sodium-pertechnetate-tc-99m and Vascular-Diseases

A simplified isotope washout technique has been devised to calculate the skin perfusion pressure (SPP) and skin vascular resistance (SVR). This test is simple, requires inexpensive equipment and is well tolerated by patients. SPP and SVR were calculated in 20 patients less than 30 years of age, 13 patients greater than 30 years of age and in 15 patients with peripheral vascular disease (PVD). With increasing age the SPP and SVR were increased. The SPP was similar to the mean arterial pressure in normal individuals but was decreased in patients with PVD. The SPP is a useful indicator of the severity of the PVD. The SPP and SVR were higher in the calf than in the foot. This is probably related to the decrease in pressure in the distal arterial tree. SPP was increased by 110% and skin blood flow by 190% by arterial reconstructive surgery. This test may be of use in assessing the effectiveness of arterial surgery.

Topics: Adolescent; Adult; Age Factors; Aged; Arteries; Blood Pressure; Blood Vessel Prosthesis; Evaluation Studies as Topic; Female; Humans; Leg; Male; Middle Aged; Perfusion; Skin; Sodium Pertechnetate Tc 99m; Vascular Diseases; Vascular Resistance

Skeletal muscle blood flow (SMBF) is a crucial indicator of impaired peripheral circulation. Although 133Xe has long been used for estimation of regional SMBF, its lipophilic and volatile nature hampers precise measurement. Therefore, we established an improved method based on 99mTc-pertechnetate ion (99mTcO-4) clearance.. Ten healthy male volunteers including five rugby players and five non-athletes (each group aged 25-35 years) received injection of 99mTcO-4 into the bilateral tibialis anterior muscles and gastrocnemius muscles (GCMs). The radioactivity of 99mTcO-4 before, during, and after toe-up or treadmill exercise was traced using a gamma-camera. Regional SMBF in absolute values (in ml/min/100 g muscle) was then calculated based on the half-time obtained from the time-activity curve.. In both the groups, SMBF in tibialis anterior muscle changed similarly with values at the same levels. In contrast, SMBF in GCM showed marked difference between the two groups: in rugby players, SMBF in GCM returned to the baseline level (6.5+/-1.7, n=10) immediately after treadmill exercise, whereas that in non-athletes remained high (16.2+/-3.2, n=10).. Regional SMBF measured by 99mTcO-4 clearance can indicate effectiveness of exercise training, and would be a diagnostic tool and prognostic indicator for use in patients with impaired peripheral circulation.

Topics: Adult; Exercise; Gamma Cameras; Gamma Rays; Humans; Male; Muscle, Skeletal; Prognosis; Radiopharmaceuticals; Regional Blood Flow; Research Design; Sodium Pertechnetate Tc 99m; Sports; Time Factors; Vascular Diseases

Topics: Adult; Aged; Catheterization, Central Venous; Female; Humans; Kidney Failure, Chronic; Male; Methods; Middle Aged; Radionuclide Imaging; Renal Dialysis; Sodium Pertechnetate Tc 99m; Subclavian Vein; Vascular Diseases; Vascular Patency

Topics: Adult; Aged; Angiography; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium; Vascular Diseases

A method of measuring the function of the calf muscle pump using in vivo 99Tcm-labelled red cells is described. This new, non-invasive method can provide detailed information about the emptying and refilling of the deep and superficial veins of the calf which may prove to be superior to those methods of assessment currently used in the selection and follow-up of patients for venous surgery.

Topics: Erythrocytes; Humans; Leg; Muscle Contraction; Muscles; Physical Exertion; Plethysmography; Regional Blood Flow; Sodium Pertechnetate Tc 99m; Technetium; Vascular Diseases; Veins

Four men with clinical features of superior vena caval syndrome due to large substernal non-toxic multinodular goitre have undergone radionuclide superior vena caval studies. In all cases the dynamic scintigraphs showed a characteristic thyroidal configuration attributed to the definition of stretched thyroidal veins and their tributaries. Radiocontrast studies of two patients demonstrated the characteristic thyroid configuration. A radionuclide superior venacavogram taken post-thyroid lobectomy in one case showed the features had reverted to normal.

Topics: Adult; Aged; Constriction, Pathologic; Goiter, Substernal; Humans; Iodine Radioisotopes; Male; Radionuclide Imaging; Serum Albumin; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Aggregated Albumin; Vascular Diseases; Vena Cava, Superior

The clinical picture of ulcerated purple plaques on the legs often suggests several diagnoses: Kaposi's sarcoma, stasis dermatitis, atrophie blanche (livedoid vasculitis), and a poorly understood condition called acroangiodermatitis of Favre-Chaix (pseudo-Kaposi's sarcoma). Even the skin biopsy may not always be conclusive. We describe our experience with three patients with pseudo-Kaposi's sarcoma, one with "true" Kaposi's sarcoma and two with atrophie blanche. Clinical and histopathologic similarities among these three conditions pointed up the need for additional confirmatory studies, i.e., isotope scanning. The technetium scan was positive in both Kaposi's sarcoma and pseudo-Kaposi's sarcoma but negative in atrophie blanche.

Topics: Acrodermatitis; Adult; Aged; Diagnosis, Differential; Female; Humans; Male; Radionuclide Imaging; Sarcoma, Kaposi; Skin; Skin Neoplasms; Sodium Pertechnetate Tc 99m; Syndrome; Technetium; Vascular Diseases; Vasculitis