sodium-propionate and Breast-Neoplasms

Short-chain fatty acids (SCFAs) are ubiquitous lipids produced as a result of bacterial fermentation of dietary fiber. While their role in colorectal cancer is well known, the effect of SCFAs in breast cancer is poorly defined.. To understand the various effects of SCFAs on breast carcinogenesis, we investigated the effect of sodium butyrate (NaB) and sodium propionate (NaP) in MCF-7 cell line.. Cells were incubated with different concentrations of NaB or NaP for 24, 48, 72 or 96 h. Cell proliferation was assayed using MTT kit. Cell cycle was performed using propidium iodide staining then analyzed with a flow cytometer. Apoptosis was assessed by Hoechst technique and cell-cycle sub-G1 phase.. NaB and NaP inhibited MCF-7 cell proliferation in a dose-dependent manner with respective IC. Our results show that SCFAs may be considered as an interesting inhibitor for breast cancer progression.

Topics: Apoptosis; Breast Neoplasms; Butyric Acid; Carcinogenesis; Cell Cycle; Cell Proliferation; Disease Progression; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Propionates