; Rats, Sprague-Dawley; Recovery of Function; Reflex, Startle; Soman; Status Epilepticus; Time Factors

2014
(-)-Phenserine attenuates soman-induced neuropathology.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Animals; Carrier Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Gene Expression Regulation; Homer Scaffolding Proteins; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus

2014
Pathophysiological mechanisms underlying increased anxiety after soman exposure: reduced GABAergic inhibition in the basolateral amygdala.
    Neurotoxicology, 2014, Volume: 44

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Basolateral Nuclear Complex; Chemical Warfare Agents; Inhibitory Postsynaptic Potentials; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Soman; Status Epilepticus; Synaptic Transmission

2014
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:2

    Topics: Alanine; Amygdala; Animals; Anticonvulsants; Anxiety; Diazepam; Hippocampus; Male; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Soman; Status Epilepticus; Thymine

2014
A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists.
    Toxicology and applied pharmacology, 2015, Apr-15, Volume: 284, Issue:2

    Topics: Acetylcholinesterase; Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Disease Models, Animal; Hippocampus; Isoquinolines; Male; Nerve Degeneration; Oximes; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Soman; Status Epilepticus; Tetrazoles

2015
Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure.
    Neuromolecular medicine, 2015, Volume: 17, Issue:3

    Topics: alpha-Linolenic Acid; Animals; Antigens, Nuclear; Atropine Derivatives; Avoidance Learning; Brain Damage, Chronic; Brain-Derived Neurotrophic Factor; Diazepam; DNA Replication; Doublecortin Domain Proteins; Electroshock; Exploratory Behavior; Hippocampus; Male; Mechanistic Target of Rapamycin Complex 1; Microtubule-Associated Proteins; Multiprotein Complexes; Nerve Tissue Proteins; Neurogenesis; Neuropeptides; Neuroprotective Agents; Neurotoxins; Oximes; Proto-Oncogene Proteins c-akt; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; Sirolimus; Soman; Status Epilepticus; TOR Serine-Threonine Kinases

2015
The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala.
    The Journal of pharmacology and experimental therapeutics, 2017, Volume: 360, Issue:1

    Topics: Animals; Basolateral Nuclear Complex; Male; Paraoxon; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Soman; Status Epilepticus; Sulfonamides; Synapses; Thiadiazoles

2017
Quantitation with QUEST of brain HRMAS-NMR signals: application to metabolic disorders in experimental epileptic seizures.
    Magnetic resonance in medicine, 2008, Volume: 59, Issue:6

    Topics: Acetates; Alanine; Algorithms; Animals; Aspartic Acid; Brain; Choline; gamma-Aminobutyric Acid; Glutamine; Inositol; Lactates; Magnetic Resonance Spectroscopy; Mice; Monte Carlo Method; Soman; Status Epilepticus

2008
Changes in mouse brain metabolism following a convulsive dose of soman: a proton HRMAS NMR study.
    Toxicology, 2010, Jan-12, Volume: 267, Issue:1-3

    Topics: Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Magnetic Resonance Imaging; Male; Mice; Protons; Soman; Status Epilepticus

2010
Spontaneous recurrent seizures after status epilepticus induced by soman in Sprague-Dawley rats.
    Epilepsia, 2010, Volume: 51, Issue:8

    Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Electroencephalography; Hippocampus; Male; Neurologic Examination; Rats; Rats, Sprague-Dawley; Recurrence; Silver Staining; Soman; Status Epilepticus; Telemetry; Thalamus

2010
Pro-2-PAM therapy for central and peripheral cholinesterases.
    Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3

    Topics: Acetylcholinesterase; Animals; Apoptosis; Brain; Central Nervous System; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Activation; Guinea Pigs; Hippocampus; Isoflurophate; Male; Neurons; Peripheral Nervous System; Pralidoxime Compounds; Prodrugs; Skin; Soman; Status Epilepticus; Survival Analysis

2010
The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations.
    Journal of neuroinflammation, 2010, Jul-22, Volume: 7

    Topics: Acute-Phase Reaction; Animals; Brain; Convulsants; Cytokines; Humans; Immunoassay; Interleukin-1beta; Interleukin-6; Male; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus; Tumor Necrosis Factor-alpha

2010
Increased expression of the chemokines CXCL1 and MIP-1α by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats.
    Journal of neuroinflammation, 2011, May-02, Volume: 8

    Topics: Animals; Brain; Chemokine CCL3; Chemokine CXCL1; Convulsants; Endothelial Cells; Immunoassay; Male; Microglia; Neurons; Neutrophil Infiltration; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus

2011
A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus.
    Neurotoxicology, 2012, Volume: 33, Issue:4

    Topics: Animals; Biomarkers; Brain; Cell Count; Coloring Agents; Disease Models, Animal; Eosine I Bluish; Hematoxylin; Image Processing, Computer-Assisted; Male; Mice; Myelin Sheath; Nerve Degeneration; Neurons; Soman; Staining and Labeling; Status Epilepticus; Time Factors

2012
Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after a toxic status epilepticus in mice.
    Toxicology and applied pharmacology, 2012, Mar-01, Volume: 259, Issue:2

