sodium-pertechnetate-tc-99m and Salivary-Gland-Neoplasms

Topics: Humans; Radionuclide Imaging; Salivary Duct Calculi; Salivary Gland Calculi; Salivary Gland Neoplasms; Salivary Glands; Sialadenitis; Sodium Pertechnetate Tc 99m; Xerostomia

Topics: Abscess; Adenolymphoma; Adenoma, Pleomorphic; Cysts; Humans; Parotitis; Radionuclide Imaging; Salivary Duct Calculi; Salivary Gland Diseases; Salivary Gland Neoplasms; Salivary Glands; Sialadenitis; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m; Xerostomia

Topics: Adenolymphoma; Adenoma; Carcinoma; Gallium Radioisotopes; Humans; Radionuclide Imaging; Saliva; Salivary Gland Diseases; Salivary Gland Fistula; Salivary Gland Neoplasms; Sialadenitis; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m; Technetium; Tuberculosis, Oral

The aim of this study was to compare dual-isotope (99Tc(m) and 201Tl) SPET imaging with computed tomography (CT) and magnetic resonance imaging (MRI) in the differentiation of various lesions of the major salivary glands. Twenty-two patients underwent dual-isotope SPET imaging, of whom 12 also had CT and 15 also had an MRI study. The uptake ratio and retention index for 99Tc(m) and 201Tl were calculated by drawing regions of interest on the involved and normal glands. Both CT and MRI were interpreted by two radiologists. All malignant tumours were detected by all three modalities. Warthin's tumours were detected by dual-isotope SPET imaging; however, MRI failed to differentiate Warthin's tumour from pleomorphic adenoma. Of 13 other benign tumours, dual-isotope SPET correctly diagnosed 12. Of 16 tumours showing a cold defect on the 99Tc(m) images, parametric analysis with 201Tl gave an accuracy of 94%, whereas CT gave an accuracy of 70-90%. MRI was 73-91% accurate in differentiating between benign (Warthin's) and malignant tumours. We believe that dual-isotope SPET imaging (99Tc(m) and 201Tl), together with semi-quantitative analysis, is the method of choice for differentiating between various lesions of the major salivary glands.

Topics: Adenolymphoma; Adolescent; Adult; Aged; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Prospective Studies; Radiopharmaceuticals; Salivary Gland Diseases; Salivary Gland Neoplasms; Salivary Glands; Sialadenitis; Sodium Pertechnetate Tc 99m; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Topics: Adult; Aged; Deep Learning; Feasibility Studies; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Neural Networks, Computer; Parotid Gland; Radiopharmaceuticals; Salivary Gland Calculi; Salivary Gland Neoplasms; Single Photon Emission Computed Tomography Computed Tomography; Sodium Pertechnetate Tc 99m; Thyroid Neoplasms

Warthin's tumors and oncocytomas show exceptionally good (99m)TcO4(-) (Tc) accumulation images in Tc scintigraphy. However, the mechanism of Tc accumulation in these tumors remains unclear. Sodium-iodide symporter (NIS) is a plasma membrane protein expressed in the thyroid, lactating breast, stomach and salivary glands; it facilitates uptake of I(-) and Tc. We hypothesized that Warthin's tumor cells and oncocytomas may also express NIS, which would promote uptake of Tc. We examined NIS localization and the mechanism of Tc accumulation in various salivary gland tissues.. Immunohistological localization of NIS was performed for 19 tumors from 18 patients who underwent preoperative Tc scintigraphy. Expression of mRNA for NIS in the normal salivary gland, Warthin's tumors and pleomorphic adenomas was analyzed by real-time PCR.. In normal salivary glands, striated duct cells were strongly immunostained by anti-NIS antibodies. In Warthin's tumors, eosinophilic epithelial cells exhibited positive immunostaining, but their staining was varied among the cases. Furthermore, all Tc-positive specimens were NIS-positive, and all Tc-negative specimens were NIS-negative. Real-time PCR showed that NIS mRNA expression was detectable in normal salivary glands and Warthin's tumor cells. The expression was significantly higher in normal salivary glands compared with Warthin's tumor cells and pleomorphic adenoma.. Tc-positive salivary glands expressed NIS. Our findings suggest that Tc accumulation in Warthin's tumors and oncocytomas is due to poorer Tc excretory function compared with normal salivary gland tissues, in addition to active uptake of (99m)TcO4(-) via NIS.

