sodium-pertechnetate-tc-99m and Syndrome

Patients with Turner syndrome (TS) frequently exhibit transient, recurrent and asymptomatic variations of TSH and/or thyroid hormones (TH). This work was carried out to evaluate thyroid function and structure in patients with TS who had had such variations in hormone concentrations. Our sample comprised 24 patients, 17 less than 20-years old. Evaluation included serum levels of TSH, free T4, total T3, TPO and Tg autoantibodies, thyroid ultrasound (US) and scintigraphy with 99mTc-pertechnetate. Thirteen patients had abnormal TSH and/or TH levels; 23 exhibited US features compatible with chronic thyroid disorder, particularly thyromegaly (established according to volume expected for stature) and heterogeneous echogenicity. Uptake was normal in 21 cases and tracer distribution was homogeneous in 22. The finding of abnormal hormone concentrations was independent of age, length of time since the first similar finding, thyroid autoantibodies, number of abnormalities at US and abnormal scintigraphic findings. Patients aged more than 20 years had higher frequency of thyroid antibodies and heterogeneous echogenicity, and thyroid volume was significantly correlated to length of time since detection of the first hormone variation, indicating progressive thyroid disease. These results suggest that subclinical thyroid dysfunction in TS is due to chronic autoimmune thyroid disease.

Topics: Adolescent; Adult; Autoantibodies; Child; Child, Preschool; Female; Humans; Infant; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Syndrome; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroiditis, Autoimmune; Thyrotropin; Thyroxine; Triiodothyronine; Turner Syndrome; Ultrasonography

A newborn infant with tetralogy of Fallot and absent pulmonary valve was successfully corrected in two stages. Absent pulmonary valve syndrome presenting in early infancy manifests severe respiratory symptoms that still make challenging both management and surgical treatment. This is ascribed to tracheobronchial compression by the extremely dilated pulmonary arteries, and to the resultant pulmonary obstructive lesions. We report herein the first findings of 99mTechnegas ventilation lung scanning in an infant with the syndrome to assess the pulmonary obstructive lesions.

Topics: Graphite; Humans; Infant Welfare; Infant, Newborn; Lung; Male; Pulmonary Valve; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Syndrome; Tetralogy of Fallot; Ventilation-Perfusion Ratio

The authors examined 15 patients with the syndrome of Morris by gamacamarated scintigraphy and they succeeded in depicting the gonads, found in the abdomen and their topographic localization. Grave structural changes were established in the testes during the performance of gamacamerated scintigraphy, but in 3 patients only one testis was depicted, which suggested atrophy and lack of functional parenchyma in the gonad, which was not discovered. Conclusive scintigraphic examination of topographic localization as well as of structural disturbances of the parenchyma of the testis replaced testicular biopsy, which requires laparotomy. Gamacamerated scintigraphy could establish malignant growth of the gonad and could help to remove it in time by operation.

Topics: Adolescent; Adult; Androgen-Insensitivity Syndrome; Child; Child, Preschool; Gamma Cameras; Humans; Male; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Syndrome; Testis

A dynamic gamma-camera scintigraphy is proposed as a combined method, providing morphological and functional picture for the presence of eventual pathological changes in the region of ovaries. After detailed description of the method results from the examination of 45 women are presented: 35 suffered from diseases, involving adnexal region and 10--are controls. It is established that normal ovaries are visualized medially from the large iliac vessels as clear, ovally formed homogeneous cumulation of radionuclide. No such cumulation is observed after lack of ovarian parenchyma or after not well made perfusion. The method has serious advantages, when anomalies in the development of ovaries are search for as well as in diseases, changing form and size of the ovary (deformation, lack of homogeneity, ect.). A method is proposed for its advantage that it is not invasive, the examination is performed easily and is safe for patients.

Topics: Adolescent; Adult; Amenorrhea; Estrogens; Female; Gamma Cameras; Humans; Menstruation Disturbances; Ovariectomy; Ovary; Pelvic Inflammatory Disease; Radionuclide Imaging; Scintillation Counting; Sodium Pertechnetate Tc 99m; Syndrome

The combination of a missing ovary and uterine tube on the one side (the syndrome of Slotnik-Goldfarb) with ipsilateral absence of the uterine horn is a rare anomaly, undescribed in our obstetric-gynecological literature. The difficulties in the diagnosis of this anomaly are connected with the necessity to use invasive methods for establishment of respective changes. The method was used in a woman, suffering from sterility, in connection with examining the possibilities of dynamic gamma-camera scintigraphy to discover ovarian parenchyma. Hysterosalpingography proved the presence of a hypoplastic uterine horn on the right side, an uterine tube on the same side (changed and nonpatent). Dysovulatory syndrome was established in this woman clinically. The performed scintigraphy confirmed the presence of ovarian parenchyma on the right side as well as a hypoplastic uterine horn and uterine tube and complete lack of accumulation of radionuclide on the left side, which suggested absence of ovarian parenchyma in the sideé in which the uterine horn and uterine tube were undeveloped as well. It is evaluated that the scintigraphic technique, described by the authors, could be used for establishment of such rare anomalies by noninvasive way.

