sodium-pertechnetate-tc-99m and Submandibular-Gland-Neoplasms

Topics: 3-Iodobenzylguanidine; Diagnosis, Differential; Humans; Iodine Radioisotopes; Iodobenzenes; Male; Middle Aged; Paraganglioma, Extra-Adrenal; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Submandibular Gland; Submandibular Gland Neoplasms

The usefulness of combined Tc-99m and Ga-67 scans in diagnosing salivary gland disorders was evaluated in a total of 31 patients. Out of 6 patients with Warthin's tumor, 4 showed a typical pattern of high-activity in the gland with retention of Tc-99m, but without an affinity for Ga-67. Out of 9 patients with pleomorphic adenoma, 8 showed a "cold" area in the tumor by Tc-99m and 5 of the 9 patients had accumulated Ga-67. Five of 6 patients with malignant tumor showed an affinity for Ga-67. Nine of 10 patients with sialadenitis showed diffuse uptake of both Tc-99m and Ga-67 in the involved gland. Combined Tc-99m and Ga-67 imaging was useful in detecting the cases of Warthin's tumor and sialadenitis (90% sensitivity and 89% specificity for sialadenitis), but the study had limitations in differentiating malignant tumors from benign tumors (66% sensitivity and 84% specificity). However, Ga-67 imaging showed a 91% negative predictive value. A negative scan could almost rule out the possibility of malignant disease of the salivary gland.

Topics: Adenocarcinoma; Adenolymphoma; Adenoma, Pleomorphic; Adolescent; Adult; Aged; Aged, 80 and over; Child; Citrates; Citric Acid; Female; Humans; Male; Middle Aged; Mixed Tumor, Malignant; Parotid Neoplasms; Radionuclide Imaging; Salivary Gland Diseases; Sialadenitis; Sodium Pertechnetate Tc 99m; Submandibular Gland Neoplasms

Salivary gland cavernous haemangiomas are relatively uncommon in the child and even rarer in the adult, and provide diagnostic difficulties. This paper demonstrates how the diagnosis can be established using sonography and red blood cell (RBC) scintigraphy.

Topics: Adolescent; Adult; Child; Child, Preschool; Erythrocytes; Female; Hemangioma, Cavernous; Humans; Infant; Male; Middle Aged; Parotid Neoplasms; Radionuclide Imaging; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m; Submandibular Gland Neoplasms; Ultrasonography

Topics: Adenolymphoma; Diagnosis, Differential; Humans; Iodine Radioisotopes; Male; Middle Aged; Radionuclide Imaging; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m; Submandibular Gland Neoplasms; Technetium

Salivary gland imaging with 99mTc as pertechnetate provides functional information concerning trapping and excretion of the parotid and submandibular glands. Anatomic information gained often adds little to clinical evaluation. On the other hand, functional information may detect subclinical involvement, which correlates well with biopsy of the minor labial salivary glands. Salivary gland abnormalities in systemic disease such as sarcoidosis, rheumatoid arthritis, lupus erythematosus, and other collagenvascular disorders may be detected before they result in the clinical manifestaions of Sjögren's syndrome. Such glands, after initially demonstrating increased trapping in the acute phase, tend to have decreased trapping and failure to discharge pertechnetate in response to an appropriate physiologic stimulus. Increased uptake of gallium-67 citrate often accompanies these findings. Inflammatory parotitis can be suspected when increased perfusion is evident on radionuclide angiography with any agent. The ability of the salivary gland image to detect and categorize mass lesions, which result in focal areas of diminished activity such as tumors, cysts, and most other masses, is disappointing, while its ability to detect and categorize Warthin's tumor, which concentrates pertechnetate, is much more valuable, although not specific.

Topics: Adenolymphoma; Humans; Lymphangioma; Parotid Diseases; Parotid Neoplasms; Radionuclide Imaging; Salivary Gland Diseases; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m; Submandibular Gland Diseases; Submandibular Gland Neoplasms; Technetium