sodium-pertechnetate-tc-99m and Varicose-Veins

Ultrasound-guided foam sclerotherapy (UGFS) is a technique in which a mixture of sclerosing drug and gas is used to treat varicose veins. Several authors have demonstrated transient systemic effects after UGFS. These effects are not well understood but probably originate from a systemic distribution of the sclerosing foam. Therefore, safety measures have been developed to prevent foam from flowing into the deep venous system. The aim of the study is to evaluate whether blockage of the saphenofemoral (SF) junction by either manual compression or surgical ligation prevents microbubbles from leaking into the deep venous circulation.. To detect the distribution of microbubbles, radioactive pertechnetate (99mTcO4-) was added to the foam solution. Initially, in vitro trials were performed in the laboratory to investigate the effect of 99mTc on foam stability. The time taken for foam to liquefy was measured for foam alone and for the mixture with 99mTc. In subsequent research, eight varicose great saphenous veins (GSVs) were treated by UGFS. In three patients, this treatment was preceded by surgical ligation of the SF junction. In three patients, the groin was manually compressed during UGFS. In two patients, UGFS was performed without compression of the groin.. In vitro, 99mTc did not influence foam stability; after 2.6 min all foam had reduced to liquid, regardless of whether 99mTc had been added or not. In vivo trials showed that all patients showed a decrease in the cumulative amount of 99mTc detected in the GSV following polidocanol-99mTc mixture injection. However, the decrease of radioactivity was slightly reduced when compression or ligation of the SF junction was performed.. Blocking the SF junction during UGFS using either manual compression or ligation does not prevent, but may reduce the flow of foam into the femoral vein.

Topics: Female; Femoral Vein; Humans; Ligation; Male; Microbubbles; Middle Aged; Netherlands; Pressure; Radionuclide Imaging; Radiopharmaceuticals; Saphenous Vein; Sclerosing Solutions; Sclerotherapy; Sodium Pertechnetate Tc 99m; Treatment Outcome; Ultrasonography, Doppler, Duplex; Ultrasonography, Interventional; Varicose Veins

Topics: Gastrointestinal Hemorrhage; Humans; Omentum; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Varicose Veins

In varicose vein surgery, significant postoperative morbidity results from subcutaneous haematoma formation and limb swelling after saphenous vein stripping. We investigated the effectiveness of a high-compression short-stretch adhesive bandage compared with non-adhesive crêpe in reducing haemorrhage after stripping of varicose veins. Using 99mTc-labelled red blood cells, the degree of postoperative bleeding was assessed in 10 patients with bilateral varicose veins allocated for stripping and ligation. High-compression adhesive bandaging was applied to the experimental limb and a non-adhesive bandage to the contralateral control limb. Results show that adequate compression bandaging can decrease subcutaneous haematoma formation after stripping of varicose veins.

Topics: Adult; Bandages; Connective Tissue Diseases; Female; Hemorrhage; Humans; Male; Middle Aged; Postoperative Care; Postoperative Complications; Pressure; Sodium Pertechnetate Tc 99m; Varicose Veins

Topics: Female; Gastrointestinal Hemorrhage; Humans; Middle Aged; Omentum; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium Tc 99m Pyrophosphate; Tin Polyphosphates; Varicose Veins

Comprehensive assessment of macro- and microhemodynamics of the lower limbs in 61 patients with varicosis using radionuclide angiography and the method of 99m-Tc-pertechnetate clearance from the intracutaneous depot has shown that peripheral circulatory disturbances correspond to a stage of disease and trophic skin lesions depend on the state of microcirculation. Two types of microcirculatory disturbances have been revealed using a detailed analysis of indices of the blood circulation at the stage of decompensation: I--marked retardation of the capillary blood flow; II--the presence of arteriolovenular shunting. Radionuclide methods make it possible to unravel some problems related to the pathogenesis of disease and to obtain additional diagnostic information on radiopaque and ultrasonic investigations.

Topics: Adult; Hemodynamics; Humans; Microcirculation; Middle Aged; Radionuclide Angiography; Sodium Pertechnetate Tc 99m; Technetium Tc 99m Aggregated Albumin; Varicose Veins

Topics: Acupuncture Therapy; Adolescent; Adult; Aged; Female; Humans; Injections, Subcutaneous; Leg; Male; Middle Aged; Predictive Value of Tests; Radionuclide Angiography; Sodium Pertechnetate Tc 99m; Thrombophlebitis; Varicose Veins; Veins

A case of severe, recurrent, macroscopic hematuria in which the diagnosis of renal vein varices was suggested by Tc-99m red blood cell blood pool imaging is described. Current diagnostic modalities are discussed and an integrated use of this test is proposed.

Topics: Adult; Erythrocytes; Hematuria; Humans; Male; Radionuclide Imaging; Renal Veins; Sodium Pertechnetate Tc 99m; Varicose Veins