    Topics: Animals; Area Under Curve; Atropine; Brain; Chemical Warfare Agents; Chemokine CCL5; Chemokine CXCL1; Excitatory Amino Acid Antagonists; Ketamine; Male; Mice; Muscarinic Antagonists; Neuroglia; Neutrophils; Polymerase Chain Reaction; Random Allocation; RNA, Messenger; Soman; Status Epilepticus

2012
Prediction of neuroprotective treatment efficiency using a HRMAS NMR-based statistical model of refractory status epilepticus on mouse: a metabolomic approach supported by histology.
    Journal of proteome research, 2012, Jul-06, Volume: 11, Issue:7

    Topics: Animals; Anticonvulsants; Atropine; Biomarkers; Brain; Drug Therapy, Combination; Ketamine; Magnetic Resonance Spectroscopy; Male; Metabolome; Mice; Midazolam; Multivariate Analysis; Neuroprotective Agents; Principal Component Analysis; Soman; Status Epilepticus

2012
Alterations in brain glutathione homeostasis induced by the nerve gas soman.
    Neurotoxicity research, 2003, Volume: 5, Issue:3

    Topics: Animals; Brain; Chemical Warfare Agents; Glutathione; Homeostasis; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; Soman; Status Epilepticus; Sulfhydryl Compounds; Time Factors

2003
Effects of fosphenytoin on nerve agent-induced status epilepticus.
    Drug and chemical toxicology, 2004, Volume: 27, Issue:1

    Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Injections, Intraperitoneal; Male; Phenytoin; Pralidoxime Compounds; Pyridostigmine Bromide; Soman; Status Epilepticus

2004
Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging.
    Neurotoxicology, 2005, Volume: 26, Issue:6

    Topics: Animals; Anticonvulsants; Brain; Cell Death; Cyclohexanes; Cyclohexenes; Diazepam; Diffusion Magnetic Resonance Imaging; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Seizures; Soman; Status Epilepticus

2005
Efficacy of the ketamine-atropine combination in the delayed treatment of soman-induced status epilepticus.
    Brain research, 2005, Jul-27, Volume: 1051, Issue:1-2

    Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Ketamine; Male; Midazolam; Seizures; Soman; Statistics, Nonparametric; Status Epilepticus; Time Factors

2005
Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure.
    Toxicology and industrial health, 2006, Volume: 22, Issue:6

    Topics: Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Brain; Chemical Warfare Agents; Cholinergic Antagonists; Drug Evaluation, Preclinical; Electroencephalography; Heart Rate; Lethal Dose 50; Lithium Chloride; Male; Models, Animal; Motor Activity; Muscarinic Agonists; N-Methylscopolamine; Neuroprotective Agents; Neurotoxicity Syndromes; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Soman; Status Epilepticus

2006
Protective effects of S+ ketamine and atropine against lethality and brain damage during soman-induced status epilepticus in guinea-pigs.
    Toxicology, 2007, May-20, Volume: 234, Issue:3

    Topics: Animals; Atropine; Brain Damage, Chronic; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Guinea Pigs; Ketamine; Lethal Dose 50; Male; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Soman; Status Epilepticus; Stereoisomerism

2007
[Prevention and treatment of status epilepticus induced by soman].
    Annales pharmaceutiques francaises, 1994, Volume: 52, Issue:1

    Topics: Animals; Diazepam; Guinea Pigs; Male; Phencyclidine; Rats; Rats, Wistar; Soman; Status Epilepticus

1994
Pharmacological dissociation of the motor and electrical aspects of convulsive status epilepticus induced by the cholinesterase inhibitor soman.
    Epilepsy research, 1993, Volume: 14, Issue:2

    Topics: Analysis of Variance; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Electroencephalography; Guinea Pigs; Image Processing, Computer-Assisted; Male; Pralidoxime Compounds; Pyridostigmine Bromide; Scopolamine; Soman; Status Epilepticus

1993
Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats.
    Epilepsy research, 1998, Volume: 30, Issue:2

    Topics: Animals; Cholinesterase Reactivators; Convulsants; Electroencephalography; Male; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus

1998
GM1 monosialoganglioside pretreatment protects against soman-induced seizure-related brain damage.
    Molecular and chemical neuropathology, 1998, Volume: 34, Issue:1

    Topics: Acetylcholinesterase; Animals; Brain; Brain Chemistry; Brain Damage, Chronic; Cholinesterase Inhibitors; Convulsants; Electroencephalography; G(M1) Ganglioside; Glial Fibrillary Acidic Protein; Image Processing, Computer-Assisted; Injections, Intraventricular; Male; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Seizures; Soman; Status Epilepticus

1998
Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman.
    Neuropharmacology, 1992, Volume: 31, Issue:4

    Topics: Amygdala; Animals; Brain; Cerebral Cortex; Dizocilpine Maleate; Electroencephalography; Evoked Potentials; Guinea Pigs; Hippocampus; Necrosis; Neurons; Organ Specificity; Soman; Status Epilepticus; Thalamus; Time Factors

1992