Topics: Adult; Female; Gamma Cameras; Humans; Infertility, Female; Ovary; Radionuclide Imaging; Scintillation Counting; Sodium Pertechnetate Tc 99m; Syndrome; Uterus

Topics: Adenoma; Adolescent; Choristoma; Diagnosis, Differential; Female; Humans; Hyperthyroidism; Iodine Radioisotopes; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Syndrome; Thyroid Gland; Thyroid Neoplasms; Ultrasonography

Radionuclide thyroid imaging was performed in 872 consecutive patients with hyperthyroidism. Of these, 84% were found to have diffuse toxic hyperplasia (Graves' disease), while 12% had autonomously functioning nodules (Plummer's disease), 3% had Graves' disease developing in a multinodular gland, and in the remaining 1%, either a clear diagnosis could not be established or the hyperthyroidism was due to thyroiditis or the Jod-Basedow phenomenon. It was found that a thyroid scan seldom provides additional diagnostic information in patients with Graves' disease when a diffuse goitre is present. However, if patients are to be treated with radioiodine (131I), thyroid imaging with tracer quantitation can replace a 24-h 131I uptake measurement, this having the advantages that the patients are required to attend only once, and that the gland size can be measured. In addition, visual confirmation of tracer uptake by the thyroid is obtained and patients with thyroiditis will not receive inappropriate therapy. When single or multiple thyroid nodules are palpated, a thyroid scan is crucial in establishing an accurate diagnosis, as it is not otherwise possible to differentiate between Plummer's disease and Graves' disease developing in a multinodular gland. Indeed, in 20 of our 63 patients (32%) with single autonomously functioning nodules, the initial clinical assessment had been incorrect.

Topics: Adenoma; Adolescent; Adult; Aged; Child; Diagnosis, Differential; Female; Goiter, Nodular; Graves Disease; Humans; Hyperthyroidism; Male; Middle Aged; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Syndrome; Thyroid Gland; Thyroid Neoplasms

The thesis of primariness of the disease and of its osseous tissue manifestations is discussed on the grounds of the results from a complex study on 3 patients. The periosteal ossifying hyperplasia and disturbances in the osseous tissue structure develop with no other organ symptomatics and in the absence of any changes in the available laboratory and immunological indices. The macromorphological X-ray characteristic corresponds to the radionuclide tests of the study with 99MTc-pertechnetate, 99MTc-pyrophosphate and 99MTc-sulfocolloid, informing about abnormal vascularization index, growth of bone-marrow tissue and intensified joint-tissue anabolism.

Topics: Adult; Arthrography; Diphosphates; Humans; Joints; Middle Aged; Osteoarthropathy, Primary Hypertrophic; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Syndrome; Technetium; Technetium Tc 99m Pyrophosphate; Technetium Tc 99m Sulfur Colloid

Topics: Femoral Vein; Humans; Iliac Vein; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Syndrome; Technetium; Thrombophlebitis

First pass radionuclide angiocardiography was utilized to calculate right and left ventricular ejection fraction in 74 infants and children. For the synchronization of radionuclide imaging with the cardiac cycle, the peaks and valleys of corrected ventricular time activity curve were adopted as the time reference points instead of R wave of electrocardiogram. Left ventricular ejection fractions obtained by the radionuclide technique correlated well with those derived from the contrast angiographic technique (r = 0.90), but right ventricular ejection fractions correlated less well (r = 0.74). This noninvasive technique appeared useful for evaluation of right and left ventricular ejection fraction.

Topics: Aortic Valve Insufficiency; Aortic Valve Stenosis; Cardiac Output; Cardiomyopathies; Child; Child, Preschool; Female; Heart Defects, Congenital; Heart Diseases; Humans; Infant; Male; Mitral Valve Insufficiency; Mucocutaneous Lymph Node Syndrome; Pulmonary Valve Insufficiency; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Stroke Volume; Syndrome; Technetium

The clinical picture of ulcerated purple plaques on the legs often suggests several diagnoses: Kaposi's sarcoma, stasis dermatitis, atrophie blanche (livedoid vasculitis), and a poorly understood condition called acroangiodermatitis of Favre-Chaix (pseudo-Kaposi's sarcoma). Even the skin biopsy may not always be conclusive. We describe our experience with three patients with pseudo-Kaposi's sarcoma, one with "true" Kaposi's sarcoma and two with atrophie blanche. Clinical and histopathologic similarities among these three conditions pointed up the need for additional confirmatory studies, i.e., isotope scanning. The technetium scan was positive in both Kaposi's sarcoma and pseudo-Kaposi's sarcoma but negative in atrophie blanche.

Topics: Acrodermatitis; Adult; Aged; Diagnosis, Differential; Female; Humans; Male; Radionuclide Imaging; Sarcoma, Kaposi; Skin; Skin Neoplasms; Sodium Pertechnetate Tc 99m; Syndrome; Technetium; Vascular Diseases; Vasculitis