Topics: Adenolymphoma; Adenoma; Adenoma, Oxyphilic; Adenoma, Pleomorphic; Carcinoma, Acinar Cell; Carcinoma, Mucoepidermoid; Humans; Immunohistochemistry; Lymphoma; Radionuclide Imaging; Radiopharmaceuticals; RNA, Messenger; Salivary Gland Neoplasms; Salivary Glands; Sodium Pertechnetate Tc 99m; Symporters

A 61-year-old man with medullary thyroid carcinoma and local invasion of the left lobe of the thyroid had Tc-99m MIBI SPECT and Tl-201 chloride/Tc-99m pertechnetate subtraction SPECT after left lobectomy of the thyroid, using a triple-headed gamma camera. Tl-201 chloride/Tc-99m pertechnetate subtraction demonstrated a large mass with high Tl-201 uptake in the left neck. Although there was intense uptake in the tumor in the left thyroid bed on Tc-99m MIBI neck SPECT, there was also uptake in both salivary glands and the right lobe of the thyroid gland. Thus, uptake in the right lobe of the thyroid gland and the salivary glands might not be differentiated from tumor invasion or metastasis from medullary cell carcinoma. Compared with MIBI SPECT, Tl-201 chloride/Tc-99m pertechnetate subtraction SPECT shows more apparent delineation of tumor uptake and may be a preferable technique.

Topics: Carcinoma, Medullary; Humans; Male; Middle Aged; Neoplasm, Residual; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m; Subtraction Technique; Technetium Tc 99m Sestamibi; Thallium; Thallium Radioisotopes; Thyroid Neoplasms; Tomography, Emission-Computed, Single-Photon

We investigated and compared findings on combined 99mTc pertechnetate-201Tl with those of [99mTc]pertechnetate-67Ga scintiscans to elucidate the advantages of 201Tl in detecting various salivary glands disorders.. We studied 23 patients: 6 had sialadenitis, 12 had benign tumors and 5 had malignant tumors. All but four patients had undergone [99mTc]pertechnetate (before and after lemon stimulation), 201Tl (early and delayed) and 67Ga imaging.. Five of six sialadenitis patients showed various degrees of diffuse uptake of 99mTc. All six except one showed early uptake without retention of 201Tl on delayed imaging. The 67Ga scan showed uptake in all patients except one. Nine of 12 benign tumors showed a cold defect on 99mTc scans. Patients with Warthin's tumors and plasmacytoma showed increased 99mTc uptake at the tumor with retention. The 201Tl scan showed early uptake without retention in benign tumors except in three patients, two of whom had Warthin's tumor. Five of the benign tumors, however, were positive on 67Ga scan. None of the malignant tumors showed any uptake of 99mTc. The 201Tl scan showed uptake with tumor retention on delayed images in three patients; three other patients also had positive 67Ga scans. Overall, sensitivity and specificity of 201Tl in detecting malignant tumors were 60% and 73%, respectively, with a negative predictive value of 85%. Sensitivity and specificity for 67Ga were 60% and 47%, respectively, with a negative predictive value of 80%.. In view of sensitivity, specificity and convenience of 201Tl as well as future prospects for dual-isotope acquisition, 67Ga may be replaced by 201Tl in detecting salivary gland disorder.

Topics: Adult; Aged; Aged, 80 and over; Female; Gallium Radioisotopes; Humans; Male; Middle Aged; Predictive Value of Tests; Radionuclide Imaging; Salivary Gland Neoplasms; Salivary Glands; Sensitivity and Specificity; Sialadenitis; Sodium Pertechnetate Tc 99m; Technetium; Thallium Radioisotopes

Salivary gland cavernous haemangiomas are relatively uncommon in the child and even rarer in the adult, and provide diagnostic difficulties. This paper demonstrates how the diagnosis can be established using sonography and red blood cell (RBC) scintigraphy.

Topics: Adolescent; Adult; Child; Child, Preschool; Erythrocytes; Female; Hemangioma, Cavernous; Humans; Infant; Male; Middle Aged; Parotid Neoplasms; Radionuclide Imaging; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m; Submandibular Gland Neoplasms; Ultrasonography

An original method of sialoscintigraphy was used to investigate the structure and function of the unchanged salivary glands in 108 patients and in 192 patients with various diseases of the salivary glands (chronic interstitial sialadenitis, chronic parenchymatous sialadenitis, chronic sialadenitis, reactive-dystrophic diseases and tumors. The data obtained are of great importance for the diagnosis and differential diagnosis of salivary gland diseases as well as for the evaluation of effectiveness of therapeutic measures.

Topics: Chronic Disease; Diagnosis, Differential; Humans; Methods; Radionuclide Imaging; Salivary Gland Diseases; Salivary Gland Neoplasms; Salivary Glands; Sialadenitis; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m; Time Factors

Thirty-two patients with salivary gland tumors or sialadenitis were studied with Tc-99m pertechnetate and Ga-67 imaging and, in some instances, sialography. The diagnostic algorithm presented allows the correct categorization of the salivary gland pathology in the vast majority of patients. The patients were studied serially with Tc-99m pertechnetate, Ga-67 and in certain situations sialography (or CT-sialography). Use of the algorithm can distinguish benign salivary tumors from malignant tumors and malignant tumors from inflammatory disease. The limitations and pitfalls of interpretation are discussed.

