sodium-pertechnetate-tc-99m and Transposition-of-Great-Vessels

We assessed the utility of equilibrium radionuclide ventriculography for assessing function of the systemic right ventricle by comparing it with cardiovascular magnetic resonance (CMR) in subjects who had undergone the Mustard or Senning operations for complete transposition of the great arteries. The 95% limits of agreement for right ventricular ejection fraction by the 2 techniques were 15.8% to -16.0%, demonstrating that equilibrium radionuclide ventriculography has good agreement with CMR and provides a good alternative in cases in which CMR is not available or appropriate.

Topics: Adolescent; Adult; Aftercare; Female; Gated Blood-Pool Imaging; Humans; Magnetic Resonance Imaging; Male; Observer Variation; Postoperative Care; Prospective Studies; Radiopharmaceuticals; Severity of Illness Index; Single-Blind Method; Sodium Pertechnetate Tc 99m; Stroke Volume; Transposition of Great Vessels; Ventricular Function, Left; Ventricular Function, Right

With first-pass radionuclide angiography, it is possible to visualize sequentially the cardiovascular structures and to obtain computer-generated time-activity curves for regions of interest over these structures. Analysis of these curves permits the detection, localization, and quantitation of intracardiac shunts and shunts between the great arteries. The authors present the formulae used for the quantitative analysis and discuss clinical applications.

Topics: Ductus Arteriosus, Patent; Electrocardiography; Heart Defects, Congenital; Heart Septal Defects, Atrial; Heart Septal Defects, Ventricular; Hemodynamics; Humans; Infant; Infant, Newborn; Models, Cardiovascular; Postoperative Complications; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Tetralogy of Fallot; Transposition of Great Vessels