solufenum and Arthritis--Rheumatoid

In a double-blind clinical study, the analgesic effects of ibuprofen-lysinsalt and diclofenac were compared in 59 patients with rheumatoid arthritis. In the first phase, the patients were given either 1,000 mg ibuprofen-lysinsalt or 50 mg diclofenac at 8.00 a.m. Pain intensity was assessed by the patient with the aid of the visual analog scale (VAS) and a sliding numerical scale. With respect to the rate of onset of the effect and the course of the pain, no statistically significant differences were seen between the two drugs. In a second phase, in which the already mentioned doses of the drugs were administered 3 times a day for 7 days, there was again no significant difference in pain. Drug tolerance was considered very good by 90% of the ibuprofen-lysinsalt group, and 67% of the diclofenac group. Ibuprofen-lysinsalt is a universal, well-tolerated analgetic which can also be used to combat arthritic pain. The somewhat better analgesic effect of ibuprofen-lysinsalt was too small to be statistically significant.

Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; Ibuprofen; Lysine; Pain Measurement; Random Allocation

Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Back Pain; Brachial Plexus Neuritis; Female; Humans; Ibuprofen; Joint Diseases; Lysine; Male; Middle Aged; Osteoarthritis; Palliative Care; Sciatica; Spinal Diseases

Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Ibuprofen; Lysine; Male; Middle Aged