sodium-pertechnetate-tc-99m and Retroperitoneal-Neoplasms

We have studied 181 patients with germ-cell tumours of the testis. The first group comprised 80 persons without evidence of metastasizing into retroperitoneal lymph nodes; the second group included 101 patients with germinal testicular tumours metastasizing into regional lymph nodes. Eighty patients were subjected to transperitoneal lymphadenectomy which allowed comparison of the results of lymphoscintigraphy (negative radionuclide diagnosis with colloid agents labelled with gold and technetium positive radionuclide diagnosis with 99mTc-pertechnetate) with the findings of histologic examination. We demonstrated high significance of lymphoscintigraphic methods: sensitivity 83%, specificity 90.9%, significance 86.2%. It was found that information obtained with lymphoscintigraphy can serve as clinical guidelines in determining the site, size and spread of metastasizing, which is very important in choosing fields of irradiation. Lymphoscintigraphy in testicular tumours enables more accurate staging and radicality of lymphadenectomy at different time intervals after surgery.

Topics: Adolescent; Adult; Combined Modality Therapy; Follow-Up Studies; Germinoma; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Radionuclide Imaging; Reproducibility of Results; Retroperitoneal Neoplasms; Sensitivity and Specificity; Sodium Pertechnetate Tc 99m; Testicular Neoplasms

In static scintigraphy with 99m Tc-pertechnetate of primary lesions of the retroperitoneal space in children 4 types of scintigraphic pictures were singled out for differential diagnosis of Wilms' tumors, avascular benign lesions of the retroperitoneal space and neurogenic retroperitoneal tumors. The sensitivity of diagnosis of Wilms' tumor was 92.6%, specificity 90.9%. The most objective and complete information on the kidney involvement in tumor process could be obtained in static scintigraphy with 99m Tc-pertechnetate combined with scintigraphy with 99m Tc-gluconate or 99m Tc-pyrophosphate. The sensitivity of diagnosis of secondary lesions of the lymph nodes of the retroperitoneal space was 76.8%.

Topics: Adolescent; Child; Child, Preschool; Diphosphates; Gluconates; Humans; Infant; Kidney Neoplasms; Organotechnetium Compounds; Radionuclide Imaging; Retroperitoneal Neoplasms; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Pyrophosphate; Wilms Tumor