Compounds > sofosbuvir
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sofosbuvir and Coronavirus Infections

sofosbuvir has been researched along with Coronavirus Infections in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's12 (100.00)2.80

Authors

AuthorsStudies
Elfiky, AA1
Khodarahmi, R; Sayad, B; Sobhani, M1
Khalili, H; Nourian, A1
Izzi, A; Maggi, P; Messina, V; Rinaldi, L1
Becerra, A; Campillo-Balderas, JA; Jácome, R; Lazcano, A; Ponce de León, S1
Anderson, TK; Chien, M; Jockusch, S; Ju, J; Kirchdoerfer, RN; Kumar, S; Li, X; Russo, JJ; Tao, C1
Abbaspour Kasgari, H; Alikhani, A; Babamahmoodi, F; Davoudi Badabi, AR; Davoudi, L; Garratt, A; Hedayatizadeh Omran, A; Hill, A; Levi, J; Merat, S; Moradi, S; Saeedi, M; Shabani, AM; Simmons, B; Tirgar Fakheri, H; Wentzel, H1
Afhami, S; Akbarpour, E; Ali Asgari, A; Aliannejad, R; Anushirvani, A; Davarpanah, AH; Garratt, A; Hill, A; Hosamirudsai, H; Kheiri, Z; Levi, J; Merat, S; Montazeri, M; Norouzi, A; Qavi, A; Radmard, AR; Sadeghi, A; Simmons, B; Wentzel, H1
Bitaraf, S; Eslami, G; Esmaeilian, H; Freeman, J; Hajizadeh Farsani, M; Hill, A; Jafari Kashi, AH; Jelvay, S; Lotfi, Z; Marjani, S; Mobarak, M; Mobarak, S; Momtazan, M; Mousaviasl, S; Radmanesh, E; Sadeghi, A; Salmanzadeh, S; Simmons, B; Tabibi, R; Talebzadeh, SM; Wentzel, H; Wickramatillake, A1
Perišić, O1
Chien, M; Jockusch, S; Ju, J; Kalachikov, S; Kumar, S; Li, X; Morozova, I; Russo, JJ; Tao, C1
Chien, M; Jockusch, S; Ju, J; Kalachikov, S; Kirchdoerfer, RN; Kumar, S; Li, X; Morozova, I; Russo, JJ; Tao, C1

Trials

3 trial(s) available for sofosbuvir and Coronavirus Infections

ArticleYear
Evaluation of the efficacy of sofosbuvir plus daclatasvir in combination with ribavirin for hospitalized COVID-19 patients with moderate disease compared with standard care: a single-centre, randomized controlled trial.
    The Journal of antimicrobial chemotherapy, 2020, 11-01, Volume: 75, Issue:11

    Topics: Adult; Aged; Antiviral Agents; Betacoronavirus; Carbamates; Coronavirus Infections; COVID-19; Drug Therapy, Combination; Female; Hospitalization; Humans; Imidazoles; Iran; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pyrrolidines; Ribavirin; SARS-CoV-2; Sofosbuvir; Treatment Outcome; Valine

2020
Sofosbuvir and daclatasvir compared with standard of care in the treatment of patients admitted to hospital with moderate or severe coronavirus infection (COVID-19): a randomized controlled trial.
    The Journal of antimicrobial chemotherapy, 2020, 11-01, Volume: 75, Issue:11

    Topics: Adult; Aged; Antiviral Agents; Betacoronavirus; Carbamates; Coronavirus Infections; COVID-19; Drug Therapy, Combination; Female; Humans; Imidazoles; Iran; Male; Middle Aged; Pandemics; Patient Admission; Pneumonia, Viral; Pyrrolidines; SARS-CoV-2; Severity of Illness Index; Sofosbuvir; Treatment Outcome; Valine

2020
The impact of sofosbuvir/daclatasvir or ribavirin in patients with severe COVID-19.
    The Journal of antimicrobial chemotherapy, 2020, 11-01, Volume: 75, Issue:11

    Topics: Adult; Aged; Antiviral Agents; Betacoronavirus; Carbamates; Coronavirus Infections; COVID-19; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pyrrolidines; Ribavirin; SARS-CoV-2; Sofosbuvir; Treatment Outcome; Valine

2020

Other Studies

9 other study(ies) available for sofosbuvir and Coronavirus Infections

ArticleYear
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.
    Life sciences, 2020, May-01, Volume: 248

    Topics: Adenosine Monophosphate; Alanine; Alphacoronavirus; Amino Acid Sequence; Antiviral Agents; Betacoronavirus; Catalytic Domain; Computational Biology; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Molecular Docking Simulation; Pneumonia, Viral; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Ribavirin; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sequence Alignment; Sequence Homology, Amino Acid; Sofosbuvir; Thermodynamics; Uridine Triphosphate; Viral Proteins

2020
Sofosbuvir as Repurposed Antiviral Drug Against COVID-19: Why Were We Convinced to Evaluate the Drug in a Registered/Approved Clinical Trial?
    Archives of medical research, 2020, Volume: 51, Issue:6

    Topics: Antiviral Agents; Betacoronavirus; Carbamates; Clinical Trials as Topic; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Heterocyclic Compounds, 4 or More Rings; Humans; Iran; Pandemics; Patient Safety; Pneumonia, Viral; SARS-CoV-2; Sofosbuvir

2020
Sofosbuvir as a potential option for the treatment of COVID-19.
    Acta bio-medica : Atenei Parmensis, 2020, May-11, Volume: 91, Issue:2

    Topics: Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; Sofosbuvir

2020
Editorial - Sofosbuvir/Velpatasvir as a combination with strong potential activity against SARS-CoV2 (COVID-19) infection: how to use direct-acting antivirals as broad-spectrum antiviral agents.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:10

    Topics: Antiviral Agents; Betacoronavirus; Carbamates; Coronavirus Infections; COVID-19; DNA-Directed DNA Polymerase; Drug Therapy, Combination; Heterocyclic Compounds, 4 or More Rings; Humans; Pandemics; Pneumonia, Viral; SARS-CoV-2; Sofosbuvir; Viral Proteins

2020
Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic.
    Scientific reports, 2020, 06-09, Volume: 10, Issue:1

    Topics: Antiviral Agents; Base Sequence; Betacoronavirus; Catalytic Domain; Computer Simulation; Coronavirus Infections; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Humans; Middle East Respiratory Syndrome Coronavirus; Pandemics; Pneumonia, Viral; Protein Binding; Protein Structure, Tertiary; RNA-Dependent RNA Polymerase; SARS-CoV-2; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Sofosbuvir; Viral Nonstructural Proteins

2020
Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19.
    Journal of proteome research, 2020, 11-06, Volume: 19, Issue:11

    Topics: Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Dideoxynucleosides; Humans; Pandemics; Pneumonia, Viral; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sofosbuvir; Viral Nonstructural Proteins

2020
Recognition of Potential COVID-19 Drug Treatments through the Study of Existing Protein-Drug and Protein-Protein Structures: An Analysis of Kinetically Active Residues.
    Biomolecules, 2020, 09-21, Volume: 10, Issue:9

    Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Antibodies, Viral; Antigen-Antibody Reactions; Antiviral Agents; Betacoronavirus; Binding Sites; Chloroquine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Eflornithine; Humans; Hydrophobic and Hydrophilic Interactions; Ivermectin; L-Lactate Dehydrogenase; Models, Molecular; Molecular Docking Simulation; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Proline; Protein Binding; Protein Conformation; Protein Interaction Mapping; Receptors, Glycine; Saposins; SARS-CoV-2; Sofosbuvir; Spike Glycoprotein, Coronavirus; Structure-Activity Relationship

2020
Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir.
    Scientific reports, 2020, 10-06, Volume: 10, Issue:1

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Coronavirus RNA-Dependent RNA Polymerase; COVID-19; Drug Discovery; Drug Repositioning; Exonucleases; Hepacivirus; Hepatitis C; Humans; Pandemics; Pneumonia, Viral; Prodrugs; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Sofosbuvir; Viral Nonstructural Proteins; Virus Replication

2020
Nucleotide analogues as inhibitors of SARS-CoV Polymerase.
    Pharmacology research & perspectives, 2020, Volume: 8, Issue:6

    Topics: Antiviral Agents; Betacoronavirus; Carbamates; Coronavirus Infections; COVID-19; Dideoxynucleotides; Drug Combinations; Heterocyclic Compounds, 4 or More Rings; Humans; Pandemics; Pneumonia, Viral; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sofosbuvir; Thymine Nucleotides; Zidovudine

2020