sodium-pertechnetate-tc-99m and Psoriasis

Topics: Arthritis; Diphosphates; Humans; Joints; Psoriasis; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Arthritis; Diphosphates; Humans; Joints; Psoriasis; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium; Technetium Tc 99m Pyrophosphate

A juxtaposition between the clinical-laboratory, immunologic and radionucleotide articular parameters was performed in 50 patients with psoriatic arthropathy, distributed according to the incidence of X-ray manifestations. The late and moderate changes in ESK, leukocytes, fibrinogen, DPA and phosphatasemia do not characterize the severity of the disease. A tendency to hyperuricemia and hypercalcemia is established in the period of arthralgia before the X-ray image for bone-tissue damage. The genetic HLA-B27 predetermination plays a certain role for the more frequent involvement of the spine and sacroiliac joints in the pathological process. The disturbances in the immune system are manifested with increased number of early T-lymphocytes, FcG-receptor lymphocytes, complement (C3b)--receptor lymphocytes and spontaneously blast-transformed cells. The increasing IgG content correlates with the accumulation of macromorphological X-ray images and with the index of mineral metabolism from the articular study with 99MTc-pyrophosphate. The changes in the pertechnetium index for articular vascularization are quantitatively insignificant and do not allow the joining of the psoriatic arthropathy to the group of primary synoviarthritis. The accumulation of technetium pyrophosphate in the articular structures is asymmetric, focal and precedes the changes in the X-ray image.

Topics: Adult; Alkaline Phosphatase; Arthritis; Blood Proteins; Blood Sedimentation; Calcium; Diphosphates; Female; Fibrinogen; Humans; Leukocyte Count; Male; Middle Aged; Psoriasis; Sodium Pertechnetate Tc 99m; T-Lymphocytes; Technetium; Technetium Tc 99m Pyrophosphate; Uric Acid

Application of scintigraphic techniques, especially bone scintigraphy, to a group of unselected psoriatic patients provided us with new knowledge about frequency, dimension, and valence of psoriatic osteoarthropathy. Thus scintigraphy was able to prove up to 90% of the incidences, whereas clinical and radiological investigation only revealed 7%. This result was achieved on account of better registration of the polytopical character as well as the evidence of potential early manifestations which could not be detected clinically or radiologically. In addition, we proved extraarticular manifestations of psoriatic osteopathy, especially in the skull, the long marrow bones, the ribs, and the distal phalanges.

Topics: Bone and Bones; Collagen; Humans; Joints; Osteoarthritis; Phosphates; Psoriasis; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium; Technetium Compounds