Topics: Adult; Aged; Child; Diagnosis, Differential; Female; Gallium Radioisotopes; Humans; Male; Middle Aged; Radionuclide Imaging; Salivary Gland Calculi; Salivary Gland Diseases; Salivary Gland Neoplasms; Salivary Glands; Sialadenitis; Sialography; Sodium Pertechnetate Tc 99m; Tomography, X-Ray Computed

Topics: Humans; Radionuclide Imaging; Salivary Gland Diseases; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m

Topics: Adenolymphoma; Adenoma; Adult; Aged; Female; Humans; Male; Middle Aged; Radionuclide Imaging; Salivary Gland Neoplasms; Salivary Glands; Sodium Pertechnetate Tc 99m; Subtraction Technique

A special background subtraction in dynamic scintigraphy of the salivary glands enables the production of net-time-activity-curves and the calculation of quantitative parameters of each gland. Regional functional differences within a single gland are shown by phase and gradient images. The physiological kinetics of the tracer and its modifications in different diseases of the glands (acute and chronic inflammation, tumours, Sjögrens-Syndrome) are analyzed in 367 patients.

Topics: Adenoma; Carcinoma, Adenoid Cystic; Chronic Disease; Humans; Radionuclide Imaging; Salivary Gland Diseases; Salivary Gland Neoplasms; Sialadenitis; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m

Sialographic investigation of enlarged salivary glands contribute to the important decision whether a secretion blockage is caused by a stone, chronic inflammation, sialoadenosis, or a tumour. The results of sialographic investigations have been much improved by the method described by Brands and Schnepper (1967) of specific serial sialography using a single-shot and fast-repeating camera, under fluoroscopic control. The success rate of the sialographic diagnosis on 141 patients in the ENT Department of Saarland University Hospital was 80%. The fact that in four cases spaces, occupying lesions were falsely interpreted or undetected leads to the conclusion that where a tumour is suspected negative sialography should be followed by further diagnostic steps. Scintigraphy of the salivary glands with 4 mCi 99mTechnetium Pertechnetate produces extra information which clearly increases diagnostic accuracy. However, experience to date shows that it is not an alternative to serial sialography but rather a supporting diagnostic method.

Topics: Adult; Female; Humans; Male; Middle Aged; Parotid Neoplasms; Radionuclide Imaging; Salivary Gland Diseases; Salivary Gland Neoplasms; Sialadenitis; Sialography; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m; Technetium

Topics: Adenolymphoma; Diagnosis, Differential; Humans; Iodine Radioisotopes; Male; Middle Aged; Radionuclide Imaging; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m; Submandibular Gland Neoplasms; Technetium

The clinical efficacy of salivary gland scintigraphy was evaluated in 32 histologically proven cases. In benign tumors, except Warthin's tumor, 16 of the 20 cases (80%) appeared as cold lesions. All six cases of Warthin's tumor appeared as hot lesions. In malignant tumors, one case each of mucoepidermoid carcinoma, adenopapillary carcinoma, and adenoid-cystic carcinoma were shown as cold lesions, while squamous cell carcinoma and malignant mixed tumor were delineated as a defect image (no uptake of radionuclide). On stimulation with ascorbic acid, retention of radionuclide within the tumor was noted only in Warthin's tumors, but it was noted at the periphery of the tumors in 21 of the 24 cases (87.5%), which might be due to inflammation and/or compression of the gland by the tumors. Salivary gland scintigraphy provided useful information for the evaluation of the site of the tumor and the function of the salivary gland.

Topics: Adenolymphoma; Adenoma, Pleomorphic; Adult; Aged; Carcinoma, Squamous Cell; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Parotid Neoplasms; Radionuclide Imaging; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m; Technetium

Topics: Humans; Parotid Gland; Prospective Studies; Radionuclide Imaging; Salivary Duct Calculi; Salivary Gland Diseases; Salivary Gland Neoplasms; Sialadenitis; Sodium Pertechnetate Tc 99m; Submandibular Gland; Technetium

Topics: Adenolymphoma; Humans; Male; Middle Aged; Radionuclide Imaging; Salivary Gland Neoplasms; Salivary Glands; Sodium Pertechnetate Tc 99m; Technetium

Topics: Carcinoma; Female; Humans; Middle Aged; Radionuclide Imaging; Salivary Gland Neoplasms; Sodium Pertechnetate Tc 99m; Sublingual Gland; Technetium