sodium-taurodeoxycholate has been researched along with Hypercholesterolemia* in 1 studies
1 other study(ies) available for sodium-taurodeoxycholate and Hypercholesterolemia
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Potential probiotic attributes and antagonistic activity of an indigenous isolate Lactobacillus plantarum DM5 from an ethnic fermented beverage "Marcha" of north eastern Himalayas.
A novel isolate DM5 identified as Lactobacillus plantarum displayed in vitro probiotic properties as well as antimicrobial activity. It showed adequate level of survival to the harsh conditions of the gastrointestinal tract and survived low acidic pH 2.5 for 5 h. Artificial gastric juice and intestinal fluidic environment decreased the initial viable cell population of isolate DM5 only by 7% and 13%, respectively, while lysozyme (200 µg/ml) and bile salt (0.5%) enhanced its growth. It was found to deconjugate taurodeoxycholic acid, indicating its potential to reduce hypercholesterolemia. Isolate DM5 demonstrated cell surface hydrophobicity of 53% and autoaggregation of 54% which are the prerequisite for adhesion to epithelial cells and colonization to host. Bacteriocin activity of isolate was found to be 6400 AU/ml as it inhibited the growth of food borne pathogens Escherichia coli, Staphylococcus aureus, and Alcaligenes faecalis. The bactericidal action of bacteriocin from isolate was analyzed by flow cytometry, rendering its use as prospective probiotic and starter culture in food industry. Topics: Alcaligenes faecalis; Anti-Bacterial Agents; Bacterial Adhesion; Beverages; Caco-2 Cells; Diet; Escherichia coli; Fermentation; Food Microbiology; Foodborne Diseases; Humans; Hydrophobic and Hydrophilic Interactions; Hypercholesterolemia; Intestinal Mucosa; Lactobacillus plantarum; Microbial Interactions; Probiotics; Prospective Studies; Staphylococcus aureus; Taurodeoxycholic Acid | 